EKS-EQC-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph509.21.7E-153597856260
StatusUnreviewed
Ensembl ProteinENSECAP00000008923
UniProt AccessionF7C2E5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB3
Gene Synonyms/Alias EPHB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000009755ENSECAP00000008923ENSECAT00000011414
OrganismEquus caballus
Functional Description
Protein Length962
Protein Sequence
(FASTA)
ETLMDTKWVT SELAWTSHPE SGWEEVSGYD EAMNPIRTYQ VCNVRESSQN NWLRTGFIWR 60
RDVQRVYVEL KFTVRDCNSI PNIPGSCKET FNLFYYEADS DVASASSPFW MENPYVKVDT 120
IAPDESFSRL DAGRVNTKVR SFGPLSKAGF YLAFQDQGAC MSLISVRAFY KKCASTTAGF 180
ALFPETLTGA EPTSLVIAPG TCIANAVEVS VPLKLYCNGD GEWMVPVGAC TCATGHEPAA 240
KESQCRPCPP GSYKAKQGEG PCLPCPPNSR TTSPAASICT CHNNFYRADS DSADSACTTV 300
PSPPRGVISN VNETSLILEW SEPRDLGGRD DLLYNVICKK CHGGPGAGGP SACSRCDDNV 360
EFVPRQLGLT ERRVHISHLL AHTRYTFEVQ AVNGVSGKSP LPPRYAAVNI TTNQAAPSEV 420
PTLHLHSSSG SSLTLSWAPP ERPNGVILDY EMKYFEKSEG IASTVTSQKN SVQLDGLRPD 480
ARYVVQVRAR TVAGYGQYSH PAEFETTSER GSGAQQLQEQ LPLIVGSATA GLVFVVAVVV 540
IAVVCLRKQR HGSDSEYTEK LQQYITPGMK VYIDPFTYED PNEAVREFAK EIDVSCVKIE 600
EVIGAGEFGE VCRGRLKQPG RREVFVAIKT LKVGYTERQR RDFLSEASIM GQFDHPNIIR 660
LEGVVTKSRP VMILTEFMEN CALDSFLRLN DGQFTVIQLV GMLRGIAAGM KYLSEMNYVH 720
RDLAARNILV NSNLVCKVSD FGLSRFLEDD PSDPTYTSSL GGKIPIRWTA PEAIAYRKFT 780
SASDVWSYGI VMWEVMSYGE RPYWDMSNQD VINAVEQDYR LPPPMDCPTA LHQLMLDCWV 840
RDRNLRPKFS QIVNTLDKLI RNAASLKVIA SAQSGMSQPL LDRTVPDYTT FTTVGDWLDA 900
IKMGRYKESF VSAGFASFDL VAQMTAEDLL RIGVTLAGHQ KKILSSIQDM RLQMNQTLPV 960
QV 962
Nucleotide Sequence
(FASTA)
GAGACCCTCA TGGACACAAA ATGGGTGACA TCTGAGTTGG CATGGACATC TCATCCAGAA 60
AGTGGGTGGG AAGAGGTGAG TGGCTACGAT GAGGCCATGA ACCCCATCCG CACATACCAG 120
GTGTGTAATG TGCGTGAATC AAGCCAGAAC AACTGGCTTC GCACGGGGTT CATCTGGCGG 180
CGGGACGTGC AGCGGGTCTA CGTGGAGCTC AAGTTCACGG TGCGCGACTG CAACAGCATC 240
CCCAACATCC CTGGCTCCTG CAAGGAGACC TTCAACCTGT TCTACTACGA GGCTGACAGC 300
GATGTGGCCT CAGCCTCCTC CCCCTTCTGG ATGGAGAACC CCTACGTGAA AGTGGACACC 360
ATCGCGCCCG ATGAGAGCTT CTCGCGGCTC GATGCCGGCC GTGTGAACAC CAAGGTGCGC 420
AGCTTCGGGC CACTCTCCAA GGCCGGCTTC TACTTGGCCT TCCAGGACCA GGGCGCCTGC 480
ATGTCGCTCA TCTCCGTGCG TGCCTTCTAC AAGAAGTGTG CATCCACCAC CGCGGGCTTC 540
GCCCTCTTCC CTGAGACCCT CACTGGGGCA GAGCCCACCT CACTGGTCAT CGCCCCCGGC 600
ACCTGCATCG CTAACGCTGT GGAGGTGTCG GTGCCGCTCA AGCTTTACTG CAATGGTGAC 660
