EKS-EQC-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	426.6	4.7E-128	3	271	269

Status

Unreviewed

Ensembl Protein

ENSECAP00000012557

UniProt Accession

F7DNE5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000014175	ENSECAP00000012673	ENSECAT00000015735
ENSECAG00000014175	ENSECAP00000012557	ENSECAT00000015606

Organism

Equus caballus

Functional Description

Protein Length

323

Protein Sequence
(FASTA)

LSAAFDTKTG LRVAVKKLSR PFQSIIHAKR TYRELRLLKH MKHENVIGLL DVFTPARSLE 60

EFNDVYLVTH LMGADLNNIV KCQKLTDDHV QFLIYQILRG LKYIHSADII HRDLKPSNLA 120

VNEDCELKIL DFGLARHTDD EMTGYVATRW YRAPEIMLNW MHYNQTVDIW SVGCIMAELL 180

TGRTLFPGTD HIDQLKLILR LVGTPGAELL KKISSESARN YIQSLTQMPK MNFANVFIGA 240

NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE PVADPYDQSF ESRDLLIDEW 300

KSLTYDEVIS FVPPPLDQEE MES 323

Nucleotide Sequence
(FASTA)

CTTAGTGCTG CTTTTGACAC AAAAACTGGG TTACGTGTGG CAGTGAAGAA GCTATCCAGA 60

CCGTTTCAGT CCATTATTCA TGCCAAAAGG ACCTACAGAG AACTACGGTT ACTTAAACAC 120

ATGAAACATG AAAATGTGAT TGGTCTGTTG GATGTTTTTA CACCTGCAAG GTCTCTGGAG 180

GAATTCAATG ATGTGTATCT GGTGACCCAT CTCATGGGGG CAGATCTGAA CAACATTGTG 240

AAATGTCAGA AGCTTACAGA TGACCATGTT CAGTTTCTTA TCTACCAAAT TCTCCGAGGT 300

CTCAAGTATA TACATTCAGC CGACATAATT CACAGGGACC TAAAACCTAG TAATCTAGCT 360

GTGAATGAAG ACTGCGAGCT GAAGATCTTG GATTTTGGAC TGGCTCGACA TACAGATGAT 420

GAAATGACAG GCTATGTGGC CACTAGGTGG TACAGGGCTC CTGAGATCAT GCTGAACTGG 480

ATGCATTACA ACCAGACAGT TGATATTTGG TCGGTGGGAT GCATAATGGC GGAGCTGTTG 540

ACTGGAAGAA CGTTGTTTCC TGGCACAGAC CATATTGATC AGTTGAAGCT CATTTTAAGA 600

CTCGTTGGAA CCCCAGGGGC TGAGCTTTTG AAGAAAATCT CCTCAGAGTC TGCAAGAAAC 660

TACATTCAAT CTTTGACCCA GATGCCAAAG ATGAACTTTG CAAATGTATT TATTGGTGCC 720

AATCCCTTGG CTGTCGACTT GCTGGAGAAG ATGCTTGTGT TGGACTCAGA TAAGAGGATT 780

ACAGCAGCAC AAGCCCTTGC GCATGCCTAC TTTGCTCAGT ACCACGATCC TGACGATGAA 840

CCAGTGGCTG ATCCTTACGA TCAGTCCTTT GAAAGCAGGG ACCTCCTTAT AGATGAATGG 900

AAAAGCCTGA CCTATGATGA AGTCATCAGC TTTGTGCCAC CACCCCTTGA CCAAGAAGAG 960

ATGGAATCCT GA 972

Domain Profile

S: 17    savdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpeeeleel  76

         +a+d++t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+i lldvftp+++lee+

Q: 3     AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEF  62

         6899********************************************************

S: 77    kdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNllvn  136

         +dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hsa++iHrDlKPsNl+vn

Q: 63    NDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN  122

         ************************************************************

S: 137   edcelkildFGlarsadkekekklteyvatrwYraPeillslkeytkavDiWsvGCIlaE  196

         edcelkildFGlar++d+e    +t+yvatrwYraPei+l++++y+++vDiWsvGCI+aE

Q: 123   EDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE  178

         ******************9....*************************************

S: 197   lltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdfeelfp  256

         lltg++lfpg+d+idql++il+++gtp +e lkki+se+arnyi+sl++++k++f+++f

Q: 179   LLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFI  238

         ************************************************************

S: 257   kaseealdLleklLvldpdkRisveeaLehpYl  289

          a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 239   GANPLAVDLLEKMLVLDSDKRITAAQALAHAYF  271

         *******************************96

Domain Sequence
(FASTA)

AAFDTKTGLR VAVKKLSRPF QSIIHAKRTY RELRLLKHMK HENVIGLLDV FTPARSLEEF 60

NDVYLVTHLM GADLNNIVKC QKLTDDHVQF LIYQILRGLK YIHSADIIHR DLKPSNLAVN 120

EDCELKILDF GLARHTDDEM TGYVATRWYR APEIMLNWMH YNQTVDIWSV GCIMAELLTG 180

RTLFPGTDHI DQLKLILRLV GTPGAELLKK ISSESARNYI QSLTQMPKMN FANVFIGANP 240

LAVDLLEKML VLDSDKRITA AQALAHAYF 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0000922	; C:spindle pole
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0001525	; P:angiogenesis
GO:0000902	; P:cell morphogenesis
GO:0071363	; P:cellular response to growth factor stimulus
GO:0071479	; P:cellular response to ionizing radiation
GO:0002062	; P:chondrocyte differentiation
GO:0000077	; P:DNA damage checkpoint
GO:0019395	; P:fatty acid oxidation
GO:0006006	; P:glucose metabolic process
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0030316	; P:osteoclast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032495	; P:response to muramyl dipeptide
GO:0042770	; P:signal transduction in response to DNA damage
GO:0007519	; P:skeletal muscle tissue development
GO:0090400	; P:stress-induced premature senescence
GO:0051146	; P:striated muscle cell differentiation
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013