EKS-EQC-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	387.3	3.7E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSECAP00000006262

UniProt Accession

F6TBK5;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008187	ENSECAP00000006262	ENSECAT00000008372

Organism

Equus caballus

Functional Description

Protein Length

894

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLTGRPP FDTDTVKNTL NKVVLADYKM PTFLSREAKD 240

LIHHLLRRNP ADRLSLSSVL EHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAVTASSST 300

SMSGSLFDRR RLLIGQPLPN KMTIFPKSKI ANDFSSSGDG SSFYTQWGNQ EQEISNSGRG 360

RVIQDAEERP HSRYLRRAHS SDRSGTSNTQ SPGKTYTMER CHSAEVLSKS KRSGVDENEE 420

RYSPTNSNVN IFHFFKEKAS NCSGSFERPD NDQALSNRLC PGKTPFPFPD QISQTEMVQQ 480

WFGNLQVKDP LSEQSKTRDM EPPVGYQKHT LRSITSPLTA YRLKPIRQKT KKAVVSILDS 540

EEVCVELLKE FTSQEYVKEV LQISSDGNMI TIYYPNDGRG FPLAERPPSP TDNISRYSFD 600

SLPEKYWRKY QYASRFVQLV RSKSPKITYF TRYAKCVLME NSPGADFEVW FYDGAKIHKT 660

EDLIHVIEKT GKSYTLKGES EVNSLKEELK IYMDHANEGH RICLALESII SEEENKSGGA 720

PFFPIIIGRK PGNTSSPKAL SPTPSVDPNY PMRERPSLNR MIINSAASSK QVPILSPSTV 780

TGEGLGATAL ASGTSISPSG VNDCLPKSAQ LLKSVFVKNV GWATQLTSGA VWVQFNDGSQ 840

LVVQAGVSSI SYTSPNGHTT RYGENEKLPE YIKQKLQCLS SILLMFSNPT PGFH 894

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTAGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAGCATCCT TCTATCTTGG AGTTGTATAA CTATTTTGAA 240

GATAACAATT ATGTGTACCT AGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAACA GAATGAAACC ATTCTCAGAA AATGAAGCTC GACACTTCAT GCACCAGATC 360

ATCACAGGAA TGTTATATCT CCATTCTCAT GGTATATTAC ACCGGGACCT CACGCTTTCT 420

AACCTCTTAC TTACGCGTAA TATGAACATC AAGATTGCCG ATTTTGGGCT GGCAACTCAA 480

TTGAAAATGC CACATGAAAA ACACTATACT TTATGTGGAA CTCCTAATTA CATTTCACCA 540

GAGATTGCAA CTCGAAGTGC ACATGGTCTT GAATCTGATG TTTGGTCCTT GGGCTGTATG 600

TTTTATACGT TGCTTACTGG GAGACCACCT TTTGACACGG ACACAGTTAA GAACACCTTA 660

AATAAAGTAG TATTGGCAGA TTACAAAATG CCAACTTTTT TGTCAAGAGA GGCCAAGGAC 720

CTTATTCACC ACTTACTTCG TAGAAACCCA GCAGATCGTT TAAGTCTGTC TTCAGTGTTA 780

GAGCATCCTT TTATGTCCCG GAATTCTTCA ACAAAAAGTA AAGATTTAGG AACTGTGGAA 840

GACTCAATTG ATAGTGGACA TGCCACCATT TCTACTGCTG TTACGGCTTC TTCCAGTACC 900

AGTATGAGTG GTAGTTTATT TGACAGAAGA AGGCTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTA TTTTTCCAAA GAGTAAAATT GCAAATGATT TTTCTTCTTC AGGAGATGGA 1020

