EKS-EQC-00480

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00480

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	330.8	6.5E-99	22	283	262

Status

Unreviewed

Ensembl Protein

ENSECAP00000006806

UniProt Accession

F6SCQ8;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK3

Gene Synonyms/Alias

RIPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008781	ENSECAP00000006806	ENSECAT00000009011

Organism

Equus caballus

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MSCSKLWASG APASLVPIKE LENPKFIGQG GFGTVFQAQH RSWGHDVAVK IVNREAISRE 60

VKAMANLRNP YILLLLGVTE KLEWDYVSGP ALVTAFMENG SLAGLLQPQC PRPWPLCCRL 120

LLELVLGMCY LHSQNPVLLH RDLKPSNVLL DSELHIQLAD FGLSTFQGGS RSGSWSGEPG 180

GTLAYLAPEL LADVNQKASK ASDVYSFGIL MWALLAGREA ETVTQTSVVQ EAVCERQNRP 240

PLTELPPPGP ETAGLEELKE LMQQCWSQEP KDRPSFQECQ PKTKNVFHLV KDKTDDAVSR 300

VKKFMSNHRD SNRMLSAPEP GPGRTEMDGP GGTTGSHDSM VSEMLGNLNL EGSPNSVPEK 360

CTNRPERIRA QGRQVQRGWP AGTSDSTAQP PQTPENAPFR SQIPTSAWTP GPRPQGNQGA 420

ERHSAHQPPR APGTDPTPGP PSITVVDCQG VQIGNNNYLY IQGRTTSSTQ HPALWGMGWG 480

LTAHPPQVGS QEGPPQEPQV WSGPQ 505

Nucleotide Sequence
(FASTA)

