EPS-EQC-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.0	1.8E-56	78	331	254

Status

Unreviewed

Ensembl Protein

ENSECAP00000006248

UniProt Accession

F6TCY7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008191	ENSECAP00000006248	ENSECAT00000008356

Organism

Equus caballus

Functional Description

Protein Length

601

Protein Sequence
(FASTA)

NCPSFLAAAL ARATSDEVLQ SDLSAHYIPK ETDGTEGTVE IETVKLARSV FSKLHEICCS 60

WVKDFPLRRR PQLYYETSIH AIKNMRRKME DKHVCIPDFN MLFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNLVRQ EMFPHDPAEA LCRAFRVTDE RFVQKAARES LRCGTTGVVT 180

FIRGNMLHVA WVGDSQVMLV RKGQAVELMK PHKPDREDEK QRIEALGGCV VWFGAWRVNG 240

SLSVSRAIGD AEHKPYICGD ADSASTVLDG TEDYLILACD GFYDTVNPDE AVKVVSDHLK 300

ENNGDSSMVA HKLVASARDA GSSDNITVIV VFLRDMNKAV NVSEESDWTE NSFQGGQEDG 360

GDDKENHGEC KRPWPQHQCS APADLGYDGR VDSFTDRTSL SPGSQINVLE DPGYLDLTQI 420

EASKPQSVQF LPPVEMFGPG APKKANLINE LIMEKKSVQS SLPERSGAGE FPSSFNLGSK 480

GQQIYRMESL SPVCSRLENE QFKFLGKRVS RLSHLRYHYS KRWHGFRFNP KFYSFLSARE 540

PSHKIGTSLF SLIQSGKRNR MLRSSLPWRQ SSWKGCSENM MRKLRKSNDM PYPDLPWSYK 600

I 601

Nucleotide Sequence
(FASTA)

AACTGCCCTT CCTTTTTGGC TGCTGCTTTA GCTAGAGCCA CATCAGACGA AGTGCTTCAG 60

AGTGATCTTT CTGCACATTA TATACCAAAG GAAACAGATG GCACAGAAGG GACTGTGGAG 120

ATTGAGACAG TGAAGTTGGC CCGTTCTGTC TTCAGCAAAC TACACGAGAT TTGCTGCAGC 180

TGGGTGAAAG ACTTCCCTCT CCGCAGGAGA CCCCAGCTTT ATTACGAGAC CTCAATCCAT 240

GCCATCAAGA ACATGCGCAG GAAAATGGAG GACAAACATG TCTGCATTCC TGACTTTAAT 300

ATGCTCTTCA ACCTAGAGGA CCAGGAAGAA CAAGCTTACT TTGCAGTGTT TGATGGCCAT 360

GGGGGAGTGG ATGCTGCCAT TTATGCCTCC ATTCACCTGC ATGTTAACTT AGTACGCCAG 420

GAGATGTTCC CCCACGATCC TGCTGAGGCC CTGTGCCGGG CCTTCCGGGT CACCGATGAG 480

CGGTTTGTGC AGAAAGCAGC CAGGGAGAGC TTAAGATGTG GGACCACAGG AGTGGTGACT 540

TTTATCAGAG GCAACATGCT ACATGTGGCT TGGGTGGGTG ATTCCCAGGT TATGCTTGTG 600

AGAAAGGGCC AAGCTGTTGA ACTAATGAAG CCACATAAAC CGGACAGAGA GGATGAAAAG 660

CAGCGCATTG AGGCCCTTGG AGGTTGTGTA GTCTGGTTTG GTGCCTGGAG GGTGAATGGA 720

AGTCTATCGG TCTCCAGAGC TATTGGAGAT GCTGAACATA AGCCATATAT CTGTGGGGAT 780

GCAGATTCTG CATCTACTGT TTTGGATGGA ACTGAAGACT ACCTCATTCT AGCCTGTGAT 840

GGCTTCTATG ACACCGTGAA TCCCGATGAG GCAGTGAAAG TTGTGTCTGA CCACTTGAAG 900

GAGAATAATG GAGACAGCAG CATGGTTGCC CACAAATTAG TGGCATCAGC TCGTGATGCC 960

GGGTCAAGTG ATAACATCAC TGTTATTGTG GTATTCCTGA GGGACATGAA CAAAGCTGTA 1020

AATGTTAGTG AGGAATCAGA CTGGACAGAG AACTCTTTTC AAGGAGGGCA AGAAGATGGT 1080

GGGGATGATA AGGAGAATCA TGGAGAGTGC AAACGCCCTT GGCCTCAGCA CCAGTGCTCA 1140

GCACCAGCCG ATCTAGGCTA TGATGGGCGT GTGGATTCAT TCACTGATAG AACTAGCCTG 1200

AGCCCAGGGT CCCAAATCAA CGTGCTGGAA GACCCAGGCT ACCTAGATCT CACTCAAATA 1260

GAAGCAAGCA AACCTCAAAG TGTCCAGTTT TTGCCACCAG TTGAGATGTT TGGTCCTGGT 1320

GCACCAAAGA AAGCAAATCT AATTAATGAG CTAATAATGG AGAAAAAATC AGTTCAATCA 1380

TCATTGCCTG AACGGAGTGG TGCTGGAGAG TTTCCCTCTT CTTTTAATTT GGGTTCAAAA 1440

GGGCAACAGA TATACAGAAT GGAGAGCTTG TCTCCTGTCT GTTCTAGGTT GGAAAATGAA 1500

CAGTTCAAAT TCCTGGGAAA GAGAGTTTCT AGATTGTCTC ATTTACGTTA CCACTACTCA 1560

AAGAGGTGGC ATGGATTCAG GTTTAATCCA AAGTTTTATT CATTTCTCTC TGCTCGAGAG 1620

CCTTCCCACA AAATAGGCAC TAGCCTGTTC TCACTTATTC AAAGTGGGAA GAGAAATAGG 1680

ATGTTGAGAA GTTCTCTGCC ATGGAGGCAA AGCAGTTGGA AAGGGTGCAG TGAAAACATG 1740

ATGAGGAAGC TCAGAAAGAG TAACGATATG CCATACCCAG ATCTTCCCTG GAGCTATAAA 1800

ATATAA 1806

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 78    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  137

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 138   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  191

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 192   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  250

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 251   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  310

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 311   HKLVASARDAGSSDNITVIVV  331

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013