EPS-EQC-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	280.1	2.2E-83	131	335	205

Status

Unreviewed

Ensembl Protein

ENSECAP00000007442

UniProt Accession

F6YKU1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009342	ENSECAP00000007442	ENSECAT00000009731

Organism

Equus caballus

Functional Description

Protein Length

761

Protein Sequence
(FASTA)

MGSGTSTQHH FAFQNAEKAF KAAALIQRWY RRYMARLEMR RRCTWSIFQS IEYAGQQDQV 60

KLHDFFSYLM DHFTPSSHNE RDFLSRMFTE ERLPQDSEME GCRDYDCIEV PDSYMGPRLS 120

FPLLPDHATA LLEAFRLKQQ LHARYVLNLL HETRKYLVQL PNINRVSTCY SEEITVCGDL 180

HGQLDDLIFI FYKNGLPSPE RAYVFNGDFV DRGKDSLEIL MVLFAFMLVY PKEFHLNRGN 240

HEDHMVNLRY GFTKEVMHKY KTHGKKILKV LQDVFCWLPL ATLVDEKVLI LHGGVSDKTD 300

LELLSKLDRH KIVSAMRCKT RKENEKQAEK GKANQTGSAG KPSPWFLPQS HSLPSSPLRL 360

GSHKAHKDSR SSSVPCSIPP NPQELSRQVR RSVDLELERC RQQAGFPVIK EKKEEPLLFS 420

SEADSEAGEL LQPTQEEWRQ VVDILWSDPM AQEGCKANTV RGGGCYFGPN VTEQLLQKYN 480

LQFLIRSHEC KPEGYEFCHS RKVLTIFSAS NYYEVGSNRG AYVKLGPALT PHIVQYQANK 540

ATHMLTMRQR QDFSMNDFPK NGIIESALRA LRGKLFAHSS DLLGEFKKHD KDKTGLITLS 600

DWAAAVESVL HLGLPWRMLR PQLVNSSTDN MLEYKSWLED LAKEQLSHEN IQSSLLETLY 660

RNRSNLETIF RIIDSDHSGF ISLDEFRQTW KLFSSHMKID ITDDCICDLA RSIDFNKDGH 720

IDINEFLEAF RLVEQSCSEG NASECPQATN ANSGYSRPDA H 761

Nucleotide Sequence
(FASTA)

