EKS-EQC-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	288.1	5.8E-86	9	265	257

Status

Unreviewed

Ensembl Protein

ENSECAP00000009999

UniProt Accession

F6WF09;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000011946	ENSECAP00000009999	ENSECAT00000012659

Organism

Equus caballus

Functional Description

Protein Length

476

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRR TEEAVAVKIV DMKRAIDCPE NIKKEICINK 60

MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEQDAQRF FHQLMAGVVY 120

LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 180

RKEFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 240

LLHKILVENP SVRITIPDIK KDRWYNKALK KGAKRPRVSS GGVSESPSGF SKHIQSNLDF 300

SPGHAASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL 360

GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTVSTTDRR 420

NNKLIFKVNL VEMDEKILVD FRLSKGDGLE FKRHFLKIKG KLSDVVSSQK VWLPAT 476

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CCTTTGTGGA AGACTGGGAC TTGGTGCAAA CCCTGGGAGA AGGTGCCTAT 60

GGAGAAGTTC AACTTGCTGT GAATAGAAGA ACTGAAGAAG CAGTTGCAGT GAAGATTGTA 120

GACATGAAGC GTGCCATAGA CTGTCCAGAA AATATTAAGA AAGAGATCTG TATCAATAAA 180

ATGTTAAATC ATGAGAATGT AGTGAAATTC TATGGTCACA GGAGAGAAGG CAATATTCAG 240

TATCTGTTTC TGGAGTACTG TAGTGGCGGA GAACTTTTTG ATAGAATAGA GCCAGACATA 300

GGCATGCCTG AACAAGATGC TCAGAGGTTC TTCCATCAAC TCATGGCAGG GGTGGTTTAT 360

CTGCATGGTA TTGGAATAAC TCATAGGGAT ATTAAGCCAG AAAATCTCCT ATTGGATGAA 420

AGGGATAACC TCAAAATCTC TGACTTTGGC TTGGCGACAG TGTTTCGGCA TAATAATCGT 480

GAACGTTTAT TGAACAAGAT GTGTGGTACT TTACCTTATG TTGCTCCAGA ACTCCTAAAG 540

AGAAAAGAAT TTCACGCAGA ACCAGTTGAT GTTTGGTCCT GTGGAATAGT ACTTACTGCA 600

ATGTTGGCTG GAGAATTGCC GTGGGACCAG CCCAGTGACA GTTGTCAGGA ATATTCTGAT 660

TGGAAAGAAA AAAAAACATA CCTCAACCCT TGGAAAAAAA TCGATTCTGC TCCTCTAGCT 720

TTACTGCATA AAATCCTAGT TGAGAATCCA TCAGTAAGGA TTACCATCCC AGACATCAAA 780

AAAGATAGAT GGTACAACAA AGCACTCAAG AAAGGGGCAA AGAGGCCCCG AGTTAGTTCA 840

GGTGGTGTAT CAGAGTCTCC TAGTGGATTC TCTAAGCACA TTCAATCCAA TTTGGACTTT 900

TCTCCAGGAC ATGCTGCTTC AAGTGAAGAA AATGTGAAGT ACTCCAGTTC CCAGCCAGAA 960

CCGCGGACAG GTCTTTCCTT ATGGGACACC AGCCCTTCAT ACATTGATAA ACTGGTACAG 1020

GGGATCAGTT TTTCCCAGCC CACATGTCCT GATCATATGC TTCTGAATAG TCAGTTACTT 1080

GGTACTCCAG GATCCTCACA GAACCCCTGG CAGCGCTTGG TCAAAAGAAT GACACGATTT 1140

TTTACCAAAT TGGATGCAGA CAAATCTTAC CAATGCCTGA AAGAGACTTG TGAGAAATTG 1200

GGCTATCAAT GGAAGAAGAG TTGTATGAAT CAGGTTACTG TATCAACAAC TGATAGAAGA 1260

AACAATAAAC TGATTTTCAA AGTAAATTTG GTAGAAATGG ATGAGAAGAT TTTGGTTGAC 1320

TTCCGGCTTT CTAAGGGTGA TGGATTGGAA TTCAAGAGAC ACTTCCTGAA GATTAAAGGG 1380

AAGCTGAGTG ATGTTGTAAG CAGCCAGAAG GTTTGGCTTC CTGCCACATG A 1431

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la++++t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+n+

Q: 9     WDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAI-DCPENIKKEICINKMLNHENV  67

         7899******************************7764.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +k++   ++ +  yl+ley+sggeLfd+ie +  ++e++a+++f+ql+++v Ylh  gi+

Q: 68    VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeNllld+++n+ki+DFGla++f+++   +ll+++cG++pY+aPellk+k+++++

Q: 128   HRDIKPENLLLDERDNLKISDFGLATVFRHNnreRLLNKMCGTLPYVAPELLKRKEFHAE  187

         **************************9988877799************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvWs+G+vL a+++g+lP+d++  +++e++++ +k+++  p k +++    Ll+k+Lv

Q: 188   PVDVWSCGIVLTAMLAGELPWDQPsdSCQEYSDWKEKKTYLNPWKkIDSAPLALLHKILV  247

         ***********************97679999999999999888778**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ENPSVRITIPDIKKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RRTEEAVAVK IVDMKRAIDC PENIKKEICI NKMLNHENVV 60

KFYGHRREGN IQYLFLEYCS GGELFDRIEP DIGMPEQDAQ RFFHQLMAGV VYLHGIGITH 120

RDIKPENLLL DERDNLKISD FGLATVFRHN NRERLLNKMC GTLPYVAPEL LKRKEFHAEP 180

VDVWSCGIVL TAMLAGELPW DQPSDSCQEY SDWKEKKTYL NPWKKIDSAP LALLHKILVE 240

NPSVRITIPD IKKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

ecb:100064353

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013