EKS-EQC-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC458.39.2E-138355614260
StatusUnreviewed
Ensembl ProteinENSECAP00000011791
UniProt AccessionF7BA26;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCH
Gene Synonyms/Alias PRKCH;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000013529ENSECAP00000011791ENSECAT00000014734
OrganismEquus caballus
Functional Description
Protein Length683
Protein Sequence
(FASTA)
MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD QVRVGQTSTK 60
QKTNKPTYNE EFCTNVTDGG HLELAVFHET PLGYDHFVAN CTLQFQELLR TAGASDTFEG 120
WVDLEPEGKV FVVITLTGSF TEATLQRDRI FKHFTRKRQR AMRRRVHQIN GHKFMATYLR 180
QPTYCSHCRE FIWGVFGKQG YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDSKVAEQRF 240
GINIPHKFSI HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV 300
ELAKTLAGMG LQPGNISPTS KLVSRTTLRR QGKESIKEGN GIGVNSSNRL GIDNFEFIRV 360
LGKGSFGKVM LARIKETGDL YAVKILKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF 420
CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HEKGIIYRDL 480
KLDNVLLDHE GHCKLADFGM CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM 540
GVLLYEMLCG HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL 600
TQGGEHAILR HPFFKEIDWA QLNHRQIEPP FRPRIKSRED VSNFDPDFIK EEPVLTPIDE 660
GHLPMINQDE FRNFSFVSPE MQP 683
Nucleotide Sequence
(FASTA)
ATGTCGTCCG GCACCATGAA GTTCAATGGA TACTTGAGGG TCCGTATTGG CGAGGCCGTG 60
GGGCTGCAGC CCACCCGCTG GTCCCTGCGC CACTCGCTCT TCAAGAAGGG CCACCAGCTG 120
CTGGACCCCT ACCTGACAGT GAGCGTGGAC CAGGTGCGCG TGGGCCAGAC CAGCACCAAG 180
CAGAAGACCA ACAAACCCAC GTACAATGAG GAGTTCTGCA CCAACGTCAC CGACGGTGGC 240
CACCTCGAGC TGGCCGTCTT CCACGAGACG CCCCTGGGCT ACGACCACTT CGTGGCCAAC 300
TGCACCCTGC AATTCCAGGA GCTGCTGCGC ACGGCCGGCG CCTCGGACAC CTTCGAGGGC 360
TGGGTGGATC TGGAGCCAGA AGGGAAAGTA TTTGTGGTAA TAACCCTAAC AGGGAGTTTC 420
ACTGAAGCTA CTCTCCAGAG AGACCGAATC TTCAAGCATT TTACCAGGAA GCGCCAAAGG 480
GCTATGCGAA GGCGAGTCCA CCAGATCAAC GGACACAAGT TTATGGCCAC GTACCTGCGG 540
CAGCCCACCT ACTGCTCTCA CTGCAGGGAG TTCATCTGGG GAGTATTTGG GAAACAGGGT 600
TATCAATGCC AAGTGTGCAC CTGTGTCGTC CATAAGCGCT GCCATCATCT AATTGTTACA 660
GCTTGCACTT GCCAAAACAA TATTAACAAA GTGGATTCAA AGGTTGCTGA ACAGAGGTTC 720
GGAATCAACA TCCCACACAA GTTCAGCATC CACAACTACA AAGTGCCAAC GTTCTGTGAT 780
CACTGTGGCT CCCTGCTCTG GGGGATAATG CGACAAGGAC TTCAGTGTAA AATATGTAAA 840
ATGAATGTAC ACATTCGGTG TCAGGCGAAC GTGGCTCCTA ACTGTGGGGT GAACGCGGTG 900
GAGCTCGCCA AGACTCTGGC TGGGATGGGC CTCCAGCCTG GAAATATTTC TCCAACCTCG 960
AAGCTTGTTT CCAGAACGAC TCTAAGACGA CAGGGAAAGG AGAGCATCAA AGAAGGAAAT 1020
GGCATTGGGG TTAATTCTTC CAACCGACTT GGTATCGACA ACTTTGAGTT CATCCGAGTG 1080
TTGGGGAAGG GGAGCTTTGG GAAGGTGATG CTTGCAAGAA TAAAAGAAAC AGGAGACCTC 1140
TATGCTGTGA AGATTCTGAA GAAGGACGTG ATCCTGCAGG ACGATGACGT GGAATGCACG 1200
ATGACGGAGA AGAGGATCCT GTCCTTGGCC CGCAATCACC CCTTCCTCAC TCAGCTGTTC 1260
TGCTGCTTTC AGACCCCTGA TCGTCTGTTT TTTGTGATGG AGTTTGTGAA TGGGGGCGAC 1320
TTGATGTTTC ACATTCAGAA GTCTCGTCGT TTTGATGAAG CACGAGCTCG TTTCTATGCT 1380
GCAGAAATCA TTTCGGCACT TATGTTCCTG CATGAGAAAG GAATCATCTA TAGAGATCTG 1440
AAACTGGACA ATGTACTGTT GGACCACGAG GGCCACTGTA AACTGGCCGA CTTCGGGATG 1500
