EKS-EQC-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NEK	337.9	4.7E-101	4	257	254

Status

Unreviewed

Ensembl Protein

ENSECAP00000007694

UniProt Accession

F6YW35;

Protein Name

Protein Synonyms/Alias

Gene Name

NEK8

Gene Synonyms/Alias

NEK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009500	ENSECAP00000007694	ENSECAT00000010016
ENSECAG00000009500	ENSECAP00000007675	ENSECAT00000009994

Organism

Equus caballus

Functional Description

Protein Length

692

Protein Sequence
(FASTA)

MEKYERIRVV GRGAFGIVHL CLRKADQKLV IIKQIPVEQM TKEERQAAQN ECQVLKLLNH 60

PNVIEYYENF LEDKALMIAM EYAPGGTLAE FIQKRCNSLL EEETILHFFV QILLALHHVH 120

THLILHRDLK TQNILLDKHR MVVKIGDFGI SKILSSKSKA YTVVGTPCYI SPELCEGKPY 180

NQKSDIWALG CVLYELASLK RAFEAANLPA LVLKIMSGTF APISDRYSPE LRQLVLSLLS 240

LEPAQRPPLS HIMAQPLCIR ALLNLHTDLG SVRMRRPSSS LTPGSTGSRT TSARCRGIPR 300

GPARPAIPPP LSSVYTWGGG LSAPLRLPML NTEVVQVAAG RTQKAGVTRS GRLILWEAPP 360

LGAGGGALLP GAVEQQQPQF ISRFLEGQSG VTIKHVACGD LFTACLTDRG IIMTFGSGSN 420

GCLGHGSLND ISQPTIVEAL LGYEMVQVAC GASHVLALST ERELFAWGRG DGGRLGLGTR 480

ESHSCPQQVP MPLGQEAQRV VCGIDSSMIL TVPGRALACG SNRFNKLGLD HFSLGEEPAP 540

HQQVEEALSF TPLGSAPLDQ EALLSVDLGT AHSAAVTTSG DCYTFGSNQH GQLGTSARRV 600

SRAPCRVQGL QGIKIAMVAC GDAFTVAIGA EGEVYSWGKG ARGRLGRRDE DAGLPRPVQL 660

DETHPYTVTS VSCCHGNTLL AIRPVTDEPV PP 692

Nucleotide Sequence
(FASTA)

