EKS-EQC-00238

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00238

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	336.3	1.1E-100	1	227	227

Status

Unreviewed

Ensembl Protein

ENSECAP00000008405

UniProt Accession

F6PH61;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010252	ENSECAP00000008405	ENSECAT00000010840
ENSECAG00000010252	ENSECAP00000008401	ENSECAT00000010836

Organism

Equus caballus

Functional Description

Protein Length

1233

Protein Sequence
(FASTA)

QVAIKIIDKT QLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI 60

FDHLVAHGRM AEKEARRKFK QIVAAVYFCH CRNIVHRDLK AENLLLDANL NIKIADFGFS 120

NLFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN 180

LRARVLSGKF RIPFFMSTEC EHLIRHMLVL DPNKRLSMEQ ICKHKWMKLG DTDPNFDRLI 240

AECQQLKEER QMDPLNEDVL LAMEDMGLDK ERTLQSLRSD AYDHYSAIYS LLCDRHKRHK 300

TLRVGAPPSM PRAMAFQAPV SIQAEQAGTT MNISVPQVQL INPENQIVEA IPDGAVNLDS 360

DEGEEPSPEA LVRYLSMRRH TVGVADPRTE VMEDLQKLLP GFPGVSPQAP FLQVAPNMNF 420

MHNLLPMQNL QPTGQLEYKE QSLLQPPTLQ LLNGMGPLGR RASDGGANIQ LHAQQLLKRP 480

RGPSPLVTMT PAVPAVTPVD EESSDGEPDQ EAVQSSTYKD SNTLHLPTER FSPVRRFSDG 540

AASIQAFKAH LEKMGNNSSI KQLQQECEQL QKMYGGQIDE RTLEKTQQQH MLYQQEQHHQ 600

ILQQQIQDSI CPPQPSPPLQ AACENQPALL THQLQRLRIQ PSSPPPNHPN NHVFRQPSNS 660

PPPVNSAMIQ PHGAASPSQF QGLPSRSAIF QQQPENCSPP PNVALTCLGI QQPTQSQQVT 720

IQVQEPVDML STMPGTAAAP AGRGISISPS ASQIQMQHRT NLMATFSYGH RPLSKQLSAD 780

SAEAHSLNVN RFSPANYDQA HLHPHLFSDQ SRGSPSSYSP STGVGFPPTQ ALKVPPHDQF 840

PTFPPSAHQQ PPHYTTSALQ QALLSPTPPD YTRHQQVPHI LQGLLSPRHS LTGHSDIRLP 900

PAEFAQLIKR QQQQRQQQQQ QQQQEYQELF RHMNQGDAGS LAANLGGQSM TERQALPYQN 960

ADSYHHHHTS PQHLLQIRAQ ECISQVSSPT PTHGYAHQPA LMHSESMEEE CSCEGAKDGF 1020

PDRKSSNTLT KGCHDSPLLL STGGPGDPES LLGTVSHVQE LGMHPYRHQP TAAFSRNKVS 1080

SRESVIGNCM DRSSPGQAME LPDHNGLGYP ARPSVSEHHR PRTLQRHHTI QNSDDAYVQL 1140

DNLPGMSLVA GKALSSARMS DAVLSQSSLM GSQQFQDGEN EESGQSLGGH EHSDLTDGSQ 1200

HLNSSCYPST CITDILLSYK HPEVSFSMEQ AGV 1233

Nucleotide Sequence
(FASTA)

