EKS-EQC-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	286.8	2.0E-85	257	507	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000009638

UniProt Accession

F6ZWY6;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000011726	ENSECAP00000009638	ENSECAT00000012221

Organism

Equus caballus

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

MASHLSPGVF IEELNKYRQK HNVVLDFREL SKTGPPHDLT FTFRVIINGR EFPEAEGKSK 60

KEAKNAAAKM AVEILRENKT VSSLPLLTKD TSEELSKNYI GLINTYTQRN QLSLNYEQYE 120

SRDGGPKSFR YREHFGSEDK EWIGPGKSRK RMSMRKIVSQ LQSKADPLSS GSCSPASSDF 180

RGDPCRTSSS AYESSPENGF STNSWERNCD SNENENENNR HRCKPVRLSL APTFSSPVQE 240

TNKYTVDKRF IKDFISISEI GSGGFGQVFK AQHRLDGKTY VIKRVKYDRE KKAEREVKAL 300

AELDHPNIVH YYNCWVGNDY DPEESINLSR SKTDCLFIQM EFCNKGTLEQ WIDNRRGQET 360

DKQLSLEFFE QITTGVDYIH SKELIHRDLK PSNIFLVDAK HIKIGDFGLV TSLKYDDKRT 420

SNRGTKRYMS PEQISSEVYG NEVDIYALGV ILAELLYICP TARETVEILE KLKAGIFSNV 480

FDKREKILLQ KLVSKDPKER PETFSILWTL KEWKKDTVKK NGTG 524

Nucleotide Sequence
(FASTA)

