EKS-EQC-00138
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00138
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt501.75.0E-151149407259
StatusUnreviewed
Ensembl ProteinENSECAP00000006797
UniProt AccessionF6WGH2;
Protein Name
Protein Synonyms/Alias
Gene NameAKT1
Gene Synonyms/Alias AKT1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000008264ENSECAP00000006797ENSECAT00000009000
OrganismEquus caballus
Functional Description
Protein Length479
Protein Sequence
(FASTA)
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVEQRES PLNNFSVAQC 60
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KRQEEEMDFR 120
SGSPSDNSGA EEMEVSLAKP KHRVTMNEFE YLKLLGKGTF GKVILVKEKA TGRYYAMKIL 180
KKEVIVAKDE VAHTLTENRV LQNSRHPFLT ALKYSFQTHD RLCFVMEYAN GGELFFHLSR 240
ERVFPEDRAR FYGAEIVSAL DYLHSEKNVV YRDLKLENLM LDKDGHIKIT DFGLCKEGIK 300
DGATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MVCGRLPFYN QDHEKLFELI 360
LMEEIRFPRT LSPEAKSLLS GLLKKDPKQR LGGGSEDAKE IMQHRFFASI VWQDVYEKKL 420
SPPFKPQVTS ETDTRYFDEE FTAQMITITP PDQDDTMEGV DSERRPHFPQ FSYSASGTA 479
Nucleotide Sequence
(FASTA)
ATGAACGACG TGGCCATCGT GAAGGAGGGC TGGCTGCACA AACGAGGAGA GTACATCAAG 60
ACCTGGCGGC CCCGGTACTT CCTCCTCAAG AACGACGGCA CCTTCATCGG CTACAAGGAG 120
CGGCCGCAGG ACGTGGAGCA GCGCGAGTCG CCCCTCAACA ACTTCTCGGT GGCACAGTGC 180
CAGCTGATGA AGACGGAGCG GCCCAGGCCC AACACCTTCA TCATCCGCTG CCTGCAGTGG 240
ACCACGGTGA TCGAGCGCAC CTTCCACGTG GAGACGCCCG AGGAGCGGGA GGAGTGGACG 300
ACTGCCATCC AGACAGTGGC TGATGGGCTC AAGAGGCAGG AGGAAGAGAT GGACTTCCGA 360
TCGGGCTCAC CCAGTGACAA CTCTGGGGCC GAGGAGATGG AGGTGTCCCT GGCCAAGCCC 420
AAACACCGTG TGACCATGAA CGAGTTTGAG TACCTGAAGC TCCTGGGCAA AGGCACCTTT 480
GGGAAGGTGA TTCTGGTGAA GGAGAAGGCC ACGGGCCGCT ACTACGCCAT GAAGATCCTG 540
AAGAAGGAAG TCATCGTGGC CAAGGACGAG GTGGCCCACA CGCTCACGGA GAACCGCGTG 600
CTCCAGAACT CCCGGCATCC CTTCCTGACG GCTCTCAAGT ACTCCTTCCA GACCCATGAC 660
CGCCTGTGCT TCGTCATGGA GTACGCCAAC GGGGGCGAGC TCTTCTTCCA CCTGTCCCGG 720
GAGCGCGTGT TCCCCGAGGA CCGGGCCCGC TTTTACGGCG CCGAGATCGT GTCGGCCCTG 780
GACTACCTGC ACTCTGAGAA GAATGTCGTC TACCGTGACC TCAAGCTGGA GAACCTCATG 840
CTGGACAAGG ACGGGCACAT CAAGATCACT GACTTTGGGC TGTGCAAGGA GGGCATCAAG 900
GATGGGGCCA CCATGAAGAC CTTCTGCGGG ACACCTGAGT ACCTGGCCCC CGAGGTGCTG 960
GAGGACAACG ACTACGGCCG GGCGGTGGAC TGGTGGGGGC TGGGCGTGGT CATGTACGAG 1020
ATGGTGTGCG GCCGCCTGCC CTTCTACAAC CAGGACCACG AGAAGCTCTT CGAGCTCATC 1080
CTCATGGAGG AGATCCGCTT CCCGCGCACG CTCAGCCCTG AGGCCAAGTC CCTGCTCTCG 1140
GGGCTGCTCA AGAAGGACCC CAAGCAGAGG CTGGGCGGGG GCTCCGAGGA CGCCAAGGAG 1200
ATCATGCAGC ACCGCTTCTT TGCCAGCATC GTGTGGCAGG ACGTGTATGA GAAGAAGCTC 1260
AGCCCGCCCT TCAAGCCCCA GGTCACATCG GAGACAGACA CCAGGTATTT TGATGAGGAG 1320
TTCACGGCCC AGATGATCAC CATCACGCCG CCCGACCAAG ACGACACGAT GGAGGGTGTG 1380
GACAGCGAGC GGAGGCCCCA CTTCCCCCAG TTCTCCTACT CGGCCAGCGG CACGGCCTGA 1440
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl++++hpf
Q: 149   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF  208
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119
         l+alkysfqt+++lc+v+ey+nGGelffhls+ervf edrarfygaeivsaldylhs k+
Q: 209   LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFPEDRARFYGAEIVSALDYLHSeKN  268
         ********************************************************9789
S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179
         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dyg+a
Q: 269   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA  328
