EKS-EQC-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	1.1E-95	170	407	238

Status

Unreviewed

Ensembl Protein

ENSECAP00000007345

UniProt Accession

F6X4K0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009199	ENSECAP00000007345	ENSECAT00000009619

Organism

Equus caballus

Functional Description

Protein Length

966

Protein Sequence
(FASTA)

MADPQEHLSC SSSPHLPLSE NKTFNGLQDE LAPMGSHPSP KLLKDQQEKG VVQTELTEGM 60

NSPITTTVLT SVSEDSRDQF ENSVLQLREQ DESEMAMSQG NSNTVDGEST SGTEDIKIQF 120

SRSGSSSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG 180

AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ 240

LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 300

SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 360

IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE 420

TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN 480

NLYMELSAIM LQLEMREKEL IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH 540

KPGMPTKRPD LLRSEGIPSM EVAPTASPLS GSPKMSTSSN KSRYRSKPRH RRGNSRGSHS 600

DFAAILKSQP AQENSAHPTY LDQAQSQYPS PHHHNPLQQQ YQQPPPATSQ SHHPRLNMHG 660

QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS TAMAADCWRS SEPDDGQAGP 720

WDCCQADPYD PCLQCRPEQC GSLDLPSAEP VGRSPDLFKS PAHNTLSENA QGSEKMEENE 780

FNGCRSASSL GIPHHITPPM LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS 840

SCQSYSTFSS ENFSVSDGEE GNTSDHSNSP DELADKLEDH LAEKLDELLS QTPEIPIEIS 900

SHSDGLSDKE CAVRRVKTQM SLGKLCAEER GYENPMQFEE SDCDSSDGEC SDATVRTNKH 960

YSSATW 966

Nucleotide Sequence
(FASTA)

