EKS-EQC-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	350.5	6.3E-105	2	223	222

Status

Unreviewed

Ensembl Protein

ENSECAP00000006458

UniProt Accession

F6TYF5;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK4

Gene Synonyms/Alias

RIPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008330	ENSECAP00000006458	ENSECAT00000008604

Organism

Equus caballus

Functional Description

Protein Length

725

Protein Sequence
(FASTA)

RERMELLEEA KKMEMAKFRY ILPVYGICQE PVGLVMEYME TGSLEKLLAS EPLPWDLRFR 60

IVHETAVGMN FLHCMSPPLL HLDLKPANIL LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG 120

LFGTIAYLPP ERIREKSRLF DTKHDVYSFA IVMWGVLTQK KPFADEKNIL HIMVKVVKGH 180

RPELPPVCRP RPRACGNLIR LMQRCWHGDP RERPTFQEIT SETEDLCEKP DEEVKEMTRD 240

LDVKTPPAPK SEAPVPAPLK RASAPTFDTD CSLSELLSQL DSGISQTLEG PEELSRSSSE 300

SKLPSANSGK RLSGVSSVDS AFSSRGSLSL SFEREPSTGD LGTTDVQKKK LVDAVVNGDT 360

SRLMKILQPQ DVDLVLDGGA SLLHLAVEAG QEECVKWLLL NNANPNLTNR KGSTPLHLAV 420

ERRVRGVVEL LLSRKISINA TDEDQWTALH FAAQNGDECS TRLLLEKNAS INEVDFEGRT 480

PMHVACQHGQ ESIVRILLRR GVDVGLQGKD AWVPLHYAAW QGHLPIVKLL AKQPGVSVNA 540

QTLDGRTPLH LAAQRGHYRV ARILIDLRSD INVRNLLAQT PLHVAAETGH TSTARLLLHR 600

GASREAVTAE GCTALHLASR NGHLATVKLL VEEKADVLAR GPRNQTALHL AAASGHSEVV 660

EELVSADVLN LADEQGLSAL HLAAQGRHAK TVETLLKHGA HVNLQSLKFQ GSHSPSATLL 720

RRSKT 725

Nucleotide Sequence
(FASTA)

