EKS-EQC-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	341.4	4.8E-102	1052	1315	264

Status

Unreviewed

Ensembl Protein

ENSECAP00000007829

UniProt Accession

F6ZI96;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000009919	ENSECAP00000007829	ENSECAT00000010177

Organism

Equus caballus

Functional Description

Protein Length

1319

Protein Sequence
(FASTA)

MNCMPKPERH AESLLDICHD TNSSTDTMTV TKNQNITLQS ISGSEEFEQD DDCGHSILVS 60

EGEPSADGQD PRPRTEGVEI IVTFPRDVSH PQEMSQEDLK ENNQITAAHG EWARAHSVSL 120

PNELEMVDLR TKTLTTRPLL LKKQESSKEL RDVNSGFLWP RPCLEPNISK SIAREDVSHF 180

LKGQQRKSEE CSTSDMKYSS RRIEFPLPPL SLLPMRSGLL TIPRNHKDQK ERERNMPSLM 240

SFVPKFSEPV SRRDEHQEAP FQVFVDQILR SSDGSIWSRN MCSFWKANHY QQHLEMEEDR 300

KSKETEGCDK TEISHFQKGQ SLVSSENSKK GNFPTDKDVD IDCYGSEMRK AEENSQYLSS 360

RKKEGSVARN YEQDTEVGCT MPIKCQEARH SEITPSQDQE TGNDKADSKS PSVHKGEAIE 420

PNHILEEYTV LKSLSNVVPN STIEKLPESH SGMETNIKIS IAKATKPEMN GMVPLLHVTF 480

PGDGTPKEPA LAKPSLQKRK GTLHSNSSFN ILAHQENDRH KMKTHRNKLD SKTKTSNRTP 540

PNFMISVEGS IKSTVHKTSI KTQVFPALGL VDPKPQQSPK FQRRMPQIEK KQSTYRALKP 600

KKQSFPCICK SPGIKTSSVP LSIQPTEPRL NYLDLKYSDM FKEINSTANG PGIYEMFGTP 660

VYCHMREAER HENKHYREIC SAPSGRCITN KCRSLHSERS SNSRTRLSQK RTHIKPRKPS 720

LGIKPKHKSL NSKEKGCKAV GSNLQDAENG DGISEPEWQI RSSENDFLSS KDEVQPVNLA 780

QTLEQSIQQN EFLPGSDLSI VEEVSMEDSP DEGDISNHQI LATSLRDLHE LEELHHQTSS 840

VLSENSWAVP SEKSSNKHVL QEKQKTASLG KISANQILTN DVEFDSVSDK SKTYMSFSFQ 900

EQQESASSQA YQHWAHSLDH DSLANKSITY QTFGKTLNDE NSISQEILDS VKSEELTDEL 960

LGCLAAELLA LDEKDDNSSP ITANEANHEN LNLVCSRRGN TIQELGRETT NVKRQRHSNG 1020

FRIYDKEEQF LNSNEKKTFS ENSLKYEEPI LWTKGEILGK GAYGTVYCGL TSQGQLIAVK 1080

QVALDTSEKL ATEKEYQKLQ EEVDLLKALK HVNIVAYLGT CLEENIVSIF MEFVPGGSIS 1140

SIINRFGPLP EMVFCKYTKQ ILQGVAYLHE NCVVHRDIKG NNVMLMPTGI IKLIDFGCAK 1200

RLAWAGLNGT HSDMLKSMHG TPYWMAPEVI NESGYGRKSD IWSIGCTVFE MATGKPPLAS 1260

MDRMAAMFYI GAHRGLMPPL PEHFSENAAD FVRVCLTRDQ HERPSAVQLL KHSFLKRSH 1319

Nucleotide Sequence
(FASTA)