ATGTCTTGCT CCAAGTTATG GGCCAGCGGA GCCCCAGCCT CCCTGGTGCC CATCAAGGAA 60

TTGGAGAACC CAAAGTTCAT TGGCCAAGGC GGGTTTGGCA CCGTGTTCCA GGCGCAACAC 120

CGTTCTTGGG GTCACGATGT GGCGGTCAAG ATCGTGAACC GGGAAGCTAT ATCCAGGGAG 180

GTGAAGGCCA TGGCAAATCT GCGTAACCCG TACATCCTGC TCCTGCTGGG GGTCACTGAG 240

AAGCTGGAGT GGGACTACGT GTCCGGGCCA GCTCTGGTGA CTGCATTCAT GGAGAACGGT 300

TCCCTGGCCG GGCTGCTGCA GCCCCAGTGC CCTCGGCCCT GGCCGCTCTG CTGCCGCCTG 360

CTGCTGGAGT TGGTGCTTGG GATGTGTTAC CTGCACAGCC AGAACCCTGT CCTTCTGCAC 420

CGAGACCTCA AGCCTTCCAA CGTCCTGCTG GACTCAGAGC TGCACATCCA GCTGGCAGAT 480

TTTGGCCTGT CCACATTTCA GGGAGGCTCA CGGTCAGGGT CATGGTCTGG GGAGCCAGGG 540

GGCACCCTAG CCTACTTGGC CCCAGAACTC CTGGCTGATG TAAACCAGAA GGCCTCCAAG 600

GCCAGTGATG TCTACAGCTT CGGGATTCTA ATGTGGGCAC TGCTAGCTGG AAGAGAAGCT 660

GAGACGGTGA CCCAGACATC AGTGGTGCAG GAAGCAGTAT GCGAGAGGCA GAACCGGCCC 720

CCCTTGACCG AGCTGCCCCC GCCTGGCCCT GAGACTGCTG GCTTGGAAGA ACTGAAGGAG 780

TTAATGCAGC AGTGCTGGAG CCAGGAACCC AAGGACAGGC CCTCCTTCCA AGAATGCCAA 840

CCAAAAACCA AGAACGTTTT TCACTTGGTA AAGGACAAGA CAGACGATGC TGTCTCCAGG 900

GTGAAGAAGT TCATGTCTAA CCACAGGGAC AGCAACAGGA TGTTGTCTGC CCCTGAGCCA 960

GGCCCAGGAA GGACAGAAAT GGATGGCCCT GGGGGAACCA CAGGAAGCCA TGATTCCATG 1020

GTCTCTGAGA TGCTGGGCAA CCTGAATCTG GAGGGGTCCC CCAACTCTGT TCCTGAAAAA 1080

TGTACAAACC GTCCTGAGAG GATCAGGGCA CAGGGACGGC AGGTTCAGCG TGGCTGGCCA 1140

GCAGGGACAT CTGACTCAAC AGCCCAACCT CCCCAAACTC CAGAGAACGC ACCTTTCAGA 1200

AGCCAGATCC CCACCTCAGC TTGGACCCCA GGTCCTAGGC CCCAAGGGAA TCAGGGGGCT 1260

GAGAGACACA GCGCCCACCA GCCTCCCAGG GCACCAGGGA CAGATCCGAC ACCAGGGCCC 1320

CCGTCTATTA CCGTAGTTGA CTGCCAAGGG GTACAGATTG GAAACAACAA CTACCTCTAT 1380

ATACAAGGAA GAACTACCTC GTCCACGCAG CACCCGGCAC TTTGGGGCAT GGGCTGGGGG 1440

CTGACAGCAC ACCCCCCACA AGTAGGTTCT CAAGAAGGGC CACCGCAAGA ACCTCAAGTC 1500

TGGAGTGGGC CGCAG 1515

Domain Profile

S: 2     eelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyv  61

         e+ +++g+Ggfg+vf+a+hr+w+++vavk         +++r+++++e+k+m++lr+ y+

Q: 22    ENPKFIGQGGFGTVFQAQHRSWGHDVAVK---------IVNREAISREVKAMANLRNPYI  72

         677899***********************.........999*******************

S: 62    lkllGvikeeek.....lglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLh  116

         l llGv+++ e+      +lv+ +menGsL++lL+ ++++pwpl +R+l e vlgm+yLh

Q: 73    LLLLGVTEKLEWdyvsgPALVTAFMENGSLAGLLQPQCPRPWPLCCRLLLELVLGMCYLH  132

         *************99999******************************************

S: 117   slkPpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPel  176

         s++P+llh+DLkp+n+LlD+elh+++aDfGls+f ++ s+s + s+++ gGtlaYlaPel

Q: 133   SQNPVLLHRDLKPSNVLLDSELHIQLADFGLSTF-QGGSRSGSWSGEP-GGTLAYLAPEL  190

         **********************************.*************.***********

S: 177   leevnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelP  236

         l +vn+kas++sDvYsf+i++Wa+la++e+++ +++s++ ++v++++nRP l+e++   P

Q: 191   LADVNQKASKASDVYSFGILMWALLAGREAETVTQTSVVQEAVCERQNRPPLTELPPPGP  250

         ************************************************************

S: 237   revpq...lieLmkrcWeadpeeRPsFleieekt  267

          e+++   l+eLm++cW+++p++RPsF+e+++kt

Q: 251   -ETAGleeLKELMQQCWSQEPKDRPSFQECQPKT  283

         .5555567***********************986

Domain Sequence
(FASTA)

ENPKFIGQGG FGTVFQAQHR SWGHDVAVKI VNREAISREV KAMANLRNPY ILLLLGVTEK 60

LEWDYVSGPA LVTAFMENGS LAGLLQPQCP RPWPLCCRLL LELVLGMCYL HSQNPVLLHR 120

DLKPSNVLLD SELHIQLADF GLSTFQGGSR SGSWSGEPGG TLAYLAPELL ADVNQKASKA 180

SDVYSFGILM WALLAGREAE TVTQTSVVQE AVCERQNRPP LTELPPPGPE TAGLEELKEL 240

MQQCWSQEPK DRPSFQECQP KT 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004704	; F:NF-kappaB-inducing kinase activity
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0006917	; P:induction of apoptosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR025735	; RHIM_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12721	; RHIM; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013