EKS-EQC-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	313.0	1.7E-93	5	234	230

Status

Unreviewed

Ensembl Protein

ENSECAP00000006964

UniProt Accession

F6QAH1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP4K4

Gene Synonyms/Alias

MAP4K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008730	ENSECAP00000006964	ENSECAT00000009189
ENSECAG00000008730	ENSECAP00000006954	ENSECAT00000009178

Organism

Equus caballus

Functional Description

Protein Length

1181

Protein Sequence
(FASTA)

MDVTEDEEEE IKLEINMLKK YSHHRNIATY YGAFIKKSPP GHDDQLWLVM EFCGAGSITD 60

LVKNTKGNTL KEDWIAYISR EILRGLAHLH IHHVIHRDIK GQNVLLTENA EVKLVDFGVS 120

AQLDRTVGRR NTFIGTPYWM APEVIACDEN PDATYDYRSD LWSCGITAIE MAEGAPPLCD 180

MHPMRALFLI PRNPPPRLKS KKWSKKFFSF IEGCLVKNYM QRPSTEQLLK HPFIRDQPNE 240

RQVRIQLKDH IDRTRKKRGE KDETEYEYSG SEEEEEEVPE QEGEPSSIVN VPGESTLRRD 300

FLRLQQENKE RSEALRRQQL LQEQQLREQE EYKRQLLAER QKRIEQQKEQ RRRLEEQQRR 360

EREARRQQER EQRRREQEEK RRLEELERRR KEEEERRRAE EEKRRVEREQ EYIRRQLEEE 420

QRHLEILQQQ LLQEQAMLLE CRWREMEEHR QAERLQRQLQ QEQAYLLSLQ HDHRRPHPQQ 480

PPPPQQERSK PSYHAPEPKP HYEPADRARE VEDRFRKTNH SSPEAQSKQT GRVLEPPVPS 540

RSESFSNGNS ESVHPALQRP AEPQVPVRTT SRSPVLSRRD SPLQGSGQQN SQAGQRNSTS 600

IEPRLLWERV EKLVPRPGSG SSSGSSNSGS QPGSHPGSQS GSGERFRVRS SSKSEGSPSQ 660

RLENAAKKPE DKKEVFRPLK PADLTALAKE LRAVEDVRPP HKVTDYSSSS EESGTTDEED 720

DDVEQEGAEE PSSGPEDTRA ASSLNLSNGE TESVKTMIVH EDVESEPAMT PSKEGTLIVR 780

QTQSASSTLQ KHKSSSSFTP FIDPRLLQIS PSSGTTVTSV VGFSCDGMRP EAIRQDPTRK 840

GSVVNVNPTN TRPQSDTPEI RKYKKRFNSE ILCAALWGVN LLVGTESGLM LLDRSGQGKV 900

YPLINRRRFQ QMDVLEGLNV LVTISGKKDK LRVYYLSWLR NKILHNDPEV EKKQGWTTVG 960

DLEGCVHYKV VKYERIKFLV IALKSSVEVY AWAPKPYHKF MAFKSFGELV HKPLLVDLTV 1020

EEGQRLKVIY GSCAGFHAVD VDSGSVYDIY LPTHIQCSIK PHAIIILPNT DGMELLVCYE 1080

DEGVYVNTYG RITKDVVLQW GEMPTSVAYI RSNQTMGWGE KAIEIRSVET GHLDGVFMHK 1140

RAQRLKFLCE RNDKVFFASV RSGGSSQVYF MTLGRTSLLS W 1181

Nucleotide Sequence
(FASTA)

