EKS-EQC-00077
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00077
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk624.62.4E-188575855281
StatusUnreviewed
Ensembl ProteinENSECAP00000008277
UniProt AccessionF6RTS3;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000010228ENSECAP00000008277ENSECAT00000010687
OrganismEquus caballus
Functional Description
Protein Length869
Protein Sequence
(FASTA)
MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60
WTKNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAAE SCGALQVKMK 120
PKITRPPINV KITEGLKAVL PCTTMGNPKP SVTWIKGDHA LRENARIAVL ESGSLRIHNV 180
QKEDAGHYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTATGIPV 240
PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 300
ISIAEWSKPQ KDNKGYCAQY RGEVCNAVLA KDALVFFNNS YADPEEAQEL LVHSAWNELN 360
TVSPFCRPAA EALLCNHIFQ ECNPGVVPTP IPICREYCLA VKELFCAKEW LEMEEKTHRG 420
LYRSGMHLLS VPECNKLPSM HWDPMACTRL PYLDYKKENL TTFPPMPSSK PSVDIPDLPS 480
SSSSSFAVSP TYSMTVIISI MSSFAIFVLL TITTLYCCRR RKQWKNKKRE SAAVTLTTLP 540
SELLLDRLHP NPMYQRMPLL LNPKLLSLEY PRNNIEYVRD IGEGAFGRVF QARAPGLLPY 600
EPFTMVAVKM LKEEASADMQ ADFQREAALM AEFDNPNIVK LLGVCAVGKP MCLLFEYMAY 660
GDLNEFLRSM SPHSVCSLSH SDLSTRAQVS SPGPPPLSCA EQLCIARQVA AGMAYLSERK 720
FVHRDLATRN CLVGENMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP PESIFYNRYT 780
TESDVWAYGV VLWEIFSYGL QPYYGMAHEE VIYYVRDGNI LSCPENCPLE LYNLMRLCWS 840
KLPADRPSFT SIHRILERMC ERAEGTVSV 869
Nucleotide Sequence
(FASTA)
ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTTTGGTTGC CTTCAGCGGG 60
ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120
GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ATCCCCAGCC TGAAATTTCC 180
TGGACTAAAA ATAAAATTCT CATTAAGCTC TTTGATACCC GGTACAGCAT TCGGGAGAAC 240
GGACAGCTCC TCACCATCCT GAGTGTGGAA GACAGCGATG ATGGCATCTA CTGCTGCATA 300
GCCAACAATG GTGTGGGAGG AGCTGCTGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA 360
CCTAAAATAA CTCGTCCTCC CATAAATGTA AAGATAACAG AAGGATTAAA GGCAGTTCTA 420
CCATGTACTA CAATGGGCAA TCCCAAACCA TCAGTGACAT GGATTAAGGG GGACCATGCA 480
CTCAGGGAAA ATGCCCGCAT TGCAGTTCTT GAATCTGGGA GTTTAAGGAT TCATAATGTG 540
CAAAAGGAAG ATGCAGGACA TTATCGATGT GTGGCAAAAA ACAGCCTCGG GACGGCATAT 600
TCCAAATTGG TGAAGCTGGA AGTTGAGGTT TTTGCCAGAA TCCTGCGGGC TCCTGAATCC 660
CACAATGTCA CCTTCGGCTC CTTTGTGACC CTGCGCTGTA CAGCAACAGG CATCCCTGTC 720
CCCACCATCA CCTGGATTGA AAACGGAAAT GCCGTTTCTT CTGGGTCCAT TCAAGAAAGT 780
GTGAAAGACC GAGTGATTGA TTCAAGACTA CAGCTATTCA TCACCAAGCC AGGCCTCTAT 840
ACGTGCATAG CTACTAATAA GCATGGAGAG AAATTCAGTA CTGCAAAGGC TGCAGCCACC 900
ATCAGTATAG CAGAATGGAG TAAACCACAG AAAGATAACA AAGGCTACTG CGCCCAGTAC 960
AGAGGGGAGG TGTGTAATGC TGTCCTGGCA AAAGATGCTC TTGTTTTCTT CAACAACTCC 1020
TACGCAGACC CTGAGGAGGC TCAAGAGCTA CTGGTCCACA GCGCCTGGAA TGAACTGAAC 1080
ACAGTGAGCC CGTTCTGCCG GCCAGCTGCT GAGGCTTTGC TGTGTAACCA CATCTTCCAA 1140
GAATGCAACC CTGGAGTAGT ACCTACTCCT ATACCCATTT GCAGAGAATA CTGCCTGGCA 1200
GTAAAGGAGC TCTTCTGTGC AAAAGAATGG CTGGAGATGG AAGAAAAGAC CCACAGAGGA 1260
