EKS-EQC-00089

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00089

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	447.7	3.0E-134	712	1037	326

Status

Unreviewed

Ensembl Protein

ENSECAP00000009669

UniProt Accession

F6T1S2;

Protein Name

Protein Synonyms/Alias

Gene Name

ATR

Gene Synonyms/Alias

ATR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000013285	ENSECAP00000011093	ENSECAT00000013932
ENSECAG00000013285	ENSECAP00000022957	ENSECAT00000028964
ENSECAG00000013285	ENSECAP00000009669	ENSECAT00000012259

Organism

Equus caballus

Functional Description

Protein Length

1062

Protein Sequence
(FASTA)

TQTVFSMLDH LTQWARHKFQ ALNAEKFPQS KSNRDKNLST VDYEDYQSVT RFLDLIPQDT 60

LAVASFRSKA YTRAVMHFES FITEKKQNIQ EHLGFLQKLY AAMHEPDGVA GVSAIRKAEP 120

SLKEQILEHE SIGLLRDATA CYDRAIQLEP DQIIHYHGVV KSMLGLGQLS TVITQVNGVH 180

ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW SVRLGQLLLS AKKRDATAFY 240

DTLKLVRAEQ IVPLSAASFE RGSYQRGYEY IVRLHMLCEL EHSIKPLFQQ CPGDSSQEDS 300

LNWVARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV GECWLQSARV ARKAGHHQTA 360

YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV ELCFSENKTP TESKNMLIHG 420

RAMLLVGRFM EETANFESNA VMKKYKAKDV TLFLPEWEDG HFYLAKYYDK LMPMVTDNKM 480

EKQGDLIRYI VLHFGRSLQY GNQFIYQSMP RMLSLWLDFG AKAYEWEKAS RSDRVQMRND 540

LAKINKVITE HTNHLAPYQF LTAFSQLISR ICHSHDEVFV VLMEIIAKVF LAYPQQAMWM 600

MTAVSKSSYP MRVNRCKEIL NKAIHMKKSL EKFVGDATRL TDKLLELCNK PVDGSSSTLS 660

MSTHFKMLKK LVEEATFSEI LIPLQSVMIP TLPSIPGAHA NHDPFPGHWA YIASFDDTVE 720

ILASLQKPKK ISLKGSDGKF YIMMCKPKDD LRKDCRLMEF NSLINKCLRK DAESRRRELH 780

IRTYAVIPLN DECGIIEWVN NTAGLRPILT KLYKEKGVYM TGKELRQCML PKAAALSEKL 840

KVFREFLLPR HPPVFHEWFL RTFPDPTSWY SSRSAYCRST AVMMVGYILG LGDRHGENIL 900

FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF RRACEVTMRL 960

MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAPLNETGE VVNEKAKTHV LDIEQRLQGV 1020

IKTRNRVTGL PLSIEGHVHY LIQEATDENL LCQMYLGWTP YM 1062

Nucleotide Sequence
(FASTA)

