EKS-EQC-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	247.7	1.2E-73	1008	1260	253

Status

Unreviewed

Ensembl Protein

ENSECAP00000009777

UniProt Accession

F6U335;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000011785	ENSECAP00000009777	ENSECAT00000012382

Organism

Equus caballus

Functional Description

Protein Length

1306

Protein Sequence
(FASTA)

MEDGGSAAFE ENQRSLCGSS SLPAPTESPS AQTTASEPSK SLSSARRHLS RRNGLSKLCQ 60

SRMALSEDRW SSYCLSSLAA QNICTSKLHC PATPEQADLA GSLGSTSCCS LLRGLPSGWS 120

VPLLPAPVCN PNKAVFTVDA KTTQILVAND KACQLLGYSS HNLIGQKLTQ FFLKPDSDVV 180

EALSEECVEA DGRAAVVFGT VVDIVSCSRE KIPVSVWMKR VKQEHSLCCV VVLEPVERVS 240

AWVAFQSDGT ITSCDSVFAH LHGYASGEEV VGQRITDLVP SVQLPPPGEH VPKNLKIQRS 300

VGRAKDGTTF PLSLKLKSKP SSEEAEDGKA APKWGYSASI WVFSTISGLI TLLPDGTIYG 360

INHSFALMLF GYGKTELLGK NITFLIPGFY HCMDPAYDSS LPLPDLADCL DIGSQSGPGE 420

TTVDPRQGWN LASAGEDPSV DVVLAGDHIL PRDETLKLVG SQEAFTGTQA QADTGGHLPS 480

SLPSPPAPGV DSIPEGSPPS QERQQSLPED QRNAVLEKEE AAATESLRQD RLGGSRSDPG 540

STKPFASRRG DSETPAPTED RSRNVEMCGP YQEAQLERMG SSSASNSNIR AEAAMLEPCA 600

VGQPAGLSVP MHCAAYSGER RAQQGSRDSA PSPSGMLRLS FSTPTLDEPW LGAKNDREEL 660

QTCLIKEQLS KSSFLGPLGV SYVELVPAEH PQFSAPVSLC DLQGRDLHSS RTGSSSAYYA 720

LATDLPGVLD AVEAQEAQEA DANSFSWNLR ERFFSEWTDR TSSNCSCATS ELTGTTSPLL 780

VGSDVDVSSL QGQSSDVLDD RELLLLTGTC FGLGEGRRFR ERCLGLDGTE PSETCVLSSE 840

HYEVNGRESP GCVPPVSGAS PVDACPSEEP RLGKIQVTST PVKGDSSVTP GATSLQHEIQ 900

EGTYAGSCYH RDGSRLSVQF EVKRVELQGS ATLFCCWLVK DLLHSHRDSA TRTRLLLASL 960

PSSSHSMCEL PGSSLGEMLK TKSWLEESPK AVELEGLAAC EGAYSHKYST LSPLGSGAFG 1020

FVWTAVDKEK NKEVVVKFIK KEKVLEDCWI EDPRFGKVTL EIAILSRVQH ANIIKVLDVF 1080

ENQEFFQLVM EKHGSGLDLF SFIDHHPSLD EPLASYIFRQ LVSAVGYLRS KSILHRDIKD 1140

ENIVIAEDFT IKLIDFGSAA YLERGKLFYT FCGTIEYCAP EVLMGNPYRG PELEMWSLGV 1200

TLYTLIFEEN PFCELEETME AAITPPYLVS EDLMKLVSGL LQPVPEQRTT LEKLVGDPWV 1260

TQPVNLANYT WDEVYRVNKP ESGVLSTASL EMESRSPSEV AQAPEL 1306

Nucleotide Sequence
(FASTA)

