EKS-EQC-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.3	2.6E-168	479	755	277

Status

Unreviewed

Ensembl Protein

ENSECAP00000012645

UniProt Accession

F7C9J5;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000013960	ENSECAP00000012734	ENSECAT00000015803
ENSECAG00000013960	ENSECAP00000012645	ENSECAT00000015704
ENSECAG00000013960	ENSECAP00000012770	ENSECAT00000015845

Organism

Equus caballus

Functional Description

Protein Length

785

Protein Sequence
(FASTA)

MVSWGRFICL VVVTMATLSL ARPSFNLVED TTLEPEEPPT KYQISQPEVY VAAPGESLEL 60

RCLLRDAAMI SWTKDGVHLG PSNRTVLIGE YLQIKGATPR DSGLYACTAA RTVDSETVYF 120

MVNVTDAISS GDDEDDTDGS EDFVSESSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP 180

AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI 240

NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK 300

YGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI SFHSAWLTVL 360

PAPVREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVILCRM KTTTKKPDFS SQPAVHKLTK 420

RIPLRRQVSA ESSSSMNSNT PLVRITTRLS STADTPMLAG VSEYELPEDP KWEFPRDKLT 480

LGKPLGEGCF GQVVMAEAVG IDKEKPKEAV TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG 540

KHKNIINLLG ACTQDGPLYV IVEYASKGNL REYLRARRPP GMEYSYDINR VPEEQMTFKD 600

LVSCTYQLAR GMEYLASQKC IHRDLAARNV LVTENNVMKI ADFGLARDIN NIDYYKKTTN 660

GRLPVKWMAP EALFDRVYTH QSDVWSFGVL MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM 720

DKPANCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRILT LTTNEEYLDL SQPLEPYSPC 780

YPDPR 785

Nucleotide Sequence
(FASTA)

