EKS-EQC-00394
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00394
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR601.27.1E-181587922336
StatusUnreviewed
Ensembl ProteinENSECAP00000011319
UniProt AccessionF7BCJ8;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000012032ENSECAP00000011319ENSECAT00000014185
ENSECAG00000012032ENSECAP00000011393ENSECAT00000014267
ENSECAG00000012032ENSECAP00000011188ENSECAT00000014037
OrganismEquus caballus
Functional Description
Protein Length974
Protein Sequence
(FASTA)
MRGARGAWDF LCVLLLLFRV QTGSSQPSVS PGELSPPSIH PAKSELIVSV GDEIRLLCAD 60
PGFVKWTFET WGQLSENTHK EWVTEKAEAT NTGSYTCTNE GGLSSSIYVF VRDPAKLFLF 120
DPSLYGKEGS DTLVRCPLTD PEVTNYSLMA CEGKSLPKDL TFVADPKAGI TIRNVKREYH 180
RLCLRCSADK DGKSVLSNKF TLKVRAAIRA VPVVSVSKAS YLLREGEEFS VTCLIKDVSS 240
SVDSMWIREN SRPQTKEQVK SSSSHQGDFN FVRQERLTIS PARVNDSGVF MCYANNTFGS 300
ANVTTTLEVV DKGFINVFPM MNTTVFVNDG ENVDLIVEYE SYPKPEHQQW IYMNRTSTDK 360
WEDYPKSENE SNIRYVSELH LTRLKGTEGG TYTFLVSNSD VDSSVTFNVY VNTKPEILTR 420
DRLMNGMLQC VAAGFPEPTI DWYFCPGTEQ RCSIPVGPVD VKIQNSSVSP FGKLVVQSSI 480
DYSAFKHNGT VECRAYNDVG KSSAFFNFAF KEQIHPHTLF TPLLIGFVVA AGMMCVIVMV 540
LTYKYLQKPM YEVQWKVVEE INGNNYVYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK 600
VVEATAYGLI KSDAAMTVAV KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV 660
GGPTLVITEY CCYGDLLNFL RRKRDSFICS KQEDHAEAAL YKNLLHSKES SCNDSTNEYM 720
DMKPGVSYVV PTKTDKRRAA RIGSYIERDV APSIMEDDEL ALDLEDLLSF SYQVAKGMAF 780
LASKNCIHRD LAARNILLTH GRITKICDFG LARDIKNDSN YVVKGNARLP VKWMAPESIF 840
NCVYTFESDV WSYGIFLWEL FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI 900
MKTCWDADPL KRPTFKQIVQ LIEKQISDST NHIYSNLANC SPRQENSAVD HSVRINSVGS 960
SASSTQPLLV HEDV 974
Nucleotide Sequence
(FASTA)
ATGAGAGGCG CTCGCGGCGC CTGGGATTTT CTCTGCGTCC TGCTTCTCCT GTTCCGCGTC 60
CAGACAGGCT CTTCTCAACC ATCTGTGAGT CCAGGGGAAC TGTCTCCACC ATCCATCCAT 120
CCAGCAAAAT CAGAGTTAAT CGTCAGTGTT GGCGACGAGA TTAGGCTGTT ATGCGCTGAT 180
CCAGGCTTTG TCAAATGGAC TTTTGAGACC TGGGGTCAGT TGAGTGAGAA CACACACAAA 240
GAATGGGTCA CGGAGAAAGC AGAGGCCACA AACACGGGCA GTTACACATG CACCAATGAA 300
GGCGGCCTAA GCAGTTCCAT TTATGTGTTT GTTAGAGATC CTGCAAAGCT TTTCCTCTTT 360
GATCCTTCCT TGTATGGGAA AGAAGGCAGT GATACGCTGG TCCGCTGTCC TCTGACAGAC 420
CCAGAGGTGA CCAATTACTC CCTCATGGCG TGCGAGGGGA AATCTCTTCC CAAGGACTTG 480
ACGTTCGTCG CTGATCCCAA GGCCGGCATC ACGATCAGAA ACGTGAAGCG CGAGTATCAT 540
CGACTGTGCT TGCGCTGCTC TGCAGACAAG GATGGCAAGT CAGTGCTGTC GAATAAGTTC 600
ACCCTGAAAG TGAGGGCAGC CATCAGAGCT GTGCCAGTTG TGTCTGTCTC CAAAGCAAGC 660
TATCTTCTTA GGGAGGGGGA AGAATTTTCA GTGACGTGCT TGATAAAAGA TGTGTCTAGT 720
TCCGTGGACT CAATGTGGAT AAGGGAAAAC AGCCGGCCTC AGACTAAAGA ACAGGTAAAG 780
AGTAGTAGCT CACATCAGGG TGACTTCAAT TTTGTACGTC AGGAAAGACT GACTATCAGC 840
CCAGCAAGAG TTAACGATTC TGGAGTGTTC ATGTGTTACG CCAATAATAC TTTTGGATCA 900
GCAAATGTCA CAACAACCTT GGAAGTAGTA GATAAAGGGT TCATTAATGT CTTCCCTATG 960
ATGAATACTA CCGTATTTGT GAACGATGGA GAGAATGTAG ATCTGATTGT TGAATATGAA 1020
TCCTACCCCA AACCTGAACA CCAGCAGTGG ATATATATGA ACAGGACCTC CACTGATAAG 1080
TGGGAAGATT ATCCCAAGTC TGAGAACGAA AGTAATATCA GATATGTGAG CGAACTTCAT 1140
CTGACTAGAT TAAAAGGCAC CGAAGGAGGC ACTTACACGT TTCTAGTGTC CAATTCTGAT 1200
GTCGATTCTT CCGTGACATT TAATGTTTAC GTGAACACAA AACCAGAAAT CCTGACTCGT 1260
GACAGGCTCA TGAATGGCAT GCTCCAGTGT GTGGCAGCAG GATTCCCAGA GCCCACAATA 1320
GATTGGTATT TTTGTCCAGG AACTGAGCAG AGATGTTCCA TTCCTGTGGG GCCAGTGGAT 1380
GTGAAGATAC AAAACTCATC CGTGTCACCG TTTGGAAAAC TCGTGGTTCA AAGCTCCATC 1440
GATTACAGTG CATTCAAGCA CAACGGCACG GTCGAGTGTA GGGCTTACAA TGATGTGGGC 1500
AAGAGTTCGG CCTTTTTTAA CTTTGCATTT AAAGAGCAAA TCCATCCCCA CACTCTGTTC 1560
ACGCCTTTGC TGATTGGTTT CGTGGTCGCC GCTGGCATGA TGTGCGTCAT CGTGATGGTT 1620
CTTACCTACA AATATTTACA GAAACCCATG TATGAAGTAC AGTGGAAGGT TGTTGAGGAG 1680
ATAAATGGAA ACAATTATGT GTACATAGAC CCAACGCAAC TTCCTTATGA TCACAAATGG 1740
GAGTTTCCCA GAAACAGACT GAGTTTTGGG AAAACCTTGG GTGCTGGCGC CTTCGGAAAG 1800
GTTGTTGAGG CCACTGCCTA CGGCTTAATT AAGTCGGATG CGGCCATGAC TGTTGCTGTG 1860
AAGATGCTCA AGCCAAGCGC TCATTTAACG GAACGAGAAG CCCTAATGTC TGAACTCAAA 1920
GTCTTGAGTT ACCTTGGTAA TCACATGAAT ATTGTGAATC TTCTCGGAGC ATGCACCGTT 1980
GGAGGGCCCA CCCTGGTCAT TACGGAATAT TGTTGCTATG GTGATCTTCT GAATTTTTTG 2040
AGAAGAAAAC GTGATTCATT TATTTGCTCA AAGCAGGAAG ATCACGCAGA AGCAGCACTT 2100
TATAAAAACC TTCTGCATTC AAAGGAGTCC TCCTGCAATG ATAGTACTAA TGAGTACATG 2160
GACATGAAAC CTGGAGTTTC TTATGTCGTA CCCACCAAGA CAGACAAGAG GAGAGCTGCG 2220
AGAATAGGCT CGTACATAGA AAGAGACGTG GCTCCGTCCA TCATGGAAGA TGACGAGCTG 2280
GCCCTAGACC TGGAAGACCT GCTCAGCTTT TCTTACCAGG TGGCAAAGGG CATGGCGTTC 2340
CTTGCCTCAA AGAACTGTAT TCATAGGGAC TTGGCAGCCA GAAATATCCT CCTTACTCAT 2400
GGTCGAATCA CAAAGATTTG TGATTTTGGT CTAGCCAGAG ACATCAAGAA TGATTCTAAT 2460
TATGTGGTCA AAGGAAATGC TCGGCTACCT GTGAAATGGA TGGCACCTGA AAGCATTTTC 2520
AACTGTGTGT ACACATTTGA AAGTGATGTC TGGTCCTATG GGATTTTTCT GTGGGAGTTG 2580
TTCTCTTTAG GAAGCAGCCC CTACCCTGGA ATGCCAGTCG ATTCTAAGTT CTACAAGATG 2640
ATCAAGGAAG GTTTCCGAAT GCTCAGCCCT GAGCATGCAC CTGCTGAAAT GTATGACATA 2700
ATGAAGACTT GCTGGGATGC TGATCCCCTG AAAAGGCCAA CATTCAAGCA GATCGTGCAG 2760
CTAATTGAGA AGCAGATTTC AGATAGCACC AATCATATTT ATTCCAACTT AGCGAACTGC 2820
AGCCCCCGCC AGGAGAACTC CGCGGTGGAC CATTCTGTGC GGATCAATTC TGTCGGCAGC 2880
AGCGCTTCCT CCACCCAACC TCTGCTGGTC CACGAAGATG TCTGA 2925
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 587   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  646
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 647   NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  703
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++ +s++ey+d+k++vs+v ++k+dk++ +++ s++er+v ++++e+d
Q: 704   L-----LHSKESSCNDSTNEYMDMKPGVSYVVPTKTDKRRAARIGSYIERDVAPSIMEDD  758
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 759   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  818
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 819   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  878
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 879   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  922
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCNDST NEYMDMKPGV SYVVPTKTDK RRAARIGSYI ERDVAPSIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013