EKS-EQC-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	358.7	2.2E-107	2	242	241

Status

Unreviewed

Ensembl Protein

ENSECAP00000007293

UniProt Accession

F6XV59;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000008882	ENSECAP00000007293	ENSECAT00000009563

Organism

Equus caballus

Functional Description

Protein Length

1007

Protein Sequence
(FASTA)

QKTDWEVAIK SINKKNLSKS QLLLGKEIKI LKELQHENIV ALYDVQELPN SVFLVMEYCN 60

GGDLADYLQA KGTLSEDTIR VFLHQIAAAM RILHSKGIIH RDLKPQNILL SYANRRKSSV 120

SGIRIKIADF GFARYLHSNM MAATLCGSPM YMAPEVIMSQ HYDAKADLWS IGTVIYQCLV 180

GKPPFQANSP QDLRMFYEKN RSLMPSIPRE TSPYLANLLL GLLQRNQKDR MDFEAFFSHP 240

FLEQVPVKKS CPVPVPVYAG SVSGGSCGSS PSCRFASPPS LPDMQHIQEE NLSSPPLGPP 300

NYLQVSKDSA STSSKNSSCD TDDFVLVPHN ISSDHSYDMP VGTVGRRASN EFLVCGGQCQ 360

PTVSPHSEAA PIPVPTQIRN YQRIEQNLTS AASSGTNLHG SPRSTVVRRS NTSPMGFLRL 420

GSCSPAPADT VQTVGRRLST GSSRPYSPSP LVGTIPEQLS QCCCGHPQGH ESRSRNSSGS 480

PVPQAQSPQP LLLGARLQSA PTLTDIYQNK QKLRKQHSDP VCPSHAGAGY SYSPQPSRPG 540

SLGTSPTKHM GSSPRSSDWF FKTPLPTIIG SPTKTTAPFK IPKTQASSNL LALVTRHGPS 600

EEQSKDENDP RECSHCLLVQ GSERQKPEQQ NKAVFGRSVS TGKLSDQQVK TPLGGHQGST 660

DSLNTERPMD IAPAGACGVV LSPPVGTAAS SRAVLFTVGS PPHSATAPTC THMVLRTRTT 720

SVGSSSSGGS LCSASGRVCV GSPPGPCPGS SPPGAEIAPS LRYMPYGASP PSLEGLITFE 780

APELPEETLM EREHTDTLRH LNVMLMFTEC VLDLTAVRGG NPELCTSAVS LYQIQESVVV 840

DQISQLSKDW GRVEQLVLYM KAAQLLASSL HLAKAQIKSG KLSPSTAVKQ VVKNLNERYK 900

FCITMCKKLT EKLNRFFSDK QRFIDEINSV TAEKLIYNCA VEMVQSAALD EMFQQTEDIV 960

YRYHKAALLL EGLTKILQDP ADIENVHKYK SSIERRLSAL CYSASAM 1007

Nucleotide Sequence
(FASTA)

