EKS-EQC-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.2	8.1E-104	1292	1550	259

Status

Unreviewed

Ensembl Protein

ENSECAP00000011104

UniProt Accession

F7BJU2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000012724	ENSECAP00000011104	ENSECAT00000013945

Organism

Equus caballus

Functional Description

Protein Length

1557

Protein Sequence
(FASTA)

RQECTLGDSA CKNSESDPED FPDETSTENL YGTSPPSTPR QMKRMSTKHQ RNNVGRPAGR 60

SNLKEKMNAS NQPPHKDTGK TMENVEEYSY KQEKKIRAAL RTTERDHKKN VQCSFMLDSV 120

GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV SVPMPIARTA RQTSRTDCPA DRLKFFETLR 180

LLLKLTSVSK KKDREQRGQE NTSAFWFNRS NELIWLELQA WHAGRTINDQ DLFLYTARQA 240

IPDIINEILT FKVNYESFAF VRNGASFNGT SVEGQCKALH GTRVMGYSTY HEHLQRQRVS 300

FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM 360

GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EDEGDDVEGE LKELESSTDE SEEEQISDPK 420

VPETKQPLDS SFSIQSQDCM PKKLERLESE DDPVGWGAPD CSTEAGFSRH CLTSIYRPFV 480

DKALKQMGLR KLILRLHKLM DGSLQRARIA LVKSDRPVEF SEFPDPMWGS DYVQLSRTPP 540

SSEQKCSTVS WDELRSMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ 600

LVRECKEVLK GGLLMKQYYQ FMLHEVLHDL EKTDCNIDAF EEDLHKMLMV YFDYMRSWIQ 660

MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL FCDIAGMLLK STGSFLEFGL 720

QESCAEFWTS ADDSSASDEI RRSVIEISRA LKELFHEARE RASKALGFAK MLRKDLEIAA 780

EFILSAPVRD LLEVLKSKQY VKVQIPGLEN LQVFVPDSLA EEKSIILQLL NAAAGKDCSK 840

DSDDVLIDAY LLLTKHSDRT RDSGDSWATW EAQPVKIVPQ VETVDTLRSM QVDNVLLVVM 900

QSAHLIIQRK AFQQSIEGLM TLRQEQTSSQ PVIAKALQQL KNDALELCNR ISDAIDRVDH 960

MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA 1020

RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI 1080

GKPHSPVTGL YLAIHRNSPR PVKVPRCHSD PPNPHLIIPT PEGFSTRSVP SDTRSHGSPA 1140

AAAVAAAAAT AGRPGPAGSD SAPPKPISSA HETRGSSVPE NDRLASIAAE LQFRSLSRHS 1200

SPTEERDEPA YPKGDSSGSA RRSWELRTLI SQTKDTASKQ GPIEAIQKSV RLFEEKRYRE 1260

MRRKNIIGQV CDTPKSYDNV MHVGLRKVTF KWQRGNKIGE GQYGKVYTCI SVDTGELMAM 1320

KEIRFQPNDH KTIKETADEL KIFEGIKHPN LVRYFGVELH REEMYIFMEY CDEGTLEEVS 1380

RLGLQEHVIR LYSKQITVAI NVLHEHGIVH RDIKGANIFL TSSGLIKLGD FGCSVKLKNN 1440

AQTMPGEVNS TLGTAAYMAP EVITRAKGEG HGRAADIWSL GCVVIEMVTG KRPWHEYEHN 1500

FQIMYKVGMG HTPPIPERLS PEGKDFLSHC LESEPRMRWT ASQLLDHSFV KVCTDEE 1557

Nucleotide Sequence
(FASTA)

