EKS-EQC-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	346.5	1.3E-103	848	1119	272

Status

Unreviewed

Ensembl Protein

ENSECAP00000008048

UniProt Accession

F6RE38;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009119	ENSECAP00000008048	ENSECAT00000010434

Organism

Equus caballus

Functional Description

Protein Length

1131

Protein Sequence
(FASTA)

MGMACLTMAE MEGTSVSVHQ NGDIPGNANS VKQVDPVLQV YLYHSLEKAE GDYLKFPTGE 60

YVAEEICVAA SKACGITPVY HSMFALMSET ERIWYPPNHV FHIDESARHS VLYRIRFYFP 120

YWYCNGSNRT YRHGISRGAE APLLDDFVMS YLFAQWRHDF LHGWVKVPVT HETQEECLGM 180

AVLDMMRIAK EKDQTPLTIY SSISYKTFLP KCVRAKIQDY HILTRKRIRY RFRRFIEQFS 240

HCKATARNLK LKYLINLETL QSAFYTEQFE VKEPGRGPSG EEIFATIIIT GNGGIQWSRG 300

KHKESETLTE QNLQLYCDFP DIIDVNIKQA HQEGSNESRI VTIHKQDGKT LEIELSSLRE 360

ALSFVSLIDG YYRLTADAHH YLCKEVAPPM VLENIQSNCH GPISMDFAIS KLKKAGNQTG 420

LYVLRCSPKD FNKYFLTFAV ERENVIEHKH CLITKNENGE YNLSGTKKNF SSLKDLLNCY 480

QMETVRSDSI IFQFTKCCPP KPKDKSNLLV FRTNGVSEVP TSPTLQRHNN VNQMVFHKIR 540

NEDLIFNESL GQGTFTKIFK GVRREVGDYG QLHETEVLLK VLDKSHRNYS ESFFEAASMM 600

SQLSHKYLVL NYGVCVCGEE NILVQEFVKF GSLDTYLKKN KNSINILWKL EVAKQLAWAM 660

HFLEEKTLIH GNVCAKNILL TREEDRKTGN PPFIKLSDPG ISITVLPKDI LQERIPWVPP 720

ECIENPKNLN LATDKWSFGT TLWEICSGGD KPLSALDSQR KLQFYEDRHQ LPAPKWTELA 780

NLINSCMDYE PDFRPSFRAI IRDLNSLFTP DYELLTENDM LPNMRIGALG FSGAFEDRDP 840

TQFEERHLKF LQQLGKGNFG SVEMCRYDPL QDNTGEVVAV KKLQHSTEEH LRDFEREIEI 900

LKSLQHDNIV KYKGVCYSAG RRNLRLIMEY LPYGSLRDYL QKHKERIDHK KLLQYTSQIC 960

KGMEYLGTKR YIHRDLATRN ILVENENRVK IGDFGLTKVL PQDKEYYKVK EPGESPIFWY 1020

APESLTESKF SVASDVWSFG VVLYELFTYI EKSKSPPAEF MRMIGNDKQG QMIVFHLIEL 1080

LKNNGRLPKP DGCPDEIYVI MTQCWNNNVN QRPSFRDLAL RVDQIRDNMA G 1131

Nucleotide Sequence
(FASTA)

