EKS-EQC-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.11.1E-154346605260
StatusUnreviewed
Ensembl ProteinENSECAP00000011695
UniProt AccessionF6ZLC2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000013862ENSECAP00000011695ENSECAT00000014618
OrganismEquus caballus
Functional Description
Protein Length711
Protein Sequence
(FASTA)
MFKANQEAEG CSHCPSNSRS PSEASPICTC RTGYYRADFD PPEVACTSVP SGPRNVISIV 60
NETSIILEWH PPRETGGRDD VTYNIICKKC RADRRSCSRC DDNVEFVPRQ LGLTECRVSI 120
SSLWAHTPYT FDIQAVNGVS SKSPFPPQHV SVNITTNQAA PSTVPIMHQV SATMRSITLS 180
WPQPEQPNGI ILDYEIRYYE KEHNEFNSSM ARSQTNTARI DGLRPGMVYV VQVRARTVAG 240
YGKFSGKMCF QTLTDDDYKS ELREQLPLIA GSAAAGVVFV VSLVAISIVC SRKRAYSKEA 300
VYSDKLQHYS TGRGSPGMKI YIDPFTYEDP NEAVREFAKE IDVSFVKIEE VIGAGEFGEV 360
YKGRLKLPGK REIYVAIKTL KAGYSEKQRR DFLSEASIMG QFDHPNIIRL EGVVTKSRPV 420
MIIAEFMENG ALDSFLRQND GQFTVIQLVG MLRGIAAGMK YLAEMNYVHR DLAARNILVN 480
SNLVCKVSDF GLSRYLQDDT SDPTYTSSLG GKIPVRWTAP EAIAYRKFTS ASDVWSYGIV 540
MWEVMSFGER PYWDMSNQDV INAIEQDYRL PPPMDCPAAL HQLMLDCWQK DRNSRPRFAE 600
IVNTLDKMIR NPASLKTVAT ITAVPSQPLL DRSIPDFTAF TTVDDWLSAI KMVQYRDSFL 660
TAGFTSLQLV TQMTSEDLLR IGVTLAGHQK KILNSIHSMR VQMNQSPTAM A 711
Nucleotide Sequence
(FASTA)
ATGTTCAAGG CCAACCAGGA AGCTGAGGGC TGCTCCCACT GCCCCTCCAA CAGCCGATCC 60
CCTTCAGAGG CTTCTCCCAT CTGCACCTGC CGGACTGGCT ATTACCGAGC GGATTTTGAC 120
CCTCCGGAAG TGGCATGCAC TAGTGTCCCG TCGGGTCCCC GCAACGTCAT CTCCATCGTC 180
AATGAGACAT CCATCATTCT GGAGTGGCAC CCTCCAAGGG AGACAGGTGG GCGGGATGAT 240
GTGACCTACA ACATCATCTG TAAAAAGTGC CGGGCAGACC GTCGAAGCTG CTCCCGCTGT 300
GATGACAACG TGGAGTTTGT GCCCAGGCAG CTGGGCCTGA CGGAGTGCCG TGTCTCCATC 360
AGCAGCCTGT GGGCCCACAC CCCCTACACC TTTGACATCC AGGCAGTCAA TGGAGTCTCC 420
AGCAAGAGTC CCTTCCCACC ACAGCACGTC TCTGTCAACA TCACCACAAA CCAAGCTGCC 480
CCTTCCACTG TTCCCATCAT GCACCAGGTC AGTGCCACCA TGAGGAGCAT CACCTTGTCA 540
TGGCCACAGC CCGAGCAGCC CAATGGCATC ATCCTGGACT ATGAGATCCG GTACTATGAG 600
AAGGAACACA ATGAGTTTAA CTCCTCCATG GCCAGGAGCC AGACCAACAC AGCGCGTATC 660
GATGGCCTGC GGCCGGGCAT GGTGTACGTG GTGCAGGTGC GCGCCCGCAC CGTGGCCGGC 720
TACGGCAAGT TCAGTGGCAA GATGTGCTTC CAGACTCTGA CGGACGACGA TTACAAGTCT 780
GAGCTGAGGG AGCAGCTGCC CCTGATTGCT GGCTCGGCGG CGGCTGGGGT CGTGTTCGTC 840
GTGTCCTTGG TGGCCATCTC CATCGTCTGT AGCAGGAAAC GGGCTTACAG CAAAGAGGCC 900
GTGTACAGCG ATAAGCTGCA GCATTACAGC ACGGGCCGAG GCTCCCCAGG GATGAAGATC 960
TACATTGACC CCTTCACTTA TGAGGACCCG AATGAAGCTG TCCGGGAGTT TGCCAAGGAG 1020
ATTGATGTAT CTTTTGTGAA AATCGAAGAG GTCATCGGAG CAGGAGAGTT TGGAGAGGTG 1080
TACAAGGGGC GTCTGAAACT TCCAGGCAAG AGGGAAATCT ATGTGGCCAT CAAGACGCTG 1140
AAGGCCGGGT ACTCAGAGAA GCAGCGTCGG GACTTTCTGA GTGAGGCGAG CATCATGGGC 1200