ATGAATTGTA TGCCAAAACC AGAAAGACAT GCTGAATCAT TGCTTGACAT TTGTCATGAT 60

ACAAACTCTT CAACTGATAC GATGACAGTG ACTAAAAACC AAAACATAAC CTTACAAAGT 120

ATAAGCGGCA GCGAGGAGTT TGAGCAAGAC GATGACTGCG GTCATTCCAT ATTGGTTAGT 180

GAAGGAGAGC CAAGTGCTGA TGGACAAGAC CCAAGACCCA GGACGGAAGG TGTCGAGATT 240

ATTGTTACTT TTCCAAGAGA TGTCAGTCAT CCCCAAGAAA TGAGCCAAGA AGATTTAAAA 300

GAAAACAATC AGATAACTGC AGCGCATGGA GAATGGGCGC GAGCACATTC TGTTTCTCTT 360

CCAAACGAAC TTGAGATGGT GGACCTCAGG ACAAAGACGC TGACCACGAG GCCTTTACTT 420

CTGAAGAAAC AGGAAAGTTC CAAGGAGCTC CGTGATGTGA ACTCGGGCTT TTTGTGGCCG 480

AGACCTTGCT TAGAACCAAA CATCTCCAAG TCTATAGCCA GAGAAGATGT TTCTCACTTT 540

CTGAAAGGGC AACAAAGAAA ATCTGAAGAG TGTTCTACCT CTGATATGAA GTACAGTAGC 600

CGGAGAATTG AGTTCCCTCT GCCACCATTG TCACTCTTGC CCATGAGATC TGGTCTCCTT 660

ACTATCCCCC GAAATCACAA GGATCAAAAA GAGAGAGAAA GAAACATGCC GAGCCTCATG 720

TCCTTTGTAC CTAAGTTCTC AGAGCCTGTT AGTCGACGTG ATGAGCACCA AGAAGCCCCA 780

TTCCAGGTGT TTGTGGATCA GATTCTCAGG TCCTCTGATG GCTCCATTTG GTCCAGAAAC 840

ATGTGCTCTT TTTGGAAGGC TAACCATTAC CAACAACACC TGGAGATGGA GGAGGATCGG 900

AAATCCAAGG AAACAGAAGG ATGTGACAAA ACTGAAATCT CTCACTTTCA AAAAGGGCAG 960

TCTTTGGTGT CCTCTGAGAA TTCTAAGAAA GGCAATTTTC CTACAGATAA GGATGTGGAT 1020

ATCGACTGCT ATGGTAGTGA AATGAGAAAA GCAGAAGAGA ACTCTCAATA TCTTTCATCA 1080

AGAAAGAAAG AGGGTTCAGT AGCCAGAAAC TATGAACAAG ATACAGAAGT TGGATGTACC 1140

ATGCCAATCA AATGCCAAGA AGCTCGGCAC TCAGAAATAA CTCCAAGCCA GGATCAAGAG 1200

ACTGGAAATG ATAAAGCTGA TTCAAAAAGT CCTTCAGTAC ATAAAGGTGA AGCAATTGAG 1260

CCAAATCATA TTTTGGAAGA GTATACTGTA CTTAAAAGTT TGTCCAATGT AGTCCCTAAT 1320

AGCACCATTG AAAAACTCCC AGAAAGTCAC AGCGGCATGG AGACAAACAT AAAAATATCA 1380

ATAGCAAAGG CAACCAAACC AGAAATGAAT GGGATGGTCC CTCTTCTCCA CGTCACTTTC 1440

CCTGGAGATG GAACTCCCAA GGAACCAGCA CTAGCTAAAC CAAGCCTCCA AAAAAGAAAG 1500

GGCACCCTTC ATAGCAACAG TAGCTTCAAC ATACTTGCAC ACCAAGAAAA TGACAGGCAT 1560

AAGATGAAAA CCCATAGAAA TAAATTGGAT TCAAAGACCA AGACCAGTAA CAGGACACCT 1620

CCAAATTTCA TGATTTCCGT TGAAGGTTCC ATTAAGTCTA CTGTGCATAA AACCAGCATA 1680

AAAACTCAAG TTTTTCCTGC CTTGGGGCTT GTTGACCCCA AGCCTCAGCA ATCACCCAAG 1740

TTTCAAAGGA GAATGCCACA GATCGAAAAG AAGCAGTCAA CTTATCGGGC TCTGAAACCT 1800

AAAAAGCAAT CATTTCCTTG CATCTGTAAA AGTCCAGGAA TAAAAACGTC TTCTGTTCCA 1860

CTCTCTATTC AACCAACAGA ACCAAGACTA AATTATCTAG ATCTTAAGTA TAGTGACATG 1920

TTCAAAGAAA TCAATTCAAC TGCTAATGGA CCTGGAATCT ATGAAATGTT TGGGACCCCT 1980

GTTTATTGTC ACATGCGAGA GGCTGAAAGG CATGAAAACA AACATTACCG AGAGATATGC 2040

TCAGCTCCAT CAGGCAGATG TATCACCAAT AAATGTCGGT CTTTACACAG TGAGAGAAGC 2100

AGCAATAGCA GAACAAGACT TTCTCAGAAA AGAACACATA TTAAACCCCG AAAGCCTTCG 2160

CTTGGCATTA AACCAAAGCA CAAAAGTTTA AATTCTAAAG AAAAGGGTTG CAAGGCTGTA 2220

GGTAGCAACC TACAAGATGC TGAAAATGGT GATGGTATTT CAGAACCAGA GTGGCAGATC 2280

AGGTCTTCAG AAAATGACTT TCTGTCTTCC AAAGATGAAG TTCAGCCCGT GAACTTGGCT 2340

CAGACTCTTG AGCAGTCCAT TCAACAGAAC GAATTCCTTC CTGGCTCCGA TTTGTCCATT 2400

GTTGAAGAAG TCTCTATGGA AGACTCTCCT GATGAAGGAG ACATTTCTAA CCATCAAATA 2460