ATGGAGGACG GAGGCTCCGC GGCCTTTGAA GAGAACCAGA GGTCCCTATG CGGGAGCTCC 60

TCCTTGCCAG CGCCCACAGA GAGCCCCTCT GCGCAGACCA CTGCCTCCGA GCCCAGCAAG 120

TCCTTGTCCT CGGCCCGCAG ACATCTGAGC AGAAGGAATG GGCTTTCGAA ACTCTGCCAG 180

AGTAGGATGG CGCTCTCAGA AGACAGATGG AGCTCCTACT GTTTGTCATC GTTGGCTGCC 240

CAAAATATTT GCACCAGCAA ACTGCACTGC CCAGCCACGC CTGAGCAGGC GGACCTGGCC 300

GGGTCCCTGG GCAGCACGTC CTGCTGCTCC CTGCTGCGCG GCTTGCCCTC AGGGTGGTCT 360

GTGCCCCTGC TCCCAGCCCC CGTGTGCAAC CCGAACAAGG CCGTCTTCAC CGTGGACGCC 420

AAGACTACGC AGATCCTGGT TGCCAATGAC AAAGCCTGCC AGCTCCTGGG GTACAGCAGC 480

CACAACCTGA TCGGCCAGAA GCTCACACAG TTCTTCCTGA AGCCAGATTC CGATGTGGTG 540

GAAGCCCTCA GTGAGGAGTG CGTGGAGGCT GATGGGCGCG CTGCCGTTGT GTTCGGCACA 600

GTGGTGGACA TTGTGAGCTG CAGCAGGGAA AAGATTCCGG TGTCCGTGTG GATGAAGCGG 660

GTGAAGCAGG AACACAGCCT CTGCTGCGTG GTCGTGCTGG AGCCCGTGGA GAGGGTCTCG 720

GCCTGGGTTG CCTTCCAAAG CGATGGAACC ATCACGTCAT GTGACAGCGT CTTTGCTCAT 780

TTGCACGGGT ACGCGTCTGG GGAGGAAGTG GTCGGGCAGC GCATCACAGA CCTGGTCCCT 840

TCCGTGCAGC TCCCTCCACC TGGCGAGCAT GTCCCAAAGA ATCTCAAGAT TCAGAGGTCT 900

GTTGGAAGAG CCAAGGATGG CACCACGTTC CCTCTGAGCT TAAAACTGAA ATCCAAACCC 960

AGTAGTGAGG AGGCTGAAGA TGGCAAGGCG GCCCCCAAAT GGGGTTACTC GGCATCCATC 1020

TGGGTGTTCT CCACCATCAG CGGTCTCATC ACCCTCCTGC CAGATGGGAC CATTTACGGC 1080

ATCAACCACA GCTTTGCGCT GATGCTGTTC GGCTATGGGA AGACAGAGCT CCTGGGCAAG 1140

AACATCACCT TCCTGATTCC TGGTTTCTAC CACTGCATGG ACCCCGCATA TGACAGTTCC 1200

CTGCCGCTGC CAGACCTGGC TGACTGCCTG GACATTGGCA GCCAGAGTGG GCCTGGGGAG 1260

ACGACTGTGG ACCCCCGGCA GGGCTGGAAC CTGGCCAGCG CAGGCGAGGA TCCAAGTGTT 1320

GACGTTGTGC TAGCTGGTGA CCACATTCTG CCACGAGATG AGACCCTAAA GCTAGTGGGC 1380

AGCCAAGAAG CCTTCACTGG GACCCAGGCC CAAGCGGATA CTGGAGGCCA TCTCCCTTCT 1440

TCCCTCCCAT CTCCCCCAGC TCCGGGGGTG GACAGCATCC CAGAAGGAAG CCCACCATCC 1500

CAGGAACGCC AACAGTCACT GCCTGAGGAC CAGCGGAACG CTGTCTTGGA GAAAGAGGAA 1560

GCTGCAGCAA CAGAGAGCCT CAGACAGGAC CGTTTGGGAG GAAGCAGGTC TGACCCAGGG 1620

AGCACAAAAC CATTTGCTTC ACGTAGAGGA GATTCTGAAA CTCCAGCCCC CACTGAGGAC 1680

AGGAGCAGGA ATGTTGAAAT GTGTGGCCCG TATCAGGAAG CACAGCTGGA ACGGATGGGC 1740

TCGAGCAGTG CCAGCAATTC AAACATTCGG GCTGAGGCGG CCATGCTTGA GCCGTGTGCC 1800

