EKS-EQC-00454

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00454

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	405.8	1.0E-121	1	273	273

Status

Unreviewed

Ensembl Protein

ENSECAP00000008642

UniProt Accession

F6PMR8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010551	ENSECAP00000008642	ENSECAT00000011102

Organism

Equus caballus

Functional Description

Protein Length

320

Protein Sequence
(FASTA)

SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 60

VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT 120

CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE 180

MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP 240

NADSKALDLL DKMLTFNPHK RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK 300

EKLKELIFEE TARFQPGYRS 320

Nucleotide Sequence
(FASTA)

TCTGCTTATG ATAATGTCAA CAAAGTTCGA GTAGCTATCA AGAAAATCAG TCCTTTTGAG 60

CACCAGACCT ACTGCCAGAG AACCCTGAGG GAGATAAAAA TCTTACTGCG CTTCAGACAT 120

GAGAACATCA TTGGAATCAA TGATATTATT CGAGCGCCAA CCATCGAGCA AATGAAAGAT 180

GTATATATAG TACAGGACCT CATGGAAACG GATCTCTACA AACTCTTGAA GACCCAACAC 240

CTCAGCAACG ACCATATCTG CTATTTTCTT TACCAGATCC TCAGAGGGTT AAAATATATC 300

CATTCAGCTA ACGTACTGCA TCGTGACCTC AAACCTTCCA ACCTGCTGCT CAATACCACC 360

TGTGATCTCA AGATCTGTGA CTTTGGCTTG GCCCGTGTTG CAGATCCGGA CCATGATCAC 420

ACAGGGTTCC TGACGGAGTA TGTAGCCACG CGTTGGTACA GGGCTCCAGA AATTATGTTG 480

AATTCCAAGG GCTATACCAA GTCCATTGAT ATTTGGTCTG TAGGCTGCAT TCTGGCAGAG 540

ATGCTCTCCA ACAGGCCTAT CTTCCCGGGG AAGCATTATC TTGACCAGCT GAACCACATT 600

CTGGGTATTC TTGGATCCCC ATCACAGGAA GACCTGAATT GTATAATAAA TTTAAAAGCT 660

AGAAACTATT TGCTTTCTCT TCCACACAAA AATAAGGTGC CATGGAACAG GCTGTTCCCA 720

AATGCTGACT CCAAAGCTCT CGACTTGCTG GACAAAATGT TGACATTCAA CCCTCACAAG 780

AGGATCGAAG TAGAGCAGGC TCTGGCCCAC CCGTACCTGG AGCAGTACTA TGACCCGAGT 840

GACGAGCCCA TCGCTGAAGC ACCATTCAAG TTTGACATGG AATTGGATGA TTTGCCCAAG 900

GAAAAGCTCA AAGAACTCAT TTTTGAAGAG ACTGCTAGAT TCCAGCCAGG ATACAGATCT 960

TAA 963

Domain Profile

S: 17    savdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpeeeleel  76

         sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNii + d++++ + +e++

Q: 1     SAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT-IEQM  58

         5899999*********9.**********************************999.****

S: 77    kdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNllvn  136

         kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hsanv+HrDlKPsNll+n

Q: 59    KDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN  118

         ************************************************************

S: 137   edcelkildFGlarsadkekekk..lteyvatrwYraPeillslkeytkavDiWsvGCIl  194

         ++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++k ytk++DiWsvGCIl

Q: 119   TTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL  178

         *******************999999***********************************

S: 195   aElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdfeel  254

         aE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arny+ slp+k+k ++++l

Q: 179   AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRL  238

         ************************************************************

S: 255   fpkaseealdLleklLvldpdkRisveeaLehpYl  289

         fp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 239   FPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL  273

         **********************************7

Domain Sequence
(FASTA)

SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 60

VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT 120

CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE 180

MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP 240

NADSKALDLL DKMLTFNPHK RIEVEQALAH PYL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0031143	; C:pseudopodium
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0019858	; P:cytosine metabolic process
GO:0070371	; P:ERK1 and ERK2 cascade
GO:0060716	; P:labyrinthine layer blood vessel development
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0045596	; P:negative regulation of cell differentiation
GO:0009887	; P:organ morphogenesis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0006974	; P:response to DNA damage stimulus
GO:0043330	; P:response to exogenous dsRNA
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013