EKS-EQC-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	327.5	7.2E-98	4	254	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000008449

UniProt Accession

F6SN18;

Protein Name

Protein Synonyms/Alias

Gene Name

STK36

Gene Synonyms/Alias

STK36;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010391	ENSECAP00000008449	ENSECAT00000010889

Organism

Equus caballus

Functional Description

Protein Length

1313

Protein Sequence
(FASTA)

MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 60

PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 120

ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 180

ADLWSVGCIL YELAVGTPPF YTTSIFQLVS LILKDPVRWP PTISPCFKNF LQGLLTKDPR 240

QRLSWPDLLH HPFIAGHVTI ITEPAGSDLG TPFTSRLPPE LQVLKDQQAH RLVPKGNQFR 300

ILRQACKRMA EELKQKRHQN TGPALEQEDR TSKVASGTAS PPRLRATPQE SGLLAGILAS 360

EMKSSWAECG AGEDPPAPRE NWTTQDCERA FPELRPEVMG QQSIDAVDLE NEEPDSDDEW 420

KHLLETSKPM PIQLKAPLTL LCNPDFCQRI QAQLHEAAGQ ILKGMLEGAS QILPALRVLS 480

SLLSSCSDSV PLYSFCREAG LPGLLLSLLR HSQENNSIQQ QCWCGTFLQD LMAVIQAYFA 540

CTFNLERSQT GDSLQVFQEA ANHFLDLLGK LLAQPDDSEQ NLWRDSLMCF IVLCEAMDGN 600

SWTVAKAFYC SLLTTQRAVL DGLLHGLTVL QLPVHSPPGA PQVSQPLREQ SADLPGALSS 660

ALAAICTTPV GLPGCWKAKE QITRHLANQL IEDSTQLRPS IISGLKHPIL CLHLLKILYS 720

CCHISEHLCH LLVQEPLALE SLLMLVRGKV KVVDWEESAE VTLYLLSLLV LRLQDLPSGM 780

EKLGGEIATV FTRSHVVSLV SAAACLLGQL GQQGVPFDLQ PVEWIAAATH ALSAPAEVRL 840

TPPDGCGFYD GLFILLLQLL SQEGKGSLIR EVASSEMWTV LWQRFSMALR LPEEVSAQEE 900

ELSLCSPQSP GPDWTLISPQ GMAALLSLAV ASFTQEPQLC LSHLSQRGSI LMSTLKHLLS 960

PSFLHQLGQA PHGSEFLPVM VLSVCQLLCF PFALDVDADL LVGVLADLTN SEVTAHLLQV 1020

CCHHLPLPQV ELPISLLTHL ALMDSTSLNQ FVNTVAASPR SMISFLSIAL LGDQPLLTSD 1080

LLSLLAHTVR VLSPSHLSFI QELLAGSDES YRPLRSWAHP ENSVRARTYG LLGHLLQHSM 1140

ALRGALQQTG LLNLLLLGLG DKDPAVRRSA SFAVGNAAYQ AGPLGPALAA AVPGMTQLLG 1200

DPQAGIRRNA ASALGNLGPE GLGEELLQCQ VPQRLLEMAC GDPQPNVKEA ALIALRSLRQ 1260

EPCIHQVLVS LGASEKLALL SLGNPSLPHS SPRPASAKHC RKLIHLLRPT HST 1313

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ACCACGTGTT GGAGATGATT GGAGAAGGCT CTTTTGGGAG GGTGTACAAG 60

GGTCGACGAA AATACAGTGC TCAGGTGGTG GCCCTGAAGT TCATTCCAAA GTTGGGACGC 120

TCAGAGAAGG AGCTGAGGAA TCTGCAACGA GAGATTGAAA TCATGCGGGG TCTGCGGCAT 180

CCCAACATTG TGCATATGCT CGACAGCTTT GAGACTGACA AAGAGGTGGT GGTGGTGACA 240

GACTATGCTG AAGGAGAGCT CTTTCAGATC CTGGAAGATG ATGGAAAACT TCCTGAAGAC 300

CAGGTTCAGG CCATTGCTGC CCAGTTGGTG TCGGCCCTGT ACTATCTGCA TTCCCACCGC 360

ATCCTCCACC GAGACATGAA GCCTCAGAAC ATCCTCCTTG CCAAGGGTGG TGGCATCAAG 420

CTCTGTGACT TTGGATTTGC CCGGGCTATG AGCACTAACA CAATGGTGCT GACCTCCATC 480

AAAGGCACAC CCCTCTATAT GTCTCCGGAG CTGGTGGAAG AGCGACCATA TGACCATACC 540

GCGGACCTCT GGTCTGTGGG CTGCATCCTG TATGAGCTGG CTGTTGGCAC ACCGCCCTTC 600

