EKS-EQC-00219
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00219
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE7386.57.1E-11642334293
StatusUnreviewed
Ensembl ProteinENSECAP00000008990
UniProt AccessionF7BWL2;
Protein Name
Protein Synonyms/Alias
Gene NameMAP2K1
Gene Synonyms/Alias MAP2K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000010640ENSECAP00000008990ENSECAT00000011490
OrganismEquus caballus
Functional Description
Protein Length366
Protein Sequence
(FASTA)
TNLEALQKKL EELELDEQQR KRLEAFLTQK QKVGELKDDD FEKISELGAG NGGVVFKVAH 60
KPSGLVMARK LIHLEIKPAI RNQIIRELQV LHECNSPYIV GFYGAFYSDG EISICMEHMD 120
GGSLDQVLKK AGRIPEQILG KVSIAVIKGL TYLREKHKIM HRDVKPSNIL VNSRGEIKLC 180
DFGVSGQLID SMANSFVGTR SYMSPERLQG THYSVQSDIW SMGLSLVEMA VGRYPIPPPD 240
AKELELMFGC QVEGDAAETP PRPRTPGRPL SSYGMDSRPP MAIFELLDYI VNEPPPKLPS 300
GVFSLEFQDF VNKCLIKNPA ERADLKQLMV HAFIKRSDAE EVDFAGWLCS TIGLNQPSTP 360
THAAGV 366
Nucleotide Sequence
(FASTA)
ACCAACCTGG AGGCCTTGCA GAAGAAGCTG GAGGAGCTGG AGCTCGATGA ACAGCAGCGA 60
AAGCGCCTTG AGGCCTTTCT TACTCAGAAG CAGAAGGTTG GGGAACTGAA GGATGATGAC 120
TTTGAGAAGA TCAGTGAGCT GGGTGCTGGC AATGGTGGTG TGGTATTCAA GGTTGCCCAC 180
AAACCGTCTG GTTTGGTCAT GGCCAGAAAG CTAATTCACC TGGAGATCAA GCCTGCAATC 240
CGGAACCAGA TCATAAGGGA GCTGCAGGTT CTACATGAGT GCAACTCCCC ATATATTGTG 300
GGCTTCTATG GCGCATTCTA CAGCGATGGT GAGATCAGCA TCTGCATGGA GCACATGGAT 360
GGGGGTTCCT TGGATCAAGT CCTAAAGAAA GCTGGAAGAA TTCCTGAGCA AATTTTAGGA 420
AAAGTTAGCA TTGCTGTAAT AAAAGGCCTG ACGTATCTGA GGGAGAAGCA CAAGATTATG 480
CACAGAGATG TCAAGCCCTC CAACATCCTA GTGAACTCCC GTGGGGAGAT CAAGCTGTGT 540
GATTTTGGGG TCAGCGGGCA GCTCATCGAC TCCATGGCCA ACTCCTTCGT GGGCACAAGG 600
TCTTACATGT CGCCGGAAAG ACTCCAGGGG ACTCATTATT CAGTGCAGTC GGACATCTGG 660
AGCATGGGGC TCTCTCTGGT TGAGATGGCG GTCGGGAGGT ATCCCATCCC TCCTCCAGAT 720
GCCAAGGAGC TGGAGCTGAT GTTTGGGTGC CAAGTGGAGG GAGATGCGGC TGAGACTCCG 780
CCTAGGCCAA GGACCCCTGG AAGACCCCTC AGCTCTTATG GAATGGACAG CCGACCTCCT 840
ATGGCAATTT TTGAGTTACT GGATTACATA GTCAACGAGC CTCCTCCCAA GCTGCCCAGT 900
GGAGTATTCA GTCTGGAATT TCAGGATTTT GTGAATAAAT GCTTAATCAA AAACCCTGCA 960
GAGAGAGCAG ATTTGAAGCA ACTCATGGTT CACGCTTTTA TCAAGAGATC TGATGCCGAG 1020
GAAGTGGATT TTGCAGGTTG GCTCTGCTCC ACCATTGGCC TTAACCAGCC CAGCACACCA 1080
ACCCACGCGG CTGGCGTCTA A 1101
Domain Profile
S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61
         ek++elGaGnggvV kv hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv
Q: 42    EKISELGAGNGGVVFKVAHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  100
         799**************************************************.******
S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121
         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek
Q: 101   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  156
         *****************************9....8*************************
S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181
         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv
Q: 157   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  215
         ******************************************************.*****
S: 182   ksdvWslGltlvelatgrypyeklke..................................  207
         +sd+Ws+Gl+lve+a+gryp++++++                                  
Q: 216   QSDIWSMGLSLVEMAVGRYPIPPPDAkelelmfgcqvegdaaetpprprtpgrplssygm  275
         ************************999*********************************
S: 208   .......ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259
                i+ell++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ hafi
Q: 276   dsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI  334
         *********************************************************97
Domain Sequence
(FASTA)
EKISELGAGN GGVVFKVAHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60
FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120
RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180
MGLSLVEMAV GRYPIPPPDA KELELMFGCQ VEGDAAETPP RPRTPGRPLS SYGMDSRPPM 240
AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFI 293
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00209
EKS-BOT-00227
EKS-CAE-00202
EKS-CAJ-00234
EKS-CAF-00233
EKS-CAP-00253
EKS-CII-00136
EKS-CIS-00012
EKS-DAR-00542
EKS-DRM-00116
EKS-FEC-00212
EKS-GAM-00131
EKS-GAG-00189
EKS-GAA-00280
EKS-GOG-00224
EKS-HOS-00234
EKS-LAC-00239
EKS-LOA-00226
EKS-MAM-00229
EKS-MAE-00004
EKS-MEG-00177
EKS-MOD-00225
EKS-MUM-00232
EKS-MUP-00225
EKS-MYL-00228
EKS-NOL-00211
EKS-OCP-00006
EKS-ORN-00296
EKS-ORA-00198
EKS-ORC-00204
EKS-ORL-00274
EKS-OTG-00232
EKS-PAT-00216
EKS-PES-00202
EKS-POA-00220
EKS-PTV-00008
EKS-RAN-00225
EKS-TAG-00243
EKS-TAS-00005
EKS-TEN-00286
EKS-TUB-00009
EKS-XET-00304
EKS-XIM-00289
EKS-SAC-00011
EKS-SCP-00009
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0004728; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050; P:cell cycle arrest
GO:0048870; P:cell motility
GO:0090398; P:cellular senescence
GO:0030216; P:keratinocyte differentiation
GO:0060711; P:labyrinthine layer development
GO:0008285; P:negative regulation of cell proliferation
GO:0030182; P:neuron differentiation
GO:0060674; P:placenta blood vessel development
GO:0045597; P:positive regulation of cell differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013