GGAGAGTGGA TGGTGCCTGT GGGCGCCTGC ACCTGTGCCA CCGGCCACGA GCCAGCTGCC 720
AAGGAGTCCC AGTGCCGCCC CTGTCCCCCT GGGAGCTACA AGGCGAAGCA GGGAGAGGGG 780
CCCTGCCTTC CCTGCCCCCC CAACAGCCGC ACCACCTCGC CAGCCGCCAG CATCTGCACC 840
TGCCACAATA ACTTCTACCG CGCAGATTCC GACTCTGCAG ACAGTGCCTG TACCACGGTG 900
CCCTCTCCAC CCCGGGGTGT CATCTCCAAT GTGAATGAGA CCTCACTGAT CCTCGAGTGG 960
AGCGAGCCCC GGGACCTGGG TGGCCGGGAC GACCTCCTGT ACAACGTCAT CTGCAAGAAG 1020
TGCCATGGGG GCCCCGGGGC CGGGGGTCCC TCAGCCTGCT CCCGCTGTGA TGACAACGTG 1080
GAGTTTGTGC CTCGGCAGCT GGGCCTCACA GAGCGGCGGG TGCACATCAG CCATCTGCTG 1140
GCCCACACGC GCTACACCTT TGAGGTGCAA GCAGTCAACG GGGTCTCGGG CAAGAGCCCT 1200
CTGCCTCCCC GCTACGCTGC TGTGAATATC ACCACCAACC AGGCTGCCCC GTCCGAAGTG 1260
CCTACATTAC ACCTGCACAG CAGCTCAGGC AGCAGCCTGA CCTTGTCCTG GGCACCCCCA 1320
GAGCGGCCCA ACGGAGTCAT CCTGGACTAC GAGATGAAGT ACTTTGAGAA GAGTGAGGGC 1380
ATTGCCTCCA CAGTGACCAG CCAGAAGAAC TCAGTGCAGC TGGACGGGCT GCGGCCCGAT 1440
GCCCGCTATG TGGTCCAGGT CCGCGCCCGC ACAGTAGCTG GCTATGGGCA GTATAGCCAC 1500
CCGGCCGAGT TTGAAACCAC AAGTGAGAGA GGCTCCGGTG CCCAGCAGCT CCAGGAGCAG 1560
CTTCCCCTCA TAGTGGGTTC TGCCACGGCT GGGCTTGTCT TCGTGGTGGC TGTTGTGGTC 1620
ATTGCTGTCG TCTGCCTCAG GAAGCAGCGG CACGGCTCTG ATTCCGAGTA CACCGAGAAG 1680
CTGCAGCAAT ACATTACTCC TGGAATGAAG GTTTATATTG ACCCTTTCAC CTACGAGGAC 1740
CCTAATGAAG CCGTGCGAGA GTTTGCCAAG GAGATCGACG TGTCCTGTGT CAAGATCGAG 1800
GAGGTGATTG GAGCTGGGGA GTTTGGGGAA GTGTGCCGCG GTCGGCTGAA ACAGCCTGGC 1860
CGCCGGGAGG TGTTTGTGGC CATCAAGACG CTGAAGGTGG GCTACACAGA GAGGCAACGG 1920
AGGGACTTCC TGAGCGAGGC CTCCATCATG GGTCAGTTTG ACCACCCCAA CATAATCCGC 1980
CTGGAGGGCG TGGTCACCAA AAGTCGGCCA GTCATGATCC TCACCGAGTT CATGGAGAAT 2040
TGCGCCCTGG ACTCCTTCCT CCGGCTCAAC GACGGACAGT TTACGGTCAT CCAGCTGGTG 2100
GGCATGTTGC GGGGCATTGC TGCCGGCATG AAGTACCTGT CTGAGATGAA CTACGTGCAC 2160
CGAGACCTGG CTGCCCGCAA CATCCTTGTC AACAGCAACC TGGTCTGCAA AGTCTCAGAC 2220
TTCGGCCTCT CCCGCTTCCT GGAGGATGAC CCCTCCGATC CTACCTACAC CAGCTCCCTG 2280
GGCGGGAAGA TCCCCATCCG CTGGACTGCC CCAGAGGCGA TAGCCTATCG GAAGTTCACC 2340
TCTGCTAGTG ACGTCTGGAG CTATGGGATC GTCATGTGGG AGGTCATGAG CTATGGAGAG 2400
CGACCGTACT GGGACATGAG CAACCAGGAT GTCATCAATG CTGTGGAGCA GGATTACCGG 2460
CTGCCCCCGC CCATGGACTG CCCCACAGCA CTGCACCAGC TCATGCTGGA CTGCTGGGTG 2520
CGGGACCGGA ACCTCAGGCC CAAATTCTCC CAGATTGTCA ACACCCTAGA CAAGCTCATC 2580
CGCAACGCCG CTAGCCTCAA GGTCATCGCC AGCGCCCAGT CTGGCATGTC ACAACCCCTC 2640
