EKS-EQC-00386
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00386
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl549.31.5E-165531796266
StatusUnreviewed
Ensembl ProteinENSECAP00000009860
UniProt AccessionF6VEV4;
Protein Name
Protein Synonyms/Alias
Gene NameAXL
Gene Synonyms/Alias AXL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000011471ENSECAP00000009861ENSECAT00000012482
ENSECAG00000011471ENSECAP00000009860ENSECAT00000012479
OrganismEquus caballus
Functional Description
Protein Length889
Protein Sequence
(FASTA)
PRMGRVPLAW CLVLCCWGCV TPKGTQAEAN PFVGSLGNIT GARGLMGALR CELQVQGEPP 60
EVTWLRDGQV LELADSTQTQ VPLGEDGQDD WKVVSQLRIS SLQLSDAGWY QCAVVLGGKT 120
FVSQPGYVGL EGLPYFLEEP EDRAVTANTP FNLSCRAQGP PEPVDLLWLQ DTVSLAPATG 180
HGPQHMLRVP GLNKTSSFSC EAHNAKGVTT SRTATIKVLP QRPRDLHLVS SQPTELEVAW 240
TPGLSGIYPL THCTLQVSIS YDGVGIWLGE PDPPEEPLTL QASVPPHRIR LGSLHPHTPY 300
HIRVACASTQ GPSPWTHWLP VETSEGVPLG PPENVSAMRN GSQALVRWQE PRAPLQGTLL 360
GYRLAYRGQD TPEVLMDIGL KREVTLELRG DGTVPNLTVC VAAYTAAGDG PWSLPVLLEP 420
WRPEQGQPIH QLVSEPPAPA FSWPWWYVLL GAVVAAACVL ILALFLVHRR KKETRYGEVF 480
EPTVERGELV VRYRVRKSYS RRTTEATLNS LGISEELKEK LRDVMVDRHK VALGKTLGEG 540
EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF 600
QGSEREGFPA PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST 660
KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW IAIESLADRV 720
YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPVDCL DGLYVLMSRC 780
WELNPRDRPS FAELREDLEN TLKALPPAQE PDEILYVNMD EGVGHPEPLG AAGGADPPTQ 840
PDPKDSCSCL TAAEVHPAGR YVLCPSTAPG PTLPADRGSP ASPGQEDGA 889
Nucleotide Sequence
(FASTA)
CCGAGGATGG GCAGGGTCCC GCTGGCCTGG TGCTTGGTGC TGTGTTGCTG GGGGTGCGTG 60
ACCCCCAAGG GCACACAGGC TGAGGCAAAT CCCTTTGTGG GGAGCCTAGG AAACATCACC 120
GGTGCCCGGG GACTTATGGG GGCCCTTCGG TGTGAGCTCC AGGTTCAGGG GGAACCCCCT 180
GAGGTGACCT GGCTGCGGGA TGGACAGGTC CTGGAGCTGG CGGACAGCAC CCAGACCCAG 240
GTGCCCCTGG GCGAAGACGG GCAGGACGAC TGGAAAGTGG TCAGCCAACT CAGAATCTCA 300
TCCCTGCAGC TCTCAGACGC AGGATGGTAC CAGTGTGCGG TGGTCCTGGG AGGAAAGACC 360
TTCGTGTCCC AGCCTGGCTA TGTTGGGCTG GAGGGCCTGC CTTACTTCCT GGAGGAGCCT 420
GAGGACAGGG CTGTGACCGC CAACACCCCT TTCAACCTGA GCTGCCGGGC CCAAGGACCC 480
CCAGAGCCCG TGGACCTCCT CTGGCTCCAG GATACTGTCT CCCTGGCTCC AGCCACAGGC 540
CATGGCCCCC AGCACATGCT GCGTGTTCCA GGCCTGAACA AGACATCTTC TTTCTCCTGT 600
GAAGCCCATA ATGCCAAGGG GGTCACCACA TCCCGCACAG CCACCATCAA AGTGCTCCCC 660
CAGCGGCCCC GTGACCTCCA CCTGGTTTCC AGCCAGCCCA CGGAGCTGGA GGTGGCTTGG 720
ACACCAGGCC TGAGTGGCAT CTACCCCCTC ACCCACTGCA CCCTGCAGGT GAGCATCAGC 780
TACGATGGGG TGGGCATCTG GCTGGGAGAG CCAGACCCCC CAGAGGAGCC CCTCACCTTG 840
CAAGCATCTG TTCCCCCTCA CCGAATTCGG CTGGGCAGCC TCCATCCTCA TACCCCTTAT 900
CACATCCGGG TGGCGTGTGC CAGTACCCAG GGCCCCTCAC CCTGGACCCA TTGGCTTCCC 960
GTGGAGACGT CAGAGGGAGT GCCCCTGGGC CCCCCTGAGA ATGTTAGCGC CATGCGGAAT 1020
GGGAGCCAAG CCCTCGTGCG TTGGCAGGAG CCAAGGGCGC CCCTGCAGGG CACCCTGTTA 1080
GGGTACCGGC TGGCCTATCG AGGCCAGGAC ACCCCAGAGG TGCTAATGGA CATAGGGCTA 1140
AAGCGAGAGG TGACCCTGGA GCTTCGGGGG GATGGGACTG TGCCCAACCT GACCGTGTGT 1200
GTGGCAGCCT ACACTGCTGC TGGGGACGGA CCATGGAGCC TCCCTGTGCT CCTGGAGCCC 1260
TGGCGCCCAG AGCAAGGACA GCCAATCCAC CAGCTGGTGA GTGAACCCCC AGCCCCTGCC 1320
TTCTCGTGGC CCTGGTGGTA TGTACTGCTG GGAGCAGTTG TGGCTGCTGC CTGTGTCCTC 1380
ATCTTGGCCC TGTTCCTCGT CCACCGGCGG AAGAAGGAGA CGCGCTATGG AGAGGTGTTT 1440
GAACCAACAG TGGAGAGGGG CGAGCTGGTG GTCAGATACC GCGTTCGCAA GTCCTACAGT 1500
CGGCGGACCA CTGAAGCCAC CTTGAACAGC CTGGGCATCA GCGAAGAGCT GAAGGAGAAG 1560
CTGCGGGATG TGATGGTGGA CCGGCATAAG GTGGCCCTGG GGAAGACCCT GGGAGAAGGA 1620
GAGTTTGGAG CTGTGATGGA GGGCCAGCTC AACCAGGACG ACTCCATCCT CAAGGTGGCT 1680