CTTGCCACGA GCCTCAGAGA CCTGCATGAA CTTGAAGAGC TACATCATCA GACTTCATCT 2520

GTCCTTTCAG AAAACAGCTG GGCAGTGCCC AGTGAGAAGA GTTCCAACAA GCATGTACTA 2580

CAAGAAAAGC AGAAAACAGC ATCTCTTGGT AAAATAAGTG CCAATCAAAT TTTAACTAAT 2640

GATGTAGAGT TTGATAGTGT TTCAGATAAA TCTAAAACAT ATATGAGTTT CTCTTTCCAA 2700

GAGCAACAAG AAAGTGCATC TTCCCAGGCA TATCAACATT GGGCACATTC TTTGGATCAT 2760

GATAGTTTAG CCAATAAGTC AATCACATAT CAAACATTTG GAAAAACTTT AAATGATGAA 2820

AATTCAATTT CCCAAGAAAT CCTAGACTCT GTAAAGAGCG AAGAATTGAC AGATGAGCTA 2880

TTAGGTTGTC TAGCTGCAGA ACTATTAGCT CTTGATGAGA AAGATGACAA CTCTTCCCCA 2940

ATAACAGCAA ATGAAGCAAA TCATGAAAAC CTAAATCTTG TCTGCAGTAG GAGAGGAAAT 3000

ACCATTCAAG AATTGGGCAG AGAGACAACA AATGTCAAAA GACAGAGACA TAGTAATGGG 3060

TTCAGGATAT ATGACAAGGA GGAGCAATTT CTCAACTCAA ATGAAAAGAA AACATTTTCT 3120

GAAAATAGTT TAAAGTATGA AGAACCTATC CTGTGGACCA AGGGTGAGAT CCTTGGGAAG 3180

GGAGCCTACG GCACAGTATA TTGTGGTCTA ACTAGCCAAG GACAGCTAAT AGCTGTAAAA 3240

CAGGTGGCTT TGGATACCTC TGAAAAATTG GCTACTGAAA AAGAATACCA GAAACTGCAG 3300

GAAGAAGTAG ATTTGCTCAA AGCACTGAAA CATGTCAACA TTGTGGCCTA TTTGGGGACA 3360

TGCTTGGAAG AGAACATTGT AAGCATTTTC ATGGAGTTCG TTCCGGGTGG CTCAATCTCT 3420

AGTATTATAA ACCGTTTTGG ACCATTGCCT GAGATGGTGT TCTGTAAATA TACAAAACAA 3480

ATTCTACAAG GTGTTGCTTA TCTCCATGAG AACTGTGTGG TACATCGAGA TATCAAAGGA 3540

AATAATGTTA TGCTCATGCC AACTGGAATA ATCAAGCTGA TCGACTTTGG CTGTGCCAAG 3600

CGTTTGGCCT GGGCTGGCTT AAATGGCACC CATAGTGACA TGCTTAAGTC CATGCATGGG 3660

ACTCCATATT GGATGGCCCC AGAAGTCATC AATGAGTCTG GCTATGGAAG GAAGTCAGAC 3720

ATCTGGAGCA TTGGCTGCAC TGTGTTTGAG ATGGCCACAG GGAAGCCTCC GCTGGCTTCC 3780

ATGGACAGGA TGGCAGCCAT GTTTTACATT GGAGCACACA GAGGGCTGAT GCCTCCTTTA 3840

CCAGAACACT TCTCAGAAAA TGCAGCAGAC TTCGTGCGCG TATGCCTAAC CAGGGACCAG 3900

CATGAGCGAC CTTCTGCTGT CCAGCTCCTG AAGCACTCCT TCTTGAAGAG AAGTCACTGA 3960

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1052  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSEKlATEKEYQKLQEEVDLLKALK  1110

         89*****************8.89***********8655516677****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee+ ++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1111  HVNIVAYLGTCLEENIVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  1170

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1171  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1230

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++pe++se+

Q: 1231  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPEHFSEN  1287

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1288  AADFVRVCLTRDQHERPSAVQLLKHSFL  1315

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSEKLA TEKEYQKLQE EVDLLKALKH 60

VNIVAYLGTC LEENIVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP EHFSENAADF 240

VRVCLTRDQH ERPSAVQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ecb:100050587

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013