ATGGTCAGCT GGGGTCGCTT CATCTGCCTG GTTGTGGTCA CCATGGCAAC CTTGTCCCTG 60

GCCCGGCCCT CCTTCAATTT AGTTGAGGAT ACCACATTAG AGCCGGAAGA GCCACCAACC 120

AAATACCAAA TCTCCCAACC AGAAGTGTAC GTGGCTGCGC CCGGGGAATC GCTAGAGTTG 180

CGCTGCCTGT TGAGAGATGC CGCCATGATC AGTTGGACTA AGGATGGGGT ACACTTGGGG 240

CCCAGCAATA GGACAGTGCT TATTGGGGAG TACTTGCAGA TAAAAGGTGC CACGCCTAGA 300

GACTCCGGCC TCTATGCTTG TACTGCTGCT AGGACCGTAG ACAGTGAGAC TGTCTACTTC 360

ATGGTCAATG TCACAGATGC CATCTCATCC GGAGATGACG AGGACGACAC AGATGGCTCC 420

GAGGATTTTG TCAGTGAGAG CAGTAACAAC AAGAGAGCAC CATACTGGAC CAACACAGAA 480

AAGATGGAAA AACGGCTGCA TGCCGTCCCC GCAGCCAATA CTGTCAAGTT TCGCTGTCCA 540

GCTGGGGGGA ATCCAACACC AACTATGAGG TGGCTGAAAA ACGGGAAAGA ATTTAAGCAG 600

GAGCATCGCA TCGGAGGATA TAAGGTACGA AACCAGCACT GGAGCCTTAT TATGGAAAGC 660

GTGGTCCCAT CCGACAAAGG CAATTACACC TGTGTGGTGG AGAATGAGTA CGGGTCCATC 720

AATCACACGT ACCACCTCGA TGTTGTTGAG CGATCACCAC ACCGGCCCAT CCTCCAAGCT 780

GGACTGCCAG CAAATGCCTC CACCGTGGTG GGAGGCGATG TGGAGTTTGT CTGCAAAGTT 840

TACAGCGATG CCCAGCCCCA CATCCAGTGG ATCAAACATG TGGAAAAGAA CGGCAGTAAA 900

TACGGGCCCG ACGGGCTGCC CTACCTCAAA GTTCTGAAGG CCGCCGGTGT TAATACCACG 960

GACAAAGAGA TTGAGGTTCT CTATATTCGG AATGTAACTT TTGAGGATGC TGGGGAATAT 1020

ACGTGCTTGG CGGGTAATTC TATTGGGATC TCCTTTCACT CTGCATGGTT GACAGTTCTG 1080

CCAGCTCCCG TAAGAGAAAA GGAGATTACA GCTTCCCCAG ACTACCTGGA GATAGCCATT 1140

TACTGCATAG GGGTCTTCTT AATTGCCTGT ATGGTGGTGA CGGTCATCCT GTGCCGAATG 1200

AAGACCACGA CCAAGAAGCC AGACTTCAGC AGCCAGCCGG CTGTGCACAA GCTGACCAAG 1260

CGCATCCCCT TGCGGAGACA GGTTTCTGCC GAGTCCAGCT CCTCCATGAA CTCCAACACC 1320

CCACTGGTGA GGATAACAAC GCGCCTCTCC TCGACAGCAG ACACCCCCAT GCTGGCGGGG 1380

GTCTCCGAGT ATGAACTGCC AGAAGATCCC AAATGGGAGT TTCCGAGAGA TAAGCTGACG 1440

CTGGGCAAAC CCCTGGGGGA AGGTTGCTTT GGGCAAGTGG TCATGGCTGA AGCAGTGGGA 1500

ATCGACAAAG AGAAGCCCAA GGAAGCAGTC ACTGTGGCCG TGAAGATGTT GAAAGATGAT 1560

GCCACGGAGA AGGACCTTTC TGATCTGGTG TCAGAGATGG AGATGATGAA AATGATTGGA 1620

AAACACAAAA ACATCATAAA TCTCCTTGGA GCCTGTACTC AGGATGGACC ACTCTACGTC 1680

ATAGTTGAGT ATGCCTCGAA GGGTAACCTC CGTGAGTACC TCCGAGCCCG GAGGCCGCCT 1740

GGGATGGAGT ACTCCTATGA CATTAACCGC GTTCCCGAGG AGCAGATGAC TTTCAAAGAC 1800

TTGGTGTCAT GCACCTACCA GCTGGCCAGA GGCATGGAGT ACCTGGCTTC CCAAAAATGT 1860

ATTCATCGAG ATTTAGCAGC CAGAAATGTT TTGGTAACAG AAAACAATGT GATGAAAATA 1920

GCAGACTTTG GACTGGCCAG AGATATCAAC AATATAGACT ATTACAAAAA GACCACAAAT 1980

GGGCGACTTC CGGTCAAGTG GATGGCTCCA GAAGCCCTTT TTGATAGAGT GTACACCCAT 2040

CAGAGTGATG TCTGGTCCTT CGGGGTGTTG ATGTGGGAGA TCTTCACTTT AGGGGGCTCG 2100

CCTTACCCAG GGATTCCCGT GGAGGAACTT TTTAAGCTGC TTAAGGAAGG ACACAGGATG 2160

GATAAGCCGG CAAACTGCAC CAACGAACTG TACATGATGA TGAGGGACTG TTGGCATGCA 2220

GTGCCCTCCC AGAGGCCGAC GTTCAAGCAG TTGGTGGAAG ACTTGGACCG AATTCTCACT 2280

CTCACGACCA ATGAGGAATA CTTGGACCTC AGTCAGCCTC TCGAACCGTA TTCACCTTGT 2340

TATCCTGACC CAAGATGA 2358

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dk+k+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 479   LTLGKPLGEGCFGQVVMAEAVGIDKEKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  538

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 539   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  598

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 599   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  658

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 659   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  718

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 719   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  755

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0009986	; C:cell surface
GO:0031012	; C:extracellular matrix
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0001525	; P:angiogenesis
GO:0007409	; P:axonogenesis
GO:0030282	; P:bone mineralization
GO:0060349	; P:bone morphogenesis
GO:0060667	; P:branch elongation involved in salivary gland morphogenesis
GO:0060670	; P:branching involved in labyrinthine layer morphogenesis
GO:0048755	; P:branching morphogenesis of a nerve
GO:0060449	; P:bud elongation involved in lung branching
GO:0045165	; P:cell fate commitment
GO:0048557	; P:embryonic digestive tract morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0061031	; P:endodermal digestive tract morphogenesis
GO:0060664	; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595	; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069	; P:hair follicle morphogenesis
GO:0032808	; P:lacrimal gland development
GO:0060601	; P:lateral sprouting from an epithelium
GO:0070307	; P:lens fiber cell development
GO:0060174	; P:limb bud formation
GO:0048286	; P:lung alveolus development
GO:0060463	; P:lung lobe morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0060615	; P:mammary gland bud formation
GO:0003149	; P:membranous septum morphogenesis
GO:0060915	; P:mesenchymal cell differentiation involved in lung development
GO:0060916	; P:mesenchymal cell proliferation involved in lung development
GO:0030901	; P:midbrain development
GO:0035264	; P:multicellular organism growth
GO:0008285	; P:negative regulation of cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528	; P:neuromuscular junction development
GO:0042476	; P:odontogenesis
GO:0035265	; P:organ growth
GO:0030916	; P:otic vesicle formation
GO:0003148	; P:outflow tract septum morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0051781	; P:positive regulation of cell division
GO:0060501	; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0010518	; P:positive regulation of phospholipase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791	; P:post-embryonic development
GO:0060527	; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523	; P:prostate epithelial cord elongation
GO:0046777	; P:protein autophosphorylation
GO:0060687	; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453	; P:regulation of cell fate commitment
GO:0040036	; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014	; P:regulation of multicellular organism growth
GO:0051150	; P:regulation of smooth muscle cell differentiation
GO:0008589	; P:regulation of smoothened signaling pathway
GO:0060529	; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489	; P:synaptic vesicle transport
GO:0001657	; P:ureteric bud development
GO:0055010	; P:ventricular cardiac muscle tissue morphogenesis

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013