EKS-EQC-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	408.1	1.6E-122	17	300	284

Status

Unreviewed

Ensembl Protein

ENSECAP00000008118

UniProt Accession

F6Q786;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK5

Gene Synonyms/Alias

MAPKAPK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010001	ENSECAP00000008116	ENSECAT00000010507
ENSECAG00000010001	ENSECAP00000008118	ENSECAT00000010509

Organism

Equus caballus

Functional Description

Protein Length

467

Protein Sequence
(FASTA)

MEKAIKETSI LEEYNINWTQ KLGAGISGPV RVCVKKSTQE RFALKILFDR PKARNEVRLH 60

MMCATHSNIV QIIEVFANSV QFPHESSPRA RLLIVMEMME GGELFHRISQ HRHFTEKQAS 120

QVTKQAKIAL ALQHCHLLNI AHRDLKPENL LFKDNSLDAP VKLCDFGFAK IDQGDLMTPQ 180

FTPYYVAPQV LEAQRRHQKE KSGIIPTSPT PYTYNKSCDL WSLGVIIYVM LCGYPPFYSK 240

HHSRTIPKDM RRKIMTGSFE FPEEEWSQIS EMAKDVVRKL LKVKPEERLT IEGVLDHPWL 300

NSTEALDNVL PSAQLMMDKA VVAGIQQAHA EQLANMRIQD LKVSLKPLHS VNNPILRKRK 360

LLGTKPKDCV YIHDRENGAE DSNVALEKLR DVIAQCILPQ AGENEDEKLN EVMQEAWKYN 420

RECKLLRDTL QSFSWNGRGF TDKVDRLKLA EIVKQVIEEQ TTSHESQ 467

Nucleotide Sequence
(FASTA)

ATGGAGAAAG CCATCAAGGA AACCTCCATT TTAGAGGAAT ACAATATCAA TTGGACTCAG 60

AAGCTGGGAG CTGGAATTAG TGGTCCAGTT AGAGTCTGTG TGAAGAAATC TACCCAAGAA 120

CGGTTTGCAC TGAAAATTCT TTTTGATCGT CCAAAAGCAA GAAATGAGGT ACGTCTGCAC 180

ATGATGTGTG CCACACACTC AAATATAGTT CAAATTATTG AAGTGTTTGC TAACAGTGTA 240

CAGTTTCCTC ATGAGTCCAG CCCCAGGGCT CGACTCTTAA TTGTAATGGA GATGATGGAA 300

GGGGGAGAGC TATTTCACAG AATCAGCCAG CACCGGCACT TTACAGAGAA GCAAGCCAGC 360

CAAGTAACAA AGCAGGCAAA GATCGCTTTG GCTCTACAGC ACTGTCACTT GTTGAACATC 420

GCGCATAGAG ACCTCAAGCC TGAAAACCTG CTCTTCAAGG ATAACTCTTT GGATGCCCCA 480

GTGAAGTTGT GTGACTTTGG ATTTGCCAAA ATTGACCAAG GTGACTTGAT GACACCCCAG 540

TTCACTCCTT ATTATGTAGC ACCTCAGGTA CTGGAGGCAC AGAGAAGGCA TCAGAAGGAG 600

AAATCGGGCA TCATACCTAC CTCGCCGACA CCCTATACCT ATAACAAGAG CTGTGACTTG 660

TGGTCCCTAG GGGTGATTAT CTACGTGATG TTGTGTGGAT ACCCTCCTTT TTACTCCAAA 720

CACCACAGTC GGACTATCCC AAAGGATATG CGGAGAAAGA TCATGACAGG CAGTTTTGAG 780

TTCCCAGAGG AAGAGTGGAG CCAGATCTCA GAGATGGCCA AAGATGTTGT GAGGAAGCTC 840

TTGAAGGTCA AACCAGAGGA AAGACTCACC ATCGAGGGAG TGTTGGACCA CCCCTGGCTC 900

AACTCGACTG AGGCTCTGGA TAATGTGCTA CCCTCTGCTC AGCTGATGAT GGATAAGGCG 960

GTGGTTGCAG GAATCCAGCA GGCTCACGCG GAACAGTTGG CCAACATGCG AATCCAGGAT 1020

CTGAAAGTCA GCCTCAAACC CCTGCACTCT GTGAACAACC CCATTCTGAG GAAGAGGAAA 1080

TTACTCGGCA CCAAGCCAAA GGACTGTGTT TATATCCATG ACCGTGAGAA TGGAGCCGAG 1140

GATTCAAATG TTGCCTTGGA AAAGCTCCGA GATGTGATTG CTCAGTGTAT TCTCCCCCAG 1200

GCTGGAGAGA ATGAAGATGA AAAGCTGAAT GAAGTAATGC AGGAGGCTTG GAAGTATAAC 1260

CGGGAATGCA AACTCCTACG AGATACTCTG CAAAGCTTCA GCTGGAATGG TCGTGGATTC 1320

ACAGATAAAG TAGATCGACT AAAACTGGCA GAAATTGTGA AGCAAGTGAT AGAGGAGCAA 1380

ACCACGTCCC ATGAATCTCA ATAA 1404

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidvf  61

         +++++lG+Gisg v+ cvkk+t+e++alkil dr+k+r+ev+lh+++++h+niv++i+vf

Q: 17    NWTQKLGAGISGPVRVCVKKSTQERFALKILFDRPKARNEVRLHMMCATHSNIVQIIEVF  76

         689*********************************************************

S: 62    ensfe......dekrlllvlekleGGellsriqerkaftekeasevvkd..iasalkflh  113

         +ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+  ia al+++h

Q: 77    ANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQakIALALQHCH  136

         ****99999999***********************************9755899******

S: 114   skniahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleae  173

           niahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+vlea+

Q: 137   LLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFTPYYVAPQVLEAQ  194

         **********************************..89**********************

S: 174   kee.............allydksCDlWslGvilyillcGypPfyskk.graiskklkeri  219

         +++             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++++i

Q: 195   RRHqkeksgiiptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMRRKI  254

         *999*****************************************9979***********

S: 220   qegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         ++g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 255   MTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL  300

         *********************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVRVCVKK STQERFALKI LFDRPKARNE VRLHMMCATH SNIVQIIEVF 60

ANSVQFPHES SPRARLLIVM EMMEGGELFH RISQHRHFTE KQASQVTKQA KIALALQHCH 120

LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL MTPQFTPYYV APQVLEAQRR 180

HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI PKDMRRKIMT 240

GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD HPWL 284

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013