AGCAGTTTTT ATACTCAGTG GGGAAATCAA GAACAAGAAA TCAGTAATAG TGGAAGGGGA 1080

AGAGTAATCC AAGATGCAGA AGAAAGGCCA CATTCCCGCT ACCTTCGTAG AGCCCATTCC 1140

TCTGATAGAT CTGGCACTTC TAACACTCAG TCTCCAGGAA AAACGTATAC AATGGAACGA 1200

TGTCACTCAG CAGAAGTGCT TTCAAAATCC AAAAGATCAG GAGTAGATGA AAATGAAGAA 1260

CGATACTCAC CCACAAACAG CAATGTCAAT ATTTTTCACT TCTTTAAAGA AAAGGCATCC 1320

AATTGTTCTG GATCTTTTGA AAGACCTGAT AATGATCAAG CACTTTCCAA TCGTCTTTGT 1380

CCAGGAAAAA CTCCTTTTCC ATTTCCAGAC CAGATATCTC AAACTGAAAT GGTGCAACAG 1440

TGGTTTGGGA ATCTGCAAGT AAAAGATCCT CTTTCTGAAC AAAGCAAGAC TAGGGATATG 1500

GAGCCACCAG TGGGTTATCA GAAACATACG TTACGAAGCA TTACGTCTCC TTTGACTGCT 1560

TACAGGTTAA AACCAATCAG ACAGAAAACC AAAAAGGCTG TGGTGAGCAT ACTTGATTCA 1620

GAGGAGGTAT GTGTGGAGCT TCTAAAGGAG TTTACATCTC AAGAATATGT GAAAGAAGTT 1680

CTTCAAATAT CTAGTGATGG AAATATGATC ACTATTTATT ATCCAAATGA TGGGAGAGGT 1740

TTTCCTCTTG CTGAGAGACC ACCCTCTCCT ACTGACAACA TCAGTAGGTA CAGCTTTGAC 1800

AGTTTACCAG AAAAGTACTG GCGAAAATAT CAATATGCTT CCAGATTTGT ACAGCTTGTA 1860

AGATCTAAAT CTCCCAAAAT CACTTATTTT ACAAGATATG CTAAATGTGT TTTGATGGAG 1920

AATTCTCCTG GTGCTGATTT TGAGGTTTGG TTTTATGATG GAGCAAAGAT ACACAAAACA 1980

GAAGATTTAA TTCATGTTAT TGAAAAGACT GGGAAATCTT ACACCTTAAA AGGTGAAAGT 2040

GAAGTTAATA GCTTGAAAGA GGAACTAAAA ATTTATATGG ACCATGCTAA TGAGGGTCAT 2100

CGTATTTGTT TAGCACTAGA ATCCATAATT TCAGAAGAGG AAAACAAAAG TGGAGGTGCT 2160

CCCTTTTTCC CAATAATCAT AGGAAGAAAA CCTGGTAATA CTAGTTCACC TAAGGCCTTA 2220

TCACCTACTC CTTCTGTGGA TCCAAACTAC CCAATGAGAG AGAGACCATC TTTGAATAGA 2280

ATGATCATAA ATAGTGCTGC TTCTTCGAAA CAGGTGCCGA TACTTAGTCC TTCTACGGTT 2340

ACAGGTGAAG GACTTGGCGC CACAGCTCTG GCCTCCGGAA CAAGCATCTC TCCTAGTGGT 2400

GTGAACGATT GTCTTCCTAA ATCAGCACAA CTTTTGAAGT CTGTTTTTGT GAAAAATGTT 2460

GGTTGGGCTA CACAGTTAAC TAGTGGAGCT GTGTGGGTTC AGTTTAATGA TGGGTCCCAG 2520

TTGGTTGTCC AGGCAGGAGT GTCTTCTATC AGTTATACAT CCCCAAATGG TCACACAACT 2580

AGGTATGGAG AAAATGAAAA ATTACCAGAA TACATCAAAC AGAAATTACA GTGTCTTTCT 2640

TCCATCCTTT TGATGTTTTC TAATCCAACT CCTGGTTTTC ACTGA 2685

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIITGMLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLTGRPPFDTDTVKNTLNKVVLADYKMPTFLSREAKDLIHHLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLEHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLTGRPPF DTDTVKNTLN KVVLADYKMP TFLSREAKDL IHHLLRRNPA 240

DRLSLSSVLE HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013