ATGGATGTCA CTGAGGATGA AGAGGAGGAA ATCAAACTGG AGATAAATAT GCTGAAGAAA 60

TATTCTCATC ATAGAAATAT TGCAACATAC TACGGTGCTT TTATTAAAAA GAGCCCTCCA 120

GGACATGATG ACCAACTCTG GCTTGTGATG GAGTTCTGTG GGGCTGGGTC CATTACAGAC 180

CTTGTGAAGA ACACCAAAGG GAACACGCTG AAGGAAGACT GGATAGCTTA CATCTCCAGA 240

GAGATACTGA GGGGACTGGC ACATCTTCAC ATCCATCACG TGATTCACCG GGACATCAAG 300

GGCCAGAATG TACTGCTGAC CGAGAATGCA GAGGTGAAAC TGGTTGATTT TGGTGTGAGT 360

GCTCAGCTGG ACAGGACGGT TGGGAGGAGA AATACCTTCA TAGGCACCCC CTACTGGATG 420

GCTCCTGAGG TCATCGCCTG TGACGAGAAC CCAGATGCCA CCTATGATTA CAGAAGTGAC 480

CTTTGGTCTT GTGGCATTAC GGCCATTGAG ATGGCAGAAG GTGCTCCCCC TCTCTGTGAC 540

ATGCATCCAA TGAGAGCACT GTTTCTCATT CCCAGAAACC CTCCTCCCCG GCTGAAGTCA 600

AAAAAATGGT CAAAGAAATT TTTTAGTTTT ATAGAAGGGT GCCTGGTGAA GAATTACATG 660

CAGCGGCCCT CCACAGAGCA GCTTTTGAAA CATCCTTTTA TAAGGGATCA GCCAAACGAA 720

AGGCAAGTTA GAATCCAGCT TAAGGACCAT ATAGACCGGA CCAGAAAGAA GAGAGGAGAG 780

AAAGATGAAA CGGAATATGA GTACAGTGGG AGTGAGGAAG AAGAGGAGGA AGTGCCTGAA 840

CAGGAGGGAG AGCCAAGTTC CATTGTCAAC GTGCCTGGTG AATCGACTCT GCGGCGGGAT 900

TTCTTGAGAC TGCAGCAGGA GAACAAGGAA CGTTCGGAGG CTCTTCGGAG ACAACAGCTC 960

CTGCAGGAGC AGCAGCTCCG CGAGCAGGAA GAATACAAAA GGCAGCTGCT GGCCGAGAGG 1020

CAGAAACGGA TCGAGCAGCA GAAGGAACAG AGGCGGCGGC TAGAAGAGCA ACAAAGGAGA 1080

GAGCGTGAAG CTAGACGGCA GCAGGAACGT GAACAGCGAA GGCGAGAACA AGAAGAGAAG 1140

AGGCGTCTAG AGGAATTGGA GAGAAGGCGT AAAGAAGAAG AAGAGAGGAG ACGGGCAGAA 1200

GAAGAAAAAA GAAGAGTTGA AAGAGAACAG GAGTATATCA GGCGACAGCT AGAAGAGGAG 1260

CAGCGGCACT TGGAAATCCT TCAGCAGCAG CTGCTCCAGG AGCAGGCCAT GTTACTGGAG 1320

TGCCGATGGC GGGAGATGGA GGAGCACCGG CAGGCAGAGA GGCTCCAGAG GCAGTTGCAA 1380

CAAGAACAAG CATATCTCCT GTCTCTACAG CATGACCACA GGAGGCCGCA CCCGCAGCAG 1440

CCGCCACCAC CGCAGCAGGA AAGGAGCAAG CCCAGCTATC ACGCTCCAGA GCCCAAGCCC 1500

CACTACGAAC CCGCTGACAG AGCTCGAGAG GTGGAAGATA GATTTAGGAA AACTAATCAC 1560

AGCTCCCCTG AAGCCCAGTC TAAGCAGACA GGCAGAGTAT TGGAGCCACC AGTGCCTTCC 1620

AGATCAGAGT CCTTTTCCAA TGGCAACTCC GAGTCTGTGC ATCCTGCCCT GCAGAGACCA 1680

GCCGAGCCAC AGGTCCCTGT GAGAACAACG TCTCGATCCC CTGTTCTGTC CCGTCGGGAT 1740

TCCCCACTGC AGGGCAGTGG GCAGCAAAAC AGCCAGGCGG GTCAGAGAAA CTCCACCAGT 1800

ATTGAGCCCA GGCTGCTGTG GGAGAGAGTG GAGAAGCTGG TGCCCAGGCC TGGCAGTGGC 1860

AGCTCCTCGG GGTCCAGCAA CTCAGGATCC CAGCCTGGGT CCCACCCTGG GTCTCAGAGT 1920

GGTTCCGGGG AGCGCTTCAG AGTGAGATCA TCGTCCAAAT CTGAAGGCTC TCCATCTCAG 1980

CGCCTTGAAA ATGCAGCAAA AAAACCTGAA GATAAAAAAG AAGTTTTTAG ACCTCTTAAG 2040

CCTGCTGATT TGACCGCACT GGCCAAAGAG CTCCGAGCAG TGGAAGATGT GCGCCCGCCG 2100

CACAAAGTGA CCGACTACTC CTCCTCCAGT GAGGAGTCGG GGACGACAGA CGAGGAGGAC 2160

GATGACGTGG AGCAGGAGGG CGCCGAGGAG CCCAGCTCCG GACCAGAGGA CACCAGAGCC 2220

GCGTCATCTC TGAATTTGAG CAATGGTGAA ACGGAATCTG TGAAAACCAT GATTGTCCAT 2280

GAGGATGTAG AGAGTGAACC AGCCATGACC CCATCCAAGG AGGGCACTCT AATCGTCCGC 2340

CAGACTCAGT CCGCTAGTAG CACACTCCAG AAACACAAAT CTTCCTCCTC CTTTACACCT 2400

TTTATAGACC CCAGATTACT ACAGATTTCT CCATCTAGTG GGACAACAGT GACTTCTGTG 2460