AGGCAAGAGT GCACACTGGG AGATTCAGCT TGCAAGAATT CTGAATCTGA TCCAGAGGAT 60

TTTCCGGATG AAACGAGTAC AGAGAACCTT TATGGCACCT CTCCCCCCAG CACACCTCGA 120

CAGATGAAAC GCATGTCCAC CAAACACCAG AGGAATAATG TAGGGAGGCC TGCCGGTCGA 180

TCTAATTTGA AGGAAAAAAT GAATGCATCA AACCAGCCTC CACATAAAGA CACTGGAAAA 240

ACCATGGAGA ATGTGGAAGA ATACAGCTAT AAGCAGGAGA AGAAGATCCG AGCAGCTCTT 300

AGGACAACAG AGCGCGATCA CAAGAAAAAC GTGCAGTGTT CATTCATGTT GGACTCAGTG 360

GGTGGGTCTT TGCCTAAAAA ATCAATTCCA GATGTGGATC TCAATAAGCC TTACCTCAGT 420

CTTGGCTGCA GCAATGCTAA GCTTCCGGTA TCTGTGCCCA TGCCTATAGC CAGAACTGCA 480

CGCCAGACTT CTAGGACTGA CTGTCCAGCA GATCGCTTAA AGTTTTTTGA AACTTTACGG 540

CTTCTGTTAA AGCTTACCTC AGTCTCAAAG AAGAAGGACA GGGAGCAAAG AGGACAGGAA 600

AATACGTCTG CTTTCTGGTT TAACCGATCT AATGAACTGA TCTGGTTAGA GCTCCAAGCC 660

TGGCATGCAG GACGGACCAT TAATGACCAG GACCTCTTTT TATATACAGC CCGTCAAGCC 720

ATCCCAGATA TTATCAATGA AATCCTTACT TTCAAAGTTA ATTACGAGAG CTTTGCCTTT 780

GTTAGAAATG GAGCTAGTTT TAATGGTACT TCAGTAGAAG GGCAGTGCAA AGCCCTTCAT 840

GGAACAAGGG TTATGGGTTA CTCAACATAC CATGAGCATC TCCAACGCCA GAGGGTGTCA 900

TTTGAGCAGG TAAAACGGAT AATGGAGCTG CTGGAGTACA TAGAAGCACT TTATCCATCG 960

TTGCAGGCTC TTCAAAAGGA CTATGAAAAA TATGCTGCAA AAGACTTCCA GGACAGGGTG 1020

CAGGCGCTCT GTTTGTGGTT AAACATCACG AAAGACTTAA ATCAGAAATT AAGGATTATG 1080

GGCACTGTTT TGGGCATCAA GAATTTATCA GACATTGGCT GGCCAGTGTT CGAAATTCCT 1140

TCCCCTCGAC CATCGAAAGG CAATGAGCCT GAAGATGAGG GCGATGACGT AGAAGGAGAA 1200

TTGAAAGAGT TGGAAAGTAG TACGGATGAG AGTGAAGAAG AACAAATCTC TGATCCAAAG 1260

GTACCAGAAA CCAAACAGCC CCTTGACAGC AGTTTCAGTA TCCAGTCGCA GGACTGCATG 1320

CCTAAGAAGC TCGAGAGGCT TGAATCTGAG GACGACCCTG TTGGCTGGGG AGCACCAGAC 1380

TGCAGCACAG AGGCAGGCTT TAGTAGACAT TGTCTGACTT CTATTTATAG ACCATTTGTA 1440

GACAAAGCCC TGAAGCAGAT GGGCTTAAGA AAGTTGATTT TAAGACTTCA CAAGCTGATG 1500

GACGGTTCCT TGCAGAGGGC ACGTATAGCA CTGGTAAAGA GTGACCGTCC GGTGGAGTTT 1560

TCCGAATTTC CGGATCCCAT GTGGGGTTCA GATTACGTGC AGTTGTCCAG GACGCCGCCT 1620

TCGTCGGAGC AGAAGTGCAG CACTGTGTCT TGGGACGAGT TGAGGTCCAT GGACTTACCG 1680

TCATTCGAAC CTGCCTTCTT AGTCCTCTGC CGCGTCCTTC TGAACGTGAT ACACGAGTGT 1740

CTGAAGTTAA GATTGGAGCA GAGACCTGCT GGAGAGCCAT CTCTCTTAAG TATTAAGCAG 1800