ATGGAGAAGT ACGAGCGGAT CCGAGTGGTG GGGAGAGGTG CCTTCGGGAT TGTGCACCTG 60

TGCCTGCGCA AAGCCGACCA AAAGCTGGTG ATCATCAAGC AGATCCCAGT GGAGCAGATG 120

ACCAAGGAAG AGCGGCAGGC AGCCCAAAAT GAGTGCCAGG TCCTCAAGCT GCTCAACCAC 180

CCCAATGTCA TTGAGTACTA CGAGAACTTC CTGGAGGACA AGGCCCTCAT GATCGCCATG 240

GAATATGCAC CAGGCGGCAC CCTTGCTGAG TTCATCCAAA AGCGCTGTAA TTCCCTGCTG 300

GAGGAGGAGA CCATCCTGCA CTTCTTTGTG CAGATCCTGC TCGCGTTGCA TCACGTGCAC 360

ACCCACCTCA TCCTGCACCG GGACCTCAAG ACCCAAAACA TCCTTCTTGA CAAACACCGC 420

ATGGTCGTCA AGATTGGCGA CTTCGGCATC TCCAAGATCC TTAGCAGCAA GAGCAAGGCC 480

TACACGGTGG TGGGTACTCC ATGCTACATC TCCCCTGAAC TGTGTGAGGG CAAGCCCTAC 540

AACCAGAAGA GTGACATCTG GGCCCTGGGC TGCGTCCTCT ACGAGTTGGC CAGCCTCAAG 600

AGGGCCTTTG AGGCTGCGAA CCTGCCAGCC TTGGTGCTGA AGATCATGAG CGGCACCTTC 660

GCACCCATCT CTGACCGGTA CAGCCCTGAG CTGCGCCAGC TTGTCCTGAG TCTGCTCAGC 720

CTGGAGCCAG CCCAGCGGCC ACCGCTCAGC CACATCATGG CACAGCCCCT CTGCATCCGT 780

GCCCTCCTCA ACCTCCACAC AGACCTGGGC AGTGTCCGCA TGCGGAGGCC TAGTTCGTCC 840

CTGACCCCAG GCAGCACAGG GAGCAGGACC ACCAGTGCCC GCTGCAGGGG TATCCCACGG 900

GGACCTGCAC GGCCCGCCAT TCCGCCGCCG CTGTCGTCGG TGTACACGTG GGGTGGCGGG 960

CTCAGCGCCC CGCTGCGACT GCCAATGCTC AACACAGAGG TGGTCCAGGT GGCAGCGGGG 1020

CGCACGCAGA AGGCCGGTGT CACGCGCTCT GGGCGCCTCA TCCTGTGGGA GGCCCCGCCC 1080

CTAGGCGCCG GAGGGGGCGC CCTCCTCCCC GGGGCGGTGG AGCAGCAGCA GCCCCAGTTC 1140

ATCTCACGTT TCCTGGAGGG CCAGTCAGGT GTGACCATCA AGCACGTGGC CTGCGGGGAC 1200

CTCTTCACGG CCTGCCTGAC TGACCGAGGC ATCATCATGA CCTTTGGCAG TGGGAGCAAT 1260

GGGTGCCTAG GCCATGGCAG CCTCAATGAC ATCAGCCAGC CCACTATTGT GGAGGCCCTG 1320

CTGGGCTATG AGATGGTGCA GGTGGCCTGC GGGGCTTCTC ATGTGCTGGC CCTGTCCACT 1380

GAGCGAGAAC TGTTTGCCTG GGGCCGTGGA GATGGCGGCC GGCTGGGACT AGGCACCAGG 1440

GAGTCCCACA GCTGCCCCCA GCAGGTGCCC ATGCCCCTAG GACAGGAAGC CCAGCGAGTT 1500

GTATGTGGCA TTGACTCCTC CATGATCCTC ACTGTGCCTG GCCGAGCCCT GGCCTGTGGG 1560

AGCAACAGGT TCAACAAGCT GGGCCTGGAC CACTTCTCCC TAGGGGAGGA GCCTGCCCCC 1620

CACCAGCAAG TGGAGGAGGC CCTGAGCTTC ACACCACTAG GTTCTGCACC CCTGGACCAG 1680

GAGGCCTTGC TGAGTGTGGA CCTTGGCACT GCTCATTCGG CTGCTGTGAC CACTTCCGGT 1740

GACTGCTACA CTTTTGGCAG CAATCAGCAT GGGCAGTTGG GTACCAGTGC TCGCCGGGTC 1800

AGCCGGGCAC CTTGTCGAGT CCAAGGCCTC CAGGGCATCA AGATAGCGAT GGTGGCCTGT 1860

GGGGATGCCT TCACTGTAGC CATTGGGGCA GAAGGTGAAG TGTACTCTTG GGGTAAAGGG 1920

GCCCGAGGTC GACTGGGAAG GAGGGATGAG GACGCTGGAC TCCCTCGGCC AGTGCAGCTG 1980

GATGAGACAC ACCCCTACAC AGTGACTTCT GTCTCCTGTT GCCATGGAAA TACTCTCTTG 2040

GCTATTCGTC CTGTCACAGA TGAGCCAGTC CCCCCCTGA 2079

Domain Profile

S: 1     yevlkkiGrGsfgevlkvrkksdkkllvlKeikleeldekerqklvkevsllkqlkHpni  60

         ye+++++GrG+fg v+++ +k+d+kl+++K+i +e+++++erq++++e+++lk l+Hpn+

Q: 4     YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV  63

         999*********************************************************

S: 61    veyyesfeeneelyivmeyceggdLsqlikeqkekkklleEktvlkilvqlllalkklHe  120

         +eyye+f e+++l+i mey+ gg+L++ i+++   ++lleE+t+l+++vq+llal+++H+

Q: 64    IEYYENFLEDKALMIAMEYAPGGTLAEFIQKR--CNSLLEEETILHFFVQILLALHHVHT  121

         *****************************998..9*************************

S: 121   kkilHRDlkpaNifltkkevv.klgDfGlaklleskielaktlvGtpyYlsPEvleekpY  179

         + ilHRDlk++Ni+l+k+++v k+gDfG++k+l+sk ++a t+vGtp+Y+sPE++e kpY

Q: 122   HLILHRDLKTQNILLDKHRMVvKIGDFGISKILSSK-SKAYTVVGTPCYISPELCEGKPY  180

         ******************9999*************9.9**********************

S: 180   neksDiWslgCvlyelcaLkkpFeaknllelvlkivegklepvpekyseelkeliesllk  239

         n+ksDiW+lgCvlyel++Lk++Fea nl +lvlki++g+++p++++ys el++l+ sll+

Q: 181   NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS  240

         ************************************************************

S: 240   vdpekrpsveeilkkpl  256

          +p +rp +++i+++pl

Q: 241   LEPAQRPPLSHIMAQPL  257

         ************99986

Domain Sequence
(FASTA)

YERIRVVGRG AFGIVHLCLR KADQKLVIIK QIPVEQMTKE ERQAAQNECQ VLKLLNHPNV 60

IEYYENFLED KALMIAMEYA PGGTLAEFIQ KRCNSLLEEE TILHFFVQIL LALHHVHTHL 120

ILHRDLKTQN ILLDKHRMVV KIGDFGISKI LSSKSKAYTV VGTPCYISPE LCEGKPYNQK 180

SDIWALGCVL YELASLKRAF EAANLPALVL KIMSGTFAPI SDRYSPELRQ LVLSLLSLEP 240

AQRPPLSHIM AQPL 254

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0072372	; C:primary cilium
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR000408	; Reg_chr_condens.
IPR009091	; Reg_csome_cond/b-lactamase_inh.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00415	; RCC1; 4.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50012	; RCC1_3; 5.

Prints

PR00633

; RCCNDNSATION.

Created Date

20-Feb-2013