TACACGACTA GCATCTTTCA GCTGGTCAGC CTCATCCTCA AGGACCCTGT GCGCTGGCCC 660

CCCACCATTA GTCCTTGCTT CAAGAACTTC CTGCAGGGAC TGCTCACCAA GGACCCTCGG 720

CAGCGTCTGT CCTGGCCAGA CCTCTTACAT CACCCCTTTA TTGCTGGTCA TGTCACCATA 780

ATAACTGAAC CAGCAGGCTC AGATTTGGGT ACCCCATTCA CCAGTCGCCT ACCTCCAGAA 840

CTTCAGGTGC TAAAGGACCA GCAGGCGCAT CGGCTGGTCC CCAAGGGCAA TCAATTTCGC 900

ATCTTGCGTC AAGCCTGTAA GCGCATGGCC GAGGAGCTCA AGCAGAAGAG ACACCAGAAC 960

ACAGGACCTG CCCTTGAGCA AGAGGACAGG ACCAGCAAGG TGGCTTCTGG CACAGCCTCT 1020

CCGCCCAGAC TAAGGGCCAC TCCTCAAGAA TCAGGCCTCT TGGCTGGGAT CTTGGCCTCA 1080

GAAATGAAGA GCAGCTGGGC TGAGTGTGGG GCTGGAGAGG ACCCCCCTGC ACCTCGGGAA 1140

AACTGGACCA CCCAGGATTG TGAACGAGCA TTCCCAGAGC TGAGGCCGGA GGTGATGGGC 1200

CAGCAGAGCA TCGATGCAGT GGATTTAGAG AATGAGGAGC CAGACAGCGA TGATGAGTGG 1260

AAACACCTGC TAGAGACCAG CAAGCCCATG CCCATACAGC TGAAGGCCCC TCTCACCCTG 1320

CTGTGCAATC CTGACTTCTG CCAGCGCATC CAGGCTCAGC TACATGAGGC TGCAGGGCAG 1380

ATCCTGAAAG GCATGCTGGA GGGCGCTTCC CAAATCCTTC CCGCACTCCG GGTCCTGAGC 1440

AGTCTTCTGT CCAGCTGTAG TGACTCCGTT CCCTTGTACT CCTTCTGCCG GGAGGCAGGG 1500

CTCCCTGGGC TGCTGCTCAG CCTACTCAGA CACAGCCAGG AGAACAACAG CATCCAGCAG 1560

CAATGCTGGT GTGGGACCTT CTTACAGGAC CTGATGGCCG TGATTCAGGC CTACTTTGCC 1620

TGCACCTTCA ACCTGGAGAG GAGCCAGACA GGTGACAGCC TACAGGTATT TCAAGAGGCC 1680

GCCAACCACT TTCTGGACCT GTTGGGGAAG CTGCTGGCCC AACCAGATGA CTCCGAGCAG 1740

AACTTGTGGA GGGACAGCCT TATGTGCTTT ATTGTTCTGT GTGAAGCCAT GGATGGGAAC 1800

AGCTGGACCG TTGCCAAAGC CTTTTACTGC AGCCTGCTGA CCACGCAGCG GGCTGTGTTG 1860

GACGGGCTCC TTCATGGCTT GACAGTTCTC CAGCTCCCTG TCCACAGCCC CCCAGGAGCC 1920

CCCCAAGTGA GCCAGCCACT GCGAGAGCAG AGTGCGGATC TGCCTGGAGC CCTTTCCTCT 1980

GCACTGGCAG CCATCTGTAC TACTCCTGTG GGGCTGCCGG GCTGCTGGAA AGCCAAAGAG 2040

CAGATCACTC GACATTTGGC AAATCAGCTC ATCGAAGACA GCACCCAGCT GAGGCCGTCC 2100

ATCATCTCTG GCCTGAAGCA TCCCATCCTG TGCCTACACC TTCTCAAGAT TCTCTACTCC 2160

TGCTGCCACA TCAGTGAGCA CCTGTGCCAT CTTCTAGTGC AGGAGCCCCT GGCCTTGGAG 2220

TCACTGTTGA TGTTGGTCCG GGGCAAGGTA AAGGTAGTAG ATTGGGAAGA GTCTGCCGAA 2280

GTGACGCTCT ACCTTCTCTC CCTTCTCGTC CTTCGGCTCC AAGATCTGCC TTCTGGAATG 2340

GAGAAGTTAG GCGGTGAGAT TGCTACTGTC TTTACCCGTT CACATGTCGT CTCTCTTGTG 2400

AGCGCAGCAG CCTGCCTATT GGGACAGCTT GGTCAGCAAG GGGTGCCCTT TGACCTCCAG 2460

CCTGTGGAGT GGATCGCTGC AGCCACACAT GCCCTGTCTG CCCCTGCGGA GGTCCGGTTG 2520

ACTCCACCAG ATGGCTGTGG ATTCTATGAT GGCCTCTTCA TCCTTCTGCT GCAGCTCCTC 2580

AGCCAGGAGG GGAAGGGTAG CCTGATAAGG GAAGTGGCTA GCTCAGAAAT GTGGACGGTT 2640

CTATGGCAAC GCTTCTCCAT GGCTCTGAGG CTCCCTGAGG AGGTATCAGC ACAGGAAGAG 2700

GAGCTGTCCC TGTGCAGTCC ACAAAGCCCA GGGCCAGACT GGACGCTGAT CTCACCCCAA 2760

GGCATGGCAG CCCTGCTGAG CCTGGCCGTG GCCTCCTTTA CCCAGGAGCC CCAGTTATGC 2820

CTGAGCCACC TGTCTCAGCG TGGAAGCATC CTCATGTCCA CCCTGAAGCA TCTGCTTTCC 2880

CCCAGCTTCC TGCATCAGCT GGGTCAGGCG CCTCACGGGT CTGAGTTTCT ACCTGTCATG 2940