ACACAGACTG TGTTCTCCAT GCTTGACCAT CTCACACAGT GGGCAAGACA CAAATTTCAG 60

GCACTAAATG CTGAGAAATT TCCACAAAGC AAATCAAACA GAGATAAAAA TTTATCGACT 120

GTGGATTATG AAGATTATCA GAGTGTAACT CGTTTTCTAG ACCTCATACC TCAGGATACT 180

CTGGCAGTAG CTTCCTTTCG GTCCAAAGCA TACACGCGAG CTGTAATGCA CTTTGAATCA 240

TTTATTACAG AAAAGAAGCA AAATATTCAA GAGCATCTTG GATTTTTACA GAAATTGTAT 300

GCTGCTATGC ATGAACCAGA TGGAGTGGCT GGAGTAAGTG CAATTCGAAA GGCAGAACCA 360

TCTCTAAAAG AACAGATCCT TGAACATGAA AGCATTGGCT TACTGAGGGA TGCCACTGCT 420

TGTTATGACA GGGCTATTCA GCTAGAACCA GACCAGATCA TTCATTACCA TGGTGTAGTG 480

AAGTCCATGT TAGGTCTTGG TCAGCTGTCT ACTGTAATCA CTCAGGTGAA TGGAGTGCAT 540

GCTAACAGGT CTGAATGGAC AGATGAGTTA AACACATACA GAGTGGAAGC AGCTTGGAAA 600

TTGTCACAGT GGGATTTGGT GGAAAACTAT TTGGCAGCAG ATGGGAAATC CACAACATGG 660

AGCGTCAGAC TGGGACAGCT ATTATTATCA GCCAAAAAAA GAGATGCCAC AGCTTTTTAT 720

GACACATTGA AACTAGTGAG AGCAGAACAA ATTGTACCTC TTTCAGCTGC AAGCTTTGAA 780

AGAGGCTCTT ACCAACGAGG ATATGAATAT ATTGTGAGAT TACACATGTT GTGTGAGTTG 840

GAGCATAGCA TCAAACCACT TTTTCAACAG TGTCCAGGTG ACAGTTCTCA AGAAGATTCT 900

CTAAACTGGG TAGCTCGACT AGAAATGACC CAGAATTCCT ACAGAGCCAA GGAGCCCATT 960

TTGGCTCTCC GGAGAGCTTT ATTAAGCCTC AACAAAAGAC CAGATTACAA TGAAATGGTT 1020

GGAGAATGCT GGCTACAGAG TGCCAGAGTA GCTAGAAAGG CTGGTCACCA CCAGACAGCC 1080

TACAATGCTC TCCTTAATGC TGGAGAATCA CGACTTGCTG AACTCTATGT GGAAAGGGCA 1140

AAGTGGCTGT GGTCCAAGGG TGATGTTCAT CAGGCACTAA TTGTTCTTCA AAAGGGTGTT 1200

GAATTATGTT TTTCTGAAAA TAAAACCCCA ACTGAGAGTA AGAACATGTT AATCCATGGT 1260

CGAGCTATGC TACTAGTAGG CCGATTTATG GAAGAAACAG CCAACTTTGA AAGCAATGCA 1320

GTTATGAAAA AATATAAGGC AAAGGATGTG ACCTTGTTCC TGCCAGAGTG GGAGGATGGG 1380

CATTTCTACC TTGCCAAGTA CTATGACAAA TTGATGCCCA TGGTCACAGA CAACAAAATG 1440

GAAAAGCAAG GTGATCTCAT TCGGTATATA GTCCTTCATT TCGGAAGATC TCTGCAGTAC 1500

GGAAATCAAT TTATATATCA ATCTATGCCA CGAATGTTAT CACTATGGCT TGATTTTGGT 1560

GCTAAGGCGT ACGAATGGGA AAAAGCTAGC CGCTCTGATC GTGTACAAAT GAGAAATGAT 1620

TTAGCTAAAA TAAACAAAGT TATCACAGAG CACACAAATC ACTTAGCTCC ATATCAGTTT 1680

TTGACTGCTT TTTCACAATT GATCTCCCGA ATATGTCATT CTCATGATGA AGTTTTTGTT 1740

GTCTTGATGG AAATTATAGC CAAAGTATTT CTGGCCTATC CTCAACAAGC AATGTGGATG 1800

ATGACAGCTG TGTCAAAGTC TTCTTATCCC ATGCGTGTGA ACAGATGCAA GGAAATTCTA 1860

AACAAAGCTA TTCATATGAA GAAATCCTTA GAAAAGTTTG TCGGAGATGC AACTCGCCTA 1920

ACAGATAAGC TTCTAGAATT GTGCAATAAA CCGGTGGATG GAAGTAGTTC CACATTAAGC 1980

ATGAGCACTC ACTTTAAAAT GCTTAAAAAG CTGGTAGAAG AAGCAACATT TAGTGAAATC 2040

CTCATTCCTT TACAATCAGT CATGATACCT ACTCTCCCAT CAATTCCGGG TGCCCATGCT 2100

AACCATGATC CATTTCCTGG GCACTGGGCT TATATTGCAA GCTTTGATGA TACGGTGGAA 2160

ATTCTTGCTT CTCTTCAGAA ACCAAAGAAG ATCTCTTTAA AAGGATCAGA TGGAAAGTTC 2220

