EKS-EQC-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	334.6	4.5E-100	34	292	259

Status

Unreviewed

Ensembl Protein

ENSECAP00000008608

UniProt Accession

F6Q2E5;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010212	ENSECAP00000008608	ENSECAT00000011061

Organism

Equus caballus

Functional Description

Protein Length

1242

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSK WSSTFKDFLK KCLEKNVDSR WNTSQLLQHP FVTVDSNKPI 300

RELIAEAKAE VTEEVEDGKE EDDEEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360

ESVSEKTERN TSEDKFNSEI LNEKPTTDEL EKAPEGINGH INDTHLEAMD ELHNRTTIIK 420

ENGREEKRPK LENLPDTEDQ GTLDTNSVNE GKENDMMITL ETNVEQNLKP EQERDQEKQQ 480

IFENKAVTSE EIKDTTIQTM DLVSQETGEK ETDLQTIENK VELTKEDTQE KLGKDDKTQK 540

DMISDTGNII GTNEAVDVGQ KAVENNAEDA QSNDGKEVVE VGQKLVSKPL EGPEAGGTEK 600

VPVKEVVETN EVDQKSIEGK GDEQLINSSE NIVETNEEPG TSQVEEVTES SSAEEIVIRN 660

AVIHTDQKDL GRETDDARKA TAQIDTEQKE IPCEVPSKIE PHATATSQPD EPQPVPVPSI 720

NVNSEDVENK GEIGALSKTE TMLLPDSETQ KENDTDSGTG STADNSSIDL NLSISSFLSK 780

TKDSGSISLQ ETRRQKKTLK KTRKFVVDGV EVSVTTSKIV TDSDSKTEEL RFLRRQELRE 840

LRLLQKEEQR AQQQLNSKLQ QQREQIFRRF EQEMMSKKRQ YDQEIENLEK QQKQTIERLE 900

QEHTNRLRDE AKRIKGEQEK ELSKFQNMLK NRKKEVINEV EKAPKELRKE LMKRRKEELA 960

QSQHAQEQEF VQKQQQELDG SLKKIIQQQK AELANIEREC LNNKQQLMRA REAAIWELEE 1020

RHLQEKHQLL KQQLKDQYFM QRHQLLKRHE KETEQMQRYN QRLIEELKTR QTQERARLPK 1080

IQRSEAKTRM AMFKKSLRIN STATPDQDRD KIKQFAAQEE KRQKNERMAQ HQKHENQMRD 1140

LQLQCEANVR ELHQLQNEKC HLLVEHETQK LKELDEEHSQ ELKEWREKLR PRKKTLEEEF 1200

ARKLQEQEVF FKMTGESECL NPSTQSRISK FYPVPSLHST GS 1242

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAGCAG 60

TACGAGCATG TGAAGAGGGA CCTGAACCCC GAGGAGTTTT GGGAAATTAT AGGGGAACTG 120

GGCGACGGCG CCTTCGGGAA AGTGTACAAG GCACAGAATA AAGAGACCAA TGTTTTAGCT 180

GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTACAT GGTTGAAATT 240

GATATATTAG CATCTTGTGA TCACCCAAAT ATAGTGAAGC TTCTAGATGC CTTCTATTAT 300

GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GAGCAGTGGA TGCTGTGATG 360

CTTGAGCTTG AGAGACCGTT AACTGAGTCC CAGATACAAG TAGTTTGTAA ACAGACTTTA 420

GAGGCATTGA ACTACTTACA TGATAATAAA ATCATCCACA GAGATCTAAA GGCTGGCAAC 480

ATTCTTTTTA CCTTAGATGG AGATATTAAA TTGGCGGATT TTGGAGTATC AGCTAAAAAC 540

ACAAGGACAA TTCAAAGAAG AGATTCCTTT ATTGGCACAC CGTATTGGAT GGCTCCTGAG 600

GTAGTCATGT GTGAAACATC TAAGGACAGA CCCTATGACT ACAAAGCAGA TGTTTGGTCC 660

CTGGGTATCA CTTTAATAGA AATGGCTGAG ATAGAGCCAC CTCATCATGA ATTAAATCCA 720

ATGCGAGTGC TGCTAAAAAT AGCAAAATCT GAGCCCCCTA CGTTAGCACA GCCATCCAAA 780

TGGTCTTCAA CTTTTAAGGA CTTTCTGAAG AAATGCTTGG AAAAGAATGT GGATTCCAGG 840

TGGAATACAT CTCAGCTACT GCAGCATCCC TTTGTTACTG TTGATTCCAA CAAACCAATC 900

CGAGAGTTGA TTGCAGAGGC AAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 960

GAAGATGATG AGGAAGAAAC AGAAAATTCT TTGCCAATAC CTGCAAGTAA GCGTGCCTCC 1020

TCTGATCTTA GTATTGCCAG CTCTGAAGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTCT CAGAAAAAAC AGAACGTAAT ACTTCTGAGG ATAAATTTAA CAGTGAAATT 1140

