EKS-EQC-00184
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00184
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK427.22.5E-1281209209
StatusUnreviewed
Ensembl ProteinENSECAP00000012271
UniProt AccessionF7DNN7;
Protein Name
Protein Synonyms/Alias
Gene NameCASK
Gene Synonyms/Alias CASK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000013894ENSECAP00000012269ENSECAT00000015283
ENSECAG00000013894ENSECAP00000012271ENSECAT00000015285
OrganismEquus caballus
Functional Description
Protein Length859
Protein Sequence
(FASTA)
MLKHPHIVEL LETYSSDGML YMVFEFMDGA DLCFEIVKRA DAGFVYSEAV ASHYMRQILE 60
ALRYCHDNNI IHRDVKPHCV LLASKENSAP VKLGGFGVAI QLGESGLVAG GRVGTPHFMA 120
PEVVKREPYG KPVDVWGCGV ILFILLSGCL PFYGTKERLF EGIIKGKYKM NPRQWSHISE 180
SAKDLVRRML MLDPAERITV YEALNHPWLK ERDRYAYKIH LPETVEQLRK FNARRKLKGA 240
VLAAVSSHKF NSFYGDPPEE LPDFSEDPTS SGLLAAERAV SQVLDSLEEI HALTDCSEKD 300
LDFLHSVFQD QHLHTLLDLY DKINTKSSPQ IRNPPSDAVQ RAKEVLEEIS CYPENNDAKE 360
LKRILTQPHF MALLQTHDVV AHEVYSDEAL RVTPPPTSPY LNGDSPESAN GDMDMENVTR 420
VRLVQFQKNT DEPMGITLKM NELNHCIVAR IMHGGMIHRQ GTLHVGDEIR EINGISVANQ 480
TVEQLQKMLR EMRGSITFKI VPSYRTQSSS CERDSPSTSR QSPANGHSST NNSVSDLPST 540
TQPKGRQIYV RAQFEYDPAK DDLIPCKEAG IRFRVGDIIQ IISKDDHNWW QGKLENSKNG 600
TAGLIPSPEL QEWRVACIAM EKTKQEQQAS CTWFGKKKKQ YKDKYLAKHN AVFDQLDLVT 660
YEEVVKLPAF KRKTLVLLGA HGVGRRHIKN TLITKHPDRF AYPIPHTTRP PKKDEENGKN 720
YYFVSHDQMM QDISNNEYLE YGSHEDAMYG TKLETIRKIH EQGLIAILDV EPQALKVLRT 780
AEFAPFVVFI AAPTITPGLN EDESLQRLQK ESDILQRTYA HYFDLTIINN EIDETIRHLE 840
EAVELVCTAP QWVPVSWVY 859
Nucleotide Sequence
(FASTA)
ATGCTGAAAC ATCCCCACAT TGTAGAATTA TTGGAGACAT ATAGCTCAGA TGGAATGCTT 60
TACATGGTTT TTGAATTTAT GGATGGAGCG GATCTGTGTT TTGAAATCGT AAAGCGAGCT 120
GACGCTGGTT TTGTATACAG TGAAGCTGTA GCCAGTCATT ACATGAGACA GATACTGGAA 180
GCTCTGCGCT ATTGTCATGA TAATAACATA ATTCACAGGG ATGTGAAGCC CCACTGTGTT 240
CTCCTCGCCT CAAAGGAAAA CTCAGCACCT GTTAAACTTG GGGGCTTTGG GGTAGCTATT 300
CAGTTAGGGG AGTCTGGACT GGTAGCTGGA GGACGTGTTG GAACACCTCA TTTTATGGCC 360
CCAGAAGTTG TCAAAAGAGA GCCTTATGGA AAACCTGTAG ATGTCTGGGG TTGCGGTGTC 420
ATCCTTTTTA TCCTGCTAAG TGGTTGTTTG CCTTTTTATG GAACCAAGGA AAGATTGTTT 480
GAAGGCATTA TTAAAGGAAA ATATAAGATG AATCCAAGGC AGTGGAGCCA CATCTCTGAA 540
AGTGCCAAAG ACCTCGTACG TCGCATGCTG ATGCTGGATC CAGCAGAAAG GATCACTGTT 600
TATGAAGCAC TGAATCACCC ATGGCTTAAG GAACGGGATC GTTATGCCTA CAAGATTCAT 660
CTTCCAGAAA CAGTAGAGCA ACTGAGGAAA TTCAATGCAA GGAGGAAACT AAAGGGTGCA 720