TACATCATGA TGTGTAAGCC AAAAGATGAT CTGAGAAAGG ATTGTAGACT AATGGAATTC 2280

AATTCCTTGA TTAATAAGTG CTTAAGAAAA GATGCAGAAT CTCGTAGAAG AGAACTTCAT 2340

ATCCGAACAT ACGCAGTTAT TCCACTGAAT GATGAATGTG GGATTATTGA ATGGGTTAAC 2400

AACACTGCTG GTTTGAGACC TATTCTGACC AAACTATATA AGGAAAAGGG AGTTTATATG 2460

ACAGGGAAAG AACTTCGCCA GTGTATGCTA CCAAAGGCGG CAGCTTTGTC TGAAAAACTC 2520

AAAGTATTCC GAGAATTTCT CCTACCTAGG CATCCTCCTG TTTTTCATGA GTGGTTTCTG 2580

AGAACATTCC CTGATCCTAC ATCATGGTAC AGTAGCAGAT CAGCATACTG CCGTTCCACT 2640

GCAGTTATGA TGGTTGGTTA TATCCTGGGC CTTGGAGACC GTCATGGTGA AAACATCCTC 2700

TTTGATTCTT TGACTGGTGA ATGTGTACAT GTGGATTTCA ACTGTCTCTT TAATAAGGGA 2760

GAAACCTTTG AAGTTCCAGA AATTGTTCCA TTTCGCCTGA CTCATAATAT GGTTAATGGA 2820

ATGGGTCCTA TGGGAACAGA AGGTCTTTTT CGAAGAGCTT GTGAAGTTAC AATGAGGCTG 2880

ATGCGAGATC AGAGAGAGCC TTTAATGAGT GTCTTAAAGA CTTTTCTACA TGATCCTCTT 2940

GTGGAATGGA GTAAACCAGT GAAAGGGCAT TCCAAAGCAC CACTGAATGA AACTGGGGAA 3000

GTTGTCAATG AGAAGGCAAA GACTCATGTT CTTGACATCG AGCAGAGACT GCAAGGTGTA 3060

ATCAAGACCC GAAATAGAGT GACAGGGCTA CCATTATCTA TTGAAGGACA CGTGCATTAC 3120

CTTATACAAG AAGCTACTGA TGAAAACTTA CTATGCCAAA TGTACCTTGG TTGGACCCCA 3180

TATATGTGA 3189

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         ia+fd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 712   IASFDDTVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  771

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 772   AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  823

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 824   ELRQCMLPKAAALSEKLKVFREFLLPRHPP-VFHEWFLRTFPDPTSWYSSRSAYCRSTAV  882

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         + +vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 883   M-MVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  940

         8.9**************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k++ +et+e

Q: 941   MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAPLNETGE  1000

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 1001  VVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGH  1037

         ********************************99987

Domain Sequence
(FASTA)

IASFDDTVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KAAALSEKLK VFREFLLPRH PPVFHEWFLR TFPDPTSWYS SRSAYCRSTA VMMVGYILGL 180

GDRHGENILF DSLTGECVHV DFNCLFNKGE TFEVPEIVPF RLTHNMVNGM GPMGTEGLFR 240

RACEVTMRLM RDQREPLMSV LKTFLHDPLV EWSKPVKGHS KAPLNETGEV VNEKAKTHVL 300

DIEQRLQGVI KTRNRVTGLP LSIEGH 326

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0001741	; C:XY body
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013