EKS-EQC-00209
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00209
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2589.52.1E-17750406357
StatusUnreviewed
Ensembl ProteinENSECAP00000007281
UniProt AccessionF6Y023;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000009170ENSECAP00000007281ENSECAT00000009549
OrganismEquus caballus
Functional Description
Protein Length475
Protein Sequence
(FASTA)
GLGLIEEKQA EGRRAASACE DIQAIFTQKN KLLPDPLDTR RWQGFRLEEY LIGQSIGKGC 60
SAAVYEATVP VLPQNLEVAK STGLLPGRGP DITPRGEEEE RAPRAPAFPL AIKMMWNISA 120
GSSSEAIFST MSQELVPASR VALAGEYGAV TYRTSKGGPK QLAPHPNIIR VVRAFTSPVP 180
LLPGALVDYP DVLPPRLHPG GLGHGRTLFL VMKNYPCTLR QYLRVNTPSP RLATVMALQL 240
LEGVDHLVQQ GVAHRDLKSD NILVELDADG CPWLVITDFG CCLADERIGL RLPFTSCYVD 300
RGGNGCLMAP EVSTACPGPR AVIDYSKADA WAVGALAYEI FGLPNPFYGQ GRAHLESRSY 360
QEAQLPPLPE SVPRDVRQLV RSLLQREASK RPSARVAANV LHLSLWGEHT LALKNLKPDK 420
MIGWLLQQSA AALLADRLTE KSCVETKMKV LFLANLEYEA LCQAALLLSS WRAAP 475
Nucleotide Sequence
(FASTA)
GGCCTGGGCC TCATCGAGGA GAAGCAGGCA GAGGGCCGGC GTGCGGCCTC GGCCTGTGAG 60
GACATCCAGG CAATTTTTAC CCAGAAAAAC AAGCTGCTAC CTGACCCGTT GGACACTAGA 120
CGCTGGCAGG GCTTCCGGCT GGAGGAGTAT CTGATAGGGC AGTCCATTGG CAAGGGCTGC 180
AGTGCTGCCG TGTATGAAGC CACCGTGCCT GTGTTGCCCC AGAACCTGGA GGTGGCAAAG 240
AGCACCGGGC TTCTTCCAGG GAGAGGCCCA GATATCACTC CACGAGGAGA AGAGGAGGAG 300
CGAGCGCCAC GGGCCCCTGC CTTTCCCTTA GCCATCAAGA TGATGTGGAA CATCTCGGCG 360
GGCTCTTCCA GCGAAGCCAT CTTCAGCACA ATGAGCCAGG AGCTAGTCCC AGCTAGTCGA 420
GTGGCCTTGG CCGGGGAGTA TGGAGCAGTC ACTTACAGAA CATCCAAGGG AGGTCCCAAG 480
CAACTGGCCC CTCACCCCAA TATCATCCGG GTCGTCCGCG CCTTCACCTC CCCTGTCCCA 540
CTGCTGCCAG GGGCCCTGGT CGACTACCCC GATGTGCTGC CCCCTCGTCT TCACCCCGGA 600
GGCCTGGGCC ACGGGCGGAC GCTCTTCCTT GTTATGAAGA ACTACCCCTG TACCCTGCGC 660
CAGTACCTTC GCGTGAATAC CCCAAGCCCC CGCCTCGCCA CGGTGATGGC CTTGCAGCTC 720
CTGGAAGGCG TGGACCATCT GGTGCAACAG GGCGTCGCGC ACAGAGACTT AAAGTCCGAC 780
AACATTCTCG TGGAGCTGGA CGCAGATGGC TGCCCCTGGT TGGTGATCAC AGATTTTGGT 840
TGCTGCCTGG CTGATGAGCG CATCGGCCTG CGGTTGCCTT TCACCAGCTG CTACGTAGAT 900
CGGGGCGGAA ACGGCTGCCT GATGGCTCCT GAGGTGTCCA CGGCCTGTCC TGGCCCCAGG 960
GCGGTGATCG ACTACAGCAA GGCTGATGCC TGGGCAGTGG GAGCGCTCGC CTACGAGATC 1020
TTCGGGCTCC CCAACCCCTT TTACGGCCAG GGCAGGGCCC ACCTTGAAAG CCGCAGTTAC 1080
CAAGAAGCTC AGCTGCCTCC ACTGCCCGAG TCGGTGCCTC GAGACGTGAG ACAGCTGGTG 1140
AGGTCCCTGC TCCAGCGTGA GGCCAGCAAG AGACCGTCTG CCCGAGTAGC TGCTAACGTG 1200