ATGGGAAGTG GCACCTCAAC CCAACATCAT TTTGCTTTCC AAAATGCAGA GAAAGCCTTC 60

AAGGCAGCGG CCCTGATCCA GAGATGGTAC CGGCGCTATA TGGCACGCCT GGAGATGAGG 120

CGGCGGTGCA CCTGGAGCAT CTTCCAGTCC ATAGAGTATG CTGGGCAGCA AGACCAGGTC 180

AAGCTCCACG ATTTCTTCAG CTACCTTATG GATCACTTCA CCCCCAGCAG TCACAATGAG 240

AGGGACTTCC TGAGCCGCAT GTTCACTGAG GAGAGACTCC CCCAGGACTC CGAGATGGAG 300

GGGTGCAGGG ACTATGACTG CATAGAGGTA CCGGACAGTT ACATGGGGCC ACGCCTCTCA 360

TTCCCGCTGC TTCCTGACCA TGCAACTGCC CTGCTGGAAG CCTTCAGACT GAAACAACAG 420

CTCCACGCTC GCTATGTCTT GAATCTTTTG CATGAAACCA GGAAATATCT GGTGCAACTG 480

CCGAACATCA ACCGGGTCTC CACCTGTTAC AGCGAGGAGA TCACCGTGTG TGGAGATTTA 540

CACGGCCAGT TGGATGACTT AATATTTATA TTTTATAAGA ATGGCCTCCC GTCACCAGAG 600

CGGGCCTACG TGTTCAATGG TGACTTTGTG GATCGAGGCA AGGATTCATT AGAGATCCTG 660

ATGGTTCTTT TTGCCTTCAT GTTGGTTTAC CCAAAAGAGT TCCATCTTAA CCGAGGCAAC 720

CATGAGGACC ATATGGTGAA CTTACGTTAT GGCTTCACCA AGGAAGTGAT GCATAAATAT 780

AAGACACATG GCAAGAAAAT ACTAAAAGTA CTGCAAGATG TTTTCTGTTG GCTTCCGCTG 840

GCCACTTTGG TTGATGAGAA AGTCCTGATT CTTCACGGTG GAGTGTCAGA CAAGACTGAC 900

CTGGAGCTTT TGTCCAAACT AGACAGGCAC AAGATTGTTT CCGCCATGAG GTGCAAAACG 960

AGAAAGGAGA ATGAGAAGCA GGCAGAGAAG GGAAAAGCCA ACCAGACAGG CTCTGCAGGG 1020

AAACCTTCCC CATGGTTTCT CCCCCAAAGC CACTCTCTCC CGTCTTCGCC CCTTCGCCTC 1080

GGCTCCCACA AGGCTCACAA AGACAGCCGC TCCTCCAGCG TCCCCTGCAG CATCCCCCCG 1140

AACCCCCAGG AGCTCTCCCG GCAGGTGCGG CGCTCTGTGG ACCTGGAGCT GGAGCGGTGC 1200

CGGCAGCAAG CAGGCTTCCC AGTGATCAAG GAGAAGAAGG AGGAACCCCT GCTCTTCTCA 1260

TCAGAAGCAG ACTCAGAAGC TGGGGAGCTG CTGCAGCCCA CTCAGGAGGA GTGGCGGCAG 1320

GTTGTAGATA TATTGTGGAG TGATCCCATG GCCCAGGAGG GCTGCAAGGC CAACACTGTT 1380

CGAGGAGGAG GCTGTTATTT TGGGCCTAAC GTGACAGAAC AGCTGCTACA GAAATACAAC 1440

CTGCAGTTCC TGATCCGCTC ACACGAGTGC AAACCCGAGG GCTATGAATT CTGCCACAGC 1500

CGCAAGGTGT TAACCATCTT CTCTGCCTCC AACTATTATG AAGTTGGCAG TAACCGAGGG 1560

GCCTATGTCA AACTGGGGCC GGCCCTGACC CCACACATTG TGCAGTATCA AGCTAACAAG 1620

GCAACCCACA TGCTAACCAT GAGACAAAGG CAAGATTTTT CAATGAACGA TTTTCCAAAA 1680

AATGGAATTA TTGAGTCAGC CCTGAGAGCT CTGCGGGGAA AGTTATTTGC TCATTCCTCA 1740

GATCTTCTTG GTGAATTTAA GAAGCATGAT AAAGATAAAA CTGGTTTGAT CACCCTGAGT 1800

GACTGGGCAG CCGCTGTGGA GTCCGTGTTG CATCTGGGAC TACCATGGCG GATGCTAAGG 1860

CCACAGCTGG TGAACAGCTC AACAGATAAC ATGCTGGAGT ACAAGTCCTG GCTGGAGGAC 1920

TTAGCCAAAG AACAACTGAG CCATGAGAAC ATACAGTCAA GTTTGCTGGA AACACTGTAT 1980

CGAAACAGAT CCAACCTGGA GACCATTTTT AGGATCATAG ACAGCGATCA TTCAGGGTTC 2040

ATTTCACTGG ACGAGTTCAG ACAGACTTGG AAACTGTTCA GCTCTCATAT GAAGATTGAC 2100

ATCACGGATG ACTGTATCTG TGACCTTGCT CGGAGCATTG ACTTCAACAA GGATGGCCAC 2160

ATTGACATCA ATGAGTTCCT GGAGGCCTTC CGCCTTGTGG AGCAATCCTG CTCAGAGGGC 2220

AATGCCTCAG AGTGCCCACA AGCCACAAAT GCTAACAGTG GCTACAGCAG GCCAGATGCA 2280

CACTAA 2286

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         lle+f+ k++lha+yvl++l+e++k l qlpni++vst+ s+e+tv+GdlhG+lddl+++

Q: 131   LLEAFRLKQQLHARYVLNLLHETRKYLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFI  190

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPs +++yvfnGdfvdrGk +le+l+vl +++lv+P++ +lnrGnhed+++n+ry

Q: 191   FYKNGLPSPERAYVFNGDFVDRGKDSLEILMVLFAFMLVYPKEFHLNRGNHEDHMVNLRY  250

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf+kev++kyk++gk+il++l++v+ wlPl+++vd++vl++hGG+s+ t+l+ll +++r+

Q: 251   GFTKEVMHKYKTHGKKILKVLQDVFCWLPLATLVDEKVLILHGGVSDKTDLELLSKLDRH  310

         ************************************************************

S: 184   krksvllpPeessrd....lgrldt  204

         k +s ++  +  + +    +g+ ++

Q: 311   KIVSAMRCKTRKENEkqaeKGKANQ  335

         ****998766444332222444444

Domain Sequence
(FASTA)

LLEAFRLKQQ LHARYVLNLL HETRKYLVQL PNINRVSTCY SEEITVCGDL HGQLDDLIFI 60

FYKNGLPSPE RAYVFNGDFV DRGKDSLEIL MVLFAFMLVY PKEFHLNRGN HEDHMVNLRY 120

GFTKEVMHKY KTHGKKILKV LQDVFCWLPL ATLVDEKVLI LHGGVSDKTD LELLSKLDRH 180

KIVSAMRCKT RKENEKQAEK GKANQ 205

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013