CTCTACAGAT CTGGGATGCA TCTGCTCTCA GTGCCAGAAT GCAACAAGCT TCCCAGCATG 1320
CACTGGGACC CCATGGCCTG TACCAGACTG CCATATTTAG ATTATAAAAA AGAAAACCTA 1380
ACAACATTCC CGCCCATGCC GTCCTCAAAG CCGAGTGTGG ACATTCCAGA TTTGCCTTCC 1440
TCCTCCTCTT CCTCCTTCGC TGTCTCACCT ACATACTCCA TGACTGTAAT AATTTCCATC 1500
ATGTCCAGCT TTGCGATATT TGTGCTTCTT ACCATAACTA CTCTTTACTG CTGCCGAAGA 1560
CGAAAACAAT GGAAAAATAA GAAAAGAGAA TCAGCAGCAG TAACCCTCAC TACTCTTCCT 1620
TCTGAGCTCT TGCTAGACAG ACTTCATCCC AACCCCATGT ACCAGAGGAT GCCACTCCTT 1680
CTGAATCCCA AATTGCTCAG TCTGGAGTAT CCAAGGAATA ACATTGAATA TGTGAGAGAT 1740
ATCGGAGAGG GAGCATTCGG GAGGGTCTTT CAAGCAAGGG CTCCAGGCTT ACTTCCCTAT 1800
GAACCTTTCA CCATGGTGGC AGTGAAGATG CTCAAGGAGG AAGCCTCAGC AGACATGCAG 1860
GCCGACTTCC AGAGGGAGGC AGCCCTCATG GCAGAATTTG ATAACCCGAA CATTGTGAAA 1920
CTCTTAGGCG TGTGTGCTGT CGGGAAGCCG ATGTGCCTGC TCTTTGAATA CATGGCCTAC 1980
GGGGACCTCA ACGAGTTCCT CCGCAGCATG TCTCCTCATA GCGTGTGCAG CCTCAGCCAC 2040
AGCGACCTGT CCACGAGGGC TCAGGTCTCC AGCCCTGGAC CCCCGCCCCT CTCCTGTGCC 2100
GAGCAGCTCT GCATCGCCAG GCAGGTGGCA GCTGGCATGG CTTACCTCTC AGAGCGCAAG 2160
TTTGTCCACC GGGATTTAGC CACCAGGAAC TGCCTGGTGG GTGAGAACAT GGTGGTGAAA 2220
ATTGCTGACT TTGGCCTCTC TAGAAACATC TACTCAGCTG ACTACTACAA AGCTAATGAA 2280
AACGATGCTA TCCCCATCCG TTGGATGCCA CCTGAATCCA TTTTCTATAA CCGCTACACC 2340
ACAGAGTCTG ATGTGTGGGC CTACGGGGTG GTCCTGTGGG AGATCTTCTC CTACGGCCTG 2400
CAGCCCTACT ATGGGATGGC CCATGAGGAG GTCATTTACT ATGTGCGAGA TGGCAACATC 2460
CTCTCCTGCC CTGAGAATTG CCCCCTGGAG CTGTATAATC TAATGCGGCT GTGTTGGAGC 2520
AAGCTACCTG CAGACAGACC CAGTTTCACC AGTATTCACC GAATTCTGGA ACGCATGTGT 2580
GAGAGGGCAG AGGGAACTGT GAGTGTCTAG 2610
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd
Q: 575   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  634
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp++vcslshsdls+raqvssp++
Q: 635   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHSVCSLSHSDLSTRAQVSSPGP  694
         ************************************************************
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         +pls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad
Q: 695   PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  754
         ************************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y
Q: 755   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  814
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgnil+cpen+plely+lmrlcwsklpadrpsf+sihri
Q: 815   VRDGNILSCPENCPLELYNLMRLCWSKLPADRPSFTSIHRI  855
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHS VCSLSHSDLS TRAQVSSPGP 120
PPLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180
YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240
VRDGNILSCP ENCPLELYNL MRLCWSKLPA DRPSFTSIHR I 281
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0008582; P:regulation of synaptic growth at neuromuscular junction
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering
KEGG
ecb:100058619;
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013