EKS-EQC-00398
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00398
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK409.96.1E-123184490307
StatusUnreviewed
Ensembl ProteinENSECAP00000007763
UniProt AccessionF6YZL0;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK1
Gene Synonyms/Alias IRAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000009585ENSECAP00000007763ENSECAT00000010099
OrganismEquus caballus
Functional Description
Protein Length663
Protein Sequence
(FASTA)
MCRFYKVMDA LEPADWCQFA ALIVRDQTEL RLCERSQRTA SVWPWINRNA RVADLVRILT 60
HLQLLRARDI ITAWHPPAPN KPPSTTALKP SSLSAPSEAE ALSPRKLQSS ASTLLSPAFP 120
GSQTHSGPEL GPVPSLAALR PPPASPAPSS TKQSPESQLS LLQGAHPSPF CWPLHEISRG 180
THNFSEELKI GEGGFGCVYR AVMRNTVYAV KRLKEEADLE WTTVKQSFLT EVEQLSRFRH 240
PNIVDFAGYC AQTGCYCLVY GFLPNGSLED RLHFQTQACP PLSWPQRLDI LLGTARAIQF 300
LHQDSPSLIH GDIKSSNVLL DERLMPKLGD FGLARLSRFA GANPSQSSTV ARTRTVRGTL 360
AYLPEEYVKT GRLAVDTDTF SFGVVVLESL VGQRAVRTHG ARTKYLKDLV EEEAEEAGVA 420
LKSTQTAIKA GLATDAWAAP IATQIYKKHL DPRPGPCPPE LGLALGQLAC CCLHRRAKRR 480
PPMTQVYERL EKLQVAVTGL SLEPEAASHS PPSPQENSYV STASSALSST SLRPPLAVPS 540
GAPAQTTERL QKGPNQPVES DESVSSLSAA LHSWHLTLSC PPAPALLGQA GCTQGGTARE 600
SSWGSGPGTR PTAVEGSWAA LRHRSHRRLL STRPGRRWCR SWPCMRMGSW TAYSCYHQAP 660
SQA 663
Nucleotide Sequence
(FASTA)
ATGTGCCGCT TCTACAAAGT GATGGACGCC CTGGAGCCCG CCGACTGGTG CCAGTTCGCC 60
GCCCTGATCG TGCGCGACCA GACCGAGCTG CGGCTGTGCG AGCGCTCCCA ACGCACGGCC 120
AGCGTCTGGC CCTGGATCAA CCGCAACGCC CGCGTGGCCG ACCTCGTGCG CATCCTCACG 180
CACCTGCAGC TGCTCCGGGC TCGGGACATC ATCACGGCCT GGCACCCTCC CGCCCCCAAC 240
AAGCCCCCCA GCACCACCGC CCTGAAGCCC AGCAGCCTCT CTGCACCCTC TGAGGCCGAG 300
GCTCTCAGCC CCCGGAAGTT GCAGTCGTCA GCCTCCACCC TCCTCTCCCC AGCTTTTCCA 360
GGCTCCCAGA CCCATTCTGG GCCTGAGCTC GGCCCTGTCC CAAGCCTTGC TGCCCTCCGG 420
CCACCACCGG CATCCCCAGC CCCTTCCTCT ACCAAGCAGA GCCCAGAGAG CCAGCTGTCC 480
CTCCTGCAGG GGGCCCACCC CTCTCCGTTC TGCTGGCCCC TCCATGAGAT TTCCCGGGGC 540
ACTCACAACT TCTCAGAAGA GCTGAAGATC GGGGAGGGTG GTTTTGGGTG TGTGTACCGG 600
GCTGTGATGA GGAACACAGT GTACGCTGTG AAGAGGCTGA AGGAGGAGGC AGATCTGGAG 660
TGGACCACCG TGAAGCAGAG CTTCCTGACC GAAGTGGAGC AGCTGTCACG GTTTCGTCAC 720
CCAAACATCG TGGACTTTGC AGGCTACTGT GCTCAGACTG GCTGCTACTG CCTTGTCTAC 780
GGCTTCCTGC CCAATGGCTC CCTGGAAGAC CGCCTCCACT TCCAGACCCA GGCCTGCCCC 840
CCTCTCTCCT GGCCTCAGCG ACTGGACATC CTTCTGGGCA CAGCTCGGGC AATTCAGTTT 900
TTGCATCAGG ACAGCCCCAG CCTCATCCAT GGAGACATCA AGAGTTCCAA TGTCCTTCTG 960
GATGAGAGAC TGATGCCCAA ACTGGGAGAC TTCGGCCTGG CCCGTCTCAG CCGTTTTGCA 1020
GGGGCCAACC CCAGCCAGAG CAGCACCGTG GCCCGGACAC GGACCGTGCG TGGCACCCTG 1080
GCCTACCTGC CGGAGGAGTA TGTCAAGACA GGGAGGCTGG CTGTGGACAC CGATACCTTC 1140
AGCTTCGGCG TGGTAGTGCT GGAGAGCCTG GTCGGCCAGA GAGCTGTGAG GACGCATGGT 1200
GCCAGGACCA AGTATCTGAA AGACCTGGTT GAAGAAGAGG CCGAGGAGGC CGGGGTGGCC 1260
CTGAAAAGCA CCCAGACCGC AATCAAAGCA GGTCTGGCCA CAGATGCCTG GGCTGCCCCA 1320
ATCGCCACCC AGATCTACAA GAAGCACCTG GATCCGAGGC CTGGGCCATG TCCACCCGAG 1380
CTGGGCCTAG CCCTGGGCCA GCTGGCTTGC TGCTGCCTGC ACCGCCGGGC CAAGAGGAGA 1440
CCCCCCATGA CACAGGTGTA CGAGAGGCTG GAGAAGCTAC AGGTAGCAGT GACAGGGCTG 1500
TCCCTGGAGC CAGAGGCTGC CAGCCACAGC CCCCCTTCCC CGCAGGAGAA CTCCTACGTG 1560