CTTAACGAAA AACCCACCAC TGATGAACTT GAAAAAGCTC CAGAAGGTAT TAATGGACAT 1200

ATTAACGATA CTCATTTAGA AGCCATGGAT GAACTCCATA ATAGAACAAC AATAATCAAG 1260

GAAAATGGGA GAGAGGAGAA GAGACCTAAG CTTGAAAATC TACCTGACAC AGAAGACCAA 1320

GGAACATTGG ACACTAATTC AGTTAATGAA GGAAAAGAGA ATGATATGAT GATAACTTTA 1380

GAAACAAATG TTGAACAGAA TCTGAAACCT GAGCAAGAAA GGGATCAGGA AAAGCAACAG 1440

ATATTTGAAA ATAAGGCTGT AACATCTGAA GAAATTAAAG ATACTACTAT TCAAACAATG 1500

GATTTAGTTT CTCAAGAGAC TGGAGAAAAA GAGACAGATC TTCAGACAAT TGAAAATAAA 1560

GTTGAGCTTA CAAAGGAAGA TACCCAAGAG AAATTGGGAA AAGATGATAA AACTCAAAAA 1620

GATATGATCA GTGATACAGG CAATATTATA GGAACAAATG AGGCAGTAGA TGTTGGTCAG 1680

AAGGCAGTTG AAAACAATGC TGAGGATGCC CAGAGTAATG ATGGGAAAGA AGTGGTTGAA 1740

GTAGGCCAGA AATTAGTAAG TAAGCCCTTG GAGGGTCCTG AGGCTGGTGG TACTGAGAAA 1800

GTTCCTGTTA AGGAAGTAGT TGAAACTAAT GAGGTAGATC AAAAATCTAT AGAAGGTAAA 1860

GGTGATGAAC AATTAATCAA CAGTTCAGAG AACATAGTAG AGACCAATGA GGAACCTGGG 1920

ACAAGTCAAG TTGAGGAAGT TACTGAGTCA AGTAGCGCTG AAGAAATAGT GATCAGAAAT 1980

GCAGTGATTC ATACTGACCA AAAGGATTTA GGAAGGGAAA CTGACGATGC TCGTAAAGCC 2040

ACTGCTCAGA TAGATACAGA GCAAAAAGAA ATTCCCTGTG AAGTGCCAAG TAAAATAGAA 2100

CCTCACGCTA CTGCCACTTC ACAGCCTGAT GAACCTCAGC CTGTTCCAGT ACCCAGTATT 2160

AACGTCAACT CTGAAGATGT AGAAAATAAA GGGGAAATAG GTGCTTTATC AAAAACTGAA 2220

ACCATGTTGC TCCCAGACTC TGAGACTCAA AAGGAAAATG ATACCGATTC AGGCACTGGT 2280

TCTACTGCTG ATAATAGCAG CATTGACTTG AATTTATCCA TCTCTAGCTT CCTAAGCAAA 2340

ACTAAAGACA GTGGATCAAT ATCTTTACAA GAAACAAGAA GACAAAAGAA AACATTGAAG 2400

AAAACACGCA AATTTGTTGT TGATGGTGTA GAAGTGAGTG TAACAACATC AAAGATAGTT 2460

ACAGATAGTG ATTCCAAAAC TGAGGAATTG AGATTTCTTA GACGTCAGGA ACTTCGGGAA 2520

TTAAGATTGC TTCAAAAAGA AGAGCAGAGA GCTCAGCAAC AGCTCAATAG CAAACTGCAG 2580

CAACAACGAG AACAAATTTT CCGGCGCTTT GAGCAAGAAA TGATGAGCAA AAAGCGGCAA 2640

TATGACCAAG AAATTGAGAA TCTAGAAAAA CAGCAGAAAC AGACTATTGA ACGTCTAGAA 2700

CAAGAACATA CAAATCGCTT GAGAGATGAA GCCAAACGCA TTAAAGGAGA ACAAGAGAAA 2760

GAGTTGTCCA AATTTCAGAA TATGTTAAAG AACCGAAAGA AGGAGGTTAT AAATGAAGTG 2820

GAGAAAGCAC CCAAAGAGCT GAGAAAAGAG CTCATGAAAC GCAGGAAAGA GGAGCTTGCA 2880

CAAAGCCAGC ATGCTCAGGA ACAAGAATTT GTTCAGAAGC AACAACAAGA ATTAGATGGC 2940

TCTCTGAAAA AGATCATCCA ACAGCAGAAG GCAGAGTTAG CCAATATTGA AAGAGAGTGC 3000

CTGAATAACA AACAGCAGCT CATGAGAGCT CGAGAGGCTG CAATTTGGGA ACTTGAAGAA 3060

CGACACTTGC AAGAAAAACA CCAGCTGCTC AAACAGCAAC TTAAAGATCA GTATTTCATG 3120

CAAAGACATC AGCTGCTTAA GCGCCATGAG AAGGAAACAG AACAAATGCA GCGTTACAAT 3180

CAACGACTTA TTGAAGAATT GAAAACCAGA CAGACTCAAG AAAGAGCAAG ACTGCCTAAG 3240

ATTCAGCGCA GTGAAGCCAA GACTCGAATG GCCATGTTTA AGAAGAGTTT GAGAATTAAC 3300

TCGACAGCCA CACCAGATCA GGACCGTGAC AAAATTAAAC AGTTTGCTGC TCAAGAAGAA 3360

AAGAGGCAGA AAAATGAGAG AATGGCTCAG CATCAAAAGC ATGAAAATCA AATGCGGGAT 3420

CTTCAGCTGC AGTGTGAAGC CAATGTCCGG GAACTGCATC AGCTGCAGAA TGAAAAATGC 3480

CACCTATTGG TTGAGCATGA GACTCAGAAA CTAAAGGAGT TAGATGAGGA ACACAGCCAA 3540

GAATTAAAGG AATGGAGAGA GAAATTGAGA CCTAGGAAAA AGACACTGGA AGAAGAGTTT 3600

GCCAGGAAAC TGCAGGAACA GGAAGTGTTC TTTAAAATGA CCGGGGAGTC TGAATGCCTT 3660

AACCCCTCAA CACAGAGCCG GATTTCCAAA TTCTATCCTG TTCCTAGCTT GCATTCCACT 3720

GGATCGTAA 3729

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++k+s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSTFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDSRWNTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSKWSS TFKDFLKKCL 240

EKNVDSRWNT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

ecb:100059564

;

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013