CAGGTTGCCA TCAAGATCAT AGACAAGACC CAACTGGATG AAGAAAACTT GAAGAAGATT 60

TTCCGGGAAG TTCAAATTAT GAAGATGCTT TGCCACCCCC ATATCATCAG GCTTTACCAG 120

GTTATGGAGA CAGAACGGAT GATTTATCTG GTGACAGAAT ATGCTAGTGG AGGGGAAATA 180

TTTGACCACC TGGTGGCCCA TGGTAGAATG GCAGAGAAGG AGGCCCGTCG GAAGTTCAAA 240

CAGATCGTCG CAGCCGTCTA TTTTTGTCAC TGTCGGAACA TTGTTCATCG TGATCTAAAA 300

GCTGAAAATT TGCTTCTGGA TGCCAATCTG AATATCAAAA TAGCAGATTT TGGCTTCAGT 360

AACCTCTTCA CTCCTGGGCA GCTGCTGAAG ACCTGGTGTG GCAGCCCTCC CTATGCTGCA 420

CCAGAACTCT TTGAAGGAAA AGAATATGAT GGGCCCAAAG TGGACATCTG GAGCCTTGGA 480

GTCGTCCTCT ATGTGCTTGT GTGCGGTGCC CTGCCGTTTG ATGGAAGCAC ACTGCAGAAT 540

CTGCGGGCCC GGGTGTTGAG TGGAAAGTTC CGCATCCCAT TTTTTATGTC CACAGAGTGT 600

GAGCACTTGA TCCGCCACAT GCTGGTGTTA GACCCGAACA AGCGCCTCTC TATGGAGCAG 660

ATCTGCAAGC ACAAGTGGAT GAAGCTAGGG GACACCGATC CCAACTTTGA CAGGTTAATA 720

GCTGAATGCC AACAACTAAA GGAAGAAAGA CAAATGGACC CCCTGAATGA GGATGTCCTC 780

CTAGCCATGG AGGACATGGG ACTGGACAAA GAGCGGACAC TACAGTCGTT AAGATCAGAT 840

GCCTATGATC ACTATAGTGC AATCTATAGC CTGCTGTGTG ATCGACATAA GAGACACAAA 900

ACCCTGCGTG TCGGAGCACC TCCTAGCATG CCCCGAGCCA TGGCCTTTCA AGCCCCGGTC 960

AGTATCCAGG CCGAACAGGC TGGTACCACG ATGAACATCA GTGTTCCCCA GGTGCAGCTG 1020

ATCAACCCAG AGAACCAAAT TGTGGAGGCA ATTCCGGATG GAGCAGTGAA CTTGGACAGT 1080

GATGAGGGTG AAGAGCCTTC CCCTGAAGCG TTGGTCCGCT ATTTGTCAAT GAGGAGGCAC 1140

ACAGTGGGTG TGGCTGACCC ACGCACGGAA GTTATGGAAG ACCTGCAGAA GCTCCTACCT 1200

GGCTTTCCTG GAGTCAGCCC GCAGGCCCCG TTCCTGCAGG TGGCCCCTAA CATGAACTTC 1260

ATGCACAACC TGTTGCCCAT GCAAAATTTG CAACCAACTG GGCAGCTTGA GTACAAGGAG 1320

CAGTCCCTGT TACAGCCGCC CACCCTACAG CTGCTGAATG GAATGGGCCC CCTTGGCCGG 1380

AGGGCATCAG ATGGAGGAGC CAACATCCAG CTACATGCCC AGCAGCTGCT GAAGCGCCCA 1440

CGGGGACCCT CTCCTCTTGT CACCATGACA CCAGCAGTGC CAGCAGTTAC CCCTGTGGAC 1500

GAGGAGAGCT CGGATGGGGA GCCAGATCAG GAAGCTGTGC AGAGCTCTAC CTACAAGGAC 1560

TCCAACACCC TGCACCTCCC CACGGAGCGT TTCTCCCCTG TGCGCCGGTT CTCAGATGGG 1620

GCTGCAAGCA TCCAGGCCTT CAAAGCTCAC CTGGAAAAAA TGGGCAACAA CAGCAGCATC 1680

AAACAATTGC AGCAGGAGTG TGAGCAGCTG CAGAAGATGT ACGGGGGGCA GATTGATGAG 1740

AGAACCCTGG AGAAGACCCA GCAGCAGCAT ATGTTATACC AGCAGGAGCA GCACCATCAA 1800

ATTCTCCAGC AACAAATTCA AGATTCTATC TGTCCCCCTC AGCCTTCACC ACCTCTTCAG 1860

GCTGCGTGTG AAAATCAGCC AGCCCTCCTC ACCCACCAAC TCCAGAGGTT AAGGATTCAG 1920

CCTTCAAGCC CACCCCCGAA CCACCCCAAC AACCATGTCT TCAGACAGCC CAGTAATAGT 1980

CCTCCCCCCG TGAACAGTGC CATGATCCAG CCTCACGGTG CTGCATCTCC TTCCCAGTTT 2040

CAAGGCTTAC CCTCCCGCAG TGCAATCTTC CAGCAACAGC CTGAGAACTG TTCCCCTCCT 2100

CCCAATGTGG CACTAACCTG CTTAGGCATA CAGCAGCCTA CCCAGTCACA GCAGGTGACC 2160

ATCCAAGTAC AGGAGCCCGT TGACATGCTC AGCACCATGC CTGGGACAGC TGCAGCCCCT 2220

GCTGGGCGGG GCATCTCCAT TAGCCCCAGT GCCAGTCAGA TTCAGATGCA GCATCGTACC 2280

AACCTGATGG CCACCTTCAG CTACGGGCAC CGGCCCTTGT CCAAGCAGCT GAGCGCTGAC 2340

AGTGCAGAGG CCCACAGCTT GAACGTGAAT CGGTTCTCCC CTGCTAACTA CGACCAGGCG 2400

CATTTACACC CCCATCTGTT TTCGGACCAG TCCCGGGGTT CCCCCAGCAG CTACAGCCCT 2460

TCAACAGGAG TGGGGTTCCC TCCAACCCAA GCCCTGAAAG TCCCTCCACA TGACCAATTC 2520