ATGGGAATGG CTTGCCTTAC AATGGCAGAA ATGGAAGGAA CATCTGTGTC TGTGCATCAG 60

AATGGTGATA TTCCTGGAAA TGCTAATTCT GTAAAGCAAG TAGATCCAGT CCTACAGGTG 120

TATCTTTATC ATTCCCTTGA GAAAGCTGAA GGAGATTACC TGAAGTTTCC AACTGGGGAG 180

TATGTTGCGG AAGAAATTTG TGTTGCTGCT TCTAAAGCTT GCGGAATCAC ACCTGTGTAT 240

CACAGTATGT TCGCTTTAAT GAGTGAAACA GAAAGAATCT GGTATCCCCC CAACCATGTC 300

TTCCATATAG ATGAATCAGC CAGGCACAGT GTACTCTACA GAATAAGATT TTACTTTCCT 360

TACTGGTATT GTAATGGCAG CAACAGAACC TATCGGCATG GAATATCTCG AGGTGCTGAA 420

GCTCCTCTTC TTGATGACTT TGTCATGTCT TACCTTTTTG CTCAGTGGCG GCATGACTTT 480

TTGCATGGAT GGGTAAAAGT ACCTGTGACT CATGAAACAC AGGAAGAATG TCTTGGGATG 540

GCAGTGTTAG ATATGATGAG AATAGCCAAA GAAAAGGATC AAACCCCACT GACCATCTAT 600

AGCTCTATCA GCTACAAGAC ATTCTTACCA AAATGTGTTC GAGCAAAGAT CCAAGACTAT 660

CATATTTTGA CAAGGAAACG AATAAGGTAC AGATTTCGCA GATTTATTGA GCAATTCAGC 720

CATTGCAAAG CCACTGCCAG AAACTTGAAA CTTAAGTATC TTATAAATCT GGAAACTCTT 780

CAGTCTGCCT TCTACACAGA GCAATTTGAA GTAAAAGAAC CTGGAAGAGG TCCTTCAGGT 840

GAGGAGATTT TTGCAACCAT TATAATAACT GGAAACGGTG GAATTCAGTG GTCAAGAGGG 900

AAACATAAAG AAAGTGAGAC ACTGACAGAA CAGAATTTAC AGTTATATTG TGATTTTCCT 960

GATATTATTG ATGTGAATAT TAAGCAAGCA CACCAAGAAG GCTCAAATGA AAGCAGAATT 1020

GTAACTATCC ATAAGCAAGA TGGTAAAACT CTGGAAATTG AACTTAGCTC ATTGAGAGAA 1080

GCTTTGTCTT TTGTGTCATT AATTGATGGA TATTATAGAT TAACTGCAGA TGCACATCAT 1140

TACCTCTGTA AAGAAGTAGC ACCTCCAATG GTGCTTGAAA ATATACAAAG CAACTGTCAT 1200

GGCCCAATTT CAATGGATTT TGCCATCAGC AAGCTGAAGA AAGCAGGTAA TCAAACTGGA 1260

CTCTATGTAC TTCGATGCAG TCCTAAGGAC TTTAATAAAT ATTTTCTGAC TTTTGCTGTC 1320

GAGCGAGAAA ATGTCATTGA ACATAAGCAC TGTTTGATTA CAAAAAATGA GAATGGAGAA 1380

TACAACCTAA GTGGGACTAA GAAGAACTTC AGTAGTCTTA AAGATCTTTT GAATTGCTAT 1440

CAGATGGAAA CTGTTCGCTC AGACAGTATA ATTTTCCAGT TTACTAAATG CTGTCCCCCA 1500

AAGCCAAAAG ATAAATCAAA CCTTCTAGTC TTCAGAACCA ATGGTGTTTC TGAGGTACCG 1560

ACCTCACCAA CATTACAGAG GCATAATAAT GTGAACCAAA TGGTGTTTCA CAAAATCAGA 1620

AATGAAGATT TGATATTTAA TGAAAGCCTT GGCCAAGGCA CTTTTACAAA AATTTTTAAA 1680

GGTGTAAGAA GAGAAGTAGG AGACTATGGT CAACTGCATG AAACAGAAGT TCTTTTGAAA 1740

GTTCTGGATA AATCACATAG AAACTACTCA GAGTCTTTCT TTGAAGCAGC AAGCATGATG 1800

AGCCAGCTTT CTCACAAATA TCTGGTTTTA AATTATGGAG TGTGTGTCTG TGGAGAGGAG 1860

AATATTCTGG TTCAGGAGTT TGTAAAATTT GGATCACTAG ATACATATCT GAAAAAGAAT 1920

AAAAATTCTA TAAATATATT ATGGAAACTT GAAGTAGCTA AACAGTTGGC ATGGGCCATG 1980

CATTTTCTAG AAGAAAAAAC CCTTATTCAT GGGAATGTGT GTGCCAAAAA TATTCTACTT 2040

ACCAGAGAAG AAGACAGGAA GACAGGAAAT CCTCCTTTCA TCAAACTTAG TGATCCTGGC 2100

