EPS-EQC-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.0	1.8E-56	780	1026	247

Status

Unreviewed

Ensembl Protein

ENSECAP00000010293

UniProt Accession

F6SIU1;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000012186	ENSECAP00000010293	ENSECAT00000013010

Organism

Equus caballus

Functional Description

Protein Length

1318

Protein Sequence
(FASTA)

MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATATTTSS ASSSSDLHLV 60

LCTVETPASE ICAGEGRESL YLQLHGDLVR RLEPAERPLQ MVYDYLSRLG FDDPVRIQEE 120

ATNPDLGCML RFYGEKPCQM DHLDRILLSG IYNVRKGKTQ LHKWAERLVV LCGTCLIVSS 180

VKDCQTGKMH ILPLVGGKVE EVKRRQYSLA FSSAGAQAQT YHVSFETLAE YQRWQRQASK 240

VVSQRISTVD LSCYSLEEVP EHLFYSQDIT YLNLRHNFMQ LERPGGLDTL YKFSQLKGLN 300

LSHNKLGFFP VLLCEISTLT ELNLSCNGFH DLPSQIGNLL NLQTLCLDGN FLTTLPEELG 360

NLQQLSSLGI SFNNFSQVPE IYEKLTMLDK MVMAGNQLEV LNLGVLNRMS HIKYVDLRMN 420

HLKTMVIENL EGNKYITHMD LRDNQLTDLD LSSLCSLEQL HCERNQLREL TLSGFSLRTL 480

YANSNKLTAV NVYPVPSLLS SLELSRNLLE CVPDWACEAK KIEILDMSYN LLTEVPMRIL 540

SSLSLRKLMV GHNRVQNLPV LVEHIPLEVL DVQHNSLTRL PDTLFSKALN LRYLNASANS 600

LESLPSACAG EESLSALQLL YLTNNLLTDQ CVPILVGHPH LRILHLANNQ LQTFPASKLN 660

KLEELEELNL SGNKLKTIPT TIANCKRLHT LVAHSNNISI FPEILQLPQI QFVDLSCNDL 720

TEILIPEALP ATLQDLDLTG NTNLVLEHKT LDTFSHITTL KIDQKPLPTT DSTITSTFWS 780

HGLAEMAGQR NKLCVSALAV DNFAEGVGAV YGMFDGDRNE ELPRLLQCTM ADVLLEEVQQ 840

STNDTVFMAN TFLVSHRKLG MAGQKLGSSA LLCYIRPDTA DPTSSFSLTV ANVGTCQAVL 900

CRSGKPVPLS KVFSLEQDSE EAQRVKDQKA IITEDNKVNG VTCCTRMLGC TYLYPWILPK 960

PHISSTPLTI QDELLILGNK ALWEHLSYTE AVNAVRHVQD PLAAAKKLCT LAQSYGCQDN 1020

VGAMVVYLNI GEEGCTCEMN GLTLPGPGGF ASTTIIKDPP KPTTPSSSSG IASEFSSEMS 1080

TSEVSSEVGS TASDEHNTVG LDAGLLPRPE RRCSLHPTPT SGVFQRQPSC ATFSSNQSDN 1140

GLDSDDDQPV EGVITNGSKV EVEVDIHCCR GRDLENSPTL RENSPTPCPE EHARGVFLGI 1200

RRQNSVNSGI LLPVSKDKME LQKSPSTSCL YGKKLSNGSI VPLEDSLNLI EVATEAPKKK 1260

TGYFAAPTQL EPEDQFVVPR DLEEEVKEQM KHHQESRPEP EPSEEDRTEL PEEFDTAL 1318

Nucleotide Sequence
(FASTA)

