EKS-EQC-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.6	1.2E-135	204	491	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000010209

UniProt Accession

F6SYZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000012140	ENSECAP00000010209	ENSECAT00000012913

Organism

Equus caballus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGKLN VGTKKEDGES ASPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNEDLHPTL PPLKTRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCLKKLR PSFPNRWTSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTTCAGG AAAATTAAAT GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

GCATCCCCCA CCCCTCGTCC AAAGATCTTG CGTTGTAAAT GCCACCACCA TTGTCCAGAA 120

GACTCGGTCA ACAATATTTG CAGCACAGAT GGATATTGTT TCACAATGAT AGAAGAAGAT 180

GATTCCGGGA TGCCTGTGGT CACTTCTGGG TGTCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGTCGGGACA CCCCCATTCC TCATCAGAGA AGGTCGATTG AATGCTGCAC GGAGCGGAAT 300

GAGTGTAACG AGGACCTGCA CCCCACGCTG CCGCCCCTGA AAACCAGAGA TTTTGTTGAT 360

GGTCCTATAC ACCACAAGGC CTTACTTATT TCTGTGACCG TCTGTAGTTT GCTCTTGGTC 420

CTTATCATTT TATTCTGTTA CTTCAGGTAT AAAAGACAAG AAACCAGACC TCGGTACAGC 480

ATTGGGTTAG AACAGGACGA AACATACATT CCTCCCGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCCC AGAGCTCGGG AAGCGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACGATA 600

GCGAAGCAGA TTCAGATGGT GAAACAGATT GGCAAAGGTC GCTATGGGGA AGTCTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACTGA GGAAGCCAGC 720

TGGTTCCGAG AGACAGAAAT CTATCAGACG GTGCTGATGA GGCATGAGAA CATTTTGGGG 780

TTCATTGCTG CAGATATCAA AGGCACAGGG TCCTGGACCC AGCTGTACCT GATCACAGAC 840

TATCACGAAA ATGGCTCCCT CTATGATTAT CTGAAGTCCA CCACACTAGA CACTAAGTCC 900

ATGCTGAAGT TAGCCTATTC TTCTGTCAGT GGCTTATGTC ATTTGCACAC TGAAATCTTT 960

AGTACTCAAG GCAAACCAGC AATTGCCCAT CGAGATCTGA AAAGTAAGAA CATCTTGGTG 1020

AAGAAAAATG GAACTTGCTG TATAGCTGAC CTGGGCCTGG CTGTTAAATT TATTAGTGAC 1080

ACGAATGAAG TTGACATCCC GCCCAACACT CGAGTTGGCA CCAAACGCTA CATGCCTCCA 1140

GAAGTGCTGG ATGAGAGCTT GAATAGGAAT CACTTTCAGT CGTACATCAT GGCCGACATG 1200

TACAGTTTTG GACTCATCCT TTGGGAGGTT GCTAGGAGAT GTGTGTCTGG AGGTATAGTG 1260

GAGGAGTACC AGCTTCCCTA TCATGACCTC GTGCCCAGTG ACCCGTCCTA TGAGGACATG 1320

AGGGAGATCG TGTGCCTCAA GAAGCTGCGG CCCTCCTTCC CCAACCGGTG GACGAGCGAC 1380

GAGTGTCTAA GGCAGATGGG GAAACTCATG ACAGAATGCT GGGCTCACAA TCCTGCTTCA 1440

AGACTGACAG CCCTGCGTGT TAAGAAAACA CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAACTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCLKKLRPSFPNRWTSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCLKKLRPSF PNRWTSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

ecb:100053554

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013