CTGGTGAGGG AGTGTAAAGA GGTGCTGAAG GGCGGCCTTT TAATGAAGCA GTATTACCAG 1860

TTCATGCTGC ACGAGGTTCT CCACGACCTG GAGAAGACGG ACTGCAACAT TGACGCCTTC 1920

GAGGAGGACC TGCACAAAAT GTTGATGGTA TATTTTGATT ACATGAGAAG CTGGATCCAA 1980

ATGCTACAGC AATTACCTCA AGCATCTCAT AGTTTAAAAA ATCTGTTGGA AGAAGAGTGG 2040

AATTTCACCA AAGAAATAAC GCATTACATC CGGGGAGGAG AAGCCCAGGC CGGAAAGCTC 2100

TTCTGTGACA TTGCAGGAAT GCTGCTGAAA TCTACGGGAA GTTTTTTGGA GTTTGGCTTA 2160

CAGGAGAGCT GTGCTGAATT CTGGACCAGT GCTGATGATA GTAGTGCTTC AGATGAAATC 2220

AGGAGGTCTG TCATCGAGAT CAGTCGCGCT CTGAAGGAGC TCTTCCATGA GGCCAGGGAG 2280

AGAGCCTCCA AAGCGCTCGG ATTTGCTAAA ATGCTGAGGA AGGACCTCGA AATAGCTGCA 2340

GAGTTCATAC TTTCAGCCCC AGTTAGAGAC CTTCTGGAGG TTCTGAAATC AAAACAGTAT 2400

GTTAAGGTAC AAATTCCTGG CTTAGAAAAC TTGCAAGTGT TTGTTCCAGA CAGTCTTGCC 2460

GAGGAGAAGA GTATTATTTT GCAGTTACTC AATGCAGCTG CAGGAAAGGA TTGCTCAAAA 2520

GATTCAGATG ATGTGCTAAT TGACGCCTAT CTGCTTTTAA CCAAGCATAG TGATCGCACT 2580

CGGGATTCGG GTGACAGCTG GGCCACCTGG GAGGCACAGC CTGTCAAAAT TGTGCCTCAA 2640

GTGGAGACTG TTGACACTCT GAGAAGCATG CAGGTGGATA ATGTTTTACT AGTTGTCATG 2700

CAGTCTGCCC ATCTCATAAT TCAGAGAAAA GCGTTCCAGC AGTCCATTGA AGGACTCATG 2760

ACTCTACGCC AGGAGCAGAC GTCCAGTCAG CCGGTCATCG CCAAAGCTTT GCAGCAGCTA 2820

AAGAATGATG CATTAGAGCT TTGCAACAGA ATAAGTGATG CCATTGACCG AGTGGACCAC 2880

ATGTTCACTT CAGAGTTTGA TGCTGAAGTT GATGAATCTG AATCTGTCAC GTTGCAACAG 2940

TACTACCGAG AAGCGATGAT TCAGGGGTAC AATTTTGGGT TTGAGTATCA TAAAGAAGTT 3000

GTTCGTTTAA TGTCTGGAGA GTTTAGACAG AAGATAGGAG ACAAATATAT AAGCTTTGCT 3060

CGGAAATGGA TGAATTATGT CCTGACTAAA TGTGAGAGTG GCAGAGGTAC CAGACCCAGG 3120

TGGGCGACTC AAGGTTTTGA CTTTCTGCAA GCCATCGAAC CTGCGTTTAT TTCAGCTCTA 3180

CCAGAAGATG ACTTCTTGAG TTTACAGGCC TTGATGAATG AATGCATTGG CCACGTGATA 3240

GGAAAGCCGC ACAGTCCTGT TACAGGTTTG TACCTTGCGA TTCATCGGAA CAGCCCCCGT 3300

CCTGTGAAGG TACCGCGATG CCACAGCGAC CCTCCTAACC CGCATCTCAT TATCCCAACC 3360

CCAGAGGGAT TCAGCACTCG GAGCGTGCCC TCAGACACGC GGAGCCACGG CAGCCCTGCT 3420

GCTGCTGCTG TCGCTGCCGC CGCCGCCACC GCCGGCCGCC CCGGCCCCGC AGGCAGCGAC 3480

TCTGCGCCGC CCAAACCCAT CAGCAGTGCC CATGAGACCA GGGGTTCCAG CGTCCCTGAG 3540