ATGAAACGCA ATGGGAGCAG AAATTGTTTG AATAGGAGAA GCAGATTTGG TTCCCGAGAA 60

AGAGACTGGC TGAGAGAAGA TGTGAAGAGA GGCTGTGTTT ACCTTTATGG AGCCGACACG 120

ACCACTGCCA CTGCAACCAC CACCTCCTCT GCCTCGTCCT CCTCTGACTT ACATCTTGTC 180

CTTTGCACAG TAGAGACCCC AGCATCAGAA ATATGTGCTG GAGAGGGAAG AGAAAGTCTT 240

TATCTACAGC TTCATGGAGA CCTGGTCAGG AGACTGGAGC CCGCTGAACG ACCTCTTCAG 300

ATGGTTTATG ATTACTTGTC CAGGCTGGGA TTTGACGATC CTGTGCGCAT ACAGGAGGAG 360

GCGACGAATC CTGACCTCGG CTGTATGCTG CGCTTCTATG GTGAAAAACC ATGCCAGATG 420

GATCATCTGG ATCGAATCCT TCTGTCTGGC ATCTATAATG TACGCAAGGG AAAGACCCAG 480

CTGCATAAGT GGGCTGAACG TCTCGTTGTT CTCTGTGGCA CCTGCCTCAT CGTTTCCTCA 540

GTAAAGGATT GTCAAACTGG AAAGATGCAC ATTCTGCCTC TGGTTGGGGG AAAGGTAGAA 600

GAAGTGAAGC GACGGCAGTA CTCGCTTGCG TTCAGTTCAG CTGGAGCCCA AGCTCAGACC 660

TATCATGTCA GCTTTGAGAC CTTAGCTGAG TACCAGAGGT GGCAGCGGCA AGCGTCCAAG 720

GTGGTGTCCC AGCGAATCAG TACTGTTGAT CTCTCATGTT ACAGCCTTGA GGAGGTTCCT 780

GAGCATCTCT TCTACAGTCA AGATATCACC TACCTCAACT TGCGACACAA CTTCATGCAA 840

TTAGAAAGAC CAGGGGGCCT TGACACTCTC TACAAATTTT CTCAGCTGAA GGGCCTGAAC 900

TTGTCCCACA ATAAACTTGG ATTTTTTCCT GTATTGTTAT GTGAGATTTC TACCCTGACT 960

GAGCTCAACC TTTCCTGTAA TGGATTTCAT GACCTGCCGA GTCAGATTGG CAATCTACTA 1020

AATCTTCAAA CCCTCTGTCT TGATGGCAAC TTTCTGACTA CTTTACCTGA AGAATTGGGA 1080

AATCTGCAAC AGCTTTCCTC TCTGGGAATT TCCTTCAACA ACTTTAGTCA AGTTCCTGAG 1140

ATTTATGAGA AACTCACTAT GTTGGATAAA ATGGTTATGG CAGGAAATCA ACTGGAAGTC 1200

CTAAACTTAG GGGTGCTGAA CAGAATGAGC CATATCAAAT ATGTTGATTT AAGGATGAAC 1260

CATTTGAAAA CCATGGTTAT TGAAAATCTG GAGGGAAATA AATACATCAC CCACATGGAT 1320

TTGCGGGACA ATCAACTGAC TGACTTAGAT CTTAGCTCCT TGTGTAGCTT GGAGCAGCTG 1380

CATTGTGAGC GGAACCAGCT GAGGGAGCTG ACACTCAGTG GCTTCTCCCT TCGAACTCTA 1440

TACGCCAATT CTAACAAGCT GACAGCAGTG AATGTCTATC CAGTACCCAG TCTGCTGAGT 1500

TCTCTAGAAC TCTCCCGAAA CCTGCTAGAG TGTGTCCCTG ACTGGGCCTG TGAAGCAAAA 1560

AAGATAGAAA TATTAGATAT GAGCTATAAT CTTCTGACAG AGGTTCCTAT GAGAATTCTT 1620

AGTAGCTTGA GTCTTAGAAA ACTGATGGTG GGACACAATC GTGTGCAAAA CCTTCCGGTA 1680

CTGGTGGAGC ACATCCCCCT TGAGGTGCTG GATGTTCAGC ATAACTCACT CACCAGGCTG 1740

CCAGATACCC TCTTCTCCAA GGCCTTAAAT CTCAGATACC TGAATGCATC TGCAAACAGT 1800

CTGGAGTCTT TGCCATCTGC CTGTGCTGGA GAGGAGAGTC TGAGTGCACT GCAGCTGCTC 1860

TATCTGACCA ACAACCTCCT GACAGATCAG TGTGTGCCCA TCCTGGTCGG GCACCCACAC 1920

CTGCGAATCT TGCATCTTGC CAACAACCAG CTACAGACTT TTCCTGCAAG CAAACTAAAT 1980

AAATTGGAGG AGTTGGAGGA ACTCAACCTA AGTGGCAACA AGCTTAAAAC CATTCCCACA 2040

ACCATAGCAA ACTGTAAAAG GCTGCACACC CTTGTCGCAC ACTCCAACAA CATCAGCATT 2100

TTCCCAGAAA TACTGCAGTT GCCTCAGATC CAGTTTGTAG ACCTAAGCTG CAATGACTTG 2160

ACAGAAATCC TGATTCCTGA GGCTTTGCCT GCTACTTTAC AAGACCTTGA CCTGACAGGA 2220

AATACAAATC TGGTTCTGGA ACACAAGACG TTGGACACAT TTAGCCATAT CACAACCCTA 2280

AAAATTGATC AGAAACCTTT GCCAACCACT GATTCTACAA TTACGTCTAC CTTCTGGAGC 2340

CATGGACTGG CTGAGATGGC AGGGCAGAGA AATAAGCTGT GTGTATCTGC CCTAGCTGTG 2400

GATAACTTTG CAGAGGGGGT GGGAGCTGTG TATGGCATGT TCGATGGGGA CCGAAATGAG 2460

GAGCTCCCTC GCCTGCTCCA GTGTACCATG GCAGACGTGC TTTTGGAAGA GGTACAGCAG 2520

