EKS-EQC-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	385.1	1.5E-115	243	492	250

Status

Unreviewed

Ensembl Protein

ENSECAP00000008926

UniProt Accession

F7C2C5;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000010972	ENSECAP00000008926	ENSECAT00000011418

Organism

Equus caballus

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

RPRPAPGPEH MEPFLRKRLT FLSFFWDKIW PAGAPDDSMP RFPDAGTDAE PEPPAAEPRS 60

PPARAQLFRA LYDFTARCAA ELSVRRGDRL YALKEDGHYI FARRLSGPPS AGLVPVAYVA 120

KATPETLSDQ PWYFSGISRT EAQQLLLSPA NAPGAFLVRP SESSHGDYSL SVRAQAKVRH 180

YRISTAADGG LYLQKGRLFS SLEELLTYYK ANWKLIQNPL LQPCVPQQPP RQDEWERPHS 240

EFTLRRRLGE GYFGEVWEGV WRGSVPVAVK VIRSADMKLA DLAKEIQTLK SLRHERLIRL 300

HAVCSTGEPV YIVTELMRKG NLQAFLGSPE GQALSPPLLL SCARQVAEGM SYLEERRIVH 360

RDLAARNVLV GDDLACKVAD FGLARLLKDD IYSPSSGSKI PVKWTAPEAA NYRIFSQKSD 420

VWSFGVLLYE VFSYGQCPYE GMSNHETLQQ IMRGYRLPRP AACPAEVYLL MLECWQDSPE 480

ERPAFAVLQE KLGAICSCLH PALM 504

Nucleotide Sequence
(FASTA)

CGCCCCCGGC CCGCCCCCGG CCCTGAGCAC ATGGAGCCCT TTCTCAGGAA GCGGCTGACC 60

TTCCTGTCCT TCTTCTGGGA CAAGATCTGG CCGGCGGGCG CGCCGGACGA CAGCATGCCG 120

CGGTTCCCCG ACGCGGGCAC CGACGCCGAG CCGGAGCCCC CCGCCGCGGA GCCCCGCAGC 180

CCCCCGGCGC GCGCGCAGCT CTTCAGGGCG CTGTACGACT TCACGGCGCG GTGCGCGGCC 240

GAGCTGAGCG TCCGCCGCGG GGACCGGCTC TACGCGCTCA AGGAGGACGG CCACTACATC 300

TTCGCGCGCA GGCTCTCGGG CCCACCCAGC GCCGGGCTGG TGCCCGTCGC CTACGTGGCC 360

AAGGCCACCC CTGAGACGCT CTCAGACCAA CCCTGGTACT TCAGTGGCAT CAGCCGAACC 420

GAGGCCCAGC AGCTGCTCCT GTCCCCGGCC AACGCACCAG GGGCCTTCCT GGTTCGGCCC 480

AGCGAGAGCA GCCACGGGGA CTACTCGCTG TCAGTCAGGG CTCAGGCCAA AGTCCGCCAC 540

TACCGCATCT CGACGGCAGC TGACGGCGGC CTCTACCTGC AGAAGGGCCG GCTTTTCTCC 600

AGCCTGGAGG AGCTGCTCAC CTACTACAAG GCCAACTGGA AGCTGATCCA GAACCCGCTG 660

CTGCAGCCCT GCGTGCCCCA GCAGCCCCCC AGGCAGGACG AGTGGGAGCG GCCGCACTCC 720

GAGTTCACCC TGAGGAGGAG GCTGGGCGAG GGCTACTTCG GGGAAGTGTG GGAAGGTGTG 780

TGGCGTGGCT CCGTGCCAGT GGCGGTCAAG GTCATCAGAT CAGCCGACAT GAAGCTCGCT 840

GACCTCGCCA AGGAGATCCA GACGCTCAAG AGCCTGAGGC ACGAGCGCCT CATCCGGCTG 900

CACGCCGTGT GCTCCACTGG CGAGCCTGTG TACATCGTCA CCGAGCTCAT GCGCAAGGGC 960

AACCTGCAGG CCTTCCTGGG CAGTCCCGAG GGCCAGGCCC TGAGCCCGCC TCTGCTCCTG 1020

AGCTGTGCCC GCCAGGTGGC CGAGGGCATG AGCTACCTGG AGGAACGGCG CATCGTGCAC 1080

CGGGACCTGG CCGCCAGAAA CGTGCTCGTG GGCGATGACC TGGCCTGCAA GGTGGCCGAC 1140

TTTGGCCTGG CCCGGCTGCT CAAGGACGAC ATCTACTCCC CGAGCAGCGG CTCCAAGATC 1200

CCTGTCAAGT GGACGGCGCC CGAGGCGGCC AACTATCGCA TCTTCTCCCA GAAGTCGGAC 1260

GTCTGGTCCT TCGGGGTCCT GCTCTATGAG GTCTTCTCCT ATGGCCAGTG TCCCTATGAA 1320

GGAATGAGCA ACCACGAGAC GCTGCAGCAG ATCATGCGAG GGTACCGCCT GCCGCGCCCA 1380

GCAGCTTGCC CGGCTGAGGT CTACTTGCTC ATGCTGGAGT GCTGGCAGGA CAGCCCCGAG 1440

GAGCGGCCGG CCTTCGCCGT GCTGCAGGAG AAGCTGGGTG CCATCTGCAG TTGCCTCCAC 1500

CCTGCCCTCA TGTGA 1515

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

         +l ++lGeG+fGevw+g w+gsv+vavk++++++++ +++ +e+q+lk+lrhe+l++l+a

Q: 243   TLRRRLGEGYFGEVWEGVWRGSVPVAVKVIRSADMKLADLAKEIQTLKSLRHERLIRLHA  302

         689*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s++eP+yivtelm+kG+l++fl + eg++l+ p l+  a qvaeGm+ylee++++hrd

Q: 303   VCSTGEPVYIVTELMRKGNLQAFLGSPEGQALSPPLLLSCARQVAEGMSYLEERRIVHRD  362

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlvg++l++kvadfGlarl++dd+y++++g+k+P+kWtaPea++++ f++ksdvW

Q: 363   LAARNVLVGDDLACKVADFGLARLLKDDIYSPSSGSKIPVKWTAPEAANYRIFSQKSDVW  422

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++++G++Py+Gm+n+e+l+q+ rgyrlprp++cp+e+y l+lecw+ +peer

Q: 423   SFGVLLYEVFSYGQCPYEGMSNHETLQQIMRGYRLPRPAACPAEVYLLMLECWQDSPEER  482

         ************************************************************

S: 242   Ptfetlqevl  251

         P+f +lqe+l

Q: 483   PAFAVLQEKL  492

         ******9986

Domain Sequence
(FASTA)

TLRRRLGEGY FGEVWEGVWR GSVPVAVKVI RSADMKLADL AKEIQTLKSL RHERLIRLHA 60

VCSTGEPVYI VTELMRKGNL QAFLGSPEGQ ALSPPLLLSC ARQVAEGMSY LEERRIVHRD 120

LAARNVLVGD DLACKVADFG LARLLKDDIY SPSSGSKIPV KWTAPEAANY RIFSQKSDVW 180

SFGVLLYEVF SYGQCPYEGM SNHETLQQIM RGYRLPRPAA CPAEVYLLML ECWQDSPEER 240

PAFAVLQEKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013