CAGTTCGACC ATCCCAACAT CATTCGCCTG GAGGGCGTGG TCACCAAGAG TCGACCGGTC 1260
ATGATCATCG CAGAATTCAT GGAGAATGGC GCTCTGGATT CTTTCCTCAG GCAAAATGAT 1320
GGACAGTTCA CGGTGATCCA GCTGGTAGGG ATGCTCAGGG GCATCGCCGC AGGGATGAAG 1380
TACCTGGCTG AGATGAACTA TGTGCACCGG GACCTGGCTG CTAGAAACAT TCTTGTCAAC 1440
AGTAACCTGG TGTGCAAGGT GTCTGACTTT GGCCTTTCCC GCTACCTCCA GGATGATACC 1500
TCAGATCCCA CCTATACCAG CTCCTTGGGA GGGAAGATCC CCGTGAGATG GACAGCTCCG 1560
GAGGCTATCG CCTACCGCAA GTTCACGTCT GCCAGCGACG TCTGGAGCTA CGGGATCGTC 1620
ATGTGGGAAG TCATGTCATT TGGAGAGAGA CCCTACTGGG ATATGTCCAA CCAAGATGTC 1680
ATCAATGCCA TTGAGCAGGA CTACCGTCTA CCCCCACCCA TGGACTGCCC AGCTGCTCTA 1740
CATCAGCTCA TGCTGGACTG TTGGCAGAAA GACCGTAACA GCCGGCCCCG CTTTGCGGAG 1800
ATTGTCAACA CCCTGGACAA GATGATCCGG AACCCGGCAA GTCTTAAGAC TGTGGCAACC 1860
ATCACCGCCG TGCCTTCCCA GCCCCTGCTA GACCGCTCCA TCCCAGACTT CACGGCCTTT 1920
ACCACCGTGG ATGACTGGCT CAGTGCCATC AAAATGGTCC AGTACAGGGA CAGCTTCCTC 1980
ACCGCCGGCT TCACCTCCCT CCAGCTGGTC ACCCAGATGA CATCAGAAGA CCTCCTGAGA 2040
ATAGGGGTCA CCTTGGCAGG TCATCAGAAG AAGATCCTGA ACAGCATTCA TTCTATGAGG 2100
GTCCAGATGA ATCAGTCACC AACGGCAATG GCATGA 2136
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 346   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  405
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi++e+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 406   NIIRLEGVVTKSRPVMIIAEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  465
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 466   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  525
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 526   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  585
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 586   DCWQKDRNSRPRFAEIVNTL  605
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIIAE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNSR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00006
EKS-ANC-00005
EKS-BOT-00012
EKS-CAJ-00006
EKS-CAF-00006
EKS-CAP-00013
EKS-DAR-00004
EKS-FEC-00003
EKS-GOG-00005
EKS-HOS-00007
EKS-ICT-00005
EKS-LOA-00006
EKS-MAM-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORC-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-POA-00004
EKS-RAN-00006
EKS-SAH-00005
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0048593; P:camera-type eye morphogenesis
GO:0031589; P:cell-substrate adhesion
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0021631; P:optic nerve morphogenesis
GO:0051965; P:positive regulation of synapse assembly
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013