GTGAAGACAA TGAAGATTGC CATCTGCACA AGGTCAGAGC TGGAGGACTT CCTGAGTGAA 1740
GCCGTCTGCA TGAAGGAATT CGACCACCCC AACGTCATGA GGCTCATCGG CGTCTGTTTC 1800
CAGGGTTCCG AACGAGAGGG CTTCCCGGCA CCTGTGGTCA TCTTACCTTT CATGAAACAT 1860
GGAGACCTAC ACAGTTTCCT TCTCTATTCC CGGCTCGGGG ACCAGCCAGT GTTCCTGCCC 1920
ACTCAGATGC TGGTGAAGTT TATGGCAGAC ATTGCCAGTG GCATGGAGTA TCTGAGTACC 1980
AAGAGATTCA TACACCGGGA TCTGGCCGCC AGAAACTGCA TGCTGAATGA GAACATGTCC 2040
GTGTGTGTGG CGGACTTTGG GCTCTCCAAG AAGATTTACA ACGGGGACTA CTACCGCCAG 2100
GGACGCATCG CCAAGATGCC AGTCAAGTGG ATCGCCATTG AGAGTCTGGC TGACCGCGTC 2160
TACACCAGCA AGAGTGATGT GTGGTCCTTT GGGGTGACAA TGTGGGAGAT TGCCACACGG 2220
GGCCAAACCC CATATCCAGG AGTGGAGAAC AGCGAGATTT ATGACTACCT GCGCCAGGGA 2280
AACCGCCTGA AGCAGCCTGT GGACTGTCTG GATGGACTGT ATGTCCTGAT GTCCCGGTGT 2340
TGGGAGCTAA ACCCCCGGGA CCGGCCAAGT TTTGCAGAGC TGCGAGAAGA TCTGGAGAAC 2400
ACGCTGAAGG CCCTGCCCCC TGCCCAGGAG CCTGACGAAA TCCTCTATGT CAACATGGAT 2460
GAGGGTGTGG GTCATCCTGA ACCACTTGGA GCTGCTGGAG GAGCTGACCC CCCAACACAG 2520
CCTGACCCTA AGGATTCCTG CAGCTGCCTC ACTGCAGCCG AGGTCCATCC TGCTGGACGC 2580
TATGTCCTCT GCCCTTCCAC AGCCCCTGGC CCCACCCTGC CTGCTGACAG GGGCTCCCCA 2640
GCATCCCCAG GGCAGGAGGA TGGAGCCTGA 2670
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefg+vmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 531   VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH  589
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv+rl+gv++++se++ +p+pvvilpfmk+gdlh+fllysrlg++pv+lp+q+lvkfm+
Q: 590   PNVMRLIGVCFQGSEREGFPAPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMA  649
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeyls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 650   DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  709
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dc
Q: 710   WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDC  769
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly lm+rcwe++p+drpsf++lre
Q: 770   LDGLYVLMSRCWELNPRDRPSFAELRE  796
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP 60
NVMRLIGVCF QGSEREGFPA PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD 120
IASGMEYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPVDCL 240
DGLYVLMSRC WELNPRDRPS FAELRE 266
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MOD-00383
EKS-MUM-00431
EKS-MUP-00391
EKS-MYL-00394
EKS-ORN-00509
EKS-ORC-00373
EKS-ORL-00466
EKS-OTG-00401
EKS-PEM-00218
EKS-POA-00389
EKS-RAN-00410
EKS-SAH-00366
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0009986; C:cell surface
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0001786; F:phosphatidylserine binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001974; P:blood vessel remodeling
GO:0048469; P:cell maturation
GO:0031668; P:cellular response to extracellular stimulus
GO:0035457; P:cellular response to interferon-alpha
GO:0071222; P:cellular response to lipopolysaccharide
GO:0097028; P:dendritic cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0034101; P:erythrocyte homeostasis
GO:0021885; P:forebrain cell migration
GO:0006954; P:inflammatory response
GO:0001779; P:natural killer cell differentiation
GO:2000669; P:negative regulation of dendritic cell apoptotic process
GO:0032689; P:negative regulation of interferon-gamma production
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0001764; P:neuron migration
GO:0042698; P:ovulation cycle
GO:0030168; P:platelet activation
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway
GO:0032825; P:positive regulation of natural killer cell differentiation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013