GTGCTCTCCG TCTGCCAGCT CCTCTGCTTC CCCTTCGCCC TGGATGTGGA TGCTGACCTC 3000

CTTGTCGGTG TCTTGGCTGA CCTCACAAAC TCGGAAGTCA CAGCTCACCT GCTGCAGGTC 3060

TGTTGCCACC ATCTTCCGTT GCCACAAGTC GAGCTTCCCA TCAGTCTTCT CACGCACCTG 3120

GCCCTCATGG ATTCCACCTC TCTCAACCAG TTTGTGAACA CAGTGGCTGC CTCCCCTAGA 3180

AGTATGATCT CATTCCTCTC CATTGCCCTC CTTGGTGACC AGCCATTGCT GACCTCTGAC 3240

CTTCTCTCTC TGCTGGCCCA CACAGTCCGG GTACTGTCTC CTAGCCACTT GTCCTTTATC 3300

CAAGAACTCC TGGCTGGCTC TGATGAATCC TATCGGCCCC TGCGCAGCTG GGCCCACCCA 3360

GAAAATTCCG TGCGGGCCCG CACTTATGGG CTTCTGGGAC ACTTGCTGCA ACATAGCATG 3420

GCCCTGCGTG GGGCACTGCA GCAGACTGGA CTGCTTAACC TTCTGCTGCT GGGTCTTGGA 3480

GACAAGGATC CTGCTGTGCG GCGGAGTGCC AGCTTTGCTG TAGGCAATGC AGCCTACCAA 3540

GCTGGTCCCC TGGGACCTGC TCTGGCAGCC GCAGTACCTG GTATGACCCA GCTGCTTGGA 3600

GATCCTCAGG CTGGTATCCG GCGCAATGCC GCATCAGCTC TGGGCAACTT GGGGCCTGAG 3660

GGCTTGGGGG AGGAGCTGTT ACAGTGCCAA GTACCCCAGC GGCTCCTAGA GATGGCGTGT 3720

GGAGACCCCC AGCCAAATGT GAAGGAGGCC GCCCTCATTG CCCTCCGGAG CCTCCGACAG 3780

GAGCCCTGCA TCCATCAGGT GCTAGTGTCC CTGGGCGCCA GTGAGAAATT AGCCTTGCTC 3840

TCTCTGGGGA ATCCATCACT GCCGCACAGC AGTCCCAGGC CCGCCTCTGC CAAACACTGC 3900

AGGAAACTCA TTCACCTCCT GAGGCCAACC CACAGCACAT GA 3942

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e+iG+Gsf+ vykgr rk ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n

Q: 4     YHVLEMIGEGSFGRVYKGR-RKYSAQVVALKFIPKLGRsEKELRNLQREIEIMRGLRHPN  62

         8999***************.******************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i

Q: 63    IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl+        k +++kl+dFg+ar++++++m  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLA--------KGGGIKLCDFGFARAMSTNTMVlTSIKGTPLYMSPELVE  173

         *************........89********************9****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd++aDlWS+G+ilyel+vG+pPf+++si++Lv+ i k++v   ++p +is+++k++

Q: 174   ERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPV---RWPPTISPCFKNF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL++dp++R+s+ +l++hpf+

Q: 231   LQGLLTKDPRQRLSWPDLLHHPFI  254

         **********************96

Domain Sequence
(FASTA)

YHVLEMIGEG SFGRVYKGRR KYSAQVVALK FIPKLGRSEK ELRNLQREIE IMRGLRHPNI 60

VHMLDSFETD KEVVVVTDYA EGELFQILED DGKLPEDQVQ AIAAQLVSAL YYLHSHRILH 120

RDMKPQNILL AKGGGIKLCD FGFARAMSTN TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180

WSVGCILYEL AVGTPPFYTT SIFQLVSLIL KDPVRWPPTI SPCFKNFLQG LLTKDPRQRL 240

SWPDLLHHPF I 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042384	; P:cilium assembly
GO:0007228	; P:positive regulation of hh target transcription factor activity
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0009791	; P:post-embryonic development

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013