CCCACCTTCC CTCCCAGTGC ACATCAGCAG CCACCGCACT ATACCACGTC GGCACTACAG 2580

CAGGCCCTGC TGTCCCCCAC GCCGCCAGAC TATACAAGGC ACCAGCAAGT ACCCCACATC 2640

CTTCAAGGAC TGCTCTCTCC CCGACATTCG CTCACTGGCC ACTCGGACAT TCGGCTGCCC 2700

CCAGCAGAGT TTGCACAGCT CATTAAAAGG CAGCAGCAGC AGCGACAGCA GCAGCAGCAA 2760

CAGCAGCAGC AAGAGTACCA AGAATTGTTC AGGCATATGA ACCAGGGGGA TGCTGGGAGT 2820

CTGGCTGCCA ATCTTGGGGG ACAGAGTATG ACAGAGCGCC AGGCTTTACC GTATCAAAAT 2880

GCTGACTCGT ATCACCACCA CCATACCAGC CCCCAGCATC TTCTACAAAT CAGGGCGCAA 2940

GAATGTATCT CACAGGTTTC CTCACCCACC CCGACCCATG GTTATGCTCA CCAGCCGGCA 3000

CTCATGCATT CAGAGAGCAT GGAAGAGGAG TGCTCGTGTG AGGGGGCCAA GGATGGCTTT 3060

CCAGACAGGA AGAGTTCAAA TACATTGACC AAAGGTTGCC ATGACAGCCC CCTGCTCTTG 3120

AGTACTGGCG GACCTGGGGA CCCTGAATCT TTACTAGGAA CTGTGAGTCA TGTACAGGAA 3180

CTGGGGATGC ATCCGTACCG ACATCAGCCA ACTGCTGCTT TCAGTAGAAA TAAGGTGTCC 3240

AGCCGAGAGT CTGTCATAGG GAACTGCATG GATAGAAGTT CTCCAGGACA AGCAATGGAG 3300

CTGCCAGATC ACAATGGACT TGGGTACCCA GCACGCCCCT CAGTCAGTGA ACACCACAGG 3360

CCCCGGACCC TCCAGAGACA CCACACGATT CAGAACAGCG ACGATGCTTA CGTGCAACTA 3420

GATAACTTGC CCGGAATGAG TCTCGTGGCC GGGAAAGCAC TTAGTTCCGC ACGGATGTCA 3480

GATGCAGTTC TCAGTCAGTC CTCACTCATG GGGAGTCAGC AGTTTCAGGA TGGGGAAAAT 3540

GAGGAGAGCG GGCAGAGTCT AGGAGGCCAT GAGCACTCAG ACCTCACTGA TGGCAGCCAG 3600

CATTTAAACT CCTCTTGCTA TCCATCAACG TGTATTACAG ACATTCTGCT CAGCTACAAG 3660

CACCCCGAGG TCTCCTTCAG CATGGAACAG GCAGGCGTGT AA 3702

Domain Profile

S: 26    kvavKiikkkklseeslekikrEieilkklkhpniikllevietkkklylvleyasggeL  85

         +va+Kii+k++l+ee+l+ki+rE++i+k+l hp+ii+l++v+et++++ylv+eyasgge+

Q: 1     QVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  60

         69**********************************************************

S: 86    fdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGla  145

         fd+++++gr+ ekear+ fkq+v+av ++h ++ivHrDlK+eNllld++ nikiaDFG++

Q: 61    FDHLVAHGRMAEKEARRKFKQIVAAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  120

         ************************************************************

S: 146   nlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlke  205

         nlf++g+ll+t+cGsppYaaPel++gk+Y+gpkvD+WslGvvLy+lv+g+lPfd+++l++

Q: 121   NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  180

         ************************************************************

S: 206   llekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         l++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR+++e+i kh+w+

Q: 181   LRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM  227

         **********************************************8

Domain Sequence
(FASTA)

QVAIKIIDKT QLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI 60

FDHLVAHGRM AEKEARRKFK QIVAAVYFCH CRNIVHRDLK AENLLLDANL NIKIADFGFS 120

NLFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN 180

LRARVLSGKF RIPFFMSTEC EHLIRHMLVL DPNKRLSMEQ ICKHKWM 227

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013