EKS-EQC-00366
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00366
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src380.63.5E-114191440250
StatusUnreviewed
Ensembl ProteinENSECAP00000007825
UniProt AccessionF6ZIG2;
Protein Name
Protein Synonyms/Alias
Gene NamePTK6
Gene Synonyms/Alias PTK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000009935ENSECAP00000007825ENSECAT00000010172
OrganismEquus caballus
Functional Description
Protein Length450
Protein Sequence
(FASTA)
MASWGQAHLG PKYVGLWDFE ARTEEELSFR AGDLFHVARK EEEWWWATLL DEAGMALAEG 60
YVPHNYLAEK ETVESEPWFF GRISRSEALH RLQAEGNKPG AFLIRVSEKP GVDYVLSVRD 120
TQAVRHYKIW RRAGRLHLNQ AVSFPSLPDL VDHHRAQSLS HGLRLTVPCW KHEPEPLPQC 180
DDWERPREEF TLCRRLGSGY FGEVFEGLWK DQVRVAIKVI ARDDLLHQHT FQAEIQAMKQ 240
LRHKHILALY AVASVGDPVY IVTELMPKGS LLALLRDSDE TALPVSELVD ITWQVAEGMC 300
YLESQNYIHR DLAARNILVG ENHICKVGDF GLARLVKEDI YLSYDHNIPY KWTAPEALSR 360
GHYSIKSDVW SFGILLHEIF SRGQMPYPGM SNHEAFLRVE AGYRMPRPPQ CPPTAHRLML 420
SCWHKDPEQR PSFKTLREQL SSFTRYENPL 450
Nucleotide Sequence
(FASTA)
ATGGCGTCCT GGGGCCAGGC ACACCTGGGA CCCAAGTACG TGGGCCTCTG GGACTTCGAG 60
GCCCGGACAG AGGAGGAGCT GAGCTTCCGG GCAGGGGACC TCTTCCACGT GGCCAGGAAG 120
GAGGAGGAGT GGTGGTGGGC CACACTGCTG GACGAGGCGG GCATGGCCCT GGCCGAGGGC 180
TACGTGCCCC ACAACTACCT GGCCGAGAAG GAGACCGTGG AATCTGAGCC GTGGTTCTTC 240
GGCCGCATCT CCCGCTCAGA AGCCTTACAC CGACTGCAGG CCGAGGGCAA CAAGCCGGGT 300
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG GGTGTGGACT ACGTCCTCTC GGTGCGGGAC 360
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGGGCCG GCCGGCTGCA CCTCAACCAG 420
GCCGTGTCCT TCCCCAGCCT GCCTGACCTC GTGGACCACC ACAGGGCCCA GAGCCTGTCC 480
CACGGCCTGC GGCTGACCGT GCCCTGCTGG AAGCACGAGC CGGAGCCCCT GCCGCAGTGT 540
GACGACTGGG AGCGGCCGCG GGAGGAATTC ACACTCTGCA GGAGGCTGGG CTCTGGCTAC 600
TTCGGGGAGG TCTTCGAAGG GCTCTGGAAG GACCAGGTCC GAGTGGCCAT TAAGGTGATC 660
GCCCGAGATG ACCTCCTGCA CCAGCACACA TTCCAGGCGG AGATCCAGGC CATGAAGCAG 720
CTTCGGCACA AGCACATCCT GGCGCTGTAC GCCGTGGCTT CCGTGGGAGA TCCCGTGTAC 780
ATCGTCACGG AGCTCATGCC CAAGGGGAGC CTGCTGGCGC TGCTGCGGGA CTCTGACGAG 840
ACAGCCCTGC CCGTCTCAGA GCTGGTGGAC ATCACATGGC AGGTGGCCGA GGGAATGTGC 900
TACCTGGAAT CACAGAATTA CATCCACCGG GACCTGGCTG CCAGGAACAT CCTCGTGGGG 960
GAAAACCACA TCTGCAAAGT CGGGGACTTC GGGCTGGCCA GGCTCGTCAA GGAGGACATC 1020
TACCTTTCCT ATGACCACAA CATCCCCTAC AAGTGGACGG CGCCCGAGGC ACTCTCCCGA 1080
GGGCATTACT CCATCAAATC TGATGTGTGG TCCTTCGGGA TTCTCCTCCA TGAGATCTTC 1140
AGCAGGGGTC AGATGCCCTA TCCAGGCATG TCCAACCACG AGGCCTTCCT GAGGGTGGAG 1200
GCAGGCTACC GCATGCCCCG TCCCCCCCAG TGCCCTCCCA CTGCACACAG GCTGATGCTC 1260
