EKS-EQC-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	474.0	1.3E-142	310	579	270

Status

Unreviewed

Ensembl Protein

ENSECAP00000007942

UniProt Accession

F7B8J6;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009570	ENSECAP00000007942	ENSECAT00000010307

Organism

Equus caballus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MGSYLSVPAY FTSRDPFRCS ECQDSLTNWY YEKDGKLYCH KDYWGKFGEF CHGCSLLMTG 60

PVMVAGEFKY HPECFACMSC KVIIEDGDAY ALVQHATLYC GKCHNEVVLA PMFERLSTES 120

VQDQLPYSVT HISMPATTEG RRGFSVSVES GCSNYATTVQ VKEVNRMHIS PNNRNAIHPG 180

DRILEINGTP VRTLRVEEVE DAISQTSQTL QLLIEHDPVS QRLDHLRLDA RLSPHMQNTR 240

HSHTLSTLDT KENLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLLSRDISR SESLRCSSSC 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVTHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

SLDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRSVD PFPWQQKVSF AKGIASGMAY 420

LHSMCIIHRD LNSHNCLIKL DKTVVVADFG LSRLIVEERK RPPVEKATTK KRTLRKNDRK 480

KRYTVVGNPY WMAPEMLNGK SYDETVDVFS FGIVLCEIIG QVYADPDCLP RTLDFGLNVK 540

LFWEKFVPTD CPPAFFPLAA ICCKLEPESR PAFSKLEDSF EALSLYLGEL GIPLPAELEE 600

LDHTVSMQYG LTRDSPP 617

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ACTTGTCCGT CCCGGCTTAC TTCACCTCCA GAGACCCCTT TCGGTGTTCA 60

GAATGCCAGG ATTCCCTCAC CAACTGGTAC TACGAGAAGG ATGGGAAGCT TTATTGCCAC 120

AAGGACTACT GGGGGAAGTT TGGGGAGTTC TGCCATGGGT GCTCTCTGCT GATGACAGGG 180

CCCGTAATGG TGGCCGGGGA GTTCAAGTAC CACCCAGAGT GCTTTGCCTG CATGAGCTGC 240

AAGGTGATCA TCGAGGATGG GGACGCATAT GCCCTGGTGC AGCACGCCAC CCTCTACTGT 300

GGGAAGTGCC ACAATGAGGT GGTGCTGGCA CCCATGTTTG AGAGGCTCTC CACGGAGTCT 360

GTTCAGGACC AGTTGCCCTA CTCCGTGACA CACATCTCCA TGCCAGCCAC CACTGAGGGC 420

AGGCGGGGCT TCTCCGTGTC CGTGGAGAGT GGCTGCTCCA ACTACGCCAC CACTGTGCAA 480

GTAAAAGAGG TCAACCGGAT GCACATCAGT CCCAACAACC GCAACGCCAT CCACCCTGGG 540

GACCGCATCC TGGAGATCAA TGGGACCCCC GTCCGCACAC TCCGAGTGGA GGAGGTAGAG 600

GATGCAATTA GCCAGACAAG CCAGACGCTC CAGCTCTTGA TTGAACACGA CCCCGTCTCC 660

CAGCGCCTGG ACCACCTGCG GCTGGATGCC CGGCTCTCTC CCCACATGCA GAACACCAGA 720

CACTCCCATA CCCTCAGCAC CCTGGACACC AAGGAGAATT TGGAAGGGAC GCTGAGGAGA 780

CGTTCTCTGA GGCGCAGTAA CAGCATATCC AAGTCCCCTG GCCCCAGCTC CCCAAAGGAG 840

CCCCTGCTGC TTAGCCGTGA CATTAGCCGC TCAGAGTCCC TCCGCTGTTC CAGCAGCTGC 900

TCACAGCAGA TCTTCCGGCC CTGTGACCTG ATCCACGGGG AGGTCCTGGG GAAGGGCTTC 960

TTTGGGCAGG CCATCAAGGT GACGCACAAA GCCACGGGCA AAGTGATGGT CATGAAGGAG 1020

TTAATTCGGT GTGACGAGGA GACACAGAAG ACTTTCCTGA CTGAGGTGAA GGTGATGCGC 1080

AGCCTGGACC ACCCCAATGT GCTCAAGTTC ATTGGCGTGC TGTACAAGGA CAAGAAGCTG 1140

AACTTGCTGA CAGAGTACAT TGAGGGGGGC ACGCTGAAGG ACTTTCTGCG CAGTGTGGAC 1200

CCGTTCCCCT GGCAGCAGAA GGTCAGCTTT GCCAAAGGCA TCGCCTCTGG AATGGCCTAT 1260

TTGCATTCCA TGTGTATCAT CCACCGGGAT CTGAACTCAC ACAACTGCCT CATCAAACTG 1320

GACAAGACCG TGGTGGTGGC AGACTTTGGG CTGTCACGGC TCATAGTCGA GGAGAGGAAA 1380

AGGCCCCCAG TGGAGAAGGC CACCACCAAG AAACGTACCT TGCGCAAGAA CGACCGTAAG 1440

AAGCGCTACA CGGTGGTGGG AAACCCCTAC TGGATGGCCC CTGAGATGCT GAACGGAAAG 1500

AGCTACGATG AGACAGTGGA TGTCTTCTCT TTTGGGATCG TTCTCTGCGA GATCATTGGG 1560

CAGGTGTATG CAGATCCTGA TTGCCTGCCC CGAACACTGG ACTTTGGCCT CAACGTGAAG 1620

CTTTTCTGGG AGAAGTTTGT CCCCACAGAC TGCCCCCCAG CCTTCTTCCC CCTGGCTGCC 1680

ATCTGCTGCA AACTGGAGCC TGAGAGCAGA CCGGCGTTCT CAAAACTGGA GGACTCCTTT 1740

GAGGCCCTCT CCCTGTACCT TGGAGAGCTG GGCATCCCAC TGCCTGCAGA GCTGGAGGAG 1800

CTGGACCACA CTGTGAGCAT GCAGTATGGC CTGACCCGGG ACTCACCCCC CTAA 1854

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+v++ak+iasG++ylhs++iihr

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVSFAKGIASGMAYLHSMCIIHR  429

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerk++      +k+r+l+k+drkkr+tvvG+P

Q: 430   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPpvekatTKKRTLRKNDRKKRYTVVGNP  489

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 490   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  549

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 550   DCPPAFFPLAAICCKLEPESRPAFSKLEDS  579

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVS FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRPPVEKATT KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCKLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005801	; C:cis-Golgi network
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding
GO:0007283	; P:spermatogenesis

KEGG

ecb:100058419

;

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013