EKS-EQC-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.0	5.4E-137	177	464	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000009804

UniProt Accession

F6UAD3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000011686	ENSECAP00000009804	ENSECAT00000012413

Organism

Equus caballus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

ALLCACTSCL QANYTCETDG ACMVSIFNLD GMEHHVRTCI PKVELVPAGK PFYCLSSEDL 60

RNTHCCYTDF CNRIDLRVPS GHLKEPEHPS MWGPVELVGI IAGPVFLLFL IIIIVFLVIN 120

YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ 180

EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE ERSWFREAEI YQTVMLRHEN ILGFIAADNK 240

DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT IEGMIKLALS AASGLAHLHM EIVGTQGKPG 300

IAHRDLKSKN ILVKKNGMCA IADLGLAVRH DAVTDTIDIA PNQRVGTKRY MAPEVLDETI 360

NTKHFDSFKC ADIYALGLVY WEIARRCNSG GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ 420

KLRPNIPNWW QSYEALRVMG KMMRECWYAN GAARLTALRI KKTLSQLSVQ EDVKI 475

Nucleotide Sequence
(FASTA)

GCTCTGCTGT GTGCGTGCAC CAGCTGCCTA CAGGCCAACT ACACGTGTGA AACAGATGGG 60

GCCTGCATGG TCTCCATTTT CAACCTGGAT GGGATGGAGC ACCACGTGCG CACCTGCATC 120

CCCAAAGTGG AGCTGGTCCC CGCCGGGAAG CCCTTCTACT GCCTGAGCTC CGAAGACCTG 180

CGTAACACCC ACTGCTGCTA CACTGACTTC TGCAACAGGA TCGACCTGAG GGTGCCCAGT 240

GGTCACCTCA AGGAGCCTGA GCACCCTTCC ATGTGGGGCC CCGTGGAGCT GGTAGGCATT 300

ATTGCCGGCC CGGTGTTCCT CCTGTTTCTC ATCATCATCA TTGTTTTCCT TGTCATTAAC 360

TATCATCAGC GCGTCTATCA CAACCGCCAG AGACTGGACA TGGAAGATCC CTCATGTGAG 420

ATGTGTCTCT CCAAGGACAA GACGCTCCAG GATCTCGTCT ATGATCTCTC CACGTCAGGG 480

TCTGGCTCAG GGTTGCCCCT TTTTGTCCAG CGCACAGTGG CCCGAACCAT CGTCTTACAG 540

GAGATCATTG GCAAGGGCCG GTTCGGAGAA GTGTGGCGCG GCCGCTGGAG GGGTGGTGAT 600

GTGGCTGTGA AGATCTTCTC TTCTCGTGAA GAGCGGTCTT GGTTCCGGGA AGCCGAGATA 660

TACCAGACGG TCATGCTGCG CCACGAAAAC ATCCTTGGCT TCATCGCTGC CGACAACAAA 720

GATAATGGCA CCTGGACACA GCTGTGGCTC GTCTCGGACT ATCATGAGCA CGGCTCCCTG 780

TTCGATTATC TCAACCGGTA CACCGTGACG ATTGAGGGCA TGATTAAGCT GGCCTTGTCT 840

GCTGCCAGTG GGCTGGCGCA CCTGCACATG GAGATCGTGG GTACCCAAGG GAAGCCTGGA 900

ATTGCTCATC GAGACTTGAA GTCAAAGAAC ATCCTGGTGA AGAAAAACGG CATGTGCGCC 960

ATCGCAGACC TGGGCCTGGC TGTCCGTCAT GACGCGGTCA CCGACACCAT TGACATTGCC 1020

CCAAACCAGA GGGTGGGAAC CAAACGATAC ATGGCCCCTG AAGTGCTCGA CGAAACCATC 1080

AACACGAAGC ACTTCGACTC TTTCAAGTGT GCGGATATCT ACGCCCTCGG GCTCGTCTAT 1140

TGGGAGATTG CACGAAGATG CAATTCTGGA GGAGTCCACG AAGAATATCA GCTGCCATAT 1200

TACGACTTAG TGCCCTCTGA CCCTTCCATT GAGGAAATGC GAAAGGTCGT ATGTGACCAG 1260

AAGCTCCGTC CCAACATCCC CAACTGGTGG CAGAGTTACG AGGCTTTACG GGTGATGGGG 1320

AAGATGATGC GAGAGTGTTG GTACGCCAAC GGCGCAGCCC GCCTGACCGC TCTGCGCATC 1380

AAGAAGACCC TCTCACAGCT CAGCGTGCAG GAAGATGTGA AGATCTAA 1428

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 177   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  236

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 237   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  296

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 297   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  354

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 355   VLDETINTKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  413

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 414   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  464

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINTKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013