CAGAAAACTG ATTGGGAGGT AGCTATTAAA AGTATTAATA AAAAGAACTT GTCAAAATCA 60

CAACTACTAC TTGGGAAGGA AATTAAAATC TTAAAGGAAC TGCAGCACGA AAATATTGTA 120

GCTCTCTATG ATGTTCAGGA ATTACCCAAC TCTGTCTTCC TGGTGATGGA GTATTGCAAT 180

GGTGGAGACT TGGCAGATTA TTTGCAAGCT AAAGGAACTC TGAGTGAAGA TACTATCAGA 240

GTGTTTCTGC ATCAGATTGC AGCTGCCATG CGAATTCTGC ACAGCAAAGG AATAATCCAT 300

AGGGATCTGA AACCACAGAA CATCTTGCTG TCTTATGCCA ATCGCAGAAA GTCAAGTGTC 360

AGTGGTATTC GCATCAAAAT AGCGGATTTT GGTTTTGCTC GTTACCTACA TAGTAACATG 420

ATGGCTGCAA CTCTGTGTGG GTCCCCAATG TACATGGCTC CTGAGGTTAT TATGTCTCAA 480

CATTATGATG CTAAGGCAGA CTTGTGGAGC ATAGGAACAG TGATATATCA GTGCCTAGTT 540

GGAAAACCAC CTTTTCAGGC CAATAGCCCT CAAGACCTAA GGATGTTTTA TGAAAAAAAC 600

AGGAGCTTAA TGCCTAGCAT TCCCAGGGAA ACATCACCTT ATTTGGCTAA TCTCCTTTTG 660

GGTTTGCTTC AGAGAAACCA AAAAGATAGA ATGGACTTTG AAGCATTTTT TAGCCATCCT 720

TTTCTTGAGC AAGTTCCAGT AAAAAAATCC TGCCCAGTCC CAGTGCCTGT GTATGCTGGC 780

TCTGTCTCTG GAGGCTCCTG TGGCAGCTCT CCATCGTGTC GTTTTGCCTC TCCACCGTCC 840

CTTCCAGATA TGCAGCACAT TCAGGAAGAA AACTTATCCT CCCCACCGTT GGGTCCTCCC 900

AACTATCTAC AAGTGTCCAA AGATTCTGCC AGTACTAGTA GCAAGAACTC TTCTTGTGAC 960

ACGGATGACT TTGTTTTGGT TCCACACAAC ATCTCGTCAG ACCACTCATA TGATATGCCA 1020

GTGGGAACTG TTGGCAGACG TGCTTCAAAT GAGTTCTTGG TGTGTGGCGG GCAGTGTCAG 1080

CCTACTGTGT CACCTCACAG TGAAGCAGCA CCAATTCCAG TTCCTACTCA GATAAGGAAT 1140

TATCAGCGCA TCGAGCAGAA TCTTACATCT GCTGCCAGCT CTGGCACAAA TCTGCATGGT 1200

TCTCCAAGAT CTACGGTGGT ACGAAGGTCT AACACCAGCC CGATGGGCTT CCTCCGGCTG 1260

GGATCCTGCT CCCCGGCACC GGCAGACACA GTACAGACAG TTGGACGAAG ACTCTCTACT 1320

GGGTCTTCCA GGCCTTACTC ACCATCCCCT TTGGTTGGTA CCATTCCTGA GCAGTTGAGT 1380

CAGTGTTGCT GTGGGCATCC TCAGGGCCAT GAATCCAGGA GTAGAAACTC GTCAGGTTCT 1440

CCAGTGCCAC AGGCTCAGTC CCCACAGCCT CTCCTGTTGG GTGCTAGACT ACAGAGCGCC 1500

CCCACCCTCA CTGACATCTA CCAGAACAAG CAGAAGCTTA GAAAGCAGCA CTCTGACCCC 1560

GTGTGCCCAT CCCATGCCGG GGCTGGGTAC AGCTACTCAC CTCAGCCCAG TCGGCCTGGC 1620

AGCCTTGGGA CCTCTCCCAC CAAGCACATG GGGTCCTCTC CGCGGAGTTC TGACTGGTTC 1680

TTTAAAACTC CATTACCAAC AATTATTGGC TCTCCTACTA AGACCACGGC TCCTTTCAAA 1740

ATCCCTAAAA CGCAAGCATC TTCCAACCTG CTAGCCTTGG TTACTCGTCA TGGGCCTTCT 1800

GAAGAGCAAT CTAAAGATGA GAATGACCCG CGGGAATGCT CTCATTGTCT CTTAGTGCAA 1860

GGAAGTGAGA GGCAGAAGCC TGAGCAGCAG AACAAGGCAG TGTTTGGCAG ATCTGTCAGT 1920

ACTGGGAAAT TATCAGATCA ACAAGTAAAG ACGCCTTTAG GTGGACATCA AGGGAGCACG 1980

GATAGTTTAA ATACAGAACG ACCAATGGAT ATAGCCCCTG CAGGAGCCTG TGGTGTTGTA 2040

CTGTCACCTC CTGTAGGAAC AGCAGCAAGT TCCAGGGCTG TCCTCTTCAC TGTAGGATCT 2100

CCTCCACACA GTGCCACTGC CCCAACTTGT ACCCACATGG TCCTTCGAAC TAGAACAACG 2160

TCAGTGGGCT CCAGCAGCTC CGGAGGTTCC CTGTGCTCTG CAAGTGGCCG TGTGTGTGTG 2220

GGTTCCCCGC CTGGGCCATG CCCAGGGTCT TCCCCTCCAG GAGCAGAGAT AGCTCCCAGC 2280

