EKS-EQC-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	338.0	5.1E-101	210	489	280

Status

Unreviewed

Ensembl Protein

ENSECAP00000010808

UniProt Accession

F6RIT3;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK2

Gene Synonyms/Alias

IRAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000012960	ENSECAP00000010808	ENSECAT00000013603

Organism

Equus caballus

Functional Description

Protein Length

628

Protein Sequence
(FASTA)

MSCYIYQLPS WVVDDLCRNM DTLSEWDWMH FASYVITDLT QLRKIKSMER VQGVSITREV 60

LWWWGMRQAT VQQLVDLLCH LELYRAAQIV LNWKPAPEIK SSVPYFPDAV NPGRPLAASV 120

RDTKDGQEQG QPTRTAASPG SKSSVSRGPW PALLPLPPED ASSALNTEPP ASSDSKDFSA 180

SIPEEETLLS LAGDSLFWSE ADVVQATDNF NQNHKISEGT FADVYRGHRH GEPFVFKKLR 240

EASTSCLPVR RSIKKFFQAE VQICHRCCHP NVLPLLGFCT GGQFHSLVHP YMANGSLQDR 300

LQHQGGSDPL LWLQRVSICS GLLRAVEHLH GLDIIHSNIK SSNVLLDENF TPKLAHPMAH 360

LCPVNKRSRY TVMKTHLFQA SAAYLPDDFI RVGQLTKRVD VFSCGIVLAE VLTGIPAMDN 420

GRSPVYLKDL LLSEIPSSTT SLCSRKTDVE KVMAKELCQK YLEKRAGRLP EGCAEALATA 480

ACLCLRRRNA SLAEVCGSVA AVEEKLRGQD TSLPWSGLSE GTGSSSNTPE ETDDVDNSSF 540

DGSCSMRTAP SAGAAALPPP TEDGEGRPPA GGEIEADSSS EACASGEPPR DATETSWKIE 600

INEAKRKLMQ NILLYKEKKL DSIELLGL 628

Nucleotide Sequence
(FASTA)

ATGTCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGGTGG ACGACCTGTG CCGCAACATG 60