TCAACAAATG ACACAGTCTT CATGGCTAAC ACCTTCTTGG TATCTCACAG GAAATTAGGA 2580

ATGGCTGGCC AGAAGCTAGG CTCCTCTGCT CTCCTTTGTT ACATCCGCCC TGACACTGCC 2640

GACCCAACAA GTAGTTTTAG CTTGACAGTG GCCAACGTTG GCACATGCCA AGCAGTCCTG 2700

TGCCGAAGCG GGAAACCAGT GCCCCTCTCT AAAGTCTTCA GCCTGGAACA GGACTCAGAA 2760

GAGGCTCAGA GGGTGAAGGA CCAAAAAGCC ATCATAACAG AGGACAACAA AGTGAATGGG 2820

GTAACCTGCT GCACCCGGAT GCTGGGCTGC ACATACCTCT ACCCTTGGAT CCTCCCCAAG 2880

CCCCACATAT CTTCCACTCC ACTTACCATT CAAGATGAAT TGCTGATTCT GGGAAACAAA 2940

GCATTGTGGG AACATTTGTC ATATACAGAA GCTGTCAACG CAGTACGCCA TGTACAAGAC 3000

CCATTAGCAG CTGCCAAAAA ACTGTGCACA TTAGCCCAGA GCTATGGTTG TCAGGACAAT 3060

GTGGGGGCGA TGGTGGTTTA TTTGAACATT GGTGAGGAAG GCTGCACTTG TGAAATGAAT 3120

GGGCTCACCC TCCCAGGTCC TGGGGGATTT GCTTCAACCA CCATCATCAA GGACCCTCCC 3180

AAGCCAACCA CTCCTTCCTC CAGTAGTGGT ATTGCCTCTG AGTTCAGCAG TGAGATGTCA 3240

ACTTCAGAGG TGAGCAGTGA GGTGGGATCC ACTGCTTCTG ACGAACATAA CACTGTTGGC 3300

CTGGATGCTG GCTTGCTTCC AAGACCAGAG AGGCGCTGCA GCCTTCATCC AACACCCACC 3360

TCTGGGGTTT TTCAGCGCCA GCCTTCTTGT GCAACTTTCT CAAGTAACCA GTCTGACAAT 3420

GGCCTAGATA GTGATGATGA CCAGCCCGTC GAAGGGGTCA TAACAAATGG CAGCAAGGTA 3480

GAAGTAGAAG TAGATATCCA CTGCTGTAGG GGAAGGGATC TTGAGAACTC TCCCACTCTT 3540

AGAGAGAATT CTCCTACCCC ATGTCCTGAG GAACATGCTA GAGGAGTATT TTTGGGGATC 3600

CGAAGACAGA ATAGTGTGAA TAGCGGCATA CTTTTGCCAG TGAGCAAGGA CAAGATGGAA 3660

TTACAGAAGT CTCCCTCCAC TTCCTGTCTC TATGGAAAGA AACTCTCCAA TGGCTCTATT 3720

GTGCCCCTAG AAGATAGCCT GAACCTCATT GAAGTGGCCA CAGAAGCACC CAAGAAGAAA 3780

ACTGGCTATT TTGCTGCCCC CACTCAGCTG GAGCCAGAGG ATCAGTTTGT TGTCCCTCGT 3840

GACCTAGAAG AAGAAGTGAA GGAGCAAATG AAACACCACC AAGAAAGCAG GCCTGAGCCT 3900

GAGCCCAGTG AAGAGGATCG GACCGAGCTC CCGGAGGAGT TTGACACAGC ACTGTGA 3957

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  +     a++g++DG++++e  + +++++ ++l

Q: 780   SHGLAEMAGQRNKLCVSALAVDNFAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  834

         6899*********************9877.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++++ + ++a++Fl  +++l       ++ +k Gs+a++++i+++

Q: 835   LEEVQ----QSTNDTVFMANTFLVSHRKL------GMAGQKLGSSALLCYIRPDtadpts  884

         ***99....77888889************......89***************999999**

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 885   sfSLTVANVGTCQAVLCRSGKPVPLSKVFSLEQDsEEAQRVKDQKAIITEDN--KVNGVT  942

         ******************************9988699********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s++lt +de liL+ + lw+++s  eav++vr+v +

Q: 943   CCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD--  1000

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 1001  --PLAAAKKLCTLAQSYGCQDNVGAMVV  1026

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA VDNFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSTNDTVFMA NTFLVSHRKL GMAGQKLGSS ALLCYIRPDT ADPTSSFSLT VANVGTCQAV 120

LCRSGKPVPL SKVFSLEQDS EEAQRVKDQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHISSTPLT IQDELLILGN KALWEHLSYT EAVNAVRHVQ DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>