CTGGACCGCA CGGTCCCAGA TTATACGACC TTCACGACAG TTGGTGACTG GCTGGATGCC 2700
ATCAAGATGG GGCGGTACAA GGAGAGCTTC GTCAGCGCGG GGTTTGCATC CTTTGACCTG 2760
GTGGCCCAGA TGACCGCAGA AGACCTGCTA CGGATCGGGG TCACCTTGGC CGGCCATCAG 2820
AAGAAGATCC TCAGCAGTAT CCAGGACATG CGGCTGCAGA TGAACCAGAC GCTGCCCGTG 2880
CAGGTCTGA 2889
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp
Q: 597   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  656
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m
Q: 657   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  716
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay
Q: 717   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  776
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml
Q: 777   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  836
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcw +dr+ rpkf+qiv++l
Q: 837   DCWVRDRNLRPKFSQIVNTL  856
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240
DCWVRDRNLR PKFSQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00007
EKS-ANC-00006
EKS-BOT-00005
EKS-CAJ-00014
EKS-CAF-00007
EKS-CAP-00005
EKS-DAR-00007
EKS-DIO-00001
EKS-FEC-00005
EKS-GAM-00001
EKS-GAG-00007
EKS-GAA-00005
EKS-GOG-00006
EKS-HOS-00008
EKS-ICT-00006
EKS-LAC-00005
EKS-MAM-00006
EKS-MEG-00006
EKS-MUM-00007
EKS-MUP-00007
EKS-MYL-00008
EKS-NOL-00007
EKS-ORN-00006
EKS-ORA-00005
EKS-ORC-00007
EKS-ORL-00004
EKS-OTG-00006
EKS-PAT-00007
EKS-PES-00005
EKS-PEM-00001
EKS-RAN-00007
EKS-SAH-00006
EKS-SUS-00005
EKS-TAG-00006
EKS-TAR-00004
EKS-TUT-00006
EKS-XET-00006
EKS-XIM-00005
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0007413; P:axonal fasciculation
GO:0016477; P:cell migration
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0022038; P:corpus callosum development
GO:0060997; P:dendritic spine morphogenesis
GO:0048546; P:digestive tract morphogenesis
GO:0060021; P:palate development
GO:0051965; P:positive regulation of synapse assembly
GO:0046777; P:protein autophosphorylation
GO:0050770; P:regulation of axonogenesis
GO:0043088; P:regulation of Cdc42 GTPase activity
GO:0022407; P:regulation of cell-cell adhesion
GO:0032314; P:regulation of Rac GTPase activity
GO:0031290; P:retinal ganglion cell axon guidance
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0048538; P:thymus development
GO:0001655; P:urogenital system development
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013