GTGGGATTCT CCTGTGATGG AATGAGACCG GAGGCCATAA GGCAAGATCC TACCCGGAAG 2520

GGCTCAGTGG TCAATGTGAA TCCCACCAAC ACTAGGCCAC AGAGTGACAC CCCAGAGATT 2580

CGTAAATATA AGAAGAGATT TAACTCTGAG ATTCTGTGTG CTGCCTTATG GGGAGTGAAT 2640

TTGTTGGTGG GGACAGAGAG TGGCCTGATG CTGCTGGACA GAAGTGGCCA AGGGAAGGTA 2700

TATCCTCTGA TCAACCGAAG ACGATTTCAA CAAATGGATG TCCTTGAAGG CTTGAATGTC 2760

TTGGTGACAA TATCTGGCAA AAAGGATAAA TTACGTGTCT ACTATTTGTC CTGGTTAAGA 2820

AATAAAATAC TTCACAACGA TCCAGAAGTC GAGAAGAAGC AGGGATGGAC AACCGTGGGG 2880

GACTTGGAAG GGTGTGTGCA CTATAAAGTT GTAAAATATG AAAGAATCAA ATTTCTGGTA 2940

ATTGCTTTGA AGAGTTCTGT GGAAGTCTAT GCGTGGGCAC CCAAGCCATA TCACAAATTT 3000

ATGGCCTTTA AGTCATTTGG AGAATTGGTA CATAAGCCGT TACTGGTGGA TCTCACTGTT 3060

GAGGAAGGCC AGAGATTGAA AGTGATCTAT GGATCCTGTG CTGGATTCCA TGCTGTTGAT 3120

GTGGATTCAG GATCAGTCTA TGACATTTAT CTACCAACAC ACATCCAATG TAGCATCAAA 3180

CCCCATGCAA TCATCATCCT CCCCAACACA GATGGAATGG AGCTCTTGGT GTGCTATGAA 3240

GATGAAGGGG TTTATGTGAA CACCTATGGA AGAATCACCA AGGATGTGGT TCTGCAGTGG 3300

GGAGAGATGC CAACATCTGT AGCATATATT CGATCCAATC AGACGATGGG CTGGGGAGAA 3360

AAGGCCATAG AGATCCGATC TGTGGAAACT GGTCACTTGG ATGGTGTGTT TATGCACAAA 3420

AGGGCTCAAA GACTAAAATT CTTGTGTGAA CGCAATGACA AGGTATTCTT CGCCTCTGTT 3480

CGGTCTGGTG GCAGCAGTCA GGTTTATTTC ATGACGTTAG GCAGGACTTC TCTTCTGAGC 3540

TGGTAG 3546

Domain Profile

S: 37    qekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvke  89

         ++++ee++ ei++lkk++h +ni +y+++f+k      +++lwlvme++ +Gs++dlvk+

Q: 5     EDEEEEIKLEINMLKKYSHhRNIATYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKN  64

         38999************998*****************9**********************

S: 90    elkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqle  149

         ++ ++lkE++iayi re+l++L++lH ++viHrdik++n+Llte++eVkL+dfgv+aql+

Q: 65    TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD  124

         ************************************************************

S: 150   ktrkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdlepl  206

         +t+ +r+t++gtpywmAPEvia++   + +Yd+++D+ws+GItaie+aeg+pP++d++p+

Q: 125   RTVGRRNTFIGTPYWMAPEVIACDenpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPM  184

         ************************999999******************************

S: 207   kallkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         +al++i++n+pp+lksk k+sk+f +f+e cl kn+ +Rps+++llkh+F+

Q: 185   RALFLIPRNPPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI  234

         **************888.********************************7

Domain Sequence
(FASTA)

EDEEEEIKLE INMLKKYSHH RNIATYYGAF IKKSPPGHDD QLWLVMEFCG AGSITDLVKN 60

TKGNTLKEDW IAYISREILR GLAHLHIHHV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD 120

RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDLWSC GITAIEMAEG APPLCDMHPM 180

RALFLIPRNP PPRLKSKKWS KKFFSFIEGC LVKNYMQRPS TEQLLKHPFI 230

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0046328	; P:regulation of JNK cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013