EKS-EQC-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	365.6	1.8E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSECAP00000010425

UniProt Accession

F6Q7I1;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000012221	ENSECAP00000010425	ENSECAT00000013162

Organism

Equus caballus

Functional Description

Protein Length

483

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LAELRAAGLE PVGHYEEVEL TETSVNLGPE 60

HIGPHCFELL RVLGKGGYGK VFQVRKVQGT NSGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLNSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLALPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH INWDDLLARR VDPPFRPCLQ SEEDVSQFDT 360

HFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRT 420

PISPLKFSPF EGFRPSPGPP EPMEPPLPPL LPPPPPPSST APLPIRPPSG TKKSKRGRGR 480

PGR 483

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGACCT GGACCTGGAG ACAGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

CCAGAGTTCA GCCCCGCGGA CGTGTGTCCC CTTGCCGAGT TGAGGGCGGC TGGCCTGGAG 120

CCTGTAGGAC ACTATGAGGA GGTGGAGCTG ACTGAGACCA GTGTGAACCT GGGCCCTGAG 180

CACATTGGGC CCCACTGCTT TGAGCTGCTG CGTGTGCTGG GCAAGGGGGG CTATGGCAAG 240

GTGTTCCAGG TGCGAAAGGT GCAGGGCACC AACTCGGGCA AAATATATGC CATGAAAGTC 300

CTGAGGAAGG CCAAAATTGT GCGCAACGCC AAGGACACGG CACACACGCG GGCTGAGCGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTC ATTGTGGAAT TGGCCTATGC CTTCCAGACT 420

GGTGGCAAAC TCTACCTCAT CCTTGAGTGC CTCAGTGGCG GTGAGCTCTT CACACATCTG 480

GAACGAGAGG GCATCTTCCT GGAAGACACG GCCTGTTTCT ACCTGGCAGA GATCACGCTG 540

GCCCTGGGCC ATCTCCACTC CCAAGGCATC ATCTACCGGG ACCTCAAGCC GGAGAACATC 600

ATGCTTAACA GCCAGGGCCA CATCAAATTG ACGGACTTCG GACTCTGCAA GGAGTCGATT 660

CATGAGGGCG CCGTCACCCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGTCACAA CCGGGCGGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC ACCCTTCACT GCGGAGAACC GAAAGAAAAC CATGGACAAG 840

ATCATCAAAG GGAAGCTGGC ACTGCCCCCC TACCTCACCC CGGATGCCCG GGACCTTGTC 900

AAAAAGTTTC TGAAGCGGAA TCCCAGCCAG CGGATCGGGG GTGGCCCAGG GGACGCTGCC 960

GATGTGCAGA GGCACCCGTT CTTCCGGCAC ATCAATTGGG ACGACCTCCT GGCCCGCCGC 1020

GTGGACCCCC CTTTCAGGCC CTGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGACACC 1080

CACTTCACGC GGCAGACGCC AGTGGACAGT CCCGACGACA CGGCCCTCAG TGAGAGCGCC 1140

AATCAGGCCT TCCTGGGCTT CACGTATGTG GCGCCCTCCG TCCTGGACAG CATCAAGGAG 1200

GGCTTCTCCT TCCAGCCTAA GCTACGCTCC CCCAGACGCC TCAACAGCAG CCCCCGGACC 1260

CCCATCAGCC CTCTGAAGTT CTCGCCTTTT GAGGGATTCC GGCCCAGCCC CGGCCCACCA 1320

GAGCCCATGG AGCCCCCGCT ACCTCCTCTC CTGCCGCCAC CACCGCCACC CTCGAGCACT 1380

GCCCCCCTCC CCATCCGCCC CCCCTCAGGG ACCAAGAAGT CCAAGAGGGG CCGTGGGCGC 1440

CCTGGGCGCT AG 1452

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv+++++gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNSGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNSGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

ecb:100053005

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013