GTGGGCCAGC CGGCGGGGCT GAGCGTCCCG ATGCACTGTG CTGCATACTC GGGTGAGCGG 1860

AGGGCACAGC AGGGGAGCCG GGACTCGGCC CCCAGCCCCT CCGGGATGCT GCGGCTCTCG 1920

TTCTCGACGC CTACTTTGGA CGAGCCGTGG CTGGGAGCGA AGAATGACAG AGAAGAGCTG 1980

CAGACGTGCT TAATTAAGGA GCAGCTGTCC AAATCGAGCT TCTTGGGACC TCTGGGTGTC 2040

TCCTATGTCG AGCTGGTCCC AGCAGAGCAC CCCCAGTTCT CTGCCCCTGT GTCGCTGTGT 2100

GACCTGCAAG GCAGAGACCT GCACAGCAGC CGCACGGGCA GCTCCTCAGC CTATTACGCG 2160

CTAGCCACAG ACCTCCCTGG CGTCCTGGAT GCAGTGGAGG CCCAGGAAGC CCAGGAGGCC 2220

GACGCAAATT CGTTCTCCTG GAACCTCAGG GAGCGCTTTT TCAGTGAATG GACAGACCGA 2280

ACTTCTTCAA ACTGTTCCTG CGCTACGTCT GAGCTCACGG GGACGACCTC TCCTTTGCTG 2340

GTGGGGTCAG ACGTCGATGT GAGCAGTTTG CAGGGGCAGA GCTCAGATGT TCTGGACGAT 2400

AGAGAGCTGT TACTGCTGAC CGGCACCTGT TTCGGTCTTG GTGAAGGCCG GCGGTTCCGT 2460

GAGAGGTGTC TGGGACTTGA TGGGACAGAA CCATCTGAGA CATGTGTGCT GTCCTCTGAA 2520

CACTATGAAG TGAATGGCAG AGAAAGCCCG GGCTGCGTCC CTCCCGTGTC AGGAGCCAGT 2580

CCCGTGGATG CGTGCCCATC AGAGGAGCCC AGGCTCGGCA AAATCCAGGT CACCTCCACA 2640

CCTGTGAAAG GGGACAGCTC AGTGACACCC GGGGCCACCA GCCTGCAGCA TGAGATCCAG 2700

GAGGGCACCT ATGCGGGGAG CTGTTACCAC CGAGATGGCT CGCGGCTGAG TGTGCAGTTT 2760

GAGGTGAAGC GAGTGGAGCT CCAAGGTTCC GCCACCCTGT TCTGCTGCTG GCTGGTGAAA 2820

GACCTCCTCC ACAGCCACCG GGACTCGGCC ACGCGGACCC GCCTGCTCCT GGCCAGCCTG 2880

CCCAGCTCCA GCCACTCCAT GTGCGAGCTG CCCGGATCCA GCCTGGGGGA AATGCTCAAA 2940

ACCAAATCTT GGTTGGAGGA GTCCCCCAAG GCTGTAGAAC TGGAAGGGCT GGCGGCCTGT 3000

GAGGGTGCGT ACTCCCACAA GTACAGCACG CTGAGCCCGC TCGGCAGTGG GGCCTTTGGC 3060

TTTGTGTGGA CCGCAGTGGA CAAGGAAAAA AATAAGGAGG TGGTGGTGAA GTTCATTAAG 3120

AAGGAGAAGG TTTTAGAGGA TTGTTGGATT GAGGATCCCA GATTTGGAAA AGTTACTTTA 3180

GAGATTGCCA TTCTGTCCAG GGTGCAGCAC GCCAATATCA TCAAGGTATT GGATGTATTT 3240

GAAAACCAAG AATTCTTTCA GCTCGTGATG GAGAAGCATG GCTCTGGCCT GGACCTCTTC 3300

TCCTTCATTG ACCACCATCC CAGCCTTGAC GAGCCCCTGG CGAGTTACAT CTTCCGACAA 3360

CTGGTGTCGG CGGTGGGATA CCTGCGCTCG AAGAGCATCC TTCATCGGGA CATCAAGGAC 3420

GAGAACATTG TGATTGCTGA GGACTTCACA ATTAAGCTCA TAGACTTTGG CTCTGCTGCC 3480

TACTTGGAAA GGGGCAAACT ATTTTATACC TTTTGTGGAA CAATCGAGTA CTGTGCACCC 3540