AGGGAGCGCA TGGAACTTCT GGAGGAAGCC AAGAAGATGG AGATGGCCAA GTTTCGCTAC 60

ATTCTGCCCG TGTACGGCAT CTGCCAGGAA CCCGTGGGCC TGGTCATGGA GTACATGGAG 120

ACGGGCTCCC TGGAGAAGCT GCTGGCCTCT GAGCCGCTTC CGTGGGATCT GCGCTTCCGC 180

ATCGTCCATG AGACCGCGGT GGGCATGAAC TTCCTGCACT GCATGTCCCC GCCTCTGCTC 240

CACCTGGACC TCAAGCCCGC GAACATCCTG CTGGACGCCC ACTACCATGT CAAGATTTCC 300

GATTTTGGGC TGGCCAAGTG CAATGGGCTG TCCCACTCGC ACGACCTCAG CATGGACGGC 360

CTCTTTGGCA CCATCGCCTA CCTCCCTCCA GAGCGCATCC GAGAAAAGAG CCGGCTCTTC 420

GACACCAAGC ACGATGTGTA CAGCTTCGCC ATCGTGATGT GGGGCGTGCT GACCCAGAAG 480

AAGCCATTTG CAGATGAGAA GAACATCCTG CACATTATGG TGAAAGTGGT GAAGGGCCAC 540

CGCCCGGAGC TGCCGCCCGT CTGCAGACCC AGGCCGCGCG CCTGTGGGAA CCTCATACGC 600

CTCATGCAGA GATGCTGGCA TGGGGATCCG CGCGAACGGC CCACCTTCCA AGAAATTACT 660

TCTGAAACCG AGGACCTGTG TGAAAAGCCT GACGAGGAGG TAAAAGAGAT GACCCGAGAT 720

CTGGACGTGA AAACGCCGCC TGCGCCCAAG AGCGAGGCAC CCGTGCCCGC GCCCCTCAAG 780

CGAGCCTCTG CCCCGACCTT CGATACCGAC TGCAGCCTCT CCGAGCTGTT GTCTCAGCTG 840

GACTCCGGCA TCTCTCAGAC CCTCGAGGGC CCGGAAGAGC TCAGCCGCAG CTCCTCGGAG 900

TCCAAGCTGC CCTCGGCCAA CAGCGGCAAG AGGCTTTCAG GGGTGTCCTC CGTCGACTCC 960

GCCTTTTCCT CCAGAGGGTC GCTGTCCTTG TCCTTTGAGC GGGAGCCTTC GACGGGCGAT 1020

CTCGGCACAA CAGACGTCCA GAAGAAGAAG CTCGTGGACG CCGTCGTGAA CGGGGACACC 1080

AGCAGGCTGA TGAAGATCCT GCAGCCCCAG GACGTTGATC TGGTCCTGGA CGGTGGCGCC 1140

AGCCTGCTGC ACCTGGCTGT GGAGGCTGGG CAGGAGGAGT GTGTCAAGTG GCTTCTCCTC 1200

AATAATGCCA ACCCCAACCT GACCAACAGG AAGGGCTCCA CCCCCCTGCA CCTGGCTGTG 1260

GAGAGGAGGG TGCGGGGCGT CGTCGAGCTC CTGCTGTCCC GGAAGATTAG CATCAACGCC 1320

ACGGACGAGG ACCAGTGGAC GGCCCTCCAC TTCGCGGCCC AGAACGGGGA CGAGTGCAGC 1380

ACGCGGCTGC TGCTGGAGAA GAACGCCTCC ATTAATGAGG TGGACTTCGA GGGCCGGACG 1440

CCCATGCACG TGGCCTGCCA GCACGGGCAG GAGAGCATCG TGCGCATCCT GCTGCGCCGA 1500

GGTGTTGACG TGGGCCTGCA GGGGAAGGAC GCCTGGGTGC CGTTGCACTA CGCCGCCTGG 1560

CAGGGCCACC TGCCCATCGT CAAGCTGCTG GCGAAACAGC CGGGGGTGAG CGTGAACGCC 1620

CAGACGCTGG ACGGGAGGAC GCCCCTGCAC CTGGCCGCCC AGCGGGGGCA CTACCGCGTG 1680

GCCCGCATCC TCATCGACCT GCGGTCCGAC ATCAATGTCC GCAACCTGCT CGCGCAGACA 1740

CCACTGCACG TCGCCGCGGA GACGGGGCAC ACGAGCACCG CCAGGCTGCT CCTGCATCGC 1800

GGCGCCAGCA GGGAGGCAGT GACCGCGGAG GGCTGCACTG CCCTGCACCT GGCTTCCCGG 1860

AACGGGCACC TGGCGACTGT CAAGCTGCTC GTGGAGGAGA AGGCCGATGT GCTGGCCCGG 1920

GGGCCCCGGA ACCAGACGGC GCTGCACCTG GCCGCCGCCA GCGGGCACTC GGAGGTGGTG 1980

GAGGAGCTGG TCAGCGCTGA CGTGCTCAAC CTGGCCGACG AGCAGGGCCT CAGCGCGCTG 2040

CACCTGGCCG CCCAGGGCCG GCACGCCAAG ACAGTGGAGA CGCTGCTCAA GCACGGGGCC 2100

CACGTCAACC TGCAGAGCCT CAAGTTCCAG GGCAGCCACA GCCCCTCAGC CACACTTCTC 2160

CGGCGGAGCA AGACCTAG 2178

Domain Profile

S: 42    erkelleeakkmeklrfsyvlkllGvikeeeklglvmeymenGsLeklLkseielpwplk  101

         er+elleeakkme+++f+y+l+++G+++e+  +glvmeyme+GsLeklL+se +lpw+l+

Q: 2     ERMELLEEAKKMEMAKFRYILPVYGICQEP--VGLVMEYMETGSLEKLLASE-PLPWDLR  58

         799***************************..********************.*******

S: 102   fRilkevvlgmnyLhslkPpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevs  161

         fRi++e+++gmn+Lh+++Ppllh+DLkp+niLlD+++hvki+DfGl+k+ ++ s+s+++s

Q: 59    FRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKC-NGLSHSHDLS  117

         *************************************************.**********

S: 162   ssaegGtlaYlaPelleevnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvk  221

         +++++Gt+aYl+Pe+++e+++ +++k+DvYsfaiv+W+vl++k+p+++ekn+l+i+++v

Q: 118   MDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVMWGVLTQKKPFADEKNILHIMVKVV  177

         ************************************************************

S: 222   kgnRPeleevseelPrevpqlieLmkrcWeadpeeRPsFleieekt  267

         kg+RPel +v++ +Pr++ +li+Lm+rcW+ dp+eRP+F+ei+++t

Q: 178   KGHRPELPPVCRPRPRACGNLIRLMQRCWHGDPRERPTFQEITSET  223

         ******************************************9986

Domain Sequence
(FASTA)

ERMELLEEAK KMEMAKFRYI LPVYGICQEP VGLVMEYMET GSLEKLLASE PLPWDLRFRI 60

VHETAVGMNF LHCMSPPLLH LDLKPANILL DAHYHVKISD FGLAKCNGLS HSHDLSMDGL 120

FGTIAYLPPE RIREKSRLFD TKHDVYSFAI VMWGVLTQKK PFADEKNILH IMVKVVKGHR 180

PELPPVCRPR PRACGNLIRL MQRCWHGDPR ERPTFQEITS ET 222

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0002009	; P:morphogenesis of an epithelium

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 4.
PF00069	; Pkinase; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 9.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013