EKS-EQC-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	470.9	9.3E-142	363	613	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000007805

UniProt Accession

F6ZPE1;

Protein Name

Protein Synonyms/Alias

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009530	ENSECAP00000007805	ENSECAT00000010148

Organism

Equus caballus

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60

KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120

HPNFWMDGKW RCCAQLEKLA VGCAQYDPTK NASKKPLPPT PEDNRRPLQE PEETLVIALY 180

DYQANGPQEL TLQRNDEYYL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240

NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIVSENNPCI KHYHIKETNE 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WRQKAPVTAG LRYGKWVIDP 360

SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LYGVCLEQAP ICLVFEFMEH GCLSDYLRNQ RGLFAAETLL GMCLDVCEGM AYLEKVCVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTCSTGTKF PVKWASPEVF SFNRYSSKSD 540

VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ITTGFRLYKP RLASSHIYQI MNHCWKEKPE 600

DRPPFSRLLS QLSEIAESGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TTATCCTCCT GGAAGAACAG CTAATTAAGA AATCCCAACA AAAGAGAAGA 60

ACTTCTCCCT CGAACTTTAA AGTCCGTTTC TTTGTTTTAA CCAAAACCAG CCTGGCGTAC 120

TTTGAGGATC GTCATGGGAA GAAGCGCACA TTGAAGGGCT CCATTGAACT CTCCCGAATC 180

AAATGTGTGG AGATTGTGAA AAGTGACATT AGCATCCCGT GCCACTATAA ATACCCATTT 240

CAGGTTGTAC ATGACAACTA CCTCCTGTAT GTATTCGCTC CAGACCGAGA GAGCCGGCAG 300

CGCTGGGTGC TGGCCCTTAA AGAAGAAACA AGGAATAATA ACAGTTTGGT GCCCAAGTAT 360

CATCCTAATT TCTGGATGGA TGGGAAGTGG AGGTGCTGCG CTCAGCTGGA GAAGCTTGCA 420

GTGGGCTGTG CCCAATACGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAAGACA ACAGGCGACC ACTTCAGGAA CCTGAAGAAA CCCTGGTCAT TGCCTTGTAT 540

GACTACCAAG CAAACGGTCC GCAGGAACTC ACTCTCCAAC GCAATGATGA GTACTACCTG 600

CTGGACAGTT CCGAGATTCA CTGGTGGAGA GTTCAAGATA GGAATGGGCA TGAAGGATAT 660

GTACCAAGCA GTTATCTGGT GGAAAAGTCG CCAAATAACC TGGAAACCTA TGAGTGGTAC 720

AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780

GCCTTCATGG TACGAGACTC CAGGACTCCA GGAACATACA CCGTGTCTGT TTTTACCAAG 840

GCCATCGTAA GTGAGAACAA CCCCTGTATC AAGCACTATC ACATCAAAGA AACGAATGAG 900

AACCCCAAGC GATATTATGT GGCTGAAAAG TATGTGTTTG ACTCCATCCC TCTCCTCATC 960

AATTATCACC AACACAATGG AGGAGGCCTG GTCACGAGAC TCCGGTATCC AGTTTGCTCC 1020

TGGAGGCAGA AAGCCCCAGT CACGGCAGGG CTGCGATACG GCAAATGGGT GATCGATCCC 1080

TCGGAGCTCA CTTTTGTGCA GGAGATTGGC AGCGGGCAGT TTGGGCTGGT GCACCTCGGC 1140

TACTGGCTCA ACAAGGACAA GGTTGCCATC AAAACCATTC AGGAAGGGGC TATGTCGGAG 1200

GAGGATTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCACCCCAA ACTGGTCCAG 1260

CTCTATGGGG TGTGCCTGGA GCAGGCCCCT ATCTGCCTGG TGTTTGAGTT CATGGAACAC 1320

GGCTGCCTGT CGGATTACCT GCGCAACCAG CGGGGGCTCT TTGCTGCAGA GACCCTGCTG 1380

GGCATGTGCC TTGATGTGTG TGAGGGCATG GCCTACCTGG AAAAGGTGTG CGTCATCCAC 1440

AGAGACCTGG CTGCCCGGAA TTGTTTAGTG GGAGAAAACC AAGTCATCAA GGTGTCCGAC 1500

TTTGGGATGA CAAGGTTCGT CCTTGATGAT CAATACACCT GTTCCACAGG CACCAAATTC 1560

CCGGTGAAGT GGGCATCCCC GGAAGTCTTC TCTTTCAATC GCTATAGCAG CAAGTCAGAT 1620

GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTCTTCAGTG AAGGCAAAAT CCCGTATGAA 1680

AACAGAAGCA ACTCAGAGGT GGTGGAAGAC ATCACTACCG GATTTCGGTT ATACAAACCC 1740

CGATTAGCCT CCTCACATAT CTACCAAATC ATGAATCATT GCTGGAAAGA GAAACCAGAA 1800

GACCGACCAC CCTTCTCCAG ACTCTTGAGT CAACTGTCTG AAATTGCAGA ATCAGGACTT 1860

TAG 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle+ ++ihrd

Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRNQRGLFAAETLLGMCLDVCEGMAYLEKVCVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ s+g+kfpvkw++pev+s+++yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTCSTGTKFPVKWASPEVFSFNRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++++g+rly+p+las+++y++m++cwkekpe+r

Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDITTGFRLYKPRLASSHIYQIMNHCWKEKPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f++lls+l+

Q: 603   PPFSRLLSQLS  613

         ********986

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRNQRG LFAAETLLGM CLDVCEGMAY LEKVCVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TCSTGTKFPV KWASPEVFSF NRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIT TGFRLYKPRL ASSHIYQIMN HCWKEKPEDR 240

PPFSRLLSQL S 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

ecb:100071232

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR013315	; Spectrin_alpha_SH3.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR01887	; SPECTRNALPHA.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013