EKS-EQC-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	254.1	1.4E-75	272	467	196

Status

Unreviewed

Ensembl Protein

ENSECAP00000006744

UniProt Accession

F6T9G2;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008319	ENSECAP00000006744	ENSECAT00000008942

Organism

Equus caballus

Functional Description

Protein Length

467

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGCAYSLSI RDWDDMKGDH VKHYKIRKLD NGGYYITTRA QFETLQQLVQ HYSERAAGLC 240

CRLVVPCHKG MPRLTDLSVK TKDVWEIPRE SLQLIKRLGN GQFGEVWMAF WFGNTQVAKT 300

TYKFMKRIPD DHHVQNQPLH KTKYSLLLGI FIFQSKLKRF YVLFIGSLLD FLKDGEGRAL 360

KLPNLVDMAA QVAAGMAYIE RMNYIHRDLR SANILVGNGL ICKIADFGLA RLIEDNEYTA 420

RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELVTK GRVPYPG 467

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACAGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCCGG GTACCGCTAT GGCACAGACC CCACTCCTCA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCAAACTAC AACAACTTCC ACGCAGCCGG GGGCCAAGGA 180

CTCACCGTCT TTGGGGGTGT GAACTCTTCG TCTCATACTG GGACCTTGCG TACGAGAGGA 240

GGAACAGGAG TGACCCTGTT CGTGGCCCTT TATGATTATG AAGCACGGAC GGAAGATGAC 300

CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATTCTGAACA GCTCGGAAGG AGACTGGTGG 360

GAAGCCCGCT CCTTGACGAC CGGAGAGACG GGTTACATTC CCAGCAATTA TGTGGCTCCA 420

GTGGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGAAA AGATGCTGAG 480

CGACAGCTTT TGTCCTTTGG AAACCCAAGA GGTACCTTTC TCATCCGCGA GAGTGAAACC 540

ACCAAAGGGT GTGCCTATTC ACTTTCTATC CGTGATTGGG ATGATATGAA AGGAGACCAC 600

GTCAAACATT ATAAAATTCG CAAACTTGAC AATGGTGGAT ACTATATCAC CACCCGGGCC 660

CAGTTTGAAA CCCTTCAGCA GCTTGTACAG CATTACTCAG AGAGAGCCGC AGGTCTCTGC 720

TGCCGCCTAG TAGTTCCCTG TCACAAAGGG ATGCCAAGGC TTACCGATCT GTCTGTCAAA 780

ACCAAAGATG TCTGGGAAAT CCCTCGAGAA TCCCTGCAGT TGATCAAGAG ACTGGGAAAT 840

GGGCAGTTTG GGGAAGTATG GATGGCTTTC TGGTTTGGGA ACACTCAAGT AGCAAAGACC 900

ACCTACAAAT TCATGAAAAG AATCCCCGAT GACCATCATG TGCAGAACCA GCCTCTGCAC 960

AAAACCAAAT ACAGCCTTTT GTTGGGAATT TTTATCTTTC AAAGCAAACT GAAACGGTTT 1020

TATGTTTTGT TCATAGGAAG TTTACTCGAT TTCTTAAAAG ATGGAGAAGG AAGAGCTCTG 1080

AAGTTACCAA ATCTCGTGGA CATGGCAGCC CAGGTTGCTG CCGGAATGGC TTACATCGAG 1140

CGCATGAATT ATATCCACAG AGATCTGCGG TCAGCAAACA TTCTGGTGGG GAATGGACTC 1200

ATATGCAAGA TTGCCGACTT TGGACTGGCC CGATTGATCG AAGACAACGA GTACACAGCA 1260

AGACAAGGTG CAAAGTTCCC CATTAAGTGG ACGGCCCCTG AAGCAGCCCT GTACGGGAGG 1320

TTCACAATCA AGTCTGACGT GTGGTCTTTT GGAATCTTAC TCACAGAGCT GGTCACCAAA 1380

GGGAGAGTGC CGTACCCAGG T 1401

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw++ w g+++va  t k  +  p++   + q l+k +++ l+ ++

Q: 272   LQLIKRLGNGQFGEVWMAFWFGNTQVAKTTYKFMKRIPDDHHVQNQPLHKTKYSLLLGIF  331

         689*******************************9999999999****************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

            s+ + +y++      Gslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 332   IFQSKLKRFYVL----FIGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  387

         *****9999986....57******************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 388   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  447

         ************************************************************

S: 181   WsfGillteivtkGkvPypG  200

         WsfGillte+vtkG+vPypG

Q: 448   WSFGILLTELVTKGRVPYPG  467

         *******************9

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMAFW FGNTQVAKTT YKFMKRIPDD HHVQNQPLHK TKYSLLLGIF 60

IFQSKLKRFY VLFIGSLLDF LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS 120

ANILVGNGLI CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG 180

ILLTELVTKG RVPYPG 196

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005768	; C:endosome
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0050798	; P:activated T cell proliferation
GO:0048813	; P:dendrite morphogenesis
GO:0050966	; P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900	; P:forebrain development
GO:0010629	; P:negative regulation of gene expression
GO:0042177	; P:negative regulation of protein catabolic process
GO:0001764	; P:neuron migration
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0008360	; P:regulation of cell shape
GO:0045471	; P:response to ethanol
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013