ATGGCTGACC CTCAGGAGCA CCTGAGCTGC TCCTCCTCCC CACACTTACC CTTGAGTGAA 60

AACAAAACCT TCAATGGACT ACAAGATGAA CTCGCACCAA TGGGGAGCCA CCCTTCACCC 120

AAGCTCCTTA AGGACCAACA GGAAAAGGGA GTGGTGCAAA CAGAGCTAAC TGAGGGCATG 180

AACAGCCCCA TCACCACGAC AGTGTTGACA AGTGTAAGCG AGGATTCCAG GGACCAGTTT 240

GAGAACAGTG TCCTTCAGCT AAGGGAACAA GATGAATCAG AGATGGCCAT GTCTCAGGGG 300

AACAGCAACA CTGTGGATGG AGAGAGCACG AGTGGAACTG AAGACATCAA GATTCAGTTC 360

AGCAGGTCGG GCAGCAGCAG TGGTGGGTTT CTTGAAGGAC TATTTGGATG CTTAAGGCCT 420

GTCTGGAATA TCATTGGGAA GGCATATTCC ACTGATTACA AATTACAGCA ACAAGATACT 480

TGGGAAGTGC CATTTGAGGA GATCTCAGAG CTGCAGTGGC TGGGTAGTGG AGCCCAAGGA 540

GCTGTCTTCT TGGGCAAGTT CCGAGCGGAG GAGGTGGCCA TCAAGAAAGT GAGAGAGCAG 600

AATGAGACGG ATATCAAGCA TTTGAGGAAG TTGAAGCACC CTAACATCAT CGCTTTCAAG 660

GGTGTTTGTA CTCAGGCCCC ATGTTATTGT ATCATCATGG AATACTGTGC CCATGGACAG 720

CTCTACGAGG TTTTGCGAGC TGGCAGGAAG ATCACGCCTC GATTGCTAGT AGACTGGTCC 780

ACGGGAATTG CAAGCGGAAT GAATTATTTG CACCTCCATA AAATTATTCA TCGTGATCTC 840

AAATCACCTA ATGTTTTAGT GACTCACACA GATGCAGTAA AAATTTCAGA TTTTGGTACG 900

TCTAAAGAAC TCAGCGATAA AAGCACCAAG ATGTCCTTCG CCGGCACAGT TGCATGGATG 960

GCACCAGAGG TGATACGTAA TGAACCTGTC TCTGAAAAAG TCGATATATG GTCTTTTGGA 1020

GTGGTGCTTT GGGAGCTGCT GACAGGAGAG ATCCCTTACA AAGATGTAGA CTCTTCAGCC 1080

ATTATTTGGG GTGTTGGAAG CAACAGCCTA CACCTTCCAG TTCCTTCCAC TTGCCCTGAT 1140

GGATTCAAAA TCCTTATGAA ACAGACATGG CAGAGTAAAC CTCGCAACCG ACCTTCTTTT 1200

CGGCAGACGC TCATGCATTT AGACATCGCA TCCGCAGACG TACTTGCCAC CCCACAAGAA 1260

ACTTACTTCA AGTCTCAGGC TGAATGGAGA GAAGAAGTGA AGAAACACTT CGAGAAGATC 1320

AAAAGTGAAG GAACTTGTAT ACACCGATTA GATGAAGAAC TGATTCGAAG GCGCAGAGAA 1380

GAGCTCAGGC ATGCTTTGGA TATTCGTGAA CACTATGAGA GAAAACTTGA GCGGGCTAAT 1440

AATTTGTACA TGGAACTGAG TGCCATCATG CTGCAGCTAG AAATGCGGGA GAAGGAGCTC 1500

ATTAAGCGAG AGCAAGCAGT GGAAAAGAAG TATCCTGGGA CCTACAAACG ACACCCTGTC 1560

CGTCCAATAA TCCACCCTAA CGCCATGGAG AAACTCATGA AGAGGAAAGG CGTGCCTCAC 1620

AAACCGGGGA TGCCGACCAA ACGGCCAGAT CTGTTACGAT CTGAAGGTAT CCCCAGTATG 1680

GAGGTGGCTC CCACTGCATC CCCTTTGTCC GGAAGTCCCA AAATGTCCAC CTCAAGCAAC 1740

AAGAGCCGGT ATCGCAGCAA ACCACGCCAC CGCAGAGGGA ACAGCAGAGG CAGCCATAGT 1800

GACTTTGCAG CAATCTTGAA AAGCCAGCCA GCCCAGGAAA ATTCAGCCCA TCCCACTTAT 1860

CTAGACCAGG CTCAATCCCA ATACCCTTCT CCCCATCACC ATAATCCTCT GCAGCAGCAA 1920

TACCAGCAAC CCCCTCCTGC CACGTCTCAG AGTCACCATC CCAGACTCAA TATGCACGGA 1980

CAGGACATTG CAACCTGCGC CAACAACCTG AGGTATTTTG GCCCAGCAGC AGCCCTGCGG 2040

AGCCCACTCA GCAACCATGC TCAAAGACAG TTGCCTGGCT CTAGCCCTGA CCTCATCTCC 2100

ACAGCCATGG CAGCAGATTG TTGGAGAAGT TCTGAGCCTG ACGACGGCCA GGCTGGCCCC 2160

TGGGACTGTT GTCAGGCTGA CCCTTATGAC CCCTGCCTCC AGTGCAGGCC AGAACAGTGT 2220

GGGTCCTTAG ACCTACCCTC TGCTGAGCCA GTGGGGAGGA GCCCCGACCT TTTCAAGTCA 2280

CCAGCACACA ATACCCTCTC AGAAAATGCC CAAGGTTCTG AGAAAATGGA AGAAAACGAA 2340

TTCAACGGCT GTCGGTCTGC ATCCTCCCTT GGCATCCCTC ATCACATCAC CCCCCCAATG 2400

CTACCTCGAA AAACAAGGCC CCTTCAAAAG AGTGGAGATG ACTCCTCAGA AGAGGAAGAA 2460

GGAGAAGTGG ACAGCGAAGT TGAATTTCCA CGGAGACAGA GGCCCCATCG CTGTATCAGC 2520

AGCTGCCAGT CATATTCAAC CTTTAGCTCT GAGAATTTCT CTGTGTCTGA TGGAGAGGAG 2580

GGAAATACCA GTGACCACTC AAACAGTCCT GATGAGTTAG CAGATAAACT TGAAGACCAC 2640

CTGGCGGAGA AACTAGACGA GCTGCTGTCC CAGACGCCGG AGATCCCCAT TGAGATATCC 2700

TCACATTCGG ATGGGCTCTC TGACAAGGAG TGTGCTGTGC GCCGCGTGAA GACACAGATG 2760

TCTCTAGGCA AGCTGTGTGC GGAGGAACGT GGCTATGAGA ATCCTATGCA GTTTGAAGAA 2820

TCGGACTGTG ACTCTTCAGA TGGAGAGTGT TCTGATGCCA CAGTTAGGAC CAATAAACAC 2880

TACAGCTCTG CTACTTGGTA A 2901

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 170   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  220

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 221   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  275

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 276   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  334

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 335   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  394

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 395   RNRPSFRQTLMHL  407

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007254	; P:JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation

KEGG

ecb:100059237

;

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013