TCTACCGCCA GCAGTGCCCT GAGCAGTACC AGCCTGAGGC CACCCCTGGC AGTGCCCTCA 1620
GGAGCCCCAG CCCAAACTAC AGAGCGGCTC CAGAAAGGCC CCAACCAGCC CGTGGAGAGT 1680
GACGAGAGTG TGTCCAGCCT GTCTGCTGCC CTGCATTCCT GGCATCTGAC CCTGAGTTGC 1740
CCCCCGGCCC CAGCACTCCT TGGGCAGGCC GGCTGTACTC AAGGGGGCAC TGCCCGAGAG 1800
TCAAGCTGGG GGAGTGGCCC GGGTACCCGG CCCACAGCTG TGGAAGGTAG CTGGGCAGCT 1860
CTGCGTCATC GCAGCCACCG CAGATTGTTA TCAACCCGGC CCGGCAGAAG ATGGTGCAGA 1920
AGCTGGCCTT GTATGAGGAT GGGGTCCTGG ACAGCCTACA GCTGCTATCA TCAAGCTCCC 1980
TCCCAGGCCT AG 1992
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         fse+ +igeGgfg+vyr+ ++nt++avk+lkeeadl+++++kqsfltE+++l+rfrH+ni
Q: 184   FSEELKIGEGGFGCVYRAVMRNTVYAVKRLKEEADLEWTTVKQSFLTEVEQLSRFRHPNI  243
         899*********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHe  119
         ++++gy+a+++ +cLvY++++nGsLedrL+ q ++++pLsWpqRl+illGtarai+fLH+
Q: 244   VDFAGYCAQTGCYCLVYGFLPNGSLEDRLHFQtQACPPLSWPQRLDILLGTARAIQFLHQ  303
         *******************************99***************************
S: 120   aspslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYl  176
         +spslihgdiks+N+LLDe+l+pKlgDfglar   fa+++++qsstv+rt +vrgtlaYl
Q: 304   DSPSLIHGDIKSSNVLLDERLMPKLGDFGLARlsrFAGANPSQSSTVARTRTVRGTLAYL  363
         *******************************99999************************
S: 177   peefirvgqltvkvDvySfGiVllEvltGlra.vdedrktkyLkdllkeeieeekv....  231
         pee++++g+l+v++D++SfG+V+lE l G+ra ++++++tkyLkdl++ee+ee++v    
Q: 364   PEEYVKTGRLAVDTDTFSFGVVVLESLVGQRAvRTHGARTKYLKDLVEEEAEEAGValks  423
         ********************************77899***********************
S: 232   ....................eilekfldkkagkleeellealielalaclaekakkrPtm  271
                             +i++k+ld ++g++++el  al +la++cl+++ak+rP+m
Q: 424   tqtaikaglatdawaapiatQIYKKHLDPRPGPCPPELGLALGQLACCCLHRRAKRRPPM  483
         ************************************************************
S: 272   sqvlell  278
         +qv+e+l
Q: 484   TQVYERL  490
         ****987
Domain Sequence
(FASTA)
FSEELKIGEG GFGCVYRAVM RNTVYAVKRL KEEADLEWTT VKQSFLTEVE QLSRFRHPNI 60
VDFAGYCAQT GCYCLVYGFL PNGSLEDRLH FQTQACPPLS WPQRLDILLG TARAIQFLHQ 120
DSPSLIHGDI KSSNVLLDER LMPKLGDFGL ARLSRFAGAN PSQSSTVART RTVRGTLAYL 180
PEEYVKTGRL AVDTDTFSFG VVVLESLVGQ RAVRTHGART KYLKDLVEEE AEEAGVALKS 240
TQTAIKAGLA TDAWAAPIAT QIYKKHLDPR PGPCPPELGL ALGQLACCCL HRRAKRRPPM 300
TQVYERL 307
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00394
EKS-BOT-00406
EKS-CAJ-00411
EKS-CAF-00406
EKS-DAR-00793
EKS-DRM-00191
EKS-ERE-00006
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-ORN-00520
EKS-ORA-00354
EKS-ORC-00381
EKS-OTG-00408
EKS-PEM-00221
EKS-POA-00398
EKS-RAN-00420
EKS-SAH-00376
EKS-SUS-00360
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007250; P:activation of NF-kappaB-inducing kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0051259; P:protein oligomerization
GO:0001959; P:regulation of cytokine-mediated signaling pathway
GO:0032494; P:response to peptidoglycan
GO:0034134; P:toll-like receptor 2 signaling pathway
GO:0034142; P:toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013