GTACTAGCAG CTGTGTCAAG TCACAAGTTT AACTCATTCT ACGGGGATCC CCCTGAAGAG 780
TTGCCAGATT TCTCCGAAGA CCCTACCTCC TCAGGACTTC TAGCAGCAGA AAGAGCAGTC 840
TCACAGGTGC TGGACAGCCT GGAAGAAATT CATGCCCTTA CAGACTGCAG TGAAAAGGAC 900
TTAGATTTTC TACACAGTGT TTTCCAGGAT CAGCATCTTC ATACACTATT AGATCTGTAT 960
GACAAAATTA ATACAAAGTC CTCACCACAG ATCAGGAACC CTCCAAGTGA TGCAGTACAG 1020
AGAGCCAAAG AGGTATTGGA AGAAATTTCA TGTTACCCTG AGAACAATGA TGCAAAGGAA 1080
CTAAAGCGTA TTTTAACACA ACCTCATTTC ATGGCCTTAC TTCAGACTCA TGATGTAGTG 1140
GCACATGAAG TTTACAGTGA TGAAGCATTG AGGGTCACAC CTCCTCCCAC CTCTCCCTAT 1200
TTAAATGGTG ATTCTCCAGA AAGCGCAAAC GGAGACATGG ATATGGAGAA CGTGACCAGA 1260
GTTCGGCTGG TCCAGTTCCA AAAGAACACA GATGAACCAA TGGGAATCAC TTTAAAAATG 1320
AATGAGCTAA ATCATTGTAT TGTTGCGAGA ATTATGCATG GAGGCATGAT TCACAGGCAA 1380
GGTACACTTC ATGTTGGAGA TGAAATTCGA GAAATCAATG GCATAAGTGT GGCTAACCAA 1440
ACAGTGGAAC AGCTGCAAAA AATGCTTCGG GAAATGCGGG GGAGTATTAC CTTCAAGATC 1500
GTGCCAAGTT ACCGCACTCA GTCATCGTCC TGTGAGAGAG ATTCCCCCTC CACTTCCAGA 1560
CAGTCCCCAG CTAATGGTCA TAGCAGCACT AACAATTCTG TTTCGGACTT GCCATCAACT 1620
ACCCAACCAA AAGGACGACA GATCTATGTA AGAGCACAAT TTGAATATGA TCCAGCCAAG 1680
GATGACCTCA TCCCCTGCAA AGAAGCTGGC ATTCGATTCA GAGTTGGTGA CATTATCCAG 1740
ATTATTAGTA AGGATGATCA CAATTGGTGG CAGGGTAAAC TGGAAAACTC CAAAAATGGA 1800
ACTGCAGGTC TCATTCCTTC TCCTGAACTT CAGGAATGGC GAGTAGCTTG CATCGCCATG 1860
GAGAAGACCA AACAGGAGCA GCAGGCCAGC TGTACTTGGT TTGGCAAGAA AAAGAAGCAG 1920
TACAAAGATA AATATTTGGC AAAGCACAAT GCAGTGTTTG ATCAATTAGA TCTTGTTACA 1980
TATGAAGAAG TAGTAAAACT GCCAGCGTTC AAAAGGAAAA CACTAGTCTT ATTAGGTGCG 2040
CATGGTGTTG GGAGAAGACA CATAAAAAAC ACCCTCATCA CCAAGCACCC GGACCGGTTT 2100
GCATACCCTA TTCCACATAC AACCAGACCT CCAAAGAAAG ATGAAGAAAA TGGAAAGAAT 2160
TATTACTTTG TATCTCATGA CCAAATGATG CAAGACATCT CTAATAATGA GTACTTGGAG 2220
TATGGCAGCC ACGAGGATGC GATGTACGGG ACAAAACTGG AGACCATCCG GAAGATCCAT 2280
GAGCAGGGCC TGATTGCAAT ACTGGATGTG GAGCCTCAGG CGCTGAAGGT CCTAAGAACT 2340
GCAGAGTTCG CTCCTTTTGT TGTTTTTATT GCTGCACCGA CTATTACTCC AGGTTTAAAT 2400
GAGGATGAAT CTCTTCAGCG TCTGCAGAAG GAGTCTGATA TCTTACAGAG AACATACGCA 2460
CACTACTTCG ATCTCACAAT TATCAACAAT GAAATTGATG AGACAATCAG ACATCTGGAG 2520
GAAGCCGTCG AGCTCGTGTG CACAGCCCCG CAGTGGGTCC CCGTCTCCTG GGTCTATTAG 2580
Domain Profile
S: 57    mlkhpyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqile  116
         mlkhp+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqile
Q: 1     MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILE  60