ATTAGTATTA CAGTTTTGCC AAAGGACATT CTTCAGGAGA GAATACCATG GGTACCACCT 2160

GAATGCATTG AAAATCCTAA AAATCTAAAC TTGGCAACAG ACAAATGGAG TTTTGGTACC 2220

ACTTTGTGGG AAATTTGCAG TGGAGGAGAT AAGCCTCTGA GTGCTTTGGA TTCTCAAAGA 2280

AAGCTACAGT TTTATGAAGA TAGGCACCAG CTTCCTGCAC CAAAGTGGAC AGAATTAGCA 2340

AATCTTATCA ATAGTTGTAT GGATTACGAA CCAGATTTTA GACCTTCTTT CAGAGCCATC 2400

ATACGTGATC TTAATAGTTT GTTTACTCCA GATTATGAGC TGTTAACAGA AAATGACATG 2460

TTACCAAATA TGAGGATAGG TGCCCTAGGG TTTTCTGGTG CTTTCGAAGA CCGAGACCCT 2520

ACGCAGTTTG AAGAGAGACA CTTGAAATTT CTACAGCAAC TTGGCAAGGG TAATTTTGGG 2580

AGTGTGGAGA TGTGCCGTTA TGACCCTCTA CAAGACAACA CTGGGGAGGT GGTGGCTGTG 2640

AAAAAGCTCC AGCACAGTAC TGAAGAGCAC CTCAGAGACT TTGAAAGGGA AATTGAAATC 2700

CTTAAATCCC TGCAGCATGA CAACATTGTA AAGTACAAGG GAGTGTGCTA CAGTGCTGGC 2760

CGGCGTAATC TAAGATTAAT TATGGAATAT TTACCATATG GAAGTTTACG AGACTATCTC 2820

CAAAAACATA AAGAACGGAT AGATCATAAA AAACTTCTGC AGTACACATC TCAGATATGC 2880

AAGGGTATGG AATATCTTGG TACAAAAAGA TATATCCACA GGGATCTGGC AACAAGGAAT 2940

ATATTGGTGG AAAATGAAAA CAGAGTTAAA ATTGGAGATT TTGGGTTAAC CAAAGTCTTG 3000

CCACAAGACA AAGAATACTA CAAAGTGAAA GAACCTGGTG AAAGTCCCAT ATTCTGGTAT 3060

GCTCCAGAAT CACTGACAGA GAGCAAGTTT TCTGTGGCCT CAGATGTTTG GAGCTTTGGA 3120

GTGGTTCTGT ATGAACTTTT TACATATATT GAGAAGAGTA AAAGTCCACC AGCGGAATTT 3180

ATGCGTATGA TTGGCAATGA CAAACAAGGA CAGATGATTG TGTTTCATTT GATAGAACTC 3240

CTGAAGAATA ATGGAAGATT ACCAAAACCA GATGGATGCC CAGATGAGAT TTATGTGATC 3300

ATGACACAAT GCTGGAACAA CAATGTAAAT CAGCGCCCCT CTTTCAGAGA CCTAGCTCTT 3360

CGAGTTGATC AAATAAGGGA CAACATGGCT GGATGA 3396

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 848   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  907

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+

Q: 908   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  967

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 968   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1021

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1022  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1080

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlpkp+ cp+e++++mt+c++++ +qrpsFr+++

Q: 1081  LKNNGRLPKPDgCPDEIYVIMTQCWNNNVNQRPSFRDLA  1119

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PKPDGCPDEI YVIMTQCWNN NVNQRPSFRD LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0061180	; P:mammary gland epithelium development
GO:0030099	; P:myeloid cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

ecb:100051487

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013