EKS-EQC-00273
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00273
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR422.31.0E-126203495293
StatusUnreviewed
Ensembl ProteinENSECAP00000007215
UniProt AccessionF6YCL6;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000009133ENSECAP00000007215ENSECAT00000009473
OrganismEquus caballus
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MTLDPPRRGL LMLLMALGLT QSDPVKPSRG PLLTCTCDSP HCSRPTCQGA WCTVVLVREE 60
GSHPQEHRGC GNLHQELCRG RPTEFVNHYC CYSPLCNQNV SLVLEATPTP EQPQVDGQLP 120
LILGPVLAFL ALVALGTLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS 180
DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 240
RETEIYNTVL LRHDNILGKQ GGWSFIASDM TSRNSSTQLW LITHYHEHGS LYDFLQRQTL 300
EPQLALRLAV SAACGLAHLH VEIFGTQGKP AIAHRDLKSR NVLVKSNLQC CIADLGLAVM 360
HSQGSDYLDI GNNPRVGTKR YMAPEVLDEQ IRTDCFESYK WTDIWAFGLV LWEITRRTTV 420
NGIVEDYRPP FYDVVPNDPS FEDMKKVVCV DQQTPTIPNR LAADPVLSGL AQMMRECWYP 480
NPSARLTALR IKKTLQKLSN SLEKAKVIH 509
Nucleotide Sequence
(FASTA)
ATGACCTTGG ACCCCCCCAG GAGAGGCCTT CTGATGCTAC TGATGGCCTT GGGCCTGACC 60
CAGAGCGACC CCGTGAAGCC CTCTCGGGGC CCACTGCTGA CCTGCACATG TGACAGCCCA 120
CACTGCAGCA GGCCTACCTG CCAGGGGGCC TGGTGCACAG TAGTGCTGGT GCGGGAGGAG 180
GGCAGCCACC CCCAGGAACA TCGGGGCTGC GGGAACCTGC ACCAGGAGCT TTGCAGGGGG 240
CGCCCCACCG AGTTCGTCAA CCACTACTGC TGCTACAGCC CCCTCTGCAA CCAGAACGTG 300
TCCCTGGTGC TGGAGGCCAC CCCAACTCCG GAGCAGCCGC AAGTAGATGG CCAGCTGCCT 360
CTGATCCTGG GCCCTGTGCT GGCCTTCCTG GCCCTGGTGG CCCTGGGTAC CCTGGGCCTG 420
TGGCATGTCC GGCGGAGGCA GGAGAAACAG CGGGGCCTGC ACAGCGAGCT GGGCGAGTCC 480
AGCCTCATCC TGAAGGCGTC CGAGCAGGGG GACAGCATGT TGGGGGACCT CTTGGACAGT 540
GACTGTACCA CGGGCAGTGG CTCGGGGCTC CCCTTCCTGG TGCAGAGGAC AGTGGCACGG 600
CAGGTTGCCC TGGTGGAGTG TGTGGGAAAG GGCCGCTATG GTGAGGTATG GCGGGGCCTG 660
TGGCATGGCG AGAGTGTGGC CGTCAAGATC TTCTCCTCGA GGGATGAACA GTCCTGGTTC 720
CGGGAGACGG AGATCTACAA CACAGTGTTG CTCAGACATG ACAACATCCT AGGCAAGCAG 780
GGGGGCTGGA GCTTTATTGC CTCAGACATG ACTTCCCGCA ACTCGAGCAC ACAGCTGTGG 840
CTCATCACAC ACTACCACGA GCATGGCTCG CTCTACGACT TTCTGCAGAG GCAGACGCTG 900
GAGCCCCAGC TGGCTCTGAG GCTAGCTGTG TCCGCGGCCT GCGGCCTGGC GCACCTGCAC 960
GTAGAGATCT TCGGCACGCA GGGCAAACCG GCCATCGCCC ACCGCGACCT CAAGAGCCGC 1020
AACGTGCTGG TCAAGAGCAA CCTGCAGTGC TGCATCGCCG ACCTGGGCCT GGCTGTGATG 1080
CACTCCCAGG GTAGCGATTA CCTGGACATC GGCAACAACC CGCGAGTGGG CACCAAGCGG 1140
TACATGGCCC CTGAGGTGCT GGATGAGCAG ATCCGCACCG ACTGCTTTGA GTCCTACAAG 1200
TGGACAGACA TCTGGGCCTT TGGCCTGGTG CTGTGGGAGA TAACCCGACG GACCACTGTC 1260
AATGGCATCG TGGAGGACTA CAGGCCACCC TTCTATGATG TGGTGCCCAA TGATCCCAGC 1320
TTTGAGGACA TGAAGAAGGT GGTGTGTGTT GACCAGCAGA CCCCCACCAT CCCCAACCGG 1380
CTGGCTGCAG ACCCGGTCCT CTCAGGCCTG GCTCAGATGA TGCGCGAGTG CTGGTACCCC 1440
AACCCCTCTG CCCGCCTCAC CGCGCTTAGG ATCAAGAAGA CGCTACAGAA ACTCAGCAAC 1500
AGTCTGGAGA AAGCCAAAGT GATTCACTAG 1530
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilq....  57
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+    
Q: 203   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGkqgg  262
         689***************************************************955555
S: 58    ..fiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115
           fia+d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH e
Q: 263   wsFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVE  322
         55**********************************************************
S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175
         i+gt+g  KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkR
Q: 323   IFGTQG--KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR  380
         ******..****************************************************
S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235
         YmaPEvl+e++ +++fe++k++D++++gLvlWE+++R++  +++ve+y++pf++vv++dP
Q: 381   YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEITRRTTV-NGIVEDYRPPFYDVVPNDP  439
         **************************************99.*******************
S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         s+e+mk+vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 440   SFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  495
         ******************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGKQGG 60
WSFIASDMTS RNSSTQLWLI THYHEHGSLY DFLQRQTLEP QLALRLAVSA ACGLAHLHVE 120
IFGTQGKPAI AHRDLKSRNV LVKSNLQCCI ADLGLAVMHS QGSDYLDIGN NPRVGTKRYM 180
APEVLDEQIR TDCFESYKWT DIWAFGLVLW EITRRTTVNG IVEDYRPPFY DVVPNDPSFE 240
DMKKVVCVDQ QTPTIPNRLA ADPVLSGLAQ MMRECWYPNP SARLTALRIK KTL 293
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013