GAAGTTCTCA TGGGAAATCC TTACCGGGGG CCGGAGCTGG AGATGTGGTC GCTGGGAGTC 3600

ACGCTGTACA CACTGATCTT TGAGGAGAAC CCCTTCTGTG AGCTGGAGGA GACCATGGAG 3660

GCTGCGATAA CCCCCCCGTA CCTAGTGTCA GAAGATCTCA TGAAGCTCGT GTCTGGGCTG 3720

CTGCAGCCTG TCCCCGAGCA GCGTACCACC TTGGAGAAGC TGGTGGGAGA CCCCTGGGTG 3780

ACGCAGCCCG TGAACCTTGC TAACTACACC TGGGATGAGG TGTATCGAGT AAACAAACCA 3840

GAAAGTGGAG TTCTGTCCAC TGCGAGCCTG GAGATGGAGA GCAGGAGCCC GAGCGAGGTG 3900

GCTCAGGCGC CGGAGCTG 3918

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ lG+g+fg V +a++ke++++v+vK+ikk+k+      ++  + k++ Ei+il++

Q: 1008  YSTLSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVledcwiEDPRFGKVTLEIAILSR  1067

         88999*******************************999988878889************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h niik+l+v+e++++++lv+e + sg +Lf+ i ++ +l+e  a+ +f+qlvsav Y

Q: 1068  VQHANIIKVLDVFENQEFFQLVMEkHGSGLDLFSFIDHHPSLDEPLASYIFRQLVSAVGY  1127

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+sk+i HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aPe+l+g++

Q: 1128  LRSKSILHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP  1187

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+l++++ Pf e       e++++  ++ p+ +s++l++L++ lL

Q: 1188  YRGPELEMWSLGVTLYTLIFEENPFCEL------EETMEAAITPPYLVSEDLMKLVSGLL  1241

         *************************998......788899999999**************

S: 234   vvdpekRatieeilkhewl  252

         +  pe+R+t+e+++ ++w+

Q: 1242  QPVPEQRTTLEKLVGDPWV  1260

         ******************6

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFVWTAVD KEKNKEVVVK FIKKEKVLED CWIEDPRFGK VTLEIAILSR 60

VQHANIIKVL DVFENQEFFQ LVMEKHGSGL DLFSFIDHHP SLDEPLASYI FRQLVSAVGY 120

LRSKSILHRD IKDENIVIAE DFTIKLIDFG SAAYLERGKL FYTFCGTIEY CAPEVLMGNP 180

YRGPELEMWS LGVTLYTLIF EENPFCELEE TMEAAITPPY LVSEDLMKLV SGLLQPVPEQ 240

RTTLEKLVGD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:2000505	; P:regulation of energy homeostasis
GO:0070092	; P:regulation of glucagon secretion
GO:0043576	; P:regulation of respiratory gaseous exchange

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013