TCCTGCTGGC ACAAGGACCC GGAGCAGAGG CCCTCCTTCA AAACCCTGCG GGAGCAGCTC 1320
TCCAGCTTCA CCAGATACGA GAATCCGCTC TGA 1353
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60
         +l+++lG+G+fGev++g+wk++v+va+k++ +++ l++++f++e+q++k+lrh+++++ly
Q: 191   TLCRRLGSGYFGEVFEGLWKDQVRVAIKVIARDDlLHQHTFQAEIQAMKQLRHKHILALY  250
         799***************************9998799***********************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         av+s ++P+yivtelm kGsll++l+++++++l++++lvd+++qvaeGm+yle++n+ihr
Q: 251   AVASVGDPVYIVTELMPKGSLLALLRDSDETALPVSELVDITWQVAEGMCYLESQNYIHR  310
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dlaarn+lvge+ ++kv+dfGlarl+++d+y + + +++P+kWtaPea++ g+++iksdv
Q: 311   DLAARNILVGENHICKVGDFGLARLVKEDIYLSYD-HNIPYKWTAPEALSRGHYSIKSDV  369
         *******************************9876.99**********************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+ei+++G++PypGm+n+e++ +ve+gyr+prp +cp + ++l+l+cw+kdpe+
Q: 370   WSFGILLHEIFSRGQMPYPGMSNHEAFLRVEAGYRMPRPPQCPPTAHRLMLSCWHKDPEQ  429
         ************************************************************
S: 241   rPtfetlqevl  251
         rP+f+tl+e+l
Q: 430   RPSFKTLREQL  440
         *******9875
Domain Sequence
(FASTA)
TLCRRLGSGY FGEVFEGLWK DQVRVAIKVI ARDDLLHQHT FQAEIQAMKQ LRHKHILALY 60
AVASVGDPVY IVTELMPKGS LLALLRDSDE TALPVSELVD ITWQVAEGMC YLESQNYIHR 120
DLAARNILVG ENHICKVGDF GLARLVKEDI YLSYDHNIPY KWTAPEALSR GHYSIKSDVW 180
SFGILLHEIF SRGQMPYPGM SNHEAFLRVE AGYRMPRPPQ CPPTAHRLML SCWHKDPEQR 240
PSFKTLREQL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00349
EKS-ANC-00363
EKS-BOT-00375
EKS-CAJ-00379
EKS-CAP-00407
EKS-DAR-00754
EKS-ERE-00055
EKS-FEC-00362
EKS-GAA-00458
EKS-GOG-00364
EKS-HOS-00381
EKS-ICT-00355
EKS-LOA-00382
EKS-MAM-00374
EKS-MAE-00042
EKS-MOD-00364
EKS-MUM-00407
EKS-MUP-00369
EKS-MYL-00371
EKS-NOL-00342
EKS-ORA-00325
EKS-ORL-00444
EKS-PES-00332
EKS-POA-00364
EKS-PRC-00072
EKS-PTV-00096
EKS-RAN-00389
EKS-SAH-00345
EKS-TEN-00473
EKS-XET-00506
EKS-XIM-00472
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0016477; P:cell migration
GO:0071300; P:cellular response to retinoic acid
GO:0060575; P:intestinal epithelial cell differentiation
GO:0045926; P:negative regulation of growth
GO:0061099; P:negative regulation of protein tyrosine kinase activity
GO:0010976; P:positive regulation of neuron projection development
GO:0046777; P:protein autophosphorylation
GO:0042503; P:tyrosine phosphorylation of Stat3 protein
GO:0042506; P:tyrosine phosphorylation of Stat5 protein
KEGG
ecb:100060532;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013