CTGAGATACA TGCCTTATGG TGCTTCACCC CCTAGCCTAG AGGGGCTCAT CACCTTTGAA 2340

GCCCCGGAAC TGCCAGAGGA GACACTGATG GAGCGAGAAC ACACAGACAC CTTACGCCAC 2400

CTGAATGTGA TGTTGATGTT CACTGAGTGT GTGCTGGACC TGACAGCTGT GCGGGGAGGG 2460

AACCCAGAGC TGTGCACATC CGCTGTCTCC TTGTACCAGA TTCAGGAGAG TGTGGTTGTG 2520

GACCAGATCA GCCAACTGAG CAAAGACTGG GGGCGAGTGG AGCAGCTGGT GTTATACATG 2580

AAAGCAGCAC AGCTGCTGGC ATCATCTCTG CATCTCGCCA AAGCCCAGAT CAAGTCCGGG 2640

AAACTGAGCC CATCCACAGC TGTGAAACAA GTTGTCAAAA ATCTGAATGA ACGATATAAA 2700

TTCTGCATCA CCATGTGCAA GAAGCTTACA GAAAAGCTGA ATCGTTTCTT CTCTGACAAA 2760

CAGAGATTTA TTGATGAAAT CAACAGCGTG ACTGCAGAGA AACTCATCTA TAATTGTGCT 2820

GTAGAAATGG TTCAGTCTGC AGCCCTGGAT GAGATGTTTC AGCAGACTGA AGATATTGTT 2880

TATCGCTACC ATAAAGCAGC CCTTCTTTTG GAAGGCCTAA CTAAGATTCT CCAGGACCCT 2940

GCAGATATTG AAAATGTACA TAAATATAAA TCTAGTATTG AAAGAAGATT GTCGGCACTC 3000

TGCTATAGCG CCTCGGCCAT GTGA 3024

Domain Profile

S: 23    ktsqvvAikvvekkklkkslenlekeikilkelkhenivalldveetskevylvmeycag  82

         kt+++vAik+++kk+l+ks+  l keikilkel+henival+dv+e  ++v+lvmeyc+g

Q: 2     KTDWEVAIKSINKKNLSKSQLLLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG  61

         7899********************************************************

S: 83    gdLakllkqkkeLsedtvreflqqlasalkaLhskkivhrDlkPqniLlsyadakk.elk  141

         gdLa++l++k++Lsedt+r+fl+q+a+a+++Lhsk+i+hrDlkPqniLlsya+++k +++

Q: 62    GDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKsSVS  121

         *****************************************************99989**

S: 142   kvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellvG  201

          +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++q+ydakaDlWSiGt++y++lvG

Q: 122   GIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVG  181

         ************************************************************

S: 202   kpPfaaesiseLvekiekndvleppipkeisselkdllqsLLqrdpkkRisfeelfahpf  261

         kpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll +LLqr++k+R++fe +f+hpf

Q: 182   KPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPF  241

         ***********************************************************9

S: 262   l  262

Q: 242   L  242

Domain Sequence
(FASTA)

KTDWEVAIKS INKKNLSKSQ LLLGKEIKIL KELQHENIVA LYDVQELPNS VFLVMEYCNG 60

GDLADYLQAK GTLSEDTIRV FLHQIAAAMR ILHSKGIIHR DLKPQNILLS YANRRKSSVS 120

GIRIKIADFG FARYLHSNMM AATLCGSPMY MAPEVIMSQH YDAKADLWSI GTVIYQCLVG 180

KPPFQANSPQ DLRMFYEKNR SLMPSIPRET SPYLANLLLG LLQRNQKDRM DFEAFFSHPF 240

L 241

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048675	; P:axon extension
GO:0048671	; P:negative regulation of collateral sprouting
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy
GO:0042594	; P:response to starvation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013