TGCAAGGAGG GGATCTGTAA CGGAGTCACC ACGGCAACCT TCTGTGGCAC ACCTGACTAT 1560
ATTGCTCCAG AGATCCTCCA AGAGATGCTG TATGGGCCCG CGGTAGATTG GTGGGCAATG 1620
GGCGTGCTGC TCTACGAAAT GCTCTGCGGT CACGCGCCCT TTGAGGCAGA GAACGAAGAT 1680
GACCTCTTTG AGGCCATACT GAACGATGAA GTGGTCTACC CTACATGGCT CCATGAAGAT 1740
GCCACGGGAA TCCTGAAATC TTTCATGACC AAGAACCCCA CCATGCGCTT GGGCAGCCTG 1800
ACTCAGGGCG GTGAGCATGC CATTTTGAGA CATCCTTTCT TTAAGGAAAT CGACTGGGCC 1860
CAGCTGAACC ATCGCCAAAT AGAACCACCT TTCAGACCCA GAATCAAATC CCGAGAAGAC 1920
GTCAGTAATT TTGACCCTGA CTTCATAAAG GAAGAGCCAG TTTTAACTCC AATTGATGAG 1980
GGACATCTTC CTATGATTAA CCAGGATGAG TTTAGAAACT TTTCCTTTGT GTCTCCAGAA 2040
ATGCAACCTT AG 2052
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         fe+++vlGkGsfgkv+la+ k+t +lya+k+lkkdv+lqdddve+t++ekr+l+la+++p
Q: 355   FEFIRVLGKGSFGKVMLARIKETGDLYAVKILKKDVILQDDDVECTMTEKRILSLARNHP  414
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+qlf+cfqt drlffv+e+vnGGdlmfhiqk+r+++e+rarfyaaeii+al+flhekg
Q: 415   FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKG  474
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+eGh+kladfG+cke+i++g tt+tfcGtPdyiaPeil+e+ yg +
Q: 475   IIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPA  534
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il++ev+yP++l+++a+ ilk+++tk+p+
Q: 535   VDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPT  594
         ************************************************************
S: 241   krlGvk.eegeedikehaff  259
         +rlG+  + ge++i +h+ff
Q: 595   MRLGSLtQGGEHAILRHPFF  614
         *****65999*********9
Domain Sequence
(FASTA)
FEFIRVLGKG SFGKVMLARI KETGDLYAVK ILKKDVILQD DDVECTMTEK RILSLARNHP 60
FLTQLFCCFQ TPDRLFFVME FVNGGDLMFH IQKSRRFDEA RARFYAAEII SALMFLHEKG 120
IIYRDLKLDN VLLDHEGHCK LADFGMCKEG ICNGVTTATF CGTPDYIAPE ILQEMLYGPA 180
VDWWAMGVLL YEMLCGHAPF EAENEDDLFE AILNDEVVYP TWLHEDATGI LKSFMTKNPT 240
MRLGSLTQGG EHAILRHPFF 260
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00163
EKS-ANC-00164
EKS-BOT-00171
EKS-CAE-00130
EKS-CAJ-00175
EKS-CAF-00178
EKS-CAP-00171
EKS-DAR-00467
EKS-DRM-00083
EKS-FEC-00161
EKS-GAM-00092
EKS-GAG-00147
EKS-GAA-00209
EKS-GOG-00169
EKS-HOS-00177
EKS-ICT-00166
EKS-LAC-00185
EKS-LOA-00175
EKS-MAM-00169
EKS-MEG-00136
EKS-MIM-00077
EKS-MOD-00169
EKS-MUM-00176
EKS-MUP-00175
EKS-MYL-00180
EKS-NOL-00164
EKS-ORN-00216
EKS-ORA-00153
EKS-ORC-00158
EKS-ORL-00200
EKS-OTG-00177
EKS-PAT-00162
EKS-PES-00151
EKS-POA-00166
EKS-PTV-00149
EKS-RAN-00166
EKS-SAH-00168
EKS-SUS-00148
EKS-TAG-00199
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00217
EKS-TUT-00153
EKS-XET-00159
EKS-XIM-00211
Gene Ontology
GO:0005829; C:cytosol
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0060252; P:positive regulation of glial cell proliferation
GO:0045618; P:positive regulation of keratinocyte differentiation
GO:0010744; P:positive regulation of macrophage derived foam cell differentiation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:2000810; P:regulation of tight junction assembly
KEGG
ecb:100051560;
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013