         ************************************************************
S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239
         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+ls+eaksllsGllkkdpk
Q: 329   VDWWGLGVVMYEMVCGRLPFYNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPK  388
         ************************************************************
S: 240   krlGggkddakeireheff  258
         +rlGgg++dakei++h+ff
Q: 389   QRLGGGSEDAKEIMQHRFF  407
         ******************9
Domain Sequence
(FASTA)
FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF 60
LTALKYSFQT HDRLCFVMEY ANGGELFFHL SRERVFPEDR ARFYGAEIVS ALDYLHSEKN 120
VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA 180
VDWWGLGVVM YEMVCGRLPF YNQDHEKLFE LILMEEIRFP RTLSPEAKSL LSGLLKKDPK 240
QRLGGGSEDA KEIMQHRFF 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00133
EKS-BOT-00141
EKS-CAF-00147
EKS-CAP-00138
EKS-CII-00086
EKS-CIS-00177
EKS-GAG-00116
EKS-GOG-00140
EKS-HOS-00143
EKS-ICT-00132
EKS-LAC-00148
EKS-MAM-00138
EKS-MEG-00106
EKS-MOD-00137
EKS-MUM-00143
EKS-MUP-00144
EKS-NOL-00134
EKS-ORN-00171
EKS-ORL-00160
EKS-OTG-00144
EKS-PES-00123
EKS-PEM-00075
EKS-PRC-00020
EKS-PTV-00131
EKS-RAN-00136
EKS-SAH-00133
EKS-TAG-00168
EKS-TAR-00183
EKS-TEN-00171
EKS-XET-00127
EKS-XIM-00166
Gene Ontology
GO:0005737; C:cytoplasm
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006924; P:activation-induced cell death of T cells
GO:0042640; P:anagen
GO:0008637; P:apoptotic mitochondrial changes
GO:0071364; P:cellular response to epidermal growth factor stimulus
GO:0032869; P:cellular response to insulin stimulus
GO:0007281; P:germ cell development
GO:0042593; P:glucose homeostasis
GO:0006006; P:glucose metabolic process
GO:0015758; P:glucose transport
GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development
GO:0005977; P:glycogen metabolic process
GO:0006954; P:inflammatory response
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0060716; P:labyrinthine layer blood vessel development
GO:0001893; P:maternal placenta development
GO:0043066; P:negative regulation of apoptotic process
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031999; P:negative regulation of fatty acid beta-oxidation
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria
GO:0001649; P:osteoblast differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0032287; P:peripheral nervous system myelin maintenance
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0045600; P:positive regulation of fat cell differentiation
GO:0046326; P:positive regulation of glucose import
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0046889; P:positive regulation of lipid biosynthetic process
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051000; P:positive regulation of nitric-oxide synthase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010765; P:positive regulation of sodium ion transport
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0030163; P:protein catabolic process
GO:0000060; P:protein import into nucleus, translocation
GO:0043491; P:protein kinase B signaling cascade
GO:0016567; P:protein ubiquitination
GO:0010975; P:regulation of neuron projection development
GO:0034405; P:response to fluid shear stress
GO:0032094; P:response to food
GO:0070141; P:response to UV-A
GO:0051146; P:striated muscle cell differentiation
KEGG
ecb:100061130;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013