GACACGCTCA GCGAGTGGGA CTGGATGCAT TTCGCCTCCT ACGTGATCAC AGATCTGACC 120

CAGCTGCGGA AGATCAAGTC GATGGAGCGG GTGCAGGGCG TGAGCATCAC CCGGGAGGTG 180

CTGTGGTGGT GGGGGATGCG GCAGGCCACC GTCCAGCAGC TGGTGGACCT CCTGTGCCAC 240

CTGGAGCTCT ACCGTGCCGC CCAGATCGTC CTGAACTGGA AACCAGCTCC TGAAATCAAG 300

TCTTCTGTCC CATACTTCCC GGATGCCGTG AACCCAGGGA GGCCTTTGGC AGCGTCTGTG 360

AGAGACACCA AGGATGGACA GGAGCAGGGG CAGCCCACGA GGACGGCTGC CTCCCCAGGC 420

TCAAAGTCCT CAGTCAGCAG AGGCCCCTGG CCAGCCCTCC TCCCGCTTCC TCCTGAAGAT 480

GCCTCTTCTG CCTTAAACAC CGAGCCTCCA GCTTCATCTG ATTCAAAGGA TTTTAGCGCC 540

TCCATTCCCG AGGAAGAAAC ACTTTTGAGC CTGGCTGGAG ACAGCCTTTT CTGGAGTGAG 600

GCGGACGTGG TCCAAGCAAC AGATAACTTC AACCAAAACC ACAAAATCAG CGAGGGGACC 660

TTTGCTGATG TCTACAGAGG GCACCGGCAC GGCGAGCCAT TCGTCTTCAA GAAGCTCAGA 720

GAGGCAAGCA CATCTTGCCT TCCAGTTCGG CGATCAATCA AAAAGTTTTT CCAGGCAGAG 780

GTCCAAATCT GTCACAGATG CTGCCACCCC AACGTCTTAC CTCTGCTGGG CTTCTGCACC 840

GGAGGACAGT TTCACAGCTT GGTCCACCCC TACATGGCAA ATGGTTCTCT ACAGGACAGA 900

CTCCAGCACC AGGGTGGCTC AGACCCCCTC CTCTGGCTCC AGCGCGTCAG CATCTGCTCG 960

GGGCTGCTTC GTGCCGTGGA GCATCTGCAC GGCCTGGATA TCATCCACAG CAACATCAAG 1020

AGCTCCAATG TTTTGCTAGA CGAAAACTTC ACCCCCAAGC TGGCACATCC AATGGCTCAC 1080

CTGTGTCCTG TCAACAAAAG GTCAAGGTAC ACTGTGATGA AGACCCACCT TTTCCAGGCC 1140

TCCGCTGCGT ATCTGCCAGA CGATTTCATC AGGGTGGGGC AGCTGACGAA GCGAGTGGAC 1200

GTCTTCAGCT GTGGGATAGT GTTAGCTGAG GTCCTCACTG GCATCCCTGC GATGGATAAC 1260

GGCCGCAGCC CGGTGTACCT GAAGGATTTA CTCCTCAGTG AAATTCCCAG CAGCACCACC 1320

TCGCTGTGCT CCAGGAAGAC GGACGTGGAG AAGGTGATGG CCAAGGAGCT CTGCCAAAAG 1380

TACCTGGAGA AGAGAGCGGG GAGGCTGCCG GAGGGCTGCG CCGAGGCCTT GGCCACCGCC 1440

GCCTGCCTCT GCCTGCGGAG GCGCAACGCC AGCCTGGCGG AGGTGTGTGG CTCTGTGGCC 1500

GCCGTGGAAG AGAAGCTCAG AGGTCAGGAC ACATCTCTCC CTTGGAGTGG GCTTTCTGAG 1560

GGCACAGGCT CTTCCTCCAA CACCCCAGAA GAAACGGATG ACGTGGACAA TTCCAGCTTC 1620

GATGGCTCCT GCTCCATGAG GACGGCACCC TCGGCTGGGG CTGCTGCCTT GCCTCCCCCG 1680

ACAGAGGATG GAGAAGGCAG GCCTCCAGCT GGTGGGGAAA TAGAGGCTGA CTCCTCCTCT 1740

GAGGCCTGTG CCAGCGGGGA GCCCCCCAGG GATGCTACAG AGACTTCATG GAAAATTGAG 1800

ATCAATGAGG CCAAAAGGAA ACTGATGCAG AATATCCTGC TCTACAAAGA GAAGAAACTG 1860

GACAGCATTG AGCTTCTTGG CCTCTGA 1887

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlsl...kelkqsfltElkvlarfrH  57

         f+++++i+eG+f++vyrg++++  +++kkl+e   + l   +++k++f++E++++ r++H

Q: 210   FNQNHKISEGTFADVYRGHRHGEPFVFKKLREASTSCLpvrRSIKKFFQAEVQICHRCCH  269

         899****************************876654322268999**************

S: 58    dnilellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefL  117

         +n+l+llg+++ +++++Lv +ym+nGsL+drLq q+gs+pL W qR+si++G++ra+e+L

Q: 270   PNVLPLLGFCTGGQFHSLVHPYMANGSLQDRLQHQGGSDPLLWLQRVSICSGLLRAVEHL  329

         ************************************************************

S: 118   HeaspslihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlp  177

         H    ++ih++iks+N+LLDe++tpKl+ +++a+++p ++++++tv++t+ +++++aYlp

Q: 330   HGL--DIIHSNIKSSNVLLDENFTPKLA-HPMAHLCPVNKRSRYTVMKTHLFQASAAYLP  386

         ***..***********************.*******************************

S: 178   eefirvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekv......  231

         ++firvgqlt++vDv+S+GiVl+EvltG++a+d++r+++yLkdll +ei+++++

Q: 387   DDFIRVGQLTKRVDVFSCGIVLAEVLTGIPAMDNGRSPVYLKDLLLSEIPSSTTslcsrk  446

         *****************************************************99*****

S: 232   .........eilekfldkkagkleeellealielalaclaeka  265

                  e+++k+l+k+ag+l+e ++eal+++a+ cl +++

Q: 447   tdvekvmakELCQKYLEKRAGRLPEGCAEALATAACLCLRRRN  489

         ***************************************9765

Domain Sequence
(FASTA)

FNQNHKISEG TFADVYRGHR HGEPFVFKKL REASTSCLPV RRSIKKFFQA EVQICHRCCH 60

PNVLPLLGFC TGGQFHSLVH PYMANGSLQD RLQHQGGSDP LLWLQRVSIC SGLLRAVEHL 120

HGLDIIHSNI KSSNVLLDEN FTPKLAHPMA HLCPVNKRSR YTVMKTHLFQ ASAAYLPDDF 180

IRVGQLTKRV DVFSCGIVLA EVLTGIPAMD NGRSPVYLKD LLLSEIPSST TSLCSRKTDV 240

EKVMAKELCQ KYLEKRAGRL PEGCAEALAT AACLCLRRRN 280

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0001959	; P:regulation of cytokine-mediated signaling pathway

KEGG

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013