EPS-EQC-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	419.6	1.6E-126	51	243	193

Status

Unreviewed

Ensembl Protein

ENSECAP00000009288

UniProt Accession

F7AEP1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP2CB

Gene Synonyms/Alias

PPP2CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000011173	ENSECAP00000009288	ENSECAT00000011842

Organism

Equus caballus

Functional Description

Protein Length

309

Protein Sequence
(FASTA)

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60

QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 120

RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180

RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240

HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300

TRRTPDYFL 309

Nucleotide Sequence
(FASTA)

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TCGAGCAGCT GAACGAGTGT 60

AAACAGCTGA ACGAGAACCA AGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 120

AAAGAATCAA ATGTGCAAGA GGTTCGTTGT CCTGTTACCG TCTGTGGAGA TGTGCATGGT 180

CAATTCCATG ATCTCATGGA ACTCTTTAGA ATTGGTGGAA AATCACCAGA TACAAACTAT 240

CTATTCATGG GCGACTATGT AGACAGAGGT TATTATTCAG TGGAGACTGT GACTCTTCTT 300

GTGGCATTAA AGGTGCGTTA TCCAGAACGC ATTACAATAT TGAGAGGAAA CCACGAAAGC 360

CGACAAATAA CCCAAGTGTA TGGCTTTTAT GATGAATGTC TACGAAAGTA TGGGAATGCC 420

AATGTTTGGA AATATTTTAC GGATCTATTT GATTATCTTC CACTCACAGC TTTAGTAGAT 480

GGACAGATAT TCTGCCTCCA CGGTGGTCTC TCTCCATCCA TAGACACACT GGATCATATA 540

AGAGCCCTGG ATCGTTTACA AGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTGTTATGG 600

TCAGATCCAG ATGATCGTGG TGGATGGGGT ATTTCACCAC GTGGTGCTGG CTACACATTT 660

GGACAAGACA TTTCTGAAAC ATTTAACCAC GCCAATGGTC TCACACTGGT TTCTCGTGCT 720

CACCAACTTG TAATGGAGGG ATACAATTGG TGTCACGATC GGAACGTGGT CACCATTTTC 780

AGTGCACCCA ATTACTGTTA TCGCTGTGGG AACCAGGCTG CTATCATGGA ATTAGATGAC 840

ACTTTAAAAT ATTCCTTCCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTT 900

ACCCGGCGCA CCCCAGACTA CTTCCTGTAA 930

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvry+er

Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER  110

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl

Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh

Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230

         ************************************************************

S: 181   angleliarahql  193

         angl+l++rahql

Q: 231   ANGLTLVSRAHQL  243

         ************8

Domain Sequence
(FASTA)

PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER 60

ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120

SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180

ANGLTLVSRA HQL 193

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0000159	; C:protein phosphatase type 2A complex
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0043066	; P:negative regulation of apoptotic process
GO:0043161	; P:proteasomal ubiquitin-dependent protein catabolic process
GO:0010468	; P:regulation of gene expression
GO:0046677	; P:response to antibiotic
GO:0042542	; P:response to hydrogen peroxide

KEGG

ecb:100062224

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013