CTTCATTTAA GCCTCTGGGG GGAGCATACT CTAGCCCTGA AGAATCTGAA ACCAGACAAG 1260
ATGATTGGCT GGCTCCTCCA ACAGTCAGCT GCCGCTTTGT TGGCCGACAG GCTTACCGAG 1320
AAGAGTTGTG TGGAAACCAA AATGAAGGTG TTGTTTCTGG CCAACCTGGA GTATGAAGCG 1380
CTGTGCCAGG CGGCCCTCCT GCTCTCCTCC TGGAGGGCAG CCCCGTGA 1428
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++gkgc+aavyeat++ l+q+le+ak++gll g++++ + +++++e+a+ a++fp
Q: 50    YLIGQSIGKGCSAAVYEATVPVLPQNLEVAKSTGLLpGRGPDITPRGEEEERAPRAPAFP  109
         99*********************************99***********************
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPniv  111
         laik+m+ni+a+sssea++++msqelvpasrval+geygav        pk+la+hPni+
Q: 110   LAIKMMWNISAGSSSEAIFSTMSQELVPASRVALAGEYGAVtyrtskggPKQLAPHPNII  169
         ************************************************************
S: 112   rvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrs  171
         rv+raf++ v+llP+al+dyPd+lp+rl+p glg+g+tl+lvmk+y++tlr+yl ++++s
Q: 170   RVVRAFTSPVPLLPGALVDYPDVLPPRLHPGGLGHGRTLFLVMKNYPCTLRQYLRVNTPS  229
         ************************************************************
S: 172   trlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdg  231
         +rla+++ +qlle+vdhlv++gvahrdlksdnilveld d++P+lvi+dfGCclad+ +g
Q: 230   PRLATVMALQLLEGVDHLVQQGVAHRDLKSDNILVELDADGCPWLVITDFGCCLADERIG  289
         ************************************************************
S: 232   lrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyg  291
         lrlp++s +vd+GGn++lmaPe+sta pGp+avi+y+kad+WavGalayeifgl nPfyg
Q: 290   LRLPFTSCYVDRGGNGCLMAPEVSTACPGPRAVIDYSKADAWAVGALAYEIFGLPNPFYG  349
         ************************************************************
S: 292   egkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         +g+a+les+syqeaqlP+lpesvp ++rqlv++ll+reaskr+sa++aanvl+lsl+
Q: 350   QGRAHLESRSYQEAQLPPLPESVPRDVRQLVRSLLQREASKRPSARVAANVLHLSLW  406
         ********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEATV PVLPQNLEVA KSTGLLPGRG PDITPRGEEE ERAPRAPAFP 60
LAIKMMWNIS AGSSSEAIFS TMSQELVPAS RVALAGEYGA VTYRTSKGGP KQLAPHPNII 120
RVVRAFTSPV PLLPGALVDY PDVLPPRLHP GGLGHGRTLF LVMKNYPCTL RQYLRVNTPS 180
PRLATVMALQ LLEGVDHLVQ QGVAHRDLKS DNILVELDAD GCPWLVITDF GCCLADERIG 240
LRLPFTSCYV DRGGNGCLMA PEVSTACPGP RAVIDYSKAD AWAVGALAYE IFGLPNPFYG 300
QGRAHLESRS YQEAQLPPLP ESVPRDVRQL VRSLLQREAS KRPSARVAAN VLHLSLW 357
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013