ATGGCCAGTC ATCTTTCACC AGGTGTCTTC ATAGAAGAAC TTAATAAATA TCGTCAGAAG 60

CATAATGTGG TTCTTGATTT TCGGGAACTG TCTAAGACAG GACCTCCACA TGATTTAACG 120

TTTACATTTC GAGTTATAAT AAATGGGAGA GAATTTCCGG AAGCTGAAGG TAAATCAAAG 180

AAGGAAGCCA AAAATGCTGC AGCCAAAATG GCTGTTGAAA TACTTCGAGA AAACAAGACA 240

GTTAGTTCTT TACCACTGCT GACGAAAGAT ACTTCAGAAG AACTTTCCAA GAATTACATA 300

GGCCTTATTA ATACATATAC CCAGAGGAAT CAACTCTCTC TAAATTATGA ACAATATGAA 360

TCAAGGGATG GCGGGCCCAA AAGCTTCAGG TACCGAGAAC ACTTTGGAAG TGAGGATAAA 420

GAATGGATTG GACCTGGAAA AAGCAGAAAG CGAATGAGCA TGAGGAAGAT TGTTTCTCAG 480

CTACAGTCAA AAGCTGACCC ACTGTCTTCT GGTTCTTGCT CTCCTGCGTC CAGTGACTTC 540

AGAGGAGACC CTTGCAGGAC AAGCTCTTCT GCTTATGAAT CATCACCTGA AAATGGCTTC 600

TCAACAAATT CATGGGAAAG AAATTGTGAC AGCAACGAAA ATGAAAATGA AAACAACAGA 660

CACCGTTGCA AACCAGTCAG ATTAAGTTTG GCACCTACTT TCAGTTCTCC TGTGCAAGAA 720

ACAAATAAGT ATACCGTGGA CAAGAGGTTT ATCAAGGATT TTATAAGTAT ATCAGAAATT 780

GGCTCAGGTG GATTTGGCCA GGTTTTCAAA GCACAACACA GACTTGATGG GAAGACTTAT 840

GTTATTAAAC GTGTTAAATA TGACCGTGAA AAGAAGGCAG AGCGTGAAGT GAAAGCTTTG 900

GCAGAGCTTG ATCATCCAAA TATTGTTCAC TACTATAATT GTTGGGTTGG GAATGATTAT 960

GATCCTGAGG AAAGCATAAA TCTTTCAAGA TCAAAGACTG ACTGCCTTTT CATCCAAATG 1020

GAATTCTGTA ATAAGGGGAC GTTAGAGCAA TGGATCGACA ATAGAAGAGG CCAGGAAACA 1080

GATAAACAAT TGTCTTTGGA ATTTTTTGAA CAAATAACTA CAGGAGTAGA TTATATACAT 1140

TCAAAAGAAT TAATTCATAG AGACCTTAAG CCAAGTAACA TATTTTTAGT AGATGCAAAA 1200

CATATAAAGA TTGGAGACTT TGGACTCGTA ACATCCCTGA AATATGATGA CAAGCGGACA 1260

AGTAATAGGG GAACTAAGCG ATACATGAGC CCAGAACAGA TTTCTTCAGA AGTATATGGA 1320

AATGAAGTGG ACATCTATGC TTTGGGAGTA ATTCTTGCAG AGCTTCTTTA CATATGTCCC 1380

ACTGCTAGAG AAACAGTTGA GATCTTGGAA AAGCTAAAGG CTGGCATCTT CTCAAATGTA 1440

TTTGATAAGA GAGAAAAAAT TCTTCTACAG AAATTAGTCT CCAAAGATCC CAAGGAACGA 1500

CCTGAGACAT TTTCAATACT GTGGACGTTG AAGGAATGGA AGAAGGATAC AGTGAAAAAG 1560

AATGGTACAG GG 1572

Domain Profile

S: 4     ikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpnivrYf  63

         i  +G+Ggfg+V+ka+++ld+k+y ikr+k++ +k    k+erevkaLa+l+hpniv+Y+

Q: 257   ISEIGSGGFGQVFKAQHRLDGKTYVIKRVKYDREK----KAEREVKALAELDHPNIVHYY  312

         7789****************************977....9********************

S: 64    aawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderklle  123

         ++w  +++++              es + ++s+t++l+iqme+c+k tL++wid+r+ +e

Q: 313   NCWVGNDYDPE-------------ESINLSRSKTDCLFIQMEFCNKGTLEQWIDNRRGQE  359

         ******99777.............667778999***********************9999

S: 124   srselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealke  183

         + ++l +++f+q+ +g++y+Hsk liHrdLkpsniFl + +++KigDFgL+t+l+ + k+

Q: 360   TDKQLSLEFFEQITTGVDYIHSKELIHRDLKPSNIFLVDAKHIKIGDFGLVTSLKYDDKR  419

         9999999**********************************************8888764

S: 184   dvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstemerv  243

                      t++ gtk+ymsPeq++++ Y+++vDi++LG+il+eLly + t+ e+v

Q: 420   -------------TSNRGTKRYMSPEQISSEVYGNEVDIYALGVILAELLYICPTARETV  466

         .............99*********************************************

S: 244   etltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287

         e+l++l+ g +++ fd+    ek llqkl+s+dpkeRp++  +l

Q: 467   EILEKLKAGIFSNVFDK---REKILLQKLVSKDPKERPETFSIL  507

         *****************...9999***************98776

Domain Sequence
(FASTA)

ISEIGSGGFG QVFKAQHRLD GKTYVIKRVK YDREKKAERE VKALAELDHP NIVHYYNCWV 60

GNDYDPEESI NLSRSKTDCL FIQMEFCNKG TLEQWIDNRR GQETDKQLSL EFFEQITTGV 120

DYIHSKELIH RDLKPSNIFL VDAKHIKIGD FGLVTSLKYD DKRTSNRGTK RYMSPEQISS 180

EVYGNEVDIY ALGVILAELL YICPTARETV EILEKLKAGI FSNVFDKREK ILLQKLVSKD 240

PKERPETFSI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0033689	; P:negative regulation of osteoblast proliferation
GO:0046777	; P:protein autophosphorylation
GO:0006412	; P:translation
GO:0006926	; P:virus-infected cell apoptotic process

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 1.

Prosites

PS50137	; DS_RBD; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013