EKS-EQC-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR538.82.2E-16271338268
StatusUnreviewed
Ensembl ProteinENSECAP00000009510
UniProt AccessionF6R9D2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR
Gene Synonyms/Alias INSR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000010127ENSECAP00000022825ENSECAT00000029168
ENSECAG00000010127ENSECAP00000009510ENSECAT00000012081
ENSECAG00000010127ENSECAP00000008032ENSECAT00000010416
OrganismEquus caballus
Functional Description
Protein Length385
Protein Sequence
(FASTA)
PSNIAKIIIG PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP LYASSNPEYL SAMFPCSVYV 60
PDEWEVPREK ITLLRELGQG SFGMVYEGNA RDIVKGEAET RVAVKTVNES ASLRERIEFL 120
NEASVMKGFT CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT 180
LQEMVQMAAE IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK 240
GGKGLLPVRW MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG 300
GYLDQPDNCP ERVTDLMRMC WQFNPKMRPT FLEIVDLLKD DLHPSFPEVS FFHSEENKAP 360
ESEELEMEFE DMENVPLDRS SHSQR 385
Nucleotide Sequence
(FASTA)
CCATCAAATA TTGCAAAAAT CATCATCGGC CCCCTCATCT TTGTCTTTCT CTTCAGTGTG 60
GTCATTGGAA GCATTTACCT CTTCTTGAGA AAGAGGCAGC CAGATGGGCC CCTGGGACCG 120
CTGTACGCTT CCTCAAACCC TGAGTACCTC AGCGCCATGT TTCCCTGCTC TGTGTACGTG 180
CCGGACGAGT GGGAGGTGCC TCGGGAGAAG ATCACCCTCC TGCGGGAGCT GGGGCAGGGC 240
TCCTTCGGCA TGGTGTATGA AGGCAACGCC AGGGACATCG TCAAGGGCGA GGCGGAGACC 300
CGCGTGGCGG TGAAGACAGT CAACGAGTCT GCCAGTCTGC GAGAGAGGAT CGAGTTTCTC 360
AACGAGGCCT CAGTCATGAA GGGCTTCACC TGCCATCACG TGGTCCGCCT CCTGGGGGTG 420
GTATCGAAAG GCCAGCCAAC GCTGGTGGTG ATGGAGTTGA TGGCTCATGG AGACCTGAAG 480
AGCTACCTCC GTTCCCTGCG GCCGGAGGCT GAGAATAACC CTGGCCGCCC TCCCCCTACC 540
CTGCAAGAGA TGGTTCAGAT GGCGGCGGAG ATCGCCGACG GGATGGCGTA CCTGAACGCC 600
AAGAAGTTTG TGCACCGGGA CCTGGCAGCT CGAAACTGCA TGGTCGCCCA CGATTTTACC 660
GTCAAAATCG GAGACTTTGG AATGACCAGA GACATCTACG AAACGGATTA CTACCGGAAA 720
GGAGGCAAGG GGCTGCTCCC CGTGAGGTGG ATGGCTCCTG AATCCCTGAA GGACGGGGTC 780
TTTACTACTT CTTCTGACAT GTGGTCCTTT GGCGTGGTCC TTTGGGAAAT CACCAGCTTG 840
GCAGAACAGC CTTACCAAGG CCTGTCTAAT GAGCAGGTGT TGAAATTTGT CATGGATGGA 900
GGGTATCTGG ATCAACCCGA CAATTGTCCC GAGAGAGTCA CCGACCTGAT GCGTATGTGC 960
TGGCAGTTCA ACCCCAAGAT GCGGCCGACC TTCCTGGAGA TTGTCGACCT GCTCAAGGAT 1020
GACCTGCACC CCAGCTTTCC AGAAGTTTCC TTCTTCCACA GCGAGGAGAA CAAGGCCCCC 1080
GAGAGCGAGG AGCTGGAGAT GGAGTTTGAG GACATGGAGA ACGTCCCCCT GGATCGGTCC 1140
TCACATTCCC AGAGG 1155
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvyeG+a+d+vkge+etrva+ktvne+as reriefl+easvmk f+
Q: 71    ITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT  130
         789*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l++++qmaae
Q: 131   CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMVQMAAE  190
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 191   IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  250
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp
Q: 251   MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  310
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e++t+lmr+cwq+npk+rp+fleiv+ll
Q: 311   ERVTDLMRMCWQFNPKMRPTFLEIVDLL  338
         *************************976
Domain Sequence
(FASTA)
ITLLRELGQG SFGMVYEGNA RDIVKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60
CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMVQMAAE 120
IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240
ERVTDLMRMC WQFNPKMRPT FLEIVDLL 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Sus scrofa"; ?>
EKS-SUS-00015
Gene Ontology
GO:0005901; C:caveola
GO:0005899; C:insulin receptor complex
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0032148; P:activation of protein kinase B activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0031017; P:exocrine pancreas development
GO:0007186; P:G-protein coupled receptor signaling pathway
GO:0003007; P:heart morphogenesis
GO:0008286; P:insulin receptor signaling pathway
GO:0030238; P:male sex determination
GO:0030335; P:positive regulation of cell migration
GO:0048639; P:positive regulation of developmental growth
GO:0045740; P:positive regulation of DNA replication
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0045821; P:positive regulation of glycolysis
GO:0043410; P:positive regulation of MAPK cascade
GO:0045840; P:positive regulation of mitosis
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060267; P:positive regulation of respiratory burst
GO:0046777; P:protein autophosphorylation
GO:0045995; P:regulation of embryonic development
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0019087; P:transformation of host cell by virus
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013