EKS-EQC-00143
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00143
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk471.55.2E-142194439246
StatusUnreviewed
Ensembl ProteinENSECAP00000011609
UniProt AccessionF6ZZA7;
Protein Name
Protein Synonyms/Alias
Gene NameCSK
Gene Synonyms/Alias CSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000013581ENSECAP00000011609ENSECAT00000014515
OrganismEquus caballus
Functional Description
Protein Length449
Protein Sequence
(FASTA)
PALQAAWPSG TECIAKYNFH GTAEQDLPFC KGDVLTIVAV TKDPNWYKAK NKVGREGIIP 60
ANYVQKREGV KAGTKLSLMP WFHGKITREQ AERLLCPPET GLFLVRESTN YPGDYTLCVS 120
CDGKVEHYRI MYHASKLSID EEVYFENLMQ LVEHYTSDAD GLCTRLIKPK VMEGTVAAQD 180
EFFRSGWALN MKDLKLLQTI GKGEFGDVML GDYRGNKVAV KCIKNDATAQ AFLAEASVMT 240
QLRHSNLVQL LGVIVEEKGG LYIVTEYMAK GSLVDYLRSR GRSVLGGDCL LKFSLDVCEA 300
MEYLEGNNFV HRDLAARNVL VSEDNVAKVS DFGLTKEASS TQDTGKLPVK WTAPEALREK 360
KFSTKSDVWS FGILLWEIYS FGRVPYPRIP LKDVVPRVEK GYKMDAPDGC PPAVYDVMKN 420
CWHLDAATRP SFLQLREQLE HIKAHELHL 449
Nucleotide Sequence
(FASTA)
CCTGCCCTGC AGGCCGCTTG GCCATCCGGT ACAGAATGTA TTGCCAAGTA CAACTTCCAT 60
GGCACTGCTG AGCAAGACCT TCCCTTCTGC AAAGGAGATG TGCTCACCAT TGTGGCCGTC 120
ACCAAGGACC CCAACTGGTA CAAAGCCAAG AACAAGGTGG GCCGTGAGGG CATCATCCCA 180
GCCAACTATG TCCAGAAGCG GGAGGGCGTG AAGGCGGGCA CCAAACTCAG CCTTATGCCC 240
TGGTTCCATG GCAAGATCAC GCGGGAGCAG GCAGAGCGGC TCCTGTGCCC TCCGGAGACA 300
GGCTTGTTCC TGGTGCGGGA GAGCACCAAC TACCCCGGGG ACTACACGCT GTGTGTGAGC 360
TGCGACGGCA AGGTGGAGCA CTACCGCATC ATGTACCATG CCAGCAAGCT CAGCATCGAC 420
GAGGAGGTGT ACTTTGAGAA CCTCATGCAG CTGGTGGAGC ACTACACCTC AGATGCAGAT 480
GGACTCTGTA CTCGCCTCAT CAAGCCAAAG GTCATGGAGG GCACAGTGGC AGCCCAGGAT 540
GAGTTCTTCC GCAGCGGCTG GGCGCTGAAC ATGAAGGATC TGAAGCTGCT GCAGACCATT 600
GGGAAGGGGG AGTTTGGAGA TGTGATGCTG GGCGATTACC GAGGGAATAA AGTTGCTGTC 660
AAGTGCATTA AGAACGATGC CACGGCCCAG GCCTTCCTGG CTGAAGCCTC GGTCATGACG 720
CAACTTCGGC ATAGCAACCT GGTACAGCTT CTAGGCGTGA TCGTGGAGGA GAAAGGCGGG 780
CTCTACATCG TCACTGAGTA CATGGCCAAG GGGAGCCTGG TGGACTATCT GCGGTCACGC 840
GGTCGGTCGG TGCTAGGCGG AGACTGTCTC CTCAAGTTCT CACTAGACGT CTGCGAGGCT 900
ATGGAATACC TGGAGGGCAA CAACTTCGTG CACCGGGACC TGGCCGCCCG CAATGTGCTG 960
GTGTCCGAGG ACAACGTGGC CAAGGTCAGC GACTTTGGCC TCACCAAGGA GGCCTCCAGC 1020
ACCCAGGACA CGGGCAAGCT GCCAGTCAAG TGGACAGCCC CAGAGGCTCT GAGAGAGAAG 1080
AAATTCTCCA CCAAGTCTGA CGTGTGGAGT TTTGGAATTC TTCTCTGGGA AATCTACTCC 1140
TTTGGGCGAG TGCCTTATCC AAGAATTCCC CTGAAGGACG TTGTCCCTCG GGTGGAGAAG 1200
GGCTACAAGA TGGACGCCCC CGACGGCTGC CCGCCTGCAG TCTACGATGT CATGAAGAAC 1260
TGCTGGCACC TGGACGCCGC CACACGGCCC TCCTTCCTGC AGCTCCGGGA GCAGCTCGAG 1320
CACATCAAAG CCCACGAGCT CCACCTGTGA 1350
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv
Q: 194   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  253
         6899********************************************************
S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119
         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd
Q: 254   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  313
         *****99*****************************************************
S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179
         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi
Q: 314   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  373
         ************************************************************
S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239
         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vy++mk++w+l+aa+rpsf 
Q: 374   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPSFL  433
         ************************************************************
S: 240   klkekl  245
         +l+e+l
Q: 434   QLREQL  439
         ***997
Domain Sequence
(FASTA)
LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60
IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120
LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180
LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYDVMKNCWH LDAATRPSFL 240
QLREQL 246
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00137
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-DRM-00070
EKS-FEC-00136
EKS-GAM-00074
EKS-GAG-00123
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAM-00143
EKS-MAE-00056
EKS-MEG-00113
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-ORN-00178
EKS-ORL-00168
EKS-OTG-00150
EKS-PAT-00135
EKS-PES-00130
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAR-00188
EKS-TEN-00180
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005813; C:centrosome
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0008285; P:negative regulation of cell proliferation
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013