         8***********************************************************
S: 117   alrychdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfm  176
         alrychdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfm
Q: 61    ALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFM  119
         ********************************************.***************
S: 177   apevvkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssis  236
         apevvkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+is
Q: 120   APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHIS  179
         ************************************************************
S: 237   esakdlvrrmlaadpakrisvkealnhewl  266
         esakdlvrrml++dpa+ri+v+ealnh+wl
Q: 180   ESAKDLVRRMLMLDPAERITVYEALNHPWL  209
         *****************************7
Domain Sequence
(FASTA)
MLKHPHIVEL LETYSSDGML YMVFEFMDGA DLCFEIVKRA DAGFVYSEAV ASHYMRQILE 60
ALRYCHDNNI IHRDVKPHCV LLASKENSAP VKLGGFGVAI QLGESGLVAG GRVGTPHFMA 120
PEVVKREPYG KPVDVWGCGV ILFILLSGCL PFYGTKERLF EGIIKGKYKM NPRQWSHISE 180
SAKDLVRRML MLDPAERITV YEALNHPWL 209
KeywordComplete proteome; Reference proteome; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-ANC-00182
EKS-BOT-00189
EKS-CAE-00177
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DAR-00489
EKS-DRM-00100
EKS-FEC-00177
EKS-GAM-00106
EKS-GAG-00161
EKS-GAA-00233
EKS-GOG-00185
EKS-HOS-00194
EKS-LAC-00199
EKS-LOA-00185
EKS-MAM-00189
EKS-MEG-00146
EKS-MOD-00187
EKS-MUM-00191
EKS-MUP-00191
EKS-MYL-00194
EKS-NOL-00178
EKS-ORN-00241
EKS-ORA-00167
EKS-ORC-00172
EKS-ORL-00225
EKS-OTG-00195
EKS-PAT-00179
EKS-PES-00164
EKS-POA-00183
EKS-SAH-00181
EKS-SUS-00162
EKS-TAG-00214
EKS-TAR-00246
EKS-TEN-00240
EKS-XET-00219
EKS-XIM-00236
Gene Ontology
GO:0005604; C:basement membrane
GO:0016323; C:basolateral plasma membrane
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005652; C:nuclear lamina
GO:0016363; C:nuclear matrix
GO:0005730; C:nucleolus
GO:0045202; C:synapse
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0070509; P:calcium ion import
GO:0001953; P:negative regulation of cell-matrix adhesion
GO:0090288; P:negative regulation of cellular response to growth factor stimulus
GO:0010839; P:negative regulation of keratinocyte proliferation
GO:0061045; P:negative regulation of wound healing
GO:0090280; P:positive regulation of calcium ion import
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013