EKS-EQC-00417

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00417

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	528.5	3.7E-159	20	277	258

Status

Unreviewed

Ensembl Protein

ENSECAP00000008095

UniProt Accession

F6QXJ2;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK2

Gene Synonyms/Alias

SGK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009775	ENSECAP00000008095	ENSECAT00000010485

Organism

Equus caballus

Functional Description

Protein Length

352

Protein Sequence
(FASTA)

ANGNINLGPS ANPNARPTDF DFLKVIGKGN YGKVLLAKRK SDGTFYAVKV LQKKSILKKK 60

EQSHIMAERS VLLKNVRHPF LVGLRYSFQT PEKLYFVLDY VNGGELFFHL QRERRFLEPR 120

ARFYAAEVAS AIGYLHSLNI IYRDLKPENI LLDCQGHVVL TDFGLCKEGV EPEETTSTFC 180

GTPEYLAPEV LRKEPYDRAV DWWCLGAVLY EMLHGLPPFY SRDVSQMYEN ILHQPLQIPG 240

GRTVAACDLL QALLHKDQRQ RLGSKADFLE IKTHVFFSPI NWDDLYHKRL TPPFNPNVAG 300

PADLKHFDPE FTQEAVSTSI GCTPDTMASS SGASSAFLGF SYAPEDDAIL DC 352

Nucleotide Sequence
(FASTA)

GCCAATGGGA ACATCAACCT GGGGCCTTCA GCCAACCCAA ATGCCCGGCC CACCGACTTC 60

GACTTCCTCA AAGTCATTGG CAAAGGGAAC TATGGGAAGG TCCTCCTGGC CAAGCGCAAG 120

TCTGATGGGA CATTCTACGC AGTGAAGGTG CTGCAGAAAA AGTCCATCTT AAAGAAGAAA 180

GAGCAGAGCC ACATCATGGC AGAGCGCAGC GTGCTTCTGA AGAATGTGCG GCACCCTTTC 240

CTCGTGGGCC TGCGCTACTC CTTCCAGACG CCTGAGAAGC TCTACTTTGT GCTGGACTAT 300

GTCAACGGGG GAGAGCTCTT CTTCCACCTG CAGCGGGAGC GCCGGTTCCT GGAGCCCCGG 360

GCCCGGTTCT ATGCTGCCGA GGTGGCCAGT GCCATCGGCT ACCTGCACTC CCTCAACATC 420

ATTTACAGGG ACCTGAAACC AGAGAACATC CTCTTGGACT GCCAGGGACA CGTGGTGCTG 480

ACGGATTTTG GCCTCTGCAA GGAGGGTGTA GAGCCCGAGG AGACCACGTC CACGTTCTGT 540

GGCACCCCTG AGTACTTGGC TCCAGAAGTG CTTCGTAAAG AGCCTTACGA TCGGGCAGTG 600

GACTGGTGGT GCTTGGGGGC AGTTCTCTAC GAGATGCTGC ATGGCCTGCC GCCCTTCTAC 660

AGCCGAGATG TGTCCCAGAT GTATGAGAAC ATTCTGCACC AGCCGCTCCA GATCCCTGGG 720

GGCCGGACGG TGGCCGCCTG CGACCTCCTG CAAGCTCTTC TCCACAAGGA CCAGAGGCAG 780

CGGCTGGGCT CCAAAGCAGA CTTTCTGGAG ATAAAGACCC ATGTTTTCTT CAGCCCCATA 840

AACTGGGATG ACTTGTACCA CAAGAGGCTG ACTCCACCCT TCAACCCAAA TGTGGCAGGA 900

CCTGCTGACT TGAAACACTT TGACCCAGAG TTCACCCAGG AAGCTGTGTC AACGTCCATC 960

GGCTGCACTC CCGATACGAT GGCCAGTAGC TCTGGGGCCT CAAGCGCATT CCTGGGATTT 1020

TCCTATGCAC CAGAGGATGA TGCCATCTTG GATTGCTAG 1059

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fdflkvigkg++gkvllakrk+d++fyavkvlqkk+ilkkke++himaer+vllknv+hp

Q: 20    FDFLKVIGKGNYGKVLLAKRKSDGTFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP  79

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvgl+ysfqt+eklyfvldyvnggelffhlqrer+fleprarfyaae+asa+gylhsln

Q: 80    FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN  139

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         i+yrdlkpenilld++ghvvltdfglcke++e e+ttstfcgtpeylapevlrk+pydr+

Q: 140   IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEETTSTFCGTPEYLAPEVLRKEPYDRA  199

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyeml+glppfysrdv++my+nil++plq+++g++vaa++ll+ ll+kd++

Q: 200   VDWWCLGAVLYEMLHGLPPFYSRDVSQMYENILHQPLQIPGGRTVAACDLLQALLHKDQR  259

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         +rlg+k+dfleik hvff

Q: 260   QRLGSKADFLEIKTHVFF  277

         *****************9

Domain Sequence
(FASTA)

FDFLKVIGKG NYGKVLLAKR KSDGTFYAVK VLQKKSILKK KEQSHIMAER SVLLKNVRHP 60

FLVGLRYSFQ TPEKLYFVLD YVNGGELFFH LQRERRFLEP RARFYAAEVA SAIGYLHSLN 120

IIYRDLKPEN ILLDCQGHVV LTDFGLCKEG VEPEETTSTF CGTPEYLAPE VLRKEPYDRA 180

VDWWCLGAVL YEMLHGLPPF YSRDVSQMYE NILHQPLQIP GGRTVAACDL LQALLHKDQR 240

QRLGSKADFL EIKTHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0015459	; F:potassium channel regulator activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013