AATGATCGCT TGGCTTCCAT AGCAGCCGAA TTGCAGTTTA GGTCTCTGAG CCGTCACTCC 3600

AGCCCCACTG AGGAGAGAGA TGAACCAGCG TATCCAAAAG GTGATTCCAG TGGGTCAGCG 3660

CGGAGGAGCT GGGAACTTCG GACACTTATC AGCCAGACAA AGGATACGGC TTCTAAGCAA 3720

GGACCCATAG AAGCCATCCA GAAGTCAGTC CGATTGTTTG AAGAAAAGAG GTATCGAGAA 3780

ATGAGGAGAA AGAATATCAT CGGTCAAGTT TGTGATACCC CGAAGTCTTA TGATAATGTT 3840

ATGCATGTTG GTTTGAGGAA GGTGACCTTC AAGTGGCAAA GAGGAAACAA AATTGGGGAA 3900

GGGCAGTATG GAAAGGTTTA CACCTGCATC AGTGTCGACA CCGGTGAACT GATGGCGATG 3960

AAGGAGATTC GCTTTCAACC TAATGATCAT AAAACTATCA AGGAAACTGC AGACGAATTG 4020

AAAATCTTCG AAGGCATCAA ACACCCCAAT CTGGTTCGGT ATTTTGGTGT GGAGCTTCAT 4080

AGAGAAGAAA TGTACATCTT CATGGAGTAC TGTGACGAGG GTACATTAGA AGAGGTGTCG 4140

AGGCTGGGAC TTCAGGAGCA TGTCATTAGG CTGTATTCAA AGCAGATCAC CGTTGCAATC 4200

AATGTCCTCC ATGAACATGG CATAGTTCAC CGCGACATTA AAGGTGCCAA TATCTTCCTC 4260

ACCTCGTCTG GACTAATCAA ACTGGGAGAT TTCGGATGCT CAGTGAAGCT TAAAAACAAT 4320

GCACAGACCA TGCCTGGGGA AGTGAATAGC ACACTGGGGA CAGCAGCGTA CATGGCTCCA 4380

GAAGTTATCA CTCGTGCGAA AGGAGAGGGC CATGGGCGTG CGGCCGACAT CTGGAGTCTG 4440

GGGTGTGTTG TCATAGAGAT GGTGACCGGC AAGAGGCCTT GGCATGAATA TGAACACAAC 4500

TTTCAGATTA TGTATAAAGT GGGAATGGGA CATACGCCAC CAATCCCTGA AAGATTAAGC 4560

CCAGAAGGAA AGGACTTCCT TTCTCACTGC CTTGAAAGTG AGCCCAGGAT GCGGTGGACG 4620

GCCAGCCAGC TCCTCGACCA TTCCTTCGTC AAGGTTTGCA CAGATGAAGA GTGA 4674

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1292  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1348

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1349  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1406

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1407  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1466

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + +P+ipe+ls+egkd

Q: 1467  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-TPPIPERLSPEGKD  1525

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1526  FLSHCLESEPRMRWTASQLLDHSFV  1550

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH TPPIPERLSP EGKDFLSHCL 240

ESEPRMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013