EKS-EQC-00357
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00357
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.46.9E-135268517250
StatusUnreviewed
Ensembl ProteinENSECAP00000010024
UniProt AccessionF6QH40;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000012072ENSECAP00000010024ENSECAT00000012692
OrganismEquus caballus
Functional Description
Protein Length534
Protein Sequence
(FASTA)
AATKSKPKDA SQRRRSEPAE SAHGPGAFPA AQTPQPASAK GHRGGPPRLF ALAAAEPQAL 60
PGGSNSSEKG RSQGQGGDLG GCGVTTFVAL YDYESRTETD LSFKKGERLQ IVNNTEGDWW 120
LAHSLSTGQT GYIPSNYVAP SDSIQAEEWY FGKITRRESE RLLLNVENPR GTFLVRESET 180
TKGAYCLSVS DFDNAKGLNV KHYKIRKLDS GGFYITSRTQ FNSLQQLVAY YSKHADGLCH 240
RLTTVCPTSK PQTQGLAKDA WEIPRESLRL EVKLGQGCFG EVWMGTWNGT TRVAIKTLKP 300
GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMSKGSLLDF LKGETGKYLR 360
LPQLVDMAAQ IASGMAYVER MNYVHRDLRA ANILVGENLV CKVADFGLAR LIEDNEYTAR 420
QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELTTKG RVPYPGMVNR EVLDQVERGY 480
RMPCPPECPE SLHDLMCQCW RKEPEERPTF EYLQAFLEDY FTSTEPQYQP GENL 534
Nucleotide Sequence
(FASTA)
GCAGCAACAA AAAGCAAGCC CAAGGACGCC AGCCAGCGGC GCCGCAGCGA GCCGGCCGAG 60
AGCGCGCACG GGCCCGGCGC CTTCCCCGCC GCGCAGACCC CCCAGCCGGC CTCGGCGAAG 120
GGCCACCGCG GGGGCCCCCC GCGCCTTTTC GCCCTCGCGG CCGCCGAGCC ACAAGCTCTT 180
CCGGGGGGTT CAAACTCCTC GGAAAAAGGA AGGAGCCAAG GGCAGGGAGG GGATCTTGGG 240
GGATGCGGAG TGACCACCTT TGTGGCTCTC TATGACTATG AGTCGCGCAC AGAGACTGAC 300
CTCTCCTTCA AGAAGGGGGA GCGGCTCCAG ATTGTCAACA ACACAGAGGG AGACTGGTGG 360
CTCGCCCACT CGCTCAGCAC GGGACAGACG GGCTACATAC CCAGCAACTA TGTGGCGCCC 420
TCCGACTCCA TCCAGGCCGA GGAGTGGTAC TTTGGCAAGA TCACCAGACG GGAGTCAGAG 480
CGGTTACTGC TCAACGTGGA GAACCCGAGA GGGACCTTCC TAGTGCGAGA AAGCGAGACC 540
ACAAAAGGCG CCTACTGCCT CTCCGTGTCC GACTTTGACA ACGCCAAGGG CCTCAACGTG 600
AAGCATTACA AGATCCGCAA GCTGGACAGC GGCGGCTTCT ACATCACCTC CCGCACCCAG 660
TTCAACAGCC TGCAGCAGCT GGTGGCCTAC TACTCCAAAC ACGCTGACGG CCTGTGTCAC 720
CGCCTCACCA CCGTGTGCCC CACGTCCAAG CCACAGACTC AGGGCCTGGC CAAGGACGCC 780
TGGGAGATCC CCCGGGAGTC GCTGCGGCTG GAGGTCAAGC TGGGCCAGGG CTGCTTCGGA 840
GAGGTGTGGA TGGGGACCTG GAACGGCACC ACCAGGGTGG CCATCAAAAC CCTCAAGCCG 900
GGCACGATGT CCCCAGAGGC CTTCCTGCAG GAGGCCCAGG TCATGAAGAA GCTGCGGCAC 960
GAGAAGCTGG TGCAGCTGTA CGCGGTGGTG TCGGAGGAGC CCATCTATAT CGTCACGGAG 1020
TACATGAGCA AGGGGAGTTT GCTGGACTTT CTCAAGGGGG AGACGGGCAA GTACCTGCGG 1080
CTGCCTCAGC TGGTGGACAT GGCTGCTCAG ATCGCCTCCG GCATGGCGTA CGTGGAGCGA 1140
ATGAACTACG TGCACCGGGA CCTCCGTGCT GCCAACATCC TGGTCGGAGA GAACCTCGTG 1200
TGCAAGGTGG CCGACTTCGG GCTGGCTCGG CTCATCGAGG ACAACGAGTA CACGGCCCGG 1260
CAAGGTGCCA AATTCCCCAT CAAGTGGACG GCTCCAGAAG CTGCCCTCTA CGGCCGCTTC 1320
ACCATCAAGT CGGATGTGTG GTCCTTTGGG ATCCTGCTGA CAGAGCTCAC GACAAAGGGA 1380
CGGGTGCCCT ACCCTGGGAT GGTCAACAGA GAGGTCCTGG ACCAAGTGGA GCGGGGCTAC 1440
CGCATGCCCT GCCCGCCCGA GTGTCCCGAG TCCCTGCACG ACCTCATGTG CCAGTGCTGG 1500
CGGAAGGAGC CGGAGGAGCG GCCCACCTTC GAGTACCTGC AGGCCTTCTT GGAGGACTAC 1560
TTCACATCCA CTGAGCCCCA GTACCAGCCC GGGGAGAACC TATAG 1605
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 268   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  327
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 328   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  386
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 387   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  446
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 447   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  506
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 507   RPTFEYLQAFL  517
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-DAR-00747
EKS-DIO-00054